Opioid Pharmacology: Basics, General Class Effects, and Specific Drug Differences

This presentation covers most aspects of opioids, including pain basics, natural and synthetic opioids, medicinal chemistry, absorption, distribution, metabolism, pharmacology, side effects, and unique dosage forms. Brief discussion of naloxone is included, particularly why it is combined with buprenorphine in some drug products.

[@zakirzak1494]

❤❤❤ Thanks for the effort and information ….it is really appreciated

[@AVW_Dr.Dr.]

My pleasure 😊

[@krishnakrishna6354]

I hope you continue creating more great content ❤❤

[@AVW_Dr.Dr.]

Thank you very much! What sort of content would you like to see?

[@krishnakrishna6354]

@@AVW_Dr.Dr. could you do a video on autacoids.I also came across this question on biology stack exchange and l would love your feedback:What structural features make a molecule a potent opioid receptor agonist?How can molecules with structures so radically different from those of endorphins mimic the action of endorphins?

[@polaosinska4614]

Thank You for sharing, the video was very insightful and helped me a lot!

[@AVW_Dr.Dr.]

You're very welcome!

[@milicapenjisevic]

This is better than all my opioid chapters from Anestehsiology residency
Which is sad ofc

[@milicapenjisevic]

So, anestehsiology residents will be grateful if you continue to release anestehsiology drugs lessons
Hipnos, benzo, vasoactive drugs, and IA 🤓

[@AVW_Dr.Dr.]

Thank you! I feel like I made this an eternity ago. Glad there's someone out there watching!

[@zakirzak1494]

Hi Can please explain the physiology behind excessive yawning in opioid withdrawal ?

[@AVW_Dr.Dr.]

Hi! I'm no expert on yawning, but this reference suggests that opioids inhibit oxytocin release. Oxytocin can trigger yawning. I propose that the oxytocin-mediated yawning is overactive when you stop an opioid due to upregulation of oxytocin receptors while taking an opioid, and then when you stop the opioid, the inhibition of oxytocin release is no longer there, but the oxytocin receptors are more abundant, so you have too much receptor activity overall. This is just a hypothesis I came up with. Still not sure.

[@zakirzak1494]

@@AVW_Dr.Dr. Thank you. That is a possible hypothesis.