MS + Another Autoimmune Disease: Treatment Options
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- čas přidán 16. 05. 2024
- 4:24 Rheumatoid Arthritis + MS (rituximab)
5:01 Lupus + MS
5:18 Psoriasis + MS
6:38 Rheumatoid Arthritis + MS (Aubagio)
7:53 Chron’s disease
9:08 Ulcerative Colitis
9:57 Ankylosing Spondylitis
What if you have multiple sclerosis and an additional autoimmune disease such as rheumatoid arthritis or lupus? Can you take a single medication to treat both conditions. This video shows some data on treating multiple simultaneous autoimmune conditions and the importance of avoiding anti-TNF alpha blocking drugs if you have multiple sclerosis.
Selected Sources:
Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disorders: pubmed.ncbi.nlm.nih.gov/34457...
Autoimmune disease in multiple sclerosis: www.researchgate.net/figure/C...
Anti-Tumor Necrosis Factor Alpha-Associated Multiple Sclerosis: www.ajnr.org/content/26/6/1548
Risk for Multiple Sclerosis with TNF Inhibitors: www.jwatch.org/na55613/2023/0...
Rituximab product label: www.accessdata.fda.gov/drugsa...
Arava product label: www.accessdata.fda.gov/drugsa...
Efficacy and safety of LAS41008 (dimethyl fumarate) in adults with moderate-to-severe chronic plaque psoriasis: a randomized, double-blind, Fumaderm®- and placebo-controlled trial (BRIDGE): onlinelibrary.wiley.com/doi/1...
Tysabri product label: www.accessdata.fda.gov/drugsa...
Mycophenolate versus Azathioprine as Maintenance Therapy for Lupus Nephritis: www.nejm.org/doi/full/10.1056...
Zeposia product label: www.accessdata.fda.gov/drugsa...
Ozanimod Induction and Maintenance Treatment for Ulcerative Colitis: www.nejm.org/doi/full/10.1056...
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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.
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Music: INNER GRACE - Copyright 2018 Wilton Vought Source: Really Really Free Music Link: • Video T
he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information. - Věda a technologie
Excellent! Keeping this info handy. Thank you!
Thanks Dr. Beaber! So many autoimmune diseases! Are they on the rise in general? I would love to see a video on that and hear your thoughts on it.
Thanks for the suggestion. I talk about it a little bit in this video connecting gains in national wealth with multiple sclerosis: czcams.com/video/jWGS4Be1Ynk/video.html Some potential culprits include changes in diet, low sunlight exposure, low parasite exposure during use, antibiotic exposure changing the gut microbiome, etc. I also talk about it in this video: czcams.com/video/EdrEDPazeik/video.html
@@DrBrandonBeaber thanks!!
Awesome video ! I really liked this topic. Thank you, doctor Beaber.
I'm glad you liked it.
Thanks for this video Dr. Beaber, it's an interesting topic. I have a mother with ankylosing spondylitis, and a cousin with Hashimoto's on the same side of the family. My grandfather was also diagnosed with ATTR-CM, a rare heart condition, in his mid 80s (not autoimmune, but possibly related genetically). All are from the same branch of my family tree, which seems to support some genetic predisposition to autoimmune disease along that line.
Video suggestion: Can you discuss CAR T-cell therapy KYV-101 and how it compares to current b-cell therapies like Ocrevus?
Super helpful! I thought there was more of a correlation between autoimmune conditions. Good to know and I will change my communication appropriately :) Also, super helpful to know about the potential effects of some treatments for IBS.
For most autoimmune diseases, there is a strong connection. For instance, vitiligo, hashimoto's disease, and lupus are all linked. MS is unique in this respect.
Great video! Thank you for sharing this info!
Great minds think alike... or do they? Different minds, different approaches, great info from both of yall. I would have never found this channel if you didn't "force" me to check him out!
It really is Doctor Boster! I started Kesimpta in July for my RMS and i theorised that it would also calm my Uveitis (Pars Planitis) and Psoriatic Arthritis (fingers only, intermittent, without Psoriasis). No incidences of any of the conditions since commencing treatment 🙂
I also have Hashimotos T, Pernicious Anaemia, and Asthma. so 🤞🏼although, due to the systemic existing damage to my thyroid and the gut mucosal cell homocysteine~>methionine->methyl-THF
->THF pathway-maybe a bridge too far? x
Ty for this video had been struggling with this issue kinda still am but got some help with few issues .... I had developed intermediate uveitis with snow banking or pars planitis..... I was lucky/unlucky and my ms relapsed around this time and since I got a new lison on my mri my nero decided to let me up my med to ocruvis and to my opinion no surprise as it got the uveitis undercontrol though there's still controversy on whether or not intermediate uveitis is a part of MS the factor that my Ms got worse around the time my uveitis became worse and the one Med fixed both of then I'm kind of happy for that but as you said in the video it's kind of a generalized immunosuppressant anyways and could be used to treat both though my ophthalmologist says b cell depleter don't normally work on uveitis but since it's safe to say mine was in connection to my ms ... as nornsly thats how they treat intermediate uveitis is by normally treating the underline autoimmue condition
Why no mention of autologous stem cell transplant (aSCT)? I was diagnosed with secondary progressive multiple sclerosis (MS) about 5 yrs ago, with a recent (~2yrs ago) diagnosis of multiple myeloma (MM). After reading some medical journals, I asked for an aSCT. My oncologist readily agreed, with the neurologist acquiescing. I received the aSCT last February (~12 mos ago.). So far, both diseases appear quiet, per blood tests for MM and mri for MS. Although neither disease has progressed, I still have neurologic damage from the MS (i.e., imbalance, leg spasms). At 12mos post-transplant, am happy with the results.
Where did you have it down...?
Problem is neuros don't like hsct cause they worry it will put them out of business with no retirement.
There's been some reports that aHSCT triggers new autoimmune diseases, e.g. thyroid autoimmunity. This is a similar situation to Lemtrada, which is currently not recommended for anyone with multiple autoimmunities before treatment. There is a trial happening now that will report performance and side effects of aHSCT in MS just like a drug trial, so we'll know more in a few years. Multiple myeloma is a blood cancer, so the treatment decisions are a bit different in your case.
@@moggiedon4934 They have been doing HSCT trials since 1999 one after another..nothing will reveal after all this time. Anyone with ms can get another AI disease at any time for any reason..it is
genetic.
Thanks Doctor.
I have RMS, Hashimotos Thyroiditis, Uveitis, Psoriatic Arthritis (fingers only without Psoriasis), Pernicious Anaemia and Asthma since age 2
I started Kesimpta in July 23.
No bouts of MS, PsA or Uveitis since.
Is it likely that the Kesimpta is helping many of my conditions?
Thank you x
Dr Beaber would you be able to do a video about what a bad prognosis actually looks like to you generally? I've had MS that's been aggressive at onset (but decent recovery from relapses, they're just frequent and I sense quite a lot of PIRA) and I'm still waiting to get on the B cell depleters 2 years from onset, but my mum had it (no DMTs) and spent 10 years not being able to move any limbs, gradually being unable to eat, swallow, communicate, or move anything, god knows if she still has thoughts, she's just a shell. She was only in her forties when it became like this. I just want to get a better representation of what bad prognosis means because I think (hope, really) that mum is an extreme case rather than the average for bad prognosis, at least on DMTs (because I have lesions on spine, one on brain stem, and my relapses aren't spaced far apart, so obviously I have lots of indicators - just want to know what that's likely to look like for me).
Dr. Brandon i take vit d and magnsium oxide and will start probiotics soon. If vit b levels r normal would u advise b complex to improve my muscle strength because im in a wheelchair from vertigo. I was advised to take vit e.
Dear Dr. Baeber, do you know a good channel similar to yours specialised or more intensely looking at the gut (like ulcerative colitis) and/or neuro immunological issues?
Hi Dr. Beaber
Excellent video! I only have RRMS, but I have Asperger’s Syndrome/ Autism level I since age 14. I don’t have any other autoimmune disease at this time.
How frequent are mental disorders on people with MS?
Thanks
Very interesting!
Thanks
What do you think of Methylene Blue?
Great video Doc, I know that there are a few biologics out there for other AI disorders that overlap diagnosis categories. My child has Crohn’s-❤🙏🏻
This was very informative.
# Sharingiscaring
I fell 2 years ago and hyper extended my left thumb was has not healed making me think that a tendon was permanently stretched (Gamekeeper's Thumb or Skier's Thumb) I'm 59, PPMS have mild psoriasis,
But my doctor said the thumb Ultrasound image was only age related OA which I don't have anywhere else in my body. Should I get a second opinion?
If you're looking at ideas for your next videos, I would love to know about BDNF and it's potential role in MS. I stumbled upon the term and the research seems way over my head. Are there things we can do to increase BDNF, if that's desirable, like exercise, nutrition, etc?
Hi Dr
I have MS and vasculitis with Mycophenolate mofetil treatment
It possible to have one more autoimmune disease???
Also interested to hear peoples thoughts on a possible link between the cortisol hormone which is produced when a person is stressed, or in a flight/fight situation. The Cortisol hormone suppresses the immune system, which is good for MS. However, after prolong periods of exposure/production, the body has low levels of the Cortisol hormone potentially leading to a MS relapse. I personally have suffered two episodes of optic neuritis following a stressful life event. I know Brandon Beaber has mentioned a possible link between stress and worse outcomes for people with MS. Maybe its not stress specifically, but stressful events that lead to high, followed by low levels of Cortisol hormone in people suffering with MS which leads to a relapse? Steroids used to treat MS are derived from cortisol. Has anybody else had a similar experience?
Suggestion for a video, Dr. Sam Gartland claims to have reverse his own MS following a plant based diet; similar to Dr. Terry Wahls. He is a UK based doctor and may give a different prospective on a plant based diet and how MS is treated in the UK.
Dr. Wahls doesn't recommend a plant-based diet. In fact, she was previously a vegetarian prior to diagnosis of MS.
Dr. Brandon is CFS considered an autoimmune problem? Is it true ppl have gotten it from COVID especially long haulers? I want to heal it naturally without antivirals
Ben Türkiyeden sizi takip ediyorum inşallah en kısa sürede başarısınız ms in çaresini bulursunuz 2014 beri hastayım fingya ve famprya kullanıyorum
Have you ever had your omega 3 and vitamin d blood levels measured?
google translate: I am following you from Turkey. I hope you will find success and a cure for MS as soon as possible. I have been sick since 2014 and I use fingya and famprya.
@@mballer kan tahlili veriyorum normal seviyede kanka
Selam merhaba kardeşim
Ben multıpl skleroz var. Allah razı olsun
Could you pls talk about MS and endometrosis ? I've been diagnosed with both recently, at 45. Thank you
I'm not aware of a specific association between MS and endometriosis.
I have Hashimotos prior to MS
Since Kesimpta my thyroid antibodies are now normal. Why there's no research of Hashimotos
Theres no money for pharma in eating healthy, not being stressed etc
@@Jess-kn8vl People eat healthy and exercise and still get disease and cancers..
mostly because of genetics.
Ms and Mollii Suit therapy - video option 🙆🏼♀️🥰
Please can you make a video on secondary progressive ms. With spinal lesions and vaginal pain and weird sensation like worms crawling inside of me or having constant stimulation of the clitoris. I never experienced this in my life until I first had T3-T5 C-2-C3. Enhancing lesion in 2010. I don’t mean to sound vulgar but I’m suffering. Are they related? Every neuro told me know. I’ve been getting Botox injection but now the doctor I get the injections from is no longer doing it. Due to Medicare low payment. Thank Dr B. Do you have any female patients with such problems.
When I was given the choice between Ocrevus and Lemtrada, my doctor explained how there is a risk of some new autoimmune diseases with Lemtrada, one of which, ITP, a platelet immune disease. When I asked if it was treatable, he laughed saying that rituximab could be used. So, in this unlikely scenario, I would end up on a B cell depleting therapy (I ended up chosing Ocrevus)
Interested to understand if people are aware of the link between Autoimmune Diseases and Autism Spectrum Disorders. 80% of people with Autism have an autoimmune disease. I personally met three people with Asperger's Syndrome/high functioning Autism that have MS. Also worth mentioning is that some of the genes linked to MS are also link to Autism. There are over 100 genes linked to autism which have been documented by Cambridge University in the UK. Genes linked to MS were discussed in Brandon Beaber last video. Does having Autism increase your risk of developing MS? The number one career choice for somebody with Asperger's Syndrome is Doctor. The signs for Asperger’s syndrome is poor handwriting and poor interpersonal skills/bedside manner. A lot of doctors fit this discription. It would be really interesting to understand if Dr. Terry Wahls and other doctors who have been diagnosis with MS may also have Asperger's Syndrome?
any info about NMO?
NMO is often treated with b cell depleters such as rituximab or general immunosuppressants such as azathioprine or mycophenolate mofetil. anti IL-6 agents such as actemra or complement blockers such as eculizumab have not been used in MS. Dedicated video on NMO here: czcams.com/video/xBCke5TsDGA/video.html
Why the need for multiple doctors? Eczema see a dermatologist. Arthritis see a rhematologist. Bowel issues see a gastroenterologist. And, a neurologist for your MS. As common as this is, why isn't there a more multidisciplinary approach for these chronic conditions? It's so frustrating.
The short answer is I simply would not have the knowledge/experience to treated a complicated condition such as Chron's disease.
I get that. What's missing is oversight of the entire patient's medical experience. I'm not aware of a team/multidisciplinary approach where there's a medical professional overseeing the myriad of drugs given by all of these doctors.
These videos are extremely helpful. Thank you.
I find some non-insurance anti-aging doctors exist to consider a patients whole health but I don't think they would or maybe even could generally prescribe MS drugs given it would not be covered. I think a more affordable approach would be to have a deep relationship with your GP and they may be able to more effectively advise between multidisciplinary specialty doctors and fill in as needed if a patient needs more help, understanding, medication support, or otherwise. Like I'm happy with my neurologist and if I had anything else my GP can assist further, and if I'm feeling rich and want to know exactly all my micronutrient relative levels or advisement over supplements then I might see the an anti-aging doctor for a very limited period.
@@shironhagens2721
MS centers he ave the multi disciplinary approach.
@@shironhagens2721what an awesome question! I've struggled with this very question. I only have one immune system.
functional medicine comes to mind. but also comprehensive care is available for MS, but notable that none of them include IBD based on a response I got from the national MS society
I have Thyroid disease, actually had a thyroidectomy
I stopped the video at 1:14 to leave this comment:
Yes, here: From personal experience: Because I ended up on Welfare; for a time, I too was mistreated and poorly provided medical services; Well Below The Stancard of Care.
Often: Medical Problems, do express themselves in such a way, that only Professional Medical Level Healthcare, Which is { Comprehensive}.., until such time as a ' Proper Medical Diagnosis, Combined with the Necessary Medical Treatment Is Reached, -;Must Be The Required Standard of Care. Otherwise: I find, to that, and more and more: Differential Diagnoses Does lead to Disease Progression, Greater Impairment, Exacerbation of Existing Symptoms , and to
* importantly:
One's {Inability to Function AND Return to Work}. I hope this is helpful}.
My Best,
MDM , JD Candidate.
Mt 3 auto immune diseases: PPMS + mild psoriasis +a proclivity towards 'Dad" jokes
I have thyroid (Hashimoto) and Sjogren. . I'm on Ocrevus and I feel much better with my saliva. Its great 🤤🤤🤤
Hydroxychloroquine 1- Tab 200mg daily and every other day 400mg. Is this a TNF Alpha blocker and if so why shouldn’t someone with MS take this?
Hydroxychloroquine is not a TNF alpha blocker.
Thank you… I am hoping you will do a video strictly for Tumefactive MS. There is not much credible information out there on these types of lesions. Be it singular or multiple brain lesions. Please make one.
Several AI conditions, but MS and Behçets Disease are my big 2.
I’ve decided to take action myself by regulating my Gut Microbiome and work on the rest of my body through cellular level. After being told I have another form of AD aside from MS, I was fed up. Hate meds, just nasty (side effects). Tired of these doctors.
Promo'SM 😻
Will Astaxanthin help MS?
It looks like there is a study in a mouse model of MS here: pubmed.ncbi.nlm.nih.gov/29536745/ There is no human data that I could find.