TWiV 1120: Clinical update with Dr. Daniel Griffin
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- čas přidán 6. 06. 2024
- In his weekly clinical update, Dr. Griffin reports the third case of influenza H5N1 infection in a human, this time with respiratory symptoms, an H5 avian influenza virus wastewater dashboard, FDA approves Moderna’s mRNA vaccine for respiratory syncytial virus, vaccine advisors to FDA recommend switching from the XBB.1.5 variant to JN.1 for fall COVID-19 vaccine formulations, weekly US COVID update, a controlled human exhaled breath aerosol experimental study on the relative efficacy of masks and respirators as source control for viral aerosol shedding from people infected with SARS-CoV-2, systematic review of early use of oral antiviral drugs and the risk of post COVID-19 syndrome, long-COVID autonomic syndrome in working age and work ability impairment, Centers for Disease Control and Prevention estimates that 5.3% of Americans currently have long COVID, and the National Academies of Sciences, Engineering, and Medicine presented a report with a number of conclusions about long-COVID diagnosis, symptoms, and impact on daily function.
Show notes at www.microbe.tv/twiv/twiv-1120/
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Early release today - I'll need to find another microbe tv episide for bedtime! Great content as always, thanks.
Thank you, gentlemen! (Wishing you safe travels, Dr. Racaniello!)
I listened to Mountains Beyond Mountains about 20 years ago and found it incredibly moving and inspiring. Since then, the only other person I’ve found who is aware of Paul Farmer is Dr. Griffin. Other great books by Tracy Kidder are Among School Children and Old Friends. He is a most wonderful author.
I appreciate Daniel's mention of Paul Farmer and I look forward to watching the film mentioned. While reading about Paul Farmer I learned that he worked with Ophelia Dahl, whose father Roald was the famous author. He helped develop the Wade-Dahl-Till shunt for hydrocephalus after his son suffered a brain injury!
Thank you!
I see the variant soup in the USA is changing very quickly. KP.2 & KP.3 and now LB.1. It's far too early to think the pandemic is over particularly as Aussie & NZ are in a big spike.
Its Winter in Australia and they have little immunity from previous infections and rely mainly on that from vaccines.
Regarding Covid in the west, this is merely a data point, but I am an internist in an outpatient telemedicine practice and have seen a very noticeable uptick in Covid cases this past week. Never fear, I am an avid Paxlovid prescriber. Portland, Oregon.
I looked up the Stanford wastewater virus dashboard and they have several viruses and locations view. It is very interesting and thanks for the mention of it.
If you don't have insurance, Paxlovid prescription is over $1000. Calling the drug company for their aid program is useless- you have to be old with immune system problems to get help.
Isn't paxlovid composed of two generic drugs ? Shouldn't the government take steps to limit the profits made from this drug ????
@@jonnash5196 Nirmatrelvir is not generic. Ritonavir is generic, it wasn't an expensive drug relatively to begin with.
Thank you
Thanks Dr R and Dr D.
I always love hearing Daniel’s quote for the episode.
Another quote, with absolutely nothing to do with virology, but quite funny:
From Carl Jung: “"Everyone is an atheist until they clog a toilet in someone else's house"
Filovirus are my favorite too! Ebola Reston has an interesting and scary story. It was too close for comfort!
Regarding Covid in the west, this is merely a data point, but I am an internist in an outpatient telemedicine practice and have seen a very noticeable uptick in Covid cases this past week. Never fear, I am an avid Paxlovid prescriber.
Nice! Early release!
This is super early this week !
I think because he’s in helsinki
Thx u two!
There is some evidence that higher viral load exposure during infection leads to more symptoms, so masking may not be a bad idea in some situations
Why is the national covid act now no longer providing data? This was my weekly update and I miss it.
As an aside, USA stopped reporting case data to the WHO when they announced that COVID-19 no longer constituted a public health emergency of international concern in May 2023.
Early for us, but the same time in Finland?
Could you guys recommend an authoritative written reference that we could print off and hand to our doctors when we are denied Paxlovid?
Can you please always specify whether a percentage of effectiveness cited is absolute or relative? Just the numeral is not enough to understand properly.
In such trials, the results are always relative.
@KellyRiemerCusick
The effectiveness should be reported as the relative risk reduction. The absolute risk reduction is calculated from the background risk (essentially the prevalence of a disease at a specific location and time) which is a variable. In March/April 2020 the background risk in New York City was far different then that of Fargo ND. Had a vaccine/treatment (95% RRR) been available at that time the absolute risk reduction in New York would be significantly different that that of Fargo but the relative risk reduction would be the same for both.
@@christopherrobinson7541 I'm not sure that's true. But I think it IS true that as human beings we instinctively INTERPRET the numbers as "absolute". So, in that context, I think we generally respond to these statistical details as being much more significant than they really are.
@@KellyRiemerCusick The problem is that most of the general public do not understand the difference between absolute and relative risk. Both metrics are useful in the correct context.
@@christopherrobinson7541 Yes. Absolutely. 100%. (No pun intended.) I knew absolutely nothing about this until a few years ago. And that's the point: professionals with credentials and integrity who are presumably trying to share helpful information ought to ACKNOWLEDGE THAT, and the onus is on them, to "edumacate" the general public. There is absolutely no value in nurturing misunderstanding like this. It's not that hard to just say "relative risk" every time you say a numeral. 3 syllables. Feasible. In my humble opinion.......
Wow this posted early !
Watch out for tick diseases !
I just got diagnosed with anaplasmosis in northern Baltimore county just south of PA . It looks like MD usually has 20 or less cases of anaplasmosis reported each year . I guess in younger people it can be self limiting ...
Early !
Can you discuss COVID mRNA vaccines and the possibility of prion-like disease potential compared to COVID infection. I know currently it is only hypothetical.
Will know
Experiment go on.
Gate of experimental vaccination was open
Not even hypothetically. How would an mrna segment lead to prion protein? The code is totally different.
@@kban77 If mRNA induce different Spike proteine and folding of this proteine differ from original folding ?
But that is SF
Why to be scared by fictions ?
no they don't. because nothing has anything to do with anything please move on
I am vaccinated with Pfeizer m RNA and I hope new Spike proteine will not act like prions
Maybe mask wearing not only stop droplets, but also maintain higher mucouseal respiratory temperature.
If SARS COV2 infection can be related to lower mucouseal respiratory temperature (see at TWiV 659 at min29 what Christian Drosten suggest) (?) surgical mask wearing was enaugh If thermogenesis is weakened by different causes (low thyroid function,low submucouseal circulation...)
first
4k views, 291 likes
Checks out