Dude same I was so mind blown and confused, but for me it's bc I never experienced any of the things they're talking about (aside from migraines, but those are from a disability) 😭
How does it feel to be a man the gender who gets all the shit from everyone for anything slightly wrong and who gets blamed for a large amount of problems
Hiya. Bloke here. Had breast cancer. For every 8000 women that get it, one bloke does. So yeah, lucky me. My cancer fed on estrogen. So I had an estrogen stopping drug. After they cut the cancer out, that is. The idea of the drug was to starve any cancer missed in the surgery. Took it for almost a year. Felt terrible. The drug filled my lungs up with blood clots. So yeah, lucky me again. Taken a year to get back to almost pre-cancer me. So I'm now cancer free. Yeah, lucky me! We are all the same and we are all unique. Cheers.
@@MacMcNurglemaybe you have something special that'll happen sometime in life and it was like "hey, ya know, I could kill you but I won't you're a special one"
@@ooooneeee The increase to an expected survival rate after ten years is 2.8%. So Sweet FA. But I was willing to take the risk as the side effects were described as minor and very rare. If I want that 2.8% boost to survival, I should be still on the medication but since I have had two severe reactions to pills with 'very rare' side affects, I'm being super cautious now. Thanks for asking.
I remember when I had my first appointment with an endocrinologist, I asked if hormones change your sexuality, and she told me no. In cases where it does change after starting HRT, she said it's probably from feeling more confident and like yourself and your perspective on life starts to change, you become more open and willing to explore and realize other aspects about yourself that you didn't know before because things like dysphoria are so heavy and prominent before it starts getting treated.
I realised I was attracted to men too, and it was what opened the door for my girl self. It took 2 or 3 years between saying "I'm bi (even pan)" and saying "Im a girl". But now that I'm under E (still recent) I really wanna go out with a guy. I perfectly know it's psychological, I'm looking for approval. From a man.
iirc testicle size also goes down for cis men who take T aswell cause the testes see there’s more sex hormone in their blood (E, Prog, or T) and so they atrophy cause they go like ‘yeah there’s enough hormone here i don’t need to work’ that’s also why it shrinks for us trans women and it’s why E monotherapy works and also why Prog also blocks T
It's called the HPG (hypothalamic-pituitary-gonadal) axis. I think it's actually the brain that detects that there's enough hormone present already and stops sending the hormonal signals (in this case, GnRH, FSH, and LH) that tell the testes to make/release more testosterone. If this continues for long enough, eventually the testicles lose function and shrink from disuse, because it's a "use it or lose it" sort of thing. Some of them work differently, but there are similar "negative feedback systems" for many other hormones, such as the HPA (hypothalamic-pituitary-adrenal) axis for cortisol, which works VERY similarly, and the adrenals can lose function and shrink in the same way.
@@Nejove the estradiol will bind to the estrogen receptors in the hypothalamus to make it secrete less or no GnRH. I think you mean the HPTA, hypothalamus pituitary testicular axis.
@@qwertasdf5044 That's how I thought it worked with estradiol and the hypothalamus, but I went general and just said "brain" because I wasn't sure if I had all of the details right. The hypothalamus and pituitary are both in the brain, and less/no GnRH also means less/no FSH and LH, so everything I said was still accurate. And I've never seen it referred to as the HPTA versus the HPG axis, but maybe there are multiple names for it that are used by different people. HPG axis is a general term that applies to both AMAB and AFAB people, because "gonads" is a general term that can refer to ovaries OR testes.
so steroid shrinks testicles, estrogen shrinks testicles, testosterone shrinks testicles. what doesnt shrink testicles as this point? poor baIIs can't get a break 😅
As a trans woman who's been on HRT for over 3½ years, I can definitely relate. I'm in the U.S. and my doctor never told me about implants for HRT. When I had my consult back in 2020, the good doctor gave me the options of pills, patches, or injections. I've been on the pills since day one. There was a time when I was six months in and I asked my doctor about switching my estradiol from pills to injections, but she felt no need to do that because my E was already in the cis female range at that point. My testosterone has been nuked for a long time now, such that it won't show up in a blood test at all. This whole time, I've noticed breast growth, softer skin, smaller testes, some spider veins around my ankles, brighter eye color, even some period-like symptoms. Obviously, I don't bleed downstairs for five days a month, but the other stuff that comes with periods (cramps, bloating, mood swings, chocolate cravings, etc.) is there. Body hair now grows slower for me. The same couldn't quite be said for my facial hair, but I've also had laser hair removal done. Still waiting for fat redistribution to the right places, though. My mood is much better overall. I still have bad days, but my baseline is higher than it was when I ran on testosterone. Highs are higher and lows are lower. I cry a lot more than I did before, both for sadness and joy. I was far angrier on T and I always thought that was all guys and mascs ever felt. But I've long since met a variety of other trans+ people, including trans mascs. And it seems to mainly be REPRESSED transfems who experience the anger and depression when running on T. Turns out many cis men and trans mascs actually LIKE how testosterone makes them feel. My precious estradiol makes them feel like shit! I can't salute the general quite like I used to. I still can, though, just not spontaneously. It has to be induced. Before I transitioned, I masqueraded as a straight guy. Since starting HRT, I turned out to be a lesbian. I know some girls who've been transitioning longer than me (even dated one of them), and they were surprised that I never displayed any interest in guys at all. By the time I was coming up on two years of HRT, I started dating another trans girl. She's pansexual and was always shocked at how I'd never experienced sexy time before we dated. She was also baffled as to how I've never so much as looked at a guy. She and many other girls I know turned out to be bi or pan after transitioning. One woman I know kept telling me I'd develop interest in men, but that's never gonna happen for me. Maybe it's because she's a Boomer who transitioned under the old Harry Benjamin rules. Prior to the WPATH reformation in 2011, there was this diagnostic scale that Dr. Harry Benjamin (a German endocrinologist and early advocate for trans people) created. It was quite limiting, though. There were six tiers that Dr. Benjamin placed his patients on based on their level of dysphoria and misery. If you didn't land on Tier 5 or 6, known as "true transsexual" (that was the language used back then), you were usually considered a fake or crossdresser and denied treatment. To land on those higher tiers, you had to have known you were trans from childhood, have intense physical dysphoria, demand medical transition, and have lived for at least a year as your true gender without hormone therapy. You also had to be attracted to members of your assigned sex. Dr. Benjamin thought that transition had to make you straight, not gay, bi, or pan. If I'd transitioned before 2011, I'd have had to lie about my orientation and have some guy pose as my boyfriend. I would have risked losing my estrogen for being a lesbian or not dressing "feminine enough". Trans men would risk losing their testosterone if they didn't seem "manly enough". Thankfully, those old rules were scrapped when the WPATH released a whole new standards of care in 2011 (this time, with input from actual trans people). They switched to focusing on specific individual symptoms and divorced gender identity from sexual orientation altogether.
Thank you for your testimony and all this historical explanation. Pretty interesting. Really thank you. As for me I considered my self a lesbian for a long time even though I knew I could sometimes be attracted to men. Now I'm still early in my hrt, but I'm not so definitive about anything anymore. (But still think Im a huge lesbian deep in my heart, because " _I knew I was a lesbian before I knew girls like me could be_ ")
I've been on hrt since early January and I've definitely felt my sexuality change, because i feel more comfortable and confident and am able to be attracted to other people for the first time in years. I'm also madly in love with a guy, we're hanging out tomorrow, but i think he's clueless about how i feel 😅 Anyway yea, i met a girl on a trip last weekend. While we were talking one time, I felt like I was melting cause she's just so pretty... And when she asked me for my phone number I felt like an excited school girl Before hrt, i felt no attraction towards anyone, i started to think i was asexual and aromantic. But no, I just really hated myself.
Interesting. I'm aeroace myself and I had a fascination with my sisters clothes when I was growing up. Pretty sure I'm good with how I am, but it does make me wonder if I'm not even aware of things myself and if doing HRT would cause me to learn more about myself.
Cool fact on the implants: they're also used to treat certain kinds of cancer (though I don't know what specifically). I used to have a customer who had one of those E tablets implanted in a fold of skin on his arm as part of his cancer treatment.
AFAIK, it probably is endometrial cancer. Probably not E, but rather progesterone, which inhibits endometrial cancer, for reasons of periods. Either that or it was a SERM for breast cancer, but I doubt they make those into implants. Cyproterone acetate, an antiandrogen, is also used for prostate cancer, btw.
@@pedroff_1 I'm fairly sure he was a cis man, so the first one would be unlikely, but it very well could've been an antiandrogen for prostate cancer or something. I didn't know exactly what it was at the time and it was many years ago now that I knew him. I just know that it was some form of slow release chemical that they had put into a fold of skin on his arm and that it was something that made me immediately think "huh, that's used in HRT."
As a trans man I don't feel like I'm getting a worse deal on orgasms because instead of having to spend 2 hours trying to have it happen with a tiny little bead, things down there have changed into something easier to target, and I can have it easily and my body doesn't seem to be actively fighting against it. I had a very difficult time with it before. So I don't think anyone's getting a worse deal, it's entirely about what suits you more.
After a bit over 3 years, I noticed my dark brown/black eyes turned a noticeably lighter dark brown after hrt, my eyes are absolutely more almond shaped and my face looks completely different. I don't think I could overstate the changes, they've been immeasurable and far beyond anything I expected after hearing other people talk about HRT. My body is completely different, I jiggle *everywhere*, I actually have a female-typical waist to hip ratio now and way bigger boobs than i ever expected as well. Like my hips go crazy dumb. My hair also used to be so much curlier, now its a lot straighter, silkier, still curly but much more manageable, and my super thick eyebrows are much thinner as well. Orgasms are exactly as described, much longer, more pleasurable, full body experiences, and I can have 2 or 3 in a row, especially when the progesterone is hitting like a truck. After hearing so many people downplaying the effects of HRT and me being scared of the fearmongering, it has given me so many drastic changes that I consider it a modern miracle. Oh, and people of all sorts want to rail me like all the time now.
As a closeted trans girl, I have been subbed to you for a little while now. Love the type of content ya create. I'm in my early 30's it's time to let my inner-girl whos trapped finally out this year. You encourage to come out to my close improv community little by little. Thanks icky.
One of the weirder effects that I've experienced was the introduction of a "menstrual cycle" of sorts. Now, uh, technically speaking. It's not menstruating because there's, y'know, the lack of a uterus, and thus a lack of a uterine lining to shed. So there's no actual menstruation happening. BUT! The body will process the estrogen and prep you for shedding the lining (because the body doesn't know what it does and does not have, other than what hormones tell it), causing pre-menstrual syndrome (PMS) including headaches, nausea, soreness in the breast, and abdominal cramps. It was the first major effect that I got hit with after starting estrogen and spiro, and that was a weird experience. I thought I was sick, until I went to the doctor and they told me that it'd be a monthly thing.
As an Intersex person, I have had periods since I was in Middle School, but having Hyperestrogenism has caused my periods to be even more noticeable. I can even poop blood jelly sometimes.
I recently saw a great tweet about testosterone HRT "changing" your sexuality: "What T does is remove the dysphoria that makes you think being attracted to men would be straight." 100% accurate for me.
Just wanted to comment and say thanks to the both of you goobers, you helped me a lot with my body image issues and now I just feel more comfortable in general. Keep up the life changing work you queens
Been on E and spiro since may 2023. One thing I did not expect at all from E is that I have a hormonal cycle now! That's wild! It seems to be maybe 5 or 6 weeks cycle. My sex drive is changing and I'm delighted with the changes! My face finally no longer looks like my dad (nothing against my dad, just that I don't want to look like a boy anymore). And just this past week I've noticed my sweat smell has changed. It's lighter now, not as sharp smelling. E is letting my brain be me and whoo-buddy, I've never been more joyous or at peace.
An effect i almost never see mentioned is the skin changes - not softening (which started almost immediately for me) but the change in skin tone/colour. I thought I knew every possible effect of HRT but this one caught me off-guard. I was always warm toned, neutral undertone. About 3 months into HRT I discovered my foundations suddenly didn't match anymore, my skin had a new, yellowish-hue to it, and my veins looked green through my forearm instead of blue. Suddenly my skin had taken on a more olive-tone, matching my mum + sister instead of my dad. I love this change, just as i love every other change so far, but it surprised me a lot! I looked it up and found that yeah, that does happen - though I think most trans women will get fairer, but not necessarily have their tone/undertone change
Two months on E and Spiro, I noticed lots of the usual things. Probably what surprised me most was that after about a month my body odor changed, got sweeter.
Australia does have implants. We don't really do injections, and patches are uncommon, so they recommend implants for people on HRT for a long time since oral estrogen increases the liklihood of cancer. I'm getting mine in a few weeks and it should last a year or two!
Gentle fascia/lymphatic massage, light aerobic exercise and compression can help a lot with both spider and thrombose veins. People tend to see massage as something just for muscles, but gently massaging the surface area of your body can help a lot with drainage and circulation as well as promote collagen production for more spongy fascia (which promotes better blood flow) and better skin elasticity.
To anyone reading this, I cannot stress enough how much massaging lymph nodes (in the chin, neck, and underarm especially) can help you feel better if you are under the weather.
Definitely changes orgasms.. I've been doing injections for 6 months and I haven't seen more than two drops after an orgasm for months.! Plus it totally doesn't let you go all the way to a full orgasm, it's crazy. And yes, definitely alcohol tolerance, I can't have more than a light beer without getting dizzy! All good points here, thanks yall 👏
Atrophy of the downstairs can be difficult to deal with so for anyone transfem not interested in bottom surgery, perhaps research topical t and tadalifil bc fibrosis is a headache to combat retroactively, often with limited success.
After two years of using my girl cock regularly, it finally started to atrophy and my erections got painful. The pain has gone away as I picked up more usage again, but I'm looking forward to trying topical T cream i was prescribed to help with sex drive and being able to reach orgasm, because it can be pretty difficult and a fuss sometimes.
Would it be possible to use human chorionic gonadotropin combined with an anti androgen? The hCG will stimulate the testes to produce testoserone, but because of the competitive binding that an anti androgen provides, virilizatiion is minimized
@@qwertasdf5044 idrk bc there aren’t a lot of things I’ve read on that and always ask ur doctor but topical t doesn’t really raise systemic t significantly enough when ur applied correctly and I believe just formulated without a penetrant plus for those on monotherapy, it’s not nearly as expensive as the other two in combination. I didn’t even know about hcg tho so I’ll def read on it.
Something else I discovered after almost 8 years of HRT is , if you have a fore skin it can become fused . It happened to me and was very painful to peel it back a little bit at a time. Oh and hygiene is important to avoid yeast infections.
not me identifying as a lesbian and saying to myself ‘if i was a man id date other men’ and then suddenly realising i was a man. though i only date t4t right now because dysphoria makes me wanna square up to cis men and im basically pre-everything transition wise.
A lot of the HRT products that are implanted are really rough on the liver and heart, too, so if someone has a risk for blood pressure or heart issues then they wouldnt be able to go on the implants. So a lot of healthcare companies wont use them at all, due to the health risks.
Australian here, in the most backwards state (South Australia), we've only had informed consent for a year now. I mean it was legal for 3 years now but we only just got people who will do it. 3 of them. Am on Estradiol Valerate injections (just started 3 weeks ago). The implants have been available for a long time. None of these are covered by the Pharmaceutical Benefits Scheme (government subsidised), but like $100 for a vial that lasts 5 months. It's cheaper than spending $20 on patches every fortnight.
I don't take hrt, but I do take insulin. There's a similar implant for insulin (It lasts two years if I remember correctly), but the thought of how many surgeries it would require over the years turned me away. Though I definitely get the appeal of an implant, and I would really consider it if the time it lasts is extended enough.
"HRT doesn't change your sexuality" is misleading. It *does* change your sexuality, but not substantially the part that is gender & sex-specific attraction. E and T sexuality and attraction work and feel notably differently from one another. Its more accurate to say that, someone who already has the innate capacity to be attracted to say, men, but their T sexuality doesn't trigger that, while their E sexuality does trigger it because of how it'll make you attracted from different sources of inputs than what T sexuality does. It makes you see things differently, essentially.
Absolutely, never thought I would be interested on men, but after 3 years on HRT started to become more interested physically, so more Pan/Bisexual, although not romantically attracted to typical male energy/voice etc.
I disagree because even before I started transitioning to female, I felt I was always into men, and I always imagined myself in a relationship with a man as his girlfriend even before transition but I never dated because of this reason, and still have never dated, even though I am in transition to live as a woman. but yes, I definitely want a husband and maybe kids someday that would be an awesome life for me because I am a caregiver by nature, and a very nurturing individual
Maybe this is more so a T thing, bc I've seen other transmasc/FtM ppl say similar things online, but I will argue that HRT _shifted_ my sexuality. Not changed, was and am still bi, but I def have more of a preference for men and/or masculinity now 🤷🏻♂️ Idk, it's always weird to try to explain, especially as a nonbinary trans person
Im kinda new to this, so i would love to learn. How does nonbinary trans work? Do you take hormones to make your sexual characteristics less prominent? So your appearance is more in line of a nonbinary person?
@@qwertasdf5044 gender identity and gender expression are not the same thing and they don't have to line up. You can express and want (or feel like you are supposed) to look however you want and your gender is however you feel. Nb folks are trans cause transgender literally means change of gender from assigned one, which nb folks do. Transmasc/transfem folks are what you would usually describe as ftm mtf but instead they don't necessarily identify binary.
@@kul2130 ooh ofc, i thought that they said trans they were like going to a different gender like male/female, but going from assigned gender to different gender is also transgender. Thanks for the response.
@@qwertasdf5044 Yep, basically what @kul2130 said! Whether I were binary or nonbinary, I'd still be trans bc I don't identify with my gender assigned at birth. And to answer your first question about hormones, I'm taking T to get a more masculine appearance. Bc even tho I'm nonbinary, I'm also transmasc and would prefer the option to be able to pass/present as a guy. Hope that helps and offers some insight! :)
Most surprising effect of HRT on me: I started crying when watching those emotional scenes in Disney movies. Like, no one warned me about that one! Also, I would definitely say my sexuality shifted a bit. Purely sexual attraction to women was always there, but with men, before HRT, it was more of a demisexual thing. Now, I catch myself looking at a guys ass the way I was (and still am, who am I kidding) a girls ass. Also, didn't notice before HRT how some men just smell nice.
Can confirm, E implants are available in Australia, are cool, and last anywhere from 6-18 months depending on a few factors. Apparently people find that the longer you're on implants, the longer each new implant lasts when you need to get a new one put in, to a degree.
Talking about the eye color thing, that explains why I noticed my eyes dont look so bright anymore. When I was a kid I remember looking at my eyes very close in the mirror because they're hazel, people would tell me this but I didn't understand what it was so I wanted to see. My eyes were pretty bright and green brownish. Then a couple years ago I check them again and they seemed dulled and no where near as bright. I thought I was just like dead inside 😂
I have a friend in Australia who has an estrogen implant. That’s how I learned that it’s a possibility. Don’t think the US does it either because I’ve never heard of it here
Heya Icky, would you be down for making a sort of "shopping list" guide or suggestions for first going out and passing casually? Not something saying "you have to wear X", but more like "this kind of clothing will most likely work for you". I'm trans, and after 3 years of closeting I'm looking to start going out and passing, but it's been pretty hard finding everyday clothing that would work, without also being either (or both) over-the-top or nerve-racking.
As someone whos trans and bisexual there is, especially in our society, a difference in whether you date someone as a woman or as a man because we internalized these gender roles so much, that even if you reject those roles you will still subconsciously feel and be seen/treated different and you might for example not fit into the role of a man dating a woman but you might feel much more comfortable being a woman dating a woman etc. As a personal anecdote: Before I consciously realized I'm a woman I had a "lesbian phase" where I would consume a lot of lesbian romance movies and books (not in a gross sexualizing way) and I thought that was the most beautiful love ever because it was different than a man loving a woman.
I know a few friends that get the Estrogen implants. Making the body simulate the function of ovaries, pumping a lot of estrogen. BUT from what I've heard it puts estrogen at a high count and you're supposed to burn that number down slowly through the year (depending on the strength of the implant). Blood tests are necessary after several months to see how far you are from burning that number down and if it is around a certain number you'll have to go in for another implant, otherwise you might have until the next blood test appointment before the implant happens...this might vary from person to person and whichever place does the thing, perhaps...I'm not sure. Also, said friend is trying hard to see her partner in the UK during June....really hope it goes well.
ngl, finn is great, but I subbed to you because you actually try to bring out some good info....instead of the nonsense (yet funny, ngl) Finn does in their content. I love how different both of you are, and embrace it like a BFF-necklace does that we wore when we were 11. dont lie to me, you all did that. even if you didnt have friends (dw, neither did I) Sent this to my favorite friendly frienda all time, cause shes a fucking warrior imo going through this HRT as well. are you able to do a testosterone version as well? i know this isnt in your and finn's street, but I had meds since childhood that fucked up my hormones, and although not as heavy at HRT, the difference be there definitly... anyway great video!
Join us for the latest episode of "Icky and the Gremlin!" I just love the way you two interact, and I learn something new from every video you put out.
I haven't really noticed my eye shape changing, but then again, I hardly leave the house without makeup :/ But yeah, this totally answers the eye colour and spider vein thingy. I didn't know that was from HRT.
"now I'm dumb misogynistic and poor" -F1nn5ter
that was a crazy ending
just like me fr
How is F1nn poor?
Well he is from Birmingham
Estrogen effects are wild
me, a trans man who had an E dominated endocrine system for 18 years, hearing about the effects of E: that's insane
LITERALLY SAME
Dude same I was so mind blown and confused, but for me it's bc I never experienced any of the things they're talking about (aside from migraines, but those are from a disability) 😭
E dominated endocrine system😂
One way to put it
Me a trans man nb checking my leg where my spider veins used to be and they're not there
How does it feel to be a man the gender who gets all the shit from everyone for anything slightly wrong and who gets blamed for a large amount of problems
Last time I was this early I had natural testosterone running in my body. :/
only good im early comment
Hiya. Bloke here. Had breast cancer. For every 8000 women that get it, one bloke does. So yeah, lucky me. My cancer fed on estrogen. So I had an estrogen stopping drug. After they cut the cancer out, that is. The idea of the drug was to starve any cancer missed in the surgery. Took it for almost a year. Felt terrible. The drug filled my lungs up with blood clots. So yeah, lucky me again. Taken a year to get back to almost pre-cancer me. So I'm now cancer free. Yeah, lucky me! We are all the same and we are all unique. Cheers.
Hey mate, congratulations!!! Cancer is a fucked up piece of shit, and while it took its toll on you, I’m happy you are free!!!!
@@spacecat76 Thanks. It's crazt to me to think I am a cancer survivor. Cheers.
@@MacMcNurglemaybe you have something special that'll happen sometime in life and it was like "hey, ya know, I could kill you but I won't you're a special one"
Damn that sucks. Do you have to block estrogen for the rest of your life or was it only for that year?
@@ooooneeee The increase to an expected survival rate after ten years is 2.8%. So Sweet FA. But I was willing to take the risk as the side effects were described as minor and very rare. If I want that 2.8% boost to survival, I should be still on the medication but since I have had two severe reactions to pills with 'very rare' side affects, I'm being super cautious now. Thanks for asking.
Icky's hair looks so good omg 😭😭
finn needs a trim 💀
Truth ❤
@@julienmarcuse9023it's always been wild to me how fast finns hair seemed to grow but they're definitely in dire need of one yes 😭
Literally my dream hairstyle
I remember when I had my first appointment with an endocrinologist, I asked if hormones change your sexuality, and she told me no. In cases where it does change after starting HRT, she said it's probably from feeling more confident and like yourself and your perspective on life starts to change, you become more open and willing to explore and realize other aspects about yourself that you didn't know before because things like dysphoria are so heavy and prominent before it starts getting treated.
Amusingly... I had the whole "Wait... I like men too" before starting HRT.
@VhenRaTheRaptor Same lol I was questioning it and then after HRT it was clear
I realised I was attracted to men too, and it was what opened the door for my girl self. It took 2 or 3 years between saying "I'm bi (even pan)" and saying "Im a girl".
But now that I'm under E (still recent) I really wanna go out with a guy. I perfectly know it's psychological, I'm looking for approval. From a man.
The chemistry between those 2 is hilarious. 😂
Personally if I was F1nn I would be infuriated but that’s just me
If you are on the rly non bright side of the intelligence spectrum maybe.
iirc testicle size also goes down for cis men who take T aswell cause the testes see there’s more sex hormone in their blood (E, Prog, or T) and so they atrophy cause they go like ‘yeah there’s enough hormone here i don’t need to work’
that’s also why it shrinks for us trans women and it’s why E monotherapy works and also why Prog also blocks T
It's called the HPG (hypothalamic-pituitary-gonadal) axis. I think it's actually the brain that detects that there's enough hormone present already and stops sending the hormonal signals (in this case, GnRH, FSH, and LH) that tell the testes to make/release more testosterone. If this continues for long enough, eventually the testicles lose function and shrink from disuse, because it's a "use it or lose it" sort of thing.
Some of them work differently, but there are similar "negative feedback systems" for many other hormones, such as the HPA (hypothalamic-pituitary-adrenal) axis for cortisol, which works VERY similarly, and the adrenals can lose function and shrink in the same way.
@@Nejove the estradiol will bind to the estrogen receptors in the hypothalamus to make it secrete less or no GnRH.
I think you mean the HPTA, hypothalamus pituitary testicular axis.
@@qwertasdf5044 That's how I thought it worked with estradiol and the hypothalamus, but I went general and just said "brain" because I wasn't sure if I had all of the details right. The hypothalamus and pituitary are both in the brain, and less/no GnRH also means less/no FSH and LH, so everything I said was still accurate.
And I've never seen it referred to as the HPTA versus the HPG axis, but maybe there are multiple names for it that are used by different people. HPG axis is a general term that applies to both AMAB and AFAB people, because "gonads" is a general term that can refer to ovaries OR testes.
so steroid shrinks testicles, estrogen shrinks testicles, testosterone shrinks testicles. what doesnt shrink testicles as this point? poor baIIs can't get a break 😅
@@GrammeStudio LH and FSH don't
I’ve learned that the “downsides” of HRT for me aren’t really so bad. So uh… probably gonna ask my doctor about it next week.
Quite the journey. Have fun discovering yourself. Rooting for you!
glhf ^__^
hey if it fixes that hairline then go for it bro
@@xch00F Yeaahh fingers crossed about that too lol.
@@Rogers1977 finasteride can be a good supplement to HRT if your hair is a concern!
As a trans woman who's been on HRT for over 3½ years, I can definitely relate. I'm in the U.S. and my doctor never told me about implants for HRT. When I had my consult back in 2020, the good doctor gave me the options of pills, patches, or injections. I've been on the pills since day one. There was a time when I was six months in and I asked my doctor about switching my estradiol from pills to injections, but she felt no need to do that because my E was already in the cis female range at that point. My testosterone has been nuked for a long time now, such that it won't show up in a blood test at all. This whole time, I've noticed breast growth, softer skin, smaller testes, some spider veins around my ankles, brighter eye color, even some period-like symptoms. Obviously, I don't bleed downstairs for five days a month, but the other stuff that comes with periods (cramps, bloating, mood swings, chocolate cravings, etc.) is there. Body hair now grows slower for me. The same couldn't quite be said for my facial hair, but I've also had laser hair removal done. Still waiting for fat redistribution to the right places, though.
My mood is much better overall. I still have bad days, but my baseline is higher than it was when I ran on testosterone. Highs are higher and lows are lower. I cry a lot more than I did before, both for sadness and joy. I was far angrier on T and I always thought that was all guys and mascs ever felt. But I've long since met a variety of other trans+ people, including trans mascs. And it seems to mainly be REPRESSED transfems who experience the anger and depression when running on T. Turns out many cis men and trans mascs actually LIKE how testosterone makes them feel. My precious estradiol makes them feel like shit!
I can't salute the general quite like I used to. I still can, though, just not spontaneously. It has to be induced.
Before I transitioned, I masqueraded as a straight guy. Since starting HRT, I turned out to be a lesbian. I know some girls who've been transitioning longer than me (even dated one of them), and they were surprised that I never displayed any interest in guys at all. By the time I was coming up on two years of HRT, I started dating another trans girl. She's pansexual and was always shocked at how I'd never experienced sexy time before we dated. She was also baffled as to how I've never so much as looked at a guy. She and many other girls I know turned out to be bi or pan after transitioning. One woman I know kept telling me I'd develop interest in men, but that's never gonna happen for me. Maybe it's because she's a Boomer who transitioned under the old Harry Benjamin rules. Prior to the WPATH reformation in 2011, there was this diagnostic scale that Dr. Harry Benjamin (a German endocrinologist and early advocate for trans people) created. It was quite limiting, though. There were six tiers that Dr. Benjamin placed his patients on based on their level of dysphoria and misery. If you didn't land on Tier 5 or 6, known as "true transsexual" (that was the language used back then), you were usually considered a fake or crossdresser and denied treatment. To land on those higher tiers, you had to have known you were trans from childhood, have intense physical dysphoria, demand medical transition, and have lived for at least a year as your true gender without hormone therapy. You also had to be attracted to members of your assigned sex. Dr. Benjamin thought that transition had to make you straight, not gay, bi, or pan. If I'd transitioned before 2011, I'd have had to lie about my orientation and have some guy pose as my boyfriend. I would have risked losing my estrogen for being a lesbian or not dressing "feminine enough". Trans men would risk losing their testosterone if they didn't seem "manly enough". Thankfully, those old rules were scrapped when the WPATH released a whole new standards of care in 2011 (this time, with input from actual trans people). They switched to focusing on specific individual symptoms and divorced gender identity from sexual orientation altogether.
Thank you for your testimony and all this historical explanation. Pretty interesting.
Really thank you.
As for me I considered my self a lesbian for a long time even though I knew I could sometimes be attracted to men.
Now I'm still early in my hrt, but I'm not so definitive about anything anymore. (But still think Im a huge lesbian deep in my heart, because " _I knew I was a lesbian before I knew girls like me could be_ ")
And 7 days later I'm with a guy... lol funny how life can sometimes play tricks...
1:05 "How to build naked lady in Minecraft"......my good sir ma'am......I have search the exact same thing🤣🤣
4 millions results 😂
my good sa'am
I've been on hrt since early January and I've definitely felt my sexuality change, because i feel more comfortable and confident and am able to be attracted to other people for the first time in years. I'm also madly in love with a guy, we're hanging out tomorrow, but i think he's clueless about how i feel 😅
Anyway yea, i met a girl on a trip last weekend. While we were talking one time, I felt like I was melting cause she's just so pretty... And when she asked me for my phone number I felt like an excited school girl
Before hrt, i felt no attraction towards anyone, i started to think i was asexual and aromantic. But no, I just really hated myself.
Aw, that's sweet. Welcome to alloville :)
Interesting. I'm aeroace myself and I had a fascination with my sisters clothes when I was growing up. Pretty sure I'm good with how I am, but it does make me wonder if I'm not even aware of things myself and if doing HRT would cause me to learn more about myself.
Cool fact on the implants: they're also used to treat certain kinds of cancer (though I don't know what specifically). I used to have a customer who had one of those E tablets implanted in a fold of skin on his arm as part of his cancer treatment.
AFAIK, it probably is endometrial cancer. Probably not E, but rather progesterone, which inhibits endometrial cancer, for reasons of periods.
Either that or it was a SERM for breast cancer, but I doubt they make those into implants.
Cyproterone acetate, an antiandrogen, is also used for prostate cancer, btw.
@@pedroff_1 I'm fairly sure he was a cis man, so the first one would be unlikely, but it very well could've been an antiandrogen for prostate cancer or something. I didn't know exactly what it was at the time and it was many years ago now that I knew him. I just know that it was some form of slow release chemical that they had put into a fold of skin on his arm and that it was something that made me immediately think "huh, that's used in HRT."
Thats because nearly every trans HRT treatment was invented for something else and repurposed @Khotetsu
As a trans man I don't feel like I'm getting a worse deal on orgasms because instead of having to spend 2 hours trying to have it happen with a tiny little bead, things down there have changed into something easier to target, and I can have it easily and my body doesn't seem to be actively fighting against it. I had a very difficult time with it before. So I don't think anyone's getting a worse deal, it's entirely about what suits you more.
So what I'm hearing is taking T will make my eyes darker, capillaries stronger, and body retain water better... Interesting...
not me taking notes
After a bit over 3 years, I noticed my dark brown/black eyes turned a noticeably lighter dark brown after hrt, my eyes are absolutely more almond shaped and my face looks completely different. I don't think I could overstate the changes, they've been immeasurable and far beyond anything I expected after hearing other people talk about HRT. My body is completely different, I jiggle *everywhere*, I actually have a female-typical waist to hip ratio now and way bigger boobs than i ever expected as well. Like my hips go crazy dumb. My hair also used to be so much curlier, now its a lot straighter, silkier, still curly but much more manageable, and my super thick eyebrows are much thinner as well. Orgasms are exactly as described, much longer, more pleasurable, full body experiences, and I can have 2 or 3 in a row, especially when the progesterone is hitting like a truck. After hearing so many people downplaying the effects of HRT and me being scared of the fearmongering, it has given me so many drastic changes that I consider it a modern miracle. Oh, and people of all sorts want to rail me like all the time now.
bro at this point just take meth its gonna allow you to live the same lenght and will make u happier, since u all about happiness and fun and orgasms.
As a closeted trans girl, I have been subbed to you for a little while now. Love the type of content ya create. I'm in my early 30's it's time to let my inner-girl whos trapped finally out this year. You encourage to come out to my close improv community little by little. Thanks icky.
Best of luck to you, from one late bloomer to another 🩵🩷🤍🩷🩵
Late bloomer club!
you go girlie!
4:10 that was a bold joke coming from someone who can't even drive 🤣🤣
One of the weirder effects that I've experienced was the introduction of a "menstrual cycle" of sorts.
Now, uh, technically speaking. It's not menstruating because there's, y'know, the lack of a uterus, and thus a lack of a uterine lining to shed. So there's no actual menstruation happening.
BUT! The body will process the estrogen and prep you for shedding the lining (because the body doesn't know what it does and does not have, other than what hormones tell it), causing pre-menstrual syndrome (PMS) including headaches, nausea, soreness in the breast, and abdominal cramps.
It was the first major effect that I got hit with after starting estrogen and spiro, and that was a weird experience. I thought I was sick, until I went to the doctor and they told me that it'd be a monthly thing.
As an Intersex person, I have had periods since I was in Middle School, but having Hyperestrogenism has caused my periods to be even more noticeable. I can even poop blood jelly sometimes.
@@philiphanan1493 "Poop Blood Jelly" would make a great band name. Dirty metal with a hint of cuteness.
2:23 I unironically laughed so hard at this 🤣Also congrats on 100k 💕
Ashley, you deserve so much for putting up with Finn's gremlin antics. You are so good for Finn, and I hope that Finn realizes it every day.
I recently saw a great tweet about testosterone HRT "changing" your sexuality:
"What T does is remove the dysphoria that makes you think being attracted to men would be straight."
100% accurate for me.
Just wanted to comment and say thanks to the both of you goobers, you helped me a lot with my body image issues and now I just feel more comfortable in general. Keep up the life changing work you queens
Been on E and spiro since may 2023. One thing I did not expect at all from E is that I have a hormonal cycle now! That's wild! It seems to be maybe 5 or 6 weeks cycle. My sex drive is changing and I'm delighted with the changes! My face finally no longer looks like my dad (nothing against my dad, just that I don't want to look like a boy anymore). And just this past week I've noticed my sweat smell has changed. It's lighter now, not as sharp smelling. E is letting my brain be me and whoo-buddy, I've never been more joyous or at peace.
I'm so looking forward to all that.
I'm happy for you! :)
The effects only get better and better
An effect i almost never see mentioned is the skin changes - not softening (which started almost immediately for me) but the change in skin tone/colour. I thought I knew every possible effect of HRT but this one caught me off-guard. I was always warm toned, neutral undertone. About 3 months into HRT I discovered my foundations suddenly didn't match anymore, my skin had a new, yellowish-hue to it, and my veins looked green through my forearm instead of blue. Suddenly my skin had taken on a more olive-tone, matching my mum + sister instead of my dad. I love this change, just as i love every other change so far, but it surprised me a lot! I looked it up and found that yeah, that does happen - though I think most trans women will get fairer, but not necessarily have their tone/undertone change
Two months on E and Spiro, I noticed lots of the usual things. Probably what surprised me most was that after about a month my body odor changed, got sweeter.
The eye colour one is WILD. I'm super curious what to expect from that one!!
1. Oh no, F1nn looks softer in the tummy area.
2. Donate now!
3. I always find it funny how British people pronounce the "H" at the beginning.
I know, I love how they aspirate their H!
Australia does have implants. We don't really do injections, and patches are uncommon, so they recommend implants for people on HRT for a long time since oral estrogen increases the liklihood of cancer. I'm getting mine in a few weeks and it should last a year or two!
You also have gel over there... meanwhile NZ is stuck with just pills and patches.
both are cool on their own but together they're unimaginably cute, then everything changed when the fire nation attacked.
🤣
Estrogen also makes your skin thinner! Which means you get cold and bruise easier!
I'm cold in a hot room with 2 layers on.
Don’t I know it.
@@KrazzyKelsiesaaaaame, my hands and feet freeze when sitting in a room at 23°C even when I have a big wool shirt on 😭
Cuts & burns take wayyyyy longer to heal. Makes me feel like i had xmen healing powers back in my male days
@@KNR6292 your body is deteriorating congratz :D
Gentle fascia/lymphatic massage, light aerobic exercise and compression can help a lot with both spider and thrombose veins. People tend to see massage as something just for muscles, but gently massaging the surface area of your body can help a lot with drainage and circulation as well as promote collagen production for more spongy fascia (which promotes better blood flow) and better skin elasticity.
To anyone reading this, I cannot stress enough how much massaging lymph nodes (in the chin, neck, and underarm especially) can help you feel better if you are under the weather.
Definitely changes orgasms.. I've been doing injections for 6 months and I haven't seen more than two drops after an orgasm for months.! Plus it totally doesn't let you go all the way to a full orgasm, it's crazy. And yes, definitely alcohol tolerance, I can't have more than a light beer without getting dizzy! All good points here, thanks yall 👏
One thing I noticed was a change in my sense of taste. I lost my taste for coffee and had to get used to it all over again.
lol i started to drink a lot of coffee😂 also craving stuff so badly until i eat it was also quite new
I'm still having coffee but caffeine affects me MUCH more than before. I can't drink as much coffee without going absolutely bonkers
Atrophy of the downstairs can be difficult to deal with so for anyone transfem not interested in bottom surgery, perhaps research topical t and tadalifil bc fibrosis is a headache to combat retroactively, often with limited success.
After two years of using my girl cock regularly, it finally started to atrophy and my erections got painful. The pain has gone away as I picked up more usage again, but I'm looking forward to trying topical T cream i was prescribed to help with sex drive and being able to reach orgasm, because it can be pretty difficult and a fuss sometimes.
Would it be possible to use human chorionic gonadotropin combined with an anti androgen? The hCG will stimulate the testes to produce testoserone, but because of the competitive binding that an anti androgen provides, virilizatiion is minimized
@@qwertasdf5044 idrk bc there aren’t a lot of things I’ve read on that and always ask ur doctor but topical t doesn’t really raise systemic t significantly enough when ur applied correctly and I believe just formulated without a penetrant plus for those on monotherapy, it’s not nearly as expensive as the other two in combination. I didn’t even know about hcg tho so I’ll def read on it.
I'm pretty ignorant to all of this, so may I ask how does that work? Are you taking both E and a verison of T at the same time?
@@darienb1127 no, either test, or estradiol
Something else I discovered after almost 8 years of HRT is , if you have a fore skin it can become fused . It happened to me and was very painful to peel it back a little bit at a time.
Oh and hygiene is important to avoid yeast infections.
That's the reddest I've seen Ashley's face at the end lmaoooo
btw you looked on fucking point in this video 💙
Omg I was actually super worried about all the spider veins that appeared 😅
Thank you icky!
I love Asher's editing so freaking much oh my god, that scream at 0:10 caught me so off guard-
icky you've helped me so much by just doing your thing, thank you ❤❤❤
honestly you two are just goals
not me identifying as a lesbian and saying to myself ‘if i was a man id date other men’ and then suddenly realising i was a man. though i only date t4t right now because dysphoria makes me wanna square up to cis men and im basically pre-everything transition wise.
A lot of the HRT products that are implanted are really rough on the liver and heart, too, so if someone has a risk for blood pressure or heart issues then they wouldnt be able to go on the implants. So a lot of healthcare companies wont use them at all, due to the health risks.
Yall are a genuine delight
Australian here, in the most backwards state (South Australia), we've only had informed consent for a year now. I mean it was legal for 3 years now but we only just got people who will do it. 3 of them.
Am on Estradiol Valerate injections (just started 3 weeks ago). The implants have been available for a long time. None of these are covered by the Pharmaceutical Benefits Scheme (government subsidised), but like $100 for a vial that lasts 5 months. It's cheaper than spending $20 on patches every fortnight.
I don't take hrt, but I do take insulin. There's a similar implant for insulin (It lasts two years if I remember correctly), but the thought of how many surgeries it would require over the years turned me away. Though I definitely get the appeal of an implant, and I would really consider it if the time it lasts is extended enough.
How are you two so adorable?? Good call on making Finn change because that second outfit looked so good!
Finn really going to return to Minecraft with a building tutorial huh
Love you guys💕💫 Always brings a smile in my day. Thanks🥰
Icky's uploads really make my day better
Absolutely love the chaotic energy and very interesting information. Thank you for the content!
Perfect timing, i just wanted to make my pro/con list :3
Pros: Everything
Cons: Everything (if you're a cis guy)
"HRT doesn't change your sexuality" is misleading. It *does* change your sexuality, but not substantially the part that is gender & sex-specific attraction. E and T sexuality and attraction work and feel notably differently from one another. Its more accurate to say that, someone who already has the innate capacity to be attracted to say, men, but their T sexuality doesn't trigger that, while their E sexuality does trigger it because of how it'll make you attracted from different sources of inputs than what T sexuality does. It makes you see things differently, essentially.
Absolutely, never thought I would be interested on men, but after 3 years on HRT started to become more interested physically, so more Pan/Bisexual, although not romantically attracted to typical male energy/voice etc.
I disagree because even before I started transitioning to female, I felt I was always into men, and I always imagined myself in a relationship with a man as his girlfriend even before transition but I never dated because of this reason, and still have never dated, even though I am in transition to live as a woman. but yes, I definitely want a husband and maybe kids someday that would be an awesome life for me because I am a caregiver by nature, and a very nurturing individual
But I do agree that estrogen makes you see things from a different perspective because everything has been so much more clearer for me😊❤
Estrogen does cause some people to be attracted to men. It affects everybody differently on that particular topic.
Maybe this is more so a T thing, bc I've seen other transmasc/FtM ppl say similar things online, but I will argue that HRT _shifted_ my sexuality. Not changed, was and am still bi, but I def have more of a preference for men and/or masculinity now 🤷🏻♂️ Idk, it's always weird to try to explain, especially as a nonbinary trans person
Im kinda new to this, so i would love to learn. How does nonbinary trans work? Do you take hormones to make your sexual characteristics less prominent? So your appearance is more in line of a nonbinary person?
@@qwertasdf5044 gender identity and gender expression are not the same thing and they don't have to line up. You can express and want (or feel like you are supposed) to look however you want and your gender is however you feel. Nb folks are trans cause transgender literally means change of gender from assigned one, which nb folks do. Transmasc/transfem folks are what you would usually describe as ftm mtf but instead they don't necessarily identify binary.
@@kul2130 ooh ofc, i thought that they said trans they were like going to a different gender like male/female, but going from assigned gender to different gender is also transgender.
Thanks for the response.
@@qwertasdf5044 Yep, basically what @kul2130 said! Whether I were binary or nonbinary, I'd still be trans bc I don't identify with my gender assigned at birth. And to answer your first question about hormones, I'm taking T to get a more masculine appearance. Bc even tho I'm nonbinary, I'm also transmasc and would prefer the option to be able to pass/present as a guy. Hope that helps and offers some insight! :)
I love the energy in these videos
Can't wait for your next video. Very informative and funny at the same time.
The implants are available in the US but have been listed as experimental. They are banned in the UK. Also they are good for 6-8 weeks.
Thanks for all this helpful info :3
Great vid as always. A couple I didn't know about hehe.
y'all are so wholesome
Y'all are so adorable!
Editor needs a raise i love these :D
Most surprising effect of HRT on me: I started crying when watching those emotional scenes in Disney movies. Like, no one warned me about that one!
Also, I would definitely say my sexuality shifted a bit. Purely sexual attraction to women was always there, but with men, before HRT, it was more of a demisexual thing. Now, I catch myself looking at a guys ass the way I was (and still am, who am I kidding) a girls ass. Also, didn't notice before HRT how some men just smell nice.
Love you two
you editor has to be one of my favorites on youtube lmao
WHEN DID YOU HIT 102K?! I THOUGHT YOU HAD 60! CONGRATS ASHLEY!
your hair looks really fluffy and nice here !
100K Subs!! Congrats
last time i was this early i had an original joke
What does a fish say when he sees another fish ?
Robinson Cruzoé !
Can confirm, E implants are available in Australia, are cool, and last anywhere from 6-18 months depending on a few factors. Apparently people find that the longer you're on implants, the longer each new implant lasts when you need to get a new one put in, to a degree.
Talking about the eye color thing, that explains why I noticed my eyes dont look so bright anymore. When I was a kid I remember looking at my eyes very close in the mirror because they're hazel, people would tell me this but I didn't understand what it was so I wanted to see. My eyes were pretty bright and green brownish. Then a couple years ago I check them again and they seemed dulled and no where near as bright. I thought I was just like dead inside 😂
Education and entertainment. Your videos are always so filled with happy feelings.
Wait you hit 100k. Thats awesome
yay more goofball shaningans to make my work day better! ^_^
THIS IS SO INFORMATIVE. THSNK YOU!
you guys are great. always so cute. and finn, youre looking good
Hi icky I love your vids they help a lot
This video was very funny and well done both of you
I have a friend in Australia who has an estrogen implant. That’s how I learned that it’s a possibility. Don’t think the US does it either because I’ve never heard of it here
00:38 The picture on Icky's lock screen is soooo cute.
Heya Icky, would you be down for making a sort of "shopping list" guide or suggestions for first going out and passing casually? Not something saying "you have to wear X", but more like "this kind of clothing will most likely work for you".
I'm trans, and after 3 years of closeting I'm looking to start going out and passing, but it's been pretty hard finding everyday clothing that would work, without also being either (or both) over-the-top or nerve-racking.
As someone whos trans and bisexual there is, especially in our society, a difference in whether you date someone as a woman or as a man because we internalized these gender roles so much, that even if you reject those roles you will still subconsciously feel and be seen/treated different and you might for example not fit into the role of a man dating a woman but you might feel much more comfortable being a woman dating a woman etc.
As a personal anecdote: Before I consciously realized I'm a woman I had a "lesbian phase" where I would consume a lot of lesbian romance movies and books (not in a gross sexualizing way) and I thought that was the most beautiful love ever because it was different than a man loving a woman.
I hope your editor is on a good wage 😅 coz dammm you're videos are da bomb...
I know a few friends that get the Estrogen implants. Making the body simulate the function of ovaries, pumping a lot of estrogen. BUT from what I've heard it puts estrogen at a high count and you're supposed to burn that number down slowly through the year (depending on the strength of the implant). Blood tests are necessary after several months to see how far you are from burning that number down and if it is around a certain number you'll have to go in for another implant, otherwise you might have until the next blood test appointment before the implant happens...this might vary from person to person and whichever place does the thing, perhaps...I'm not sure. Also, said friend is trying hard to see her partner in the UK during June....really hope it goes well.
E implants are banned in most places because they couldn't prevent the issue of random strokes due to the occasional over-buildup of E.
That giant rabbit plush is so cute!
ngl, finn is great, but I subbed to you because you actually try to bring out some good info....instead of the nonsense (yet funny, ngl) Finn does in their content. I love how different both of you are, and embrace it like a BFF-necklace does that we wore when we were 11. dont lie to me, you all did that. even if you didnt have friends (dw, neither did I) Sent this to my favorite friendly frienda all time, cause shes a fucking warrior imo going through this HRT as well. are you able to do a testosterone version as well? i know this isnt in your and finn's street, but I had meds since childhood that fucked up my hormones, and although not as heavy at HRT, the difference be there definitly... anyway great video!
Join us for the latest episode of "Icky and the Gremlin!" I just love the way you two interact, and I learn something new from every video you put out.
“like a dodge charger”
*shows image of a challenger*
Yes here in Aus, implants and Injections for Estrogen are absolutely a thing
I haven't really noticed my eye shape changing, but then again, I hardly leave the house without makeup :/
But yeah, this totally answers the eye colour and spider vein thingy. I didn't know that was from HRT.
Im on implants, its a pellet and its placed in the abdominal fat or butt fat every 6mnths to a year (although it can last longer).
Wow, so many trans people posting in the comments! And here I am just a normal guy fascinated by learning about cross-sex hormones.
...uh oh.
Definitely can get it in Australia. I hopefully am switching to it soon
I really do love you guys❤❤❤
you both are so beautiful and funny, you are the best couple on the internet, much love!
Why does the effects sounds so good tho!?!?!...
In Australia you have to find a pharmacist who will prepare the implants off script but it does end up being slightly cheaper over time
Im so glad i don't get headaches on hrt