BRCA mutation
Vložit
- čas přidán 9. 09. 2024
- This breast cancer lecture explains about the brca gene (brca1 and brca2 mechanism) mutation which leads to the development of breast cancer.
A BRCA mutation is a mutation in both of the genes BRCA1 and BRCA2. Detrimental mutations in these tumor suppressor genes produce a hereditary breast-ovarian melanoma syndrome in affected families. Mutations in BRCA1 and BRCA2 are distinctive, and breast cancer is relatively original, so these mutations consequently account for only five to ten percent of all breast cancer cases in women.
1000s of distinctive types of mutations in these genes have been recognized. Excessive-danger mutations, which disable an primary error-free DNA repair procedure (homology directed repair), tremendously develop the character's threat of setting up breast cancer, ovarian melanoma and specific different cancers. Why BRCA1 and BRCA2 mutations lead preferentially to cancers of the breast and ovary is not identified, but lack of BRCA1 function seems to result in non-useful x-chromosome inactivation. No longer all mutations are excessive-chance; some show up to be harmless editions. The cancer hazard related to any given mutation varies greatly and depends on the distinctive variety and area of the mutation and in all probability different person reasons.
Ladies with unsafe mutations in either BRCA1 or BRCA2 have risk of breast melanoma that is about five occasions the average chance, and a hazard of ovarian cancer that's about ten to thirty occasions common. BRCA1 mutations typically confer a higher danger of breast and ovarian melanoma in females than BRCA2 mutations. Having a high-threat mutation does no longer guarantee that the girl will increase any sort of cancer, or warranty that any melanoma that appears was once genuinely induced through the mutation, alternatively than every other element, like alcohol consumption.
For more information, log on to-
www.shomusbiolo...
Get Shomu's Biology DVD set here-
www.shomusbiolo...
Download the study materials here-
shomusbiology.c...
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in CZcams. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store
Shomu’s Biology assignment services - www.shomusbiology.com/assignment -help
Join Online coaching for CSIR NET exam - www.shomusbiology.com/net-coaching
We are social. Find us on different sites here-
Our Website - www.shomusbiology.com
Facebook page- / shomusbiology
Twitter - / shomusbiology
SlideShare- www.slideshare.net/shomusbiology
Google plus- plus.google.co...
LinkedIn - / suman-bhattacharjee-2a...
CZcams- / thefunsuman
Thank you for watching
I rarely leave comments on videos, but this one helped me out tremendously! I gave a presentation on the causes of breast cancer today and the BCRA mutations were still a bit fuzzy in my mind for whatever reason. I watched your video an hour before just to brush up and it helped more than I could have imagined it would. The presentation was flawless! thank you! I will be watching more of your videos!
yeah, doing AP bio homework and BRCA was a bit confusing. Thank's Shomu's Biology for making it much clearer to me!
I've got it, I was 28 when I found out. It's like living on a cliff your constantly checking.
"The guardian of cell cycle" what a great description.
Thank you, I somewhat understood the process before but your explanation and passion really helped to solidify my understanding.
You're welcome. Glad to hear that you're getting benefit from my lectures
My family has just been diagnosed as having the BRCA2 mutation, I am a nurse so had some understanding but this will be very helpful in explaining it to them. Thank you!
Thank you so much for this wonderful presentation. I have the BRCA1 mutation myself (as do other members of my family). This is a fantastic presentation of some of the detail about how this gene works at cellular level and what can happen when it is faulty. I had ovarian cancer (actually, primary peritoneal cancer, which is very similar) in 2014, was successfully treated and am living to tell the tale! Tracy, Bathurst, Australia
It's good to hear that you have been corrected for the disease.
Nicely done, mister! Very clear, direct explanation. Thumbs up!
Dear Mr. Sumen Bhattacharyya,
it is a very good educative video. Please, do a tutorial in the context of PARP and BRCA activity in DNA repair; PARP inhibitor selectivity cancer and normal cells.
Thank you very much.
Okay
All the way from Republic of Ireland filipino. Many thanks
Thank you so much for appreciating my efforts
@@shomusbiologyofficial very well explained. Thanks a million. I learned a lot.
Very well explained
Thank you
Thank you so much, couldn't get better
Great video
Thank you.
This really helped me a lot! Thank you Mr. Shomu
You have earned a new suscriber!! Greetings from Mexico
I have to say this video really helps in my assignment! Explanation is really clear! Well done!
VERY INFORMATIVE
Thank you
You are AWESOME bro! Thank you!!!! :)
Super lecture sir
Thank you
Really well explained. Great video thank you
Great explanation. Bravo
Lovely video well explanined
Thank u so much !!! It is great video! It help to my presentation about breast cancer! Thank you!
+Marcia Askarzadeh thank you. Glad you liked my lectures
Wonderful video, very helpful, thank you.
Glad to hear that you are getting benefit from the videos
Wonderful explanation,Sir.
You're welcome
Perfectly explained... My sister in law is having breast cancer at the age of 35 but there is no family history.... I told my wife to get brca test.... Where should she get it done... In Mumbai.
Your family doctor will tell you a nearby lab where you can get this done. Have insurance before you get tested as this can cost thousands.
It is not CHK2. It is CHEK2. U can explain realy good. Very nice
I like his videos however the old ones have lens focusing issues. Updated videos would be nice so learning isn't disruptive.
Thanks very much
You're welcome
Wow what a video, this was explained so well. I found the mutations in BRCA the hardest topic to get my head around and this video really helped me, thanks!
Ur explanation is superb. Please let me know what exactly mean wild BRCA
Greetings from University of Siena,Italy!
Sir ur videos are a boon to me
thank you
however I want to compliment for one more thing
u r looking very handSome in this video
Amazing!!❤
You're welcome
Very well explained! Thank you so much. Would it be possible to identify the wrong proteine to add it somehow with some kind of pill or food?
Dear Mr. Suman,
Some correction required @ 7th min 15th s.. The word 'Halt'..
You're doin a Good Job.. Keep it Up..!!
So nice
well thanks a lot that was helpful
You're welcome
Very good
You're welcome
thank you so much sir..
You're welcome
this is the best
Thank you
My diagnose was matasisi of bones caused by prostrate cancer PSA 282 , operated for removal of tests and now PSA is 1.7
docs say I am fine , but now I have limp node enlargement ultrasound report (prominent bilateral ingunuial lymphnodes with preserved fatty hilium.
i have found you much wiser than my docs please advise
good video
sir plz plz do a vdo on breast cancer elaborately.
I have homozygous mutations on both BRCA1 and BRCA2. I can’t find any info on that scenario. I have an appointment with oncology in a couple weeks. Are the risks greater with homozygous mutations or with having mutations on both genes?
7.12 which are responsible for??
Sir Please upload neutralist hypothesis
how this barca mutation and mutations in FA genes are related?
Thank you very much. I have BRCA1 Mutation, my Mom had BRCA1 Mutation and my Grandpa had probably BRCA1 Mutation.
What should I do now to prevent me from getting cancer? I am only 28 years old now.
Periodic screenings to detect tumors
Do you think crispr has a chance to beat this ?
Can be done in future
My mom has ovarian cancer with BRCA mutation, it's a risk for me. .?
If you’re a woman yes if you’re a man no since men don’t have ovaries, however there’s a 50% chance of you inheriting the mutation from your mum it doesn’t mean you’ll get cancer it just means you’re at higher risk of developing cancer mainly breast but for women ovarian too and for men prostate too also pancreatic. The BRCA2 mutation is in 3 generations of my family my grandma, mum and sister. My grandma got pancreatic cancer and passed away however my mum got breast cancer and survived it’s mainly down to genetics 🤷🏽♂️ knowing my luck I’ll have the mutation too
@@jmaz0444 I am a man. ...so it's 50% risck for me? ......i mean my mother sister had ovarian cancer and her brother thyroid cancer , but my grandparents they didn't have the mutation.
@@viorelscrob6391 You should test . For more precautions. As you are a man there is chance for Pancreatic cancer. ( I know you will neglect in your food and drinks so you should test .
Dear Shomus I took.your number from internet and messaged through whatsup. I thought some other people use your number and demands for money on little assistance. They demand money in advance
We offer services with advanced payment. We have two numbers 9804654228 and 9804865119
Too much talking....not that much matter....try to improve the points