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Hi. I'm no expert on IgA nephropathy, but upon a brief search, it looks like it damages your glomeruli (filters) in the kidneys. According to Penn Medicine, ACE inhibitors may be used to help in cases of high blood pressure (hypertension) or fluid retention (edema). Unfortunately, ACE inhibitors will not directly resolve the underlying issue, which is too much IgA (an antibody) deposited in your glomeruli. IgA is a protein, and protein can get stuck in leaky capillaries, such as those in glomeruli. It is really an interesting but unfortunate disease. www.pennmedicine.org/for-patients-and-visitors/patient-information/conditions-treated-a-to-z/bergers-disease-iga-nephropathy#:~:text=IgA%20nephropathy%20is%20a%20kidney,is%20also%20called%20Berger%20disease. It looks like the only treatments currently recommended do not directly solve the underlying problem, other than perhaps corticosteroids, which can lower IgA level, but those have many side effects, which get worse when used chronically. Someone needs to fund gene therapy to lower IgA levels, without completely abolishing them. Also, to avoid affecting the other parts of the immune system.

Hi, and thanks for the questions. It's not a matter of whether or not you will get the same activity, but rather it is a matter of when you will get that activity. Once the tramadol is metabolized, you can get just as much activity as morphine, whether you are talking about a high, toxicity, or pain relief. Oxycodone is active as the parent compound, and yes, the metabolite oxymorphone is active as well. To the best of my knowledge, oxycodone is not preferred over morphine for severe pain, but rather, they are about equally effective.

Hi! I'm no expert on yawning, but this reference suggests that opioids inhibit oxytocin release. Oxytocin can trigger yawning. I propose that the oxytocin-mediated yawning is overactive when you stop an opioid due to upregulation of oxytocin receptors while taking an opioid, and then when you stop the opioid, the inhibition of oxytocin release is no longer there, but the oxytocin receptors are more abundant, so you have too much receptor activity overall. This is just a hypothesis I came up with. Still not sure.

@@AVW_Dr.Dr. Thank you. That is a possible hypothesis.

My pleasure 😊

Hi! I absolutely agree that people will be affected differently based on difference in metabolism, receptor expression, % body fat, and many other things.

So, anestehsiology residents will be grateful if you continue to release anestehsiology drugs lessons Hipnos, benzo, vasoactive drugs, and IA 🤓

Thank you! I feel like I made this an eternity ago. Glad there's someone out there watching!

speed up to the rate to 125 it helps .

I grew up in a time with Mr. Rogers and Bob Ross, where calmly and thoroughly explaining an idea was valued over speed. I also suggest adjusting the playback speed. After all, that's what it's for.

I've never heard of this.

Now, do you volunteer the FDA warning on Suboxone for tooth rot? Or do you just say Suboxone is totally safe?

Hi. It's really difficult to say, since many things can affect your heart. If it makes you uncomfortable there's no need to use it. There aren't any approved medical uses for it yet anyway.

Hi! In the USA some PharmDs go for a residency for added training. The PharmD here is a highly clinical degree, and less into the physical pharmacy as India, unless that is changing there in India. There are also PhDs in clinical pharmacology after you get your PharmD here.

It wouldn't surprise me, especially with depression, since activating alpha-2 receptors is can cause sedation. However, I have yet to see a study with proof that alpha-2 receptors are activated. Just physiological response studies suggesting alpha-2 is the cause of the response.

Sure, provided it does prove safe and an actual clinical trial is done for BP specifically. If it indeed does what clonidine does, perhaps it wouldn't be first line, since clonidine has fallen out of favor for BP.

I have heard nothing about CBG draining the eye (for Glaucoma), but that doesn't mean it doesn't happen. There are definitely CBG-enriched strains, as I have tested them in my lab, were we have a license to grow low-THC hemp.

@@AVW_Dr.Dr. I have heard of CBG draining the eye. I am going to see if I can search that out. I remember reading that. I can get a license to grow if I want. I like THC, but have a bad addiction to it. I haven't had any for 15 weeks now, because I don't control it well enough. Means too much to me. Took too many liberties with it. Never over do it; be cautious consuming..........One answer for too much THC may be to grow hemp for turpines, CBG, and or CBD, then mix it with high THC to get tamer THC like 3 to 5% THC, and 5 to 10% THC, and sell "Cooler" mixes. I need to write to lawmakers to incentive lower dosage THC, and single doses, or packs of 5 or 6 of it for cheap occasional use.

What supplements? It is likely we just don't know if any interaction exists yet. In most cases, supplements such as vitamins don't cause issues, but there are exceptions with some medications. This med we just don't know, but I would expect the most likely risk to be an increase in nausea, since some supplements can do that on their own.

Is hard to say without reading the product label. Will you share a link to it?

Hence the quotes. Check out the video!

Hi. There are many reasons for high blood pressure. The most important thing is to keep it in the recommended range.

@@AVW_Dr.Dr. I have! Autonomic dysrefflexia any pressure put on my back will push up BP up same if I put tension on it Meds do not work as adrenal glands are on..

Thank you very much! What sort of content would you like to see?

@@AVW_Dr.Dr. could you do a video on autacoids.I also came across this question on biology stack exchange and l would love your feedback:What structural features make a molecule a potent opioid receptor agonist?How can molecules with structures so radically different from those of endorphins mimic the action of endorphins?

Thank you!

You're very welcome!

Thanks! I haven't heard of many people having orthostatic hypertension, but rather it is usually hypotension. But sure it might work well for hypertension. However, clonidine isn't used much for hypertension anymore, and that's also an alpha 2 agonist.

Hi. Is that range you listed now while you are taking lisinopril or does lisinopril make creatinine go above 1.5? 1.3 is the upper limit of the normal range, but if it goes to 1.5 only while on lisinopril I personally wouldn't be too concerned. Once you start getting into your late 60s and older it is normal to have gradually declining kidney function, but it's very gradually usually. I don't see any evidence that lisinopril is harming your kidneys, and it wouldn't be true renal damage from the lisinopril, , but just low glomerular pressure. Now if you had a more severe rise in creatinine after starting lisinopril I'd be concerned you had renal artery stenosis. However, from what you've said I don't see evidence of that. Keep in mind there are many other factors that your physician would be aware of, and you should be having this conversation with him/her. I am not a physician, but I do teach renal physiology and pharmacology. So, I hope I have helped clear some things up.

Thank you for the very kind comment! I'll be adding more in the future. I took a little break while I had some projects going on. Good luck with your career.

You're very welcome! I'm glad you found it helpful.

You make a good point. I'll be making a video explaining why the formulation is not serving its intended purpose.

That's a great question. It's not supposed to be absorbed from the oral mucosa as much as buprenorphine, but the reality is naloxone's half life is too short to serve a purpose in this formulation, which is supposed to be to prevent abuse through injection.

Much appreciated!

I was referring to prednisone, methylprednisolone, fludrocortisone, and other steroids used for inflammation. These drugs bind to the same receptor and cause potassium loss and sodium retention. But you're right that midodrine raises blood pressure, just through a different mechanism.

Did your doctor mention fludrocortisone? That can be used for low sodium and low blood pressure, but it's best to ask your doctor if that's an option for you.

@@AVW_Dr.Dr. I did try fludricortisone for 18 months, but stopped it after some skin issues. It definitely causes moon face! There was not a significant difference with my blood pressure, but perhaps the dose should have been adjusted.

Please explain more about your goal. What exactly are you trying to accomplish?

Hello. Let me clarify. ARBs protect the kidneys in most cases of hypertension. It is only when someone has bilateral renal artery stenosis that RAAS inhibitors (such as ARBs) are a risk. So, you shouldn't have a cause for concern unless you have renal artery stenosis, and that it something your physician should be communicating with you. Please let me know if you have further questions.

​@@AVW_Dr.Dr. Great, you summarized everything. 🎉❤

Hello. That is a long time for that change to occur now. Have you started taking any other medications, or had any weight changes?

Hi. Do you have a tincture from a high-CBG variety?

If it is prescribed then speak to your doctor. But either way, tapering off the medication slowly is always the best plan. The slower the better. Lowering the dose by 0.25 tablets a week is even reasonable. 2.75 one week, 2.5 next week, 2.25 next week, etc.

@@AVW_Dr.Dr. thankx docter

Hi, and thank you for watching and subscribing! There are no approved OTC medications for blood pressure. In fact, the first-line treatment for blood pressure (after lifestyle modifications have been tried) is a very inexpensive medication called hydrochlorothiazide, which is prescription only. It might be the cheapest medication out there. There are also many alternatives that are not very expensive. Talk to your physician, the sooner the better.

Thanks for sharing. By the way, CBG is only found in some strains, and typically high CBG strains would have low THC, because the pathway to produce THCA in the plant has been terminated at the precursor, CBGA.

hi can i have a link thank you

​@AVW_Dr.Dr. so I have found some pretty strong cbg. There's very few that are good but there are a few company's who have focused on a few cbg plants and they are very interesting.

I wonder if it can lower serotonin

Thank you for sharing your experience. Do you mind sharing exactly how you tapered off?

I tend to pronounce the canna like in cannabinol. I suppose there isn't an agreed upon pronunciation.

Since naloxone is normally used intranasally for opioid overdose reversal, snorting suboxone would certainly make the naloxone more bioavailable, and would oppose the buprenorphine more strongly than if used sublingually. I would expect snorted suboxone to give less euphoria, and likely oppose other opioids in the system as well. Now, the answer would be very different for something with just buprenorphine, and no naloxone.

I think going more gradually than typical is not a bad idea at all, especially if you have had trouble with side effects historically when you moved up. I'm curious to see if the split dose method works for you. Thank you so much for watching the video.

@@AVW_Dr.Dr.I had multiple failures when I attempted semaglutide. The nausea was overwhelming. I was also taking HMG-CoA reductase inhibitor atorvastatin, which also caused nausea and diarrhea. I felt that the block on the reductase enzyme would create a buildup of longer hydrocarbon weight fats which are known to create nausea, thus using both drugs might cause semaglutide failure. I therefore stopped atorvastatin, then after a week restarted semaglutide, with total success. I was able to rapidly increase the dosage to 1 mg. Patient reports and my own experience indicates that certain fats such as beef fat and pork fat become undesirable and create an immediate satiety, while fruit and vegetables become more desirable to the palate, suggesting that the longer chain hydrocarbons create more nausea than other shorter more easily processed fats such as yogurt. Other patients reported similarly, and some patients are attempting to replicate my results with the statin, if safe to do so. Further, I made a slight error in my first comment, because what I intended to say was that the dosage could be increased by shaving the time by 12 hours off each dose, thus the period becomes 3 days per dose instead of 7. If I have a weekly dosage of 1 mg, or 0.5 mg per 3.5 days, how would the concentration change if you enter a 3 Day interval into your spreadsheet? Thank you for your help and reply and the feedback is being shared with physicians who are treating patients with semaglutide Thank you

(I meant to say the period becomes 3 days rather than 3.5)

That I'm not sure of. I would think possibly more weight loss could be expected due to an additive effect, but that's just guessing.