Thank you for posting. Surprised that PALB2 (which was almost named BRCA3 but is more like BRCA1.5 since it putatively joins BRCA 1&2 at some point) was not mentioned, especially since pathogenic mutations in that often results in cancer or prophylactic surgeries. Was looking for how it functions & any partial redundancies it may have w/ RAD 51 (C&D?) in conjunction w/ BRCA2 in HR/DSB repair...
First, I really thank you for making this useful video. I watched this video from South Korea, and I'm highschool student interesting in brca gene. I know human use some methods when reparing DNA, and I thought that the one you mentioned in video is HR. Is it right? If it is right, if we use brca gene for dna reparing, does it always do its role with HR? Why it do not use NHEJ? If we have gene mutation either brca 1or brca 2, not both, is the possibility of cancer same?And what are other reasons causing dna mutation? If a person is inherited mutated gene, why breast cancer(or other else) happend in realtive old age, not in childhood?I'm sorry for my poor english...But I would really appreciate if you would leave some comments with my questions. Thank you!!
Thank you. It was very nice talk and a good summary about BRCA1, BRCA2
Thank you so much for this explanation. It was very straight-forward and helpful! Please keep making videos!
Very helpful and clear! Thank you for making and publishing this video.
Thank you so much. Best regards from Colombia.
Thank you for posting. Surprised that PALB2 (which was almost named BRCA3 but is more like BRCA1.5 since it putatively joins BRCA 1&2 at some point) was not mentioned, especially since pathogenic mutations in that often results in cancer or prophylactic surgeries. Was looking for how it functions & any partial redundancies it may have w/ RAD 51 (C&D?) in conjunction w/ BRCA2 in HR/DSB repair...
First, I really thank you for making this useful video. I watched this video from South Korea, and I'm highschool student interesting in brca gene. I know human use some methods when reparing DNA, and I thought that the one you mentioned in video is HR. Is it right? If it is right, if we use brca gene for dna reparing, does it always do its role with HR? Why it do not use NHEJ? If we have gene mutation either brca 1or brca 2, not both, is the possibility of cancer same?And what are other reasons causing dna mutation? If a person is inherited mutated gene, why breast cancer(or other else) happend in realtive old age, not in childhood?I'm sorry for my poor english...But I would really appreciate if you would leave some comments with my questions. Thank you!!