![Adam VanWert, PharmD, PhD - Pharmacology and Fun](/img/default-banner.jpg)
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Adam VanWert, PharmD, PhD - Pharmacology and Fun
United States
Registrace 31. 12. 2013
Hi! I am a professor of pharmacology and toxicology. I have a doctorate in pharmacy and a Ph.D. in pharmacology and toxicology. My channel is about how medications work (pharmacology), physiology, toxicology, and some videos I created just for fun or relaxation.
Science of Soap: Creating Soothing Menthol and Coconut Oil Bars
I make bars of soap the traditional way using sodium hydroxide and coconut oil. Coconut oil gives a great lather and is very cleansing. Plus, the bars are ready to use in 1 to 2 days, which is much quicker than most types of soap. I use a small amount of menthol to help soothe an itch and cool the skin. The menthol effect is much more noticeable after getting out of a hot shower.
The first part of the video is all the science of saponification (soap making) and how soap works, while the second part is the demonstration.
The first part of the video is all the science of saponification (soap making) and how soap works, while the second part is the demonstration.
zhlédnutí: 44
Video
Studying Zen - Soothing Campfire for Relaxation, Meditation, Studying...
zhlédnutí 70Před 3 měsíci
This is a 3-hour campfire scene with a small stream of gentle water, sporadic rain, glowing embers, and nature sounds.
Logic of Naloxone in Suboxone?
zhlédnutí 87Před 5 měsíci
I describe what the intended purpose of naloxone is in suboxone, and present an unbiased set of facts with a corresponding argument.
Octanol-Water Partition Coefficient and Medication Absorption
zhlédnutí 2,3KPřed 11 měsíci
I demonstrate how medication absorption and distribution can be affected by pH and their ability to be ionized or non-ionized. In this real experiment, I use an ionizable dye to simulate how acidifying the aqueous phase can drive a drug molecule into the lipid phase (octanol). This represents how a drug can move across an epithelial cell barrier if it is made non-ionized (neutral) by altering p...
Part 10 Bioavailability And Bioequivalence 35 slides
zhlédnutí 359Před 11 měsíci
Part 10 Bioavailability And Bioequivalence 35 slides
Part 5 One Compartment IV Bolus 12 slides
zhlédnutí 320Před 11 měsíci
Part 5 One Compartment IV Bolus 12 slides
Part 4 Metabolism and Transport 50 slides
zhlédnutí 315Před 11 měsíci
Part 4 Metabolism and Transport 50 slides
Sucralose and Cancer: Why Aren't Science and Media Held to Higher Standards?
zhlédnutí 482Před rokem
I critically analyze the news reports and corresponding article on sucralose, sucralose-6-acetate, and cancer.
CBD and Caffeine Interaction
zhlédnutí 574Před rokem
I discuss how CBD can increase the effects of caffeine through an interaction in the liver.
Semaglutide - Everything to Know
zhlédnutí 8KPřed rokem
I discuss all aspects of semaglutide injections, including how it works, side effects, why it might fail in some people, how it differs from natural GLP-1, and some theoretical thoughts on improving tolerability and effectiveness.
Regulation of Renal Glomerular Filtration
zhlédnutí 483Před rokem
I describe how glomerular pressure and filtration is controlled by autoregulatory, neuronal, and hormonal mechanisms.
THC Drug and Food Interactions and Toxicity Risk
zhlédnutí 307Před rokem
THC Drug and Food Interactions and Toxicity Risk
How Do Enteric Coatings Work? Also known as "safety coatings" and "delayed release" coatings.
zhlédnutí 481Před 2 lety
How Do Enteric Coatings Work? Also known as "safety coatings" and "delayed release" coatings.
Buprenorphine and Naloxone (Suboxone) Pharmacology
zhlédnutí 20KPřed 2 lety
Buprenorphine and Naloxone (Suboxone) Pharmacology
Opioid Pharmacology: Basics, General Class Effects, and Specific Drug Differences
zhlédnutí 1,9KPřed 2 lety
Opioid Pharmacology: Basics, General Class Effects, and Specific Drug Differences
Opioid-Induced Constipation and the Enteric Nervous System
zhlédnutí 477Před 2 lety
Opioid-Induced Constipation and the Enteric Nervous System
Part 8 Multi Dosage Regimens And IV Infusion 26 slides
zhlédnutí 2,4KPřed 2 lety
Part 8 Multi Dosage Regimens And IV Infusion 26 slides
Is ACE inhibitors such as Ramipril good for treating IGA nephropathy?
Hi. I'm no expert on IgA nephropathy, but upon a brief search, it looks like it damages your glomeruli (filters) in the kidneys. According to Penn Medicine, ACE inhibitors may be used to help in cases of high blood pressure (hypertension) or fluid retention (edema). Unfortunately, ACE inhibitors will not directly resolve the underlying issue, which is too much IgA (an antibody) deposited in your glomeruli. IgA is a protein, and protein can get stuck in leaky capillaries, such as those in glomeruli. It is really an interesting but unfortunate disease. www.pennmedicine.org/for-patients-and-visitors/patient-information/conditions-treated-a-to-z/bergers-disease-iga-nephropathy#:~:text=IgA%20nephropathy%20is%20a%20kidney,is%20also%20called%20Berger%20disease. It looks like the only treatments currently recommended do not directly solve the underlying problem, other than perhaps corticosteroids, which can lower IgA level, but those have many side effects, which get worse when used chronically. Someone needs to fund gene therapy to lower IgA levels, without completely abolishing them. Also, to avoid affecting the other parts of the immune system.
But morphine is not really a pro drug, so it could explain why it’s more potent, tramadol needs to be metabolized to O-desmethyltramadol, so even if you took a huge dose of tramadol at once you wouldn’t get as high as let’s say a huge dose of tapentadol since it’s not a prodrug right? But what I don’t get is that codeine and oxycodone are prodrug, and they have morphine and oxymorphone as metabolites (among others), then why is oxycodone preferred for severe pain and cancer patients? Since we saw that even partial agonists can behave like full ones? What do you think?
Hi, and thanks for the questions. It's not a matter of whether or not you will get the same activity, but rather it is a matter of when you will get that activity. Once the tramadol is metabolized, you can get just as much activity as morphine, whether you are talking about a high, toxicity, or pain relief. Oxycodone is active as the parent compound, and yes, the metabolite oxymorphone is active as well. To the best of my knowledge, oxycodone is not preferred over morphine for severe pain, but rather, they are about equally effective.
Hi Can please explain the physiology behind excessive yawning in opioid withdrawal ?
Hi! I'm no expert on yawning, but this reference suggests that opioids inhibit oxytocin release. Oxytocin can trigger yawning. I propose that the oxytocin-mediated yawning is overactive when you stop an opioid due to upregulation of oxytocin receptors while taking an opioid, and then when you stop the opioid, the inhibition of oxytocin release is no longer there, but the oxytocin receptors are more abundant, so you have too much receptor activity overall. This is just a hypothesis I came up with. Still not sure.
@@AVW_Dr.Dr. Thank you. That is a possible hypothesis.
❤❤❤ Thanks for the effort and information ….it is really appreciated
My pleasure 😊
Great info! Thank you! Timento rethink a vouple of things gor me. But the uniformity of affection on different individual also may be false. I know many people who react completely differently to the THC. As if they were different dpecies. Lets give it time.
Hi! I absolutely agree that people will be affected differently based on difference in metabolism, receptor expression, % body fat, and many other things.
This is better than all my opioid chapters from Anestehsiology residency Which is sad ofc
So, anestehsiology residents will be grateful if you continue to release anestehsiology drugs lessons Hipnos, benzo, vasoactive drugs, and IA 🤓
Thank you! I feel like I made this an eternity ago. Glad there's someone out there watching!
Cbg has done some amazing wonders for my ADHD. Lower of blood pressure is a plus, but it's good to know the potential dangers of the substance. Luckily high blood pressure is an unaddressed problem of mine and it's good to think that maybe cbg is helping with that as well.
Omg man! Get to it!....
speed up to the rate to 125 it helps .
I grew up in a time with Mr. Rogers and Bob Ross, where calmly and thoroughly explaining an idea was valued over speed. I also suggest adjusting the playback speed. After all, that's what it's for.
HOW DOES IT WORK? BY DRASTICALLY RAISING THE PH LEVELS IN YOUR MOUTH TILL YOUR TEETH GET THESE PIN HOLES THAT THEN OPEN UP. LOST ALL MY TEETH. IM ON DISABILITY, MY FAMILY HAS A $40K+ DENTAL BILL, SUB CLINICS GASLIGHT PATIENTS AND DONT VOLUNTEER THE FDA WARNING!!
I've never heard of this.
Now, do you volunteer the FDA warning on Suboxone for tooth rot? Or do you just say Suboxone is totally safe?
hi, I've started using CBG recently and have noticed it sometimes raises my heart rate, to the point of palpitations at times. should I be worried about this ?
Hi. It's really difficult to say, since many things can affect your heart. If it makes you uncomfortable there's no need to use it. There aren't any approved medical uses for it yet anyway.
They do speak about bacteria that produce this sucralose-6-acetate? The one in the gut?
hey professor Adam i am a fourth year pharm d student in India, pharm d is new here and it has not been explored and applied to its full potential, are there any masters or additional specialty courses that one can opt for after completing pharm d.
Hi! In the USA some PharmDs go for a residency for added training. The PharmD here is a highly clinical degree, and less into the physical pharmacy as India, unless that is changing there in India. There are also PhDs in clinical pharmacology after you get your PharmD here.
It can worsen Depression and ADHD
It wouldn't surprise me, especially with depression, since activating alpha-2 receptors is can cause sedation. However, I have yet to see a study with proof that alpha-2 receptors are activated. Just physiological response studies suggesting alpha-2 is the cause of the response.
seems like CBG is a good candidate for alternative BP lowering rx medicines, esp if the patient experiences unwanted side effects or perhaps refractive to that medication. worth a trial.
Sure, provided it does prove safe and an actual clinical trial is done for BP specifically. If it indeed does what clonidine does, perhaps it wouldn't be first line, since clonidine has fallen out of favor for BP.
I have heard that CBG will aid in draining the eye just like THC, relieving any troublesome eye pressure, so I want to get into that so I can begin to avoid THC which is highly problematic for a plethora of reasons. CBG won't be addicting either like THC, whereas there won't be a high to chase. I also heard a report of CBG enhancing energy, and mental clarity, which also seems beneficial to me, and worth hobbying about with, now that there are CBG hemp strains available. I think the only reason they will prohibit CBG is big money pharma muscling them like the thug they are, whereas they want us all sick so they can make money with patentable products at exorbitant rates. 100% criminal organization ever since Rockefeller formed the model.
I have heard nothing about CBG draining the eye (for Glaucoma), but that doesn't mean it doesn't happen. There are definitely CBG-enriched strains, as I have tested them in my lab, were we have a license to grow low-THC hemp.
@@AVW_Dr.Dr. I have heard of CBG draining the eye. I am going to see if I can search that out. I remember reading that. I can get a license to grow if I want. I like THC, but have a bad addiction to it. I haven't had any for 15 weeks now, because I don't control it well enough. Means too much to me. Took too many liberties with it. Never over do it; be cautious consuming..........One answer for too much THC may be to grow hemp for turpines, CBG, and or CBD, then mix it with high THC to get tamer THC like 3 to 5% THC, and 5 to 10% THC, and sell "Cooler" mixes. I need to write to lawmakers to incentive lower dosage THC, and single doses, or packs of 5 or 6 of it for cheap occasional use.
I haven’t seen anyone discuss how taking supplements might affect someone on semaglutide. My sister started and she takes several supplements; her doctor hasn’t said anything about it.
What supplements? It is likely we just don't know if any interaction exists yet. In most cases, supplements such as vitamins don't cause issues, but there are exceptions with some medications. This med we just don't know, but I would expect the most likely risk to be an increase in nausea, since some supplements can do that on their own.
P I recently had some heartburn and was reading that licorice coat of the stomach and helped relieve heartburn and ulcers. So I saw a product that had gut health to targeted as it's main consumer. So is this safe to take daily for heartburn?
Is hard to say without reading the product label. Will you share a link to it?
Say what now? I haven’t watched the video but I was under the impression it was a full agonists. It doesn’t seem to block other opiates.
Hence the quotes. Check out the video!
TLDR: Semaglutide, a modified version of the hormone glp-1, can effectively lower glucose levels, promote weight loss, and reduce hunger, but carries potential risks and may require careful monitoring and dosage adjustments. 00:00 🔍 Semaglutide is a modified version of the hormone glp-1, designed to last longer in the body, and it regulates insulin release, glucose use, and hunger. 01:52 📌 Semaglutide lowers glucose levels by activating GLP-1 receptors, increasing insulin release and decreasing glucagon release, with low risk of hypoglycemia, and also causes weight loss. 04:30 🧠 Activation of the glp-1 receptor in the stomach can reduce hunger, and may trick the brain into feeling full, potentially leading to weight loss. 05:44 💉 Semaglutide concentration in blood is affected by weight, with lighter patients having higher concentration and heavier patients having lower concentration, potentially requiring a higher dose for effectiveness. 08:28 💉 Semaglutide is a larger protein with minimal drug interactions and common side effects including gastrointestinal issues and hair loss. 10:07 🚨 Semaglutide carries risks of heart attack, sleep apnea, and thyroid cancer, and may not be effective for weight loss until reaching the therapeutic dose. 11:51 👩⚕ Some patients may develop antibodies to semaglutide, potentially affecting its effectiveness and causing breakthrough hunger. 13:12 👩⚕ Semaglutide is a medication that can be taken at a higher frequency with a lower dose to reduce side effects and hunger, but any changes in dosage should be discussed with a healthcare professional.
I have very high BP .. Can the spine be it from a injury signal the bran to make more say adrenaline
Hi. There are many reasons for high blood pressure. The most important thing is to keep it in the recommended range.
@@AVW_Dr.Dr. I have! Autonomic dysrefflexia any pressure put on my back will push up BP up same if I put tension on it Meds do not work as adrenal glands are on..
I hope you continue creating more great content ❤❤
Thank you very much! What sort of content would you like to see?
@@AVW_Dr.Dr. could you do a video on autacoids.I also came across this question on biology stack exchange and l would love your feedback:What structural features make a molecule a potent opioid receptor agonist?How can molecules with structures so radically different from those of endorphins mimic the action of endorphins?
Nice animation! I'm interested in your channel.
Thank you!
Wow, look at the chemistry in one neuron. Now multiply that times thousands or millions and all of the other cellular interactions and a body which make life. And then try to tell me that this is all come together by chance! Can I say, supreme, being, supreme, intelligence, supreme designer?
Buprenorphine is a weak partial agonist at the mu receptors. Wich means it only tickles the receptors. Sufficiently to remove the withdrawals and craving. But not sufficiently to cause euphoria
Thank You for sharing, the video was very insightful and helped me a lot!
You're very welcome!
Very informative presentation, thank you for making it. It seems like it would be an interesting substance to treat orthostatic hypertension. I wonder how long the duration of it's anti hypertensive effects are and what an appropriate dose would be. It's incredibly difficult to quantify given the numerous variables as you stated.
Thanks! I haven't heard of many people having orthostatic hypertension, but rather it is usually hypotension. But sure it might work well for hypertension. However, clonidine isn't used much for hypertension anymore, and that's also an alpha 2 agonist.
So my situation is different and would greatly appreciate your input. My kidneys are fine. Perfect. I had my gall bladder removed (the old fashion way due to infection). I had blood loss during surgery, but not enough to require a transfusion. After surgery, my kidney values were horrible. They came back while in the hospital somewhat…..that was in 2007. I have high blood pressure but has been controlled very well for years. 2006 BUN 15 ….to 45 after surgery, now upper 20’s…….Creat. 2006 = 1 , after surgery 2.4….now around 1.3 to 1.5…… 46 yr old at time of surgery, now 63. When on Lisinopril, it increases test result creatinine and bun numbers…..when off, numbers drop down again. My question…is Lisinopril protecting my kidneys or hurting them, based only on the data above? Thank you!
Hi. Is that range you listed now while you are taking lisinopril or does lisinopril make creatinine go above 1.5? 1.3 is the upper limit of the normal range, but if it goes to 1.5 only while on lisinopril I personally wouldn't be too concerned. Once you start getting into your late 60s and older it is normal to have gradually declining kidney function, but it's very gradually usually. I don't see any evidence that lisinopril is harming your kidneys, and it wouldn't be true renal damage from the lisinopril, , but just low glomerular pressure. Now if you had a more severe rise in creatinine after starting lisinopril I'd be concerned you had renal artery stenosis. However, from what you've said I don't see evidence of that. Keep in mind there are many other factors that your physician would be aware of, and you should be having this conversation with him/her. I am not a physician, but I do teach renal physiology and pharmacology. So, I hope I have helped clear some things up.
I'm a fifth year Pharmacy student from Syria and I was having troubles with the superposition concept and the calculations, but it's all clear now thanks to you professor! Please keep adding videos you're great at explaining.
Thank you for the very kind comment! I'll be adding more in the future. I took a little break while I had some projects going on. Good luck with your career.
I'm learning about the partition coefficient in my pharmaceutical chemistry class right now and it was extremely helpful to watch the process in real life, especially with the explanations. Thank you for making this!
You're very welcome! I'm glad you found it helpful.
Naloxone gives me headaches theres no point in having the Naloxone ii can't compete with the buprenorphine
You make a good point. I'll be making a video explaining why the formulation is not serving its intended purpose.
Wouldn’t the Nalaxone block the effect of the buprenorphine ?
That's a great question. It's not supposed to be absorbed from the oral mucosa as much as buprenorphine, but the reality is naloxone's half life is too short to serve a purpose in this formulation, which is supposed to be to prevent abuse through injection.
good video and commentary Thanks Dr. Adam!
Much appreciated!
Is the medication mididrine? I am on the highest dose already and would like to suggest another option with my doctor to solve my low blood pressure and low sodium.
I was referring to prednisone, methylprednisolone, fludrocortisone, and other steroids used for inflammation. These drugs bind to the same receptor and cause potassium loss and sodium retention. But you're right that midodrine raises blood pressure, just through a different mechanism.
Did your doctor mention fludrocortisone? That can be used for low sodium and low blood pressure, but it's best to ask your doctor if that's an option for you.
@@AVW_Dr.Dr. I did try fludricortisone for 18 months, but stopped it after some skin issues. It definitely causes moon face! There was not a significant difference with my blood pressure, but perhaps the dose should have been adjusted.
Dyde i yave a naktrexobe one tgats dabgerous abd160mg avd i tave 81mg pills tgat are fir oxycidkbe oxycintin are they acailable xan i check in
It doesnt work for pain or for your teeth...it removes the enamel. Law suit pending. Do not take.Lobby to get safe, effective oxycodone back.
I'm not surprised companies would find a study just to confuse people and make them keep eating sugar, sugar will never be healthy and it causes a lot more problems than what this "sucralose" study demonstrates.
Are there any alternatives to octanol? I want to use an antacid
Please explain more about your goal. What exactly are you trying to accomplish?
Um, um, um, um, um
How do u potect the kidneys while taking an ARB?
Hello. Let me clarify. ARBs protect the kidneys in most cases of hypertension. It is only when someone has bilateral renal artery stenosis that RAAS inhibitors (such as ARBs) are a risk. So, you shouldn't have a cause for concern unless you have renal artery stenosis, and that it something your physician should be communicating with you. Please let me know if you have further questions.
@@AVW_Dr.Dr. Great, you summarized everything. 🎉❤
i've been on buprenorphine for 12yrs and now it has stopped producing the euphoric effect and i don't know why. i questioned the manufacturers about ingredient change but they denied it. what the hell can it be.
Hello. That is a long time for that change to occur now. Have you started taking any other medications, or had any weight changes?
As someone with Parkinson’s disease it’s definitely worth using IF it doesn’t exacerbate your Orthostatic Hypotension. Symptoms vary from one human to the next however Hypotension exist in most cases both atypical and Young Onset. The convenient thing with CBG is that when used from a Tincture you can really control your dose. I’ve used Cannabis for Parkinson’s going on 2 decades now because I have total control of my meds, my dosages and can switch Strains and Cannabinoids when needed WITHOUT terrible pharmaceutical withdrawals. I’ve watched my Father use the pharmaceuticals and it’s a joke, lose your drivers license, get a caretaker earlier, and stare at the walls more. ☹️
Hi. Do you have a tincture from a high-CBG variety?
How to stop this tablet I want to leave him plz tell me the right path I taking 3 tablets per day
If it is prescribed then speak to your doctor. But either way, tapering off the medication slowly is always the best plan. The slower the better. Lowering the dose by 0.25 tablets a week is even reasonable. 2.75 one week, 2.5 next week, 2.25 next week, etc.
@@AVW_Dr.Dr. thankx docter
HI Doc,what can i get over the counter to lower my blood pressure thank you....
Hi, and thank you for watching and subscribing! There are no approved OTC medications for blood pressure. In fact, the first-line treatment for blood pressure (after lifestyle modifications have been tried) is a very inexpensive medication called hydrochlorothiazide, which is prescription only. It might be the cheapest medication out there. There are also many alternatives that are not very expensive. Talk to your physician, the sooner the better.
I've been on MMJ for over a year, and I can say it does bring down the blood pressure. My doctors want to know how, then when I say it's mmj, they want nothing to do with it. I went from high 140's, low 150's over 89. Now I'm 120 over 82. They can deny, but I've seen the improvement.
Thanks for sharing. By the way, CBG is only found in some strains, and typically high CBG strains would have low THC, because the pathway to produce THCA in the plant has been terminated at the precursor, CBGA.
hi can i have a link thank you
@AVW_Dr.Dr. so I have found some pretty strong cbg. There's very few that are good but there are a few company's who have focused on a few cbg plants and they are very interesting.
I wonder if it can lower serotonin
They don't tell you how bad the withdrawal is when you taper off suboxone. On it for 10 years and even after a very slow taper, it's still months of agony
Thank you for sharing your experience. Do you mind sharing exactly how you tapered off?
i havent heard two people pronounce this word the same way
I tend to pronounce the canna like in cannabinol. I suppose there isn't an agreed upon pronunciation.
SleepyG
What happens if someone snorted it? I hear friends all the time and that's only way they use it?
Since naloxone is normally used intranasally for opioid overdose reversal, snorting suboxone would certainly make the naloxone more bioavailable, and would oppose the buprenorphine more strongly than if used sublingually. I would expect snorted suboxone to give less euphoria, and likely oppose other opioids in the system as well. Now, the answer would be very different for something with just buprenorphine, and no naloxone.
I am using the 2x weekly technique you described. I set the calendar app to Monday at 7 am and Thursday at 7pm. Question: if I advance the schedule by 24 hours per week, the next weeks schedule would become Sunday at 7am and Wednesday at 7pm. I’m estimating the dosage would be approximately 1.2 mg weekly which is a technique to more gradually taper up or acquire a dose not available with the pen. The complex schedule is programmed into my phone calendar which simply beeps and says take ozempic now. What do you think
I think going more gradually than typical is not a bad idea at all, especially if you have had trouble with side effects historically when you moved up. I'm curious to see if the split dose method works for you. Thank you so much for watching the video.
@@AVW_Dr.Dr.I had multiple failures when I attempted semaglutide. The nausea was overwhelming. I was also taking HMG-CoA reductase inhibitor atorvastatin, which also caused nausea and diarrhea. I felt that the block on the reductase enzyme would create a buildup of longer hydrocarbon weight fats which are known to create nausea, thus using both drugs might cause semaglutide failure. I therefore stopped atorvastatin, then after a week restarted semaglutide, with total success. I was able to rapidly increase the dosage to 1 mg. Patient reports and my own experience indicates that certain fats such as beef fat and pork fat become undesirable and create an immediate satiety, while fruit and vegetables become more desirable to the palate, suggesting that the longer chain hydrocarbons create more nausea than other shorter more easily processed fats such as yogurt. Other patients reported similarly, and some patients are attempting to replicate my results with the statin, if safe to do so. Further, I made a slight error in my first comment, because what I intended to say was that the dosage could be increased by shaving the time by 12 hours off each dose, thus the period becomes 3 days per dose instead of 7. If I have a weekly dosage of 1 mg, or 0.5 mg per 3.5 days, how would the concentration change if you enter a 3 Day interval into your spreadsheet? Thank you for your help and reply and the feedback is being shared with physicians who are treating patients with semaglutide Thank you
(I meant to say the period becomes 3 days rather than 3.5)
What about using T3 (cytomel) while using ozempic for weight loss.. I presume the T3 will weaken the effects of semaglutide?
That I'm not sure of. I would think possibly more weight loss could be expected due to an additive effect, but that's just guessing.