REVERSE AGING: What To Eat & When To Eat For LONGEVITY | David Sinclair
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- čas přidán 21. 08. 2024
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My guest today is a revolutionary thinker and ground-breaking scientist who’s on a mission to make you younger. He’s Australian biologist and Harvard professor David Sinclair, author of Lifespan: Why We Age - And Why We Don’t Have To. David is one of the world’s leading scientific authorities on longevity, ageing and how to slow its effects.
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Lifespan: Why We Age - And Why We Don’t Have To US amzn.to/48MsfsR UK amzn.to/3iQsHi8
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In my 20s I decided to eat well, take vitamins, exercise .... I've made this huge investment in myself from a young age with the thought that I'd be happy I did by the time I reached 60. Well, I'm over 60 now and it has paid off, and with talks like this and learning about intermittent fasting, keto, insulin resistance, better exercise/training, I've decided to UP the game. I do not listen to naysayers .... they are downers and not part of the solution. Most people think I'm in my 40s. That is not my genes or random. Do not think or do as the "world" does and the benefits are tremendous. THANK YOU for this great talk!!
Girl you definitely don’t look your age! Not that 60 is old, but you look fantastic. I’m in my 20s and investing in my health now.
Inspiring advice, thank you
Well done sister.
Keto is not healthy for you. Look at the bluezones they eat a high carb plant based diet.
Thanks for sharing your experience 😊
*Notes (**#ReverseAging** **#ReverseAgingDavidSinclair**):*
* 00:00:18 ~ What is hormesis?
* 00:01:41 ~ Eat Less: The Significance
* 00:03:59 ~ How do you view fasting?
* 00:08:58 ~ Intermittent fasting
* 00:12:58 ~ Longetivity gene (survival, adversity genes)
* 00:14:15 ~ Three pathways to longevity
* 00:18:05 ~ Focusing on root causes of diseases
* 00:23:00 ~ David Sinclair's worldview on doctor visits/healthcare (aging)
* 00:26:43 ~ A body's dashboard (Inside Tracker)
* 00:28:08 ~ Mouth swab detects biological age
* 00:29:00 ~ Biological age markers in blood test
. . . . .
* 00:31:50 ~ The epigenome and the genome
* 00:32:48 ~ Age reversal: Reversing and controlling age
* 00:35:00 ~ Not immortality, but changed view on aging
. . . . .
* 01:41:38 ~ An extra 16 years of life is easy.
* 01:44:00 ~ Some age-reversal technology
Thank you🎉
Thank you 🙏
🙏🙏🙏🙏
Merci Beaucoup 🎉
❤❤❤Much love buddy! 🇮🇳🧿
I am 62, now, but am still told I look in my 40's. Happy as !! I agree we can reverse our age of physical and mental ability. I was told by a orthopedic doctor "unfortunately my muscles were similar to the ones of age of 85 years old" after 8 months on bed. I was 41 years old at that time. I slowly trained myself and ate wisely, then I became well enough to go to Mt. Everest base camp in 2018 and I can do more mountain trails. I have started to do things discussed by Dr. Sinclair, as much as possible I can.
Be careful on this diet.
And maintain,
Your muscle.
Especially,
When your athletic.
Which is always done by
feeding,the body
3--4 times,
Daily.
And 4-6 times for athletic teens!!
Now!!
That's a healthy metabolism.
Which is not common these days for adults.
Giving an child
a fasting diet,
Is detrimental to a healthy metabolism.
Overweight
Kids should be exercising1-3 hrs everyday,
The exception:
My neighbor
Does fine fasting
Twice a month,
But he's been a long distance runner
F 40 yrs.
And.
Maintains a body weight of 150 lbs.
He's 78 now.
So fasting is fine f him!!
In moderation.
Because ,
R always hungry
Especially after a 8 to 15 mile run.
Fasting isn't necessary,
F people who are healthy.
By the way,
The Japanese
live the longest
And follow a high
Fish ,vegetable,
Moderate carbs and protein diet.....b.
Look it up
Most research
The is nonsense
And inaccurate.
P.s. --People need a gd amount of muscle and strength training, besides some cardio.
To support the joints
And live a long healthy life.
People will try and sell us the moon!
@@harveydoherty6995 Yeah, I;m getting a bit cheesed off with all the incredible claims made in podcasts that usually involve selling a book and the abiity to listen to a 2 or 3 hour sermon without losing the will to live. Some of these guests could talk a glass eye to sleep.
You had atrophied muscles from a long bed rest? You built back those muscles with exercise? How long did it take? I have the same thing with a frozen shoulder. Did you have to have physical therapy or an operation? Thanks.
I am 74 Have practised intermittent fasting for over 20 years. Walk 6 klm 5 mornings per week, excersise using weights daily .Height 5ft 6in Weight 60 kilos Feel great, Sleep pattern is a solid 7 to 8 hours. Healthy, Happy , and Stress free. Spend quality time with my 5 grandchildren .. My husband died aged 35.. After which I was motivated to live a Long and Wonderful life… Bottom line.. I have NEVER been ill in my life.. and I Live a wonderful life in Australia.. David Sinclair is an exceptional and amazing man who I admire greatly.. Thankyou Dr Sinclair for sharing your exceptional knowledge …Mimi …
Toni wow really!!!
hi! can i ask how is yout intermittent fasting like? isit like 16hour-8 fasting?
@@yeoaien8383 Best way to do it is 22/2. Eat only dinner 5-7PM and that's it. But if you are a foodie like me then you can do whatever you can. i.e i do 48 hours fasting (no food Fridays, and only eat Saturday around 6 PM) and that is absolutely amazing for what it does to your body/health even better than 18 hour fast. so basically don't eat at all one day a week and delay the next day till dinner.
35? that's incredibly young
What if you ant afford to lose weight?
*"When you arise in the morning, think of what a precious privilege it is to be alive - to breathe, to think, to enjoy, to love." - Marcus Aurelius*
My philosophy too
only an entitled person with an easy life would think like that
Demetri panini
@@Archonsx Sucks to be other people.
@@Archonsx Epictetus did it, and he was a slave.
you NEED timestamps on these lengthy podcasts
Fuck Yeah!!!
@eblman why don't you?
@@AJ-ds5gf Because you're the one who is complaining about needing it. He never asked.
@@MT-pe8bh next time you give feedback or complain about something, remember to STFU and do it yourself. No matter how small or big. See how far that takes you, you lemon.
@eblman Hey man! AJ is the 'idea man." YOUR JOB is execution. That's how it works. MY JOB is to pass the popcorn...
Im 53 still in phenomenal shape, have been doing intermitted fasting for over 20 years, I actually jumped rope on LIVE tv for an hour at 47 years old ...
Wow! What eating window do you have?
@@SylwiaKaczmarek Over the past several years, I've developed a system that works for me, where I give my stomach a break. lets use a random day for example,
I will usually just flush my stomach out with only water first thing in the morning and just sip on the gallon for the whole day, at night I will have a light meal (my wife cooks EVERY day) typically Mediterranean, Thai or some Asian dish (my wife is from Malaysia so my diet is pretty clean as it is)
Incredible conversation! Just ordered Dr. Sinclair’s book. I already eat infrequently and I take Pilates weekly with a trainer. I’m going to be 70 soon and I have no physical limitations and take no meds. I had no idea retirement could be this exciting.
Thank you for this! Inspiring.
Me too just turned 70. Always been fit & healthy all my life still am. I eat plant based infrequently mostly because I can’t be bothered to make meals.. I am a thin small female & not on any meds. I have just started taking 1000 grams of resverotol per day. Plus exercise everyday on a trampoline & take the dog for a walk daily also just started to do some weights. I am out of here at 150! 😇😍
Whaaat? That is amazing.
Me too! Age 75 and loving life! One exception is that about 5 years ago I lost up to 100 lbs and lost all sorts of ailments! Now running 50 miles per week!
@@dapawap you are obviously feeling and seeing the effect of good maintenance. what we need to do is to educate the younger to adopt good habits and they will age most gracefuly and hold off the effects of aging as long as possible.
I work for a local Age UK and we had a lady that started learning to use a computer in her 80s and then she volunteered for us until she was in her early 90s teaching older people computers. She loved it. She said she lived for her computer class.
I’m 67 and have been following similar principles for quite some time and I’m still running 3 times a week and weight training about the same. I don’t seem to have lost a lot of strength and am running well. I really don’t feel a lot different to what I did in my 20s.
That's good to hear from this here 28 year old.
Sorry to break it to you, but a 67 year old running compared to someone in their 20s is night and day.
Thank you for sharing!
@@scottymackay1801 I'm 60, deadlift over 400, still play ice hockey, gym four days a week minimum. My lifestyle is exactly the same as when I was in my twenties and thirties. Have a nine year old son, thirty three year old wife and my life is astounding. Why? Because I've always done it. I never got fat. I never stopped working out. I never lived "the good life" which for most people means glutonny and sloth. 60 is not old at all
@@craigcrawford6749 All well and good, but I reiterate that a 67 year old cannot run faster or at the same pace as that of a healthy 20-something. We just don't notice the decline as much until we're put in a race with a 20-something.
I absolutely love this guy! He is a BRILLIANT man! I’ve been copying the protocol he’s been doing for about a year. I’m 44 and everyone thinks I’m 30! My two sisters saw me at Christmas and were like “how do you not age?”
That’s great Vivian. Can you describe exactly what are you doing ? Diet, supplements, exercise? Congrats
I only eat within a 4 hour window. Usually 2-6pm. Mainly plant based - no meat or dairy. It no longer agrees with me. I take 1g of NMN and 1g if resveratrol daily - usually at 2pm with some fat like avocado. I also take 5,000mg Vit D and other daily supplements like Vit C. I also workout in the morning in a fasted state. That’s about it.
@@NVSTGTE that’s awesome. Can you share where you buy the supplements? (NMN and resveratrol )
@@alansulikowski2331 and although completely irrelevant to the topic of discussion, you are really cute! 😁
@@alansulikowski2331 my posts keep getting deleted. Sorry.
I love David’s honesty. Stop smoking, stop drinking and don’t be lazy and eat well! Not to mention what a genius!
OMG! that is genius advice. don't smoke, don't drink, exercise and eat right. truly a paradigm-shifting epochal revolutionary mind-blowing Messiah of Immortality!
David please keep encouraging people to quit smoking. I saw an interview with you 2 years ago and I'd like you to thank you for inspiring me to quit. I have 2 young boys and thanks to your generosity in sharing you're awful experiences losing your mum my boys won't go through that. 2 years free of cigarettes and delighted. Huge thank you for everything you do!!
I would like too quit smoking...i'm working on that now...how do you stop?
@@HailCeeeasar I quit cold turkey. Everytime I wanted to smoke I thought of every reason why I wanted to quit . It helped with the urges. I'm currently 2 and a half months smoke free. I also brought nicotine gum to assist.
@@MzCappalot thank you for answer, well i think this is the best way...its the hardest but the best, ok i will do that also with reminders why i quit,its so easy to forget the reasons when the strong feeling comes for a cigarette.
@@HailCeeeasar You can do it. The first 2 weeks is the hardest but I'm sure you can . I just recently lost my mom to cancer and she was only 62 yrs old that also helped me in my reasons to quit as she was also a former smoker. Good luck 🤞
@@MzCappalot oooooh this is sad im really sorry that you lost your mom😢😢this is more than understandable that you quit at that reason...i hope my writing in english is ok because im from germany. Thank you so much dear for your words to encourage me that i can stop with this shit. May god bless you and give you help in your grief about your mom!
Intermittent fasting worlds very well. I never thought at first I could do it. Now I often have one meal a day. Lots of exercise. No lost of power. Low carb is better for me. I’m 66. I love exercise now. It makes me feel happy. No one seems to mention that exercise makes you happy it’s m[not punishment.
Its a very good to practise intermittent fasting say the dinner in particular.It is also best to do away with the snacks and the beverages we use to take almost every day or atleast skip them as much as possible.Our stomach normally gets enough fuel to sustain our body but our mind not our body that craves for more food, tempted by our senses of smell and sight.So listen to your body not your mind to manage how much you eat in a day to stay fit,wardoff diseases and enhance longivity!
Tell this one meal a day bullshit to a construction worker.
Exercise is my prescription to happiness ☺️
I wanted to thank you and Dr. Sinclair for this. My mother is in her 70s and has never taken care of her body. She smoked and drank for around/over 45 years and never did physical excersize or ate with any kind of nutrition in mind. After several surgeries and a lupus diagnosis she's been declining quite rapidly - no energy, pain depression etc. None of her many doctors seemed able to do anything that helped. I was watching this podcast and my mother happened to call crying because she felt "like she was fading away and wasn't going to wake up one morning" - I asked her if she'd be willing to try taking a couple of supplements every day for a few weeks to see if that would help. We ordered some NMN and reversitrol and she started taking it. Within a few days she started feeling better. A week in she could do basic stuff around the house that she hadn't been able to do for years. All this without feeling dizzy during and exhausted afterwards (which any sort of basic movement did for her). My mom is insisting that this protol has saved her life, which may be hyperbolic but it is huge for her and I'm so grateful that I found your podcast and this information. I'm now reading Dr. Sinclair's book and will be incorporating some of the supplements into my own life.
We should also include the spiritual roots of disease. Anger, hate, bitterness, etc can cause cancer and other diseases. We need to take care of the spiritual, physical and mental. Love from 🇨🇦❤️🇨🇦
under rated comment
I've been listening to and following the work of David Sinclair for over 4 years. This is the single best interview I have heard him on. Well done Dr. Chatterjee!!!
Daily.. Taking NMN for Body healthy til last breath...
Ok
True
Is there somewhere a short list of basic recommendations on dieting and supplementing from him?
@@sidgillespie5879 He takes metformin and I don't think you can get it without prescription. He skips meals. He looks 25 but is in his 50's.
One of the best conversations with Dr Sinclair; and even watching the painter upstairs wasn't distracting ;-) Thanks Dr Chatterjee!
I absolutely love the layout of his space. Beautiful.
I imagine if that painter didn't know anything about this topic and he was overhearing the conversation, his mind must have been blown lol
@@AnifreakGedsparrow lol legit!
Love, love Dr. Sinclair's view on how indulgent our culture and society is and how detrimental it is to our health and longevity. We are so spoiled as a society and always expecting convenience and comfort. We need to challenge our mind and body for more struggle, less pleasure, and more physical pain through exercise and healthful eating.
100 per cent agree.
Thank you for this excellent conversation. I am a 60 years old Medical Doctor and have just finished my 2nd IRONMAN. Myself practicing yoga, cold exposure and 16/8 time restricted eating for more than 4 years as well as eating mostly vegetarian has led to an increase of physical and mental performance.
The lollipop
wow ! congrats on the Iron Man, that gives me a lot of motvation to keep up my own running, swimming and cycling, especially now, in cold european weather
من فضلك ماهي مميزات هذا الصيام 8--16
I am 67years old...and I have Alzheimer....
I AM SO GLAD TO HEAR ALL THIS PRECIOUS INFORMATION....!!!!
Please watch Dr Dale Bredesen too. Also, Regain your Brain series. God bless, you are in charge of this ⭐
grassfed butter has many vitamins and minerals: A,E, magnesium...
Ok
beet juice and another is MSM(sulfur) may help you
Suggest taking a look at Sherzai & Sherzai their research and outcomes. They have been having real regenerative effecrts in cognitive ability with their livestyle interventions.
David Sinclair is my hero. The work he is doing will be much more appreciated later. Wishing him long healthy years. Thank you so much for such a remarkable guest 👍👍👍👍👍👍👍👍👍👍
Watching from phils.thanks for the both of u drs.
Your guest, dr sinclair, is absolutely fascinating. He is very clear at describing what he needs to get accross. We need more guys like him to be honest. Many thanks for this discussion. Health and long life to you both.
Fabulous! I am 77 and so passionate about all that Dr Sinclair and Dr Fitzpatrick along with many informed epigenetic Dr’s are helping people live longer healthy lives! Please continue to share this eye opening way of life. I am engorged in studying! I love life and the education that I am getting. I have taught nutrition for years and now a whole new eye opening advance to study and share with others.🙂🙂🙂
In Chinese medicine your digestive power is strongest in the morning so theoretically you should skip your meal in the evening rather than the morning. Also Chinese medicine says to only eat until you're 70 percent full. Seems like some good ancient knowledge there!
Ayurvedic medicine says that also
Great interview. At 1:20:01 the host mentions a critical issue I had to discover myself in videos like this one. My A1c has been 5.8-5.9 for at least 40 yrs. (I’m 73 and getting forgetful) and called “normal”. I wasn’t really informed about the risks to my cognition that are strongly associated with (and probably caused by) insulin resistance and high glucose until I started watching DS and Dale Bredesen. Better late than never, I suppose.
Good job
Sister White was telling people on healthy reform many thought she was insane but to day everyone is talking of the same God never fails His people
Still crises about food is yet to be met
Thanks to God He revealed this to SDA church but they fear to teach others
Be blessed
You never know what would happen tomorrow just like no one expected to have such intelligent ChatGPT in 2023. Keep your good work!
How are things going? Any update?
My A1C was 5.8 in 2018, doctor said, “you’re healthy”. In 2021, my A1C was 5.7, FBG was 85, doctor said, “nothing to worry about” but this time I did more research. I realized I don’t need a “doctor” to tell me what I need to worry about and do something about. I bought a blood glucose monitor and started testing to learn what foods do to my blood glucose (no doctor ever even suggested to do that), lost 20 pounds, and started watching a bunch of YT videos. I now get my own test via Everlywell…last A1C was 5..6 and it’s going to get lower because I’m now on a low carb diet and also fasting and that seems to work. Also order other lab tests through Life Extension or directly through LabCorp and Quest. I’m sorry to say this, but I feel going to a GP is complete waste of my time and money. What I have to pay for a copay for a visit, I can get 2-3 tests on my own from the lab directly! If there’s a problem, I’ll consult with a specialist. There’s enough information available now for the layperson, that for those who have the ability to read and evaluate the knowledge, what is the point of going to these general doctors who just go through the motions!
What is the process to ask for lab work?
Wasn't aware one can send one's own blood work? How do you manage it?
LE - yah a 5.8 A1C is considered pre-diabetic... on the path to a serious flirtation with full-blown diabetes.
I've read/heard nightmare stories that the average, Western (allopathic) MD won't even mention anything about pre-diabetes- they just wait for a couple points higher, then BAM! You're diabetic 🤯...here's your prescription. (gotcha in our pharmacopeia clutches now!)😱
Have to commend you for taking control of your own health. So many don't, and naively just follow along down that path to ill health...sanctioned by their M.D. So, sad. 😔
@LE Bravo ! I haven’t been to a Dr in about 15 years.. Feel fine but great idea to monitor my own wellness! Never had a truly helpful visit with a Dr and have cured myself from the supposedly incurable ♥️🕊💪
Few doctors are going to suggest you do something that does not make them money!
I am reading David Sinclair's book at the moment , almost finished, and was pleasantly surprised when I saw him being interviewed here. The medical world is totally outdated and I love the idea of doctors taking a wellness approach instead of a sickness one. Hope physicians will read his book and perhaps change their mindset...
Let me know here top 10 points u would suggest since u read already
What is the book called ?
What is the book’s name?!
@@Avagrowthjourneylifesplan
I reversed my age ...when I lived a Naturist lifestyle and sabaticalled in my van for 2 years... Now I get it! Its was the natural gene therapy and micobioum of the beach that fed my body... not everything else I was doing!! Thank God for Naturism!! Thank you for interviewing this guy!! I get what worked for me now!! ...who hoo!!
The tendency of the medical establishment to only want to treat illness, rather than to promote wellness and longevity is the fundamental reason I rarely engage with the healthcare system in the USA. I got tired of my dr always wanting to put me on treatment medication instead of helping me prevent deterioration in the first place. It proves that the incentive is toward making money and not promoting wellness, so I have decided to take my health and longevity into my own hands, by following the research that people like Dr. Sinclair are doing. Since I started fasting, exercising and taking a few high quality supplements (multivitamin, ubiquinol, fish oil, d3, k2, niacin, magnesium), my health has turned around 180 degrees. I am the same age as Dr. Sinclair (52) and I feel far healthier with more vitality than I did at 40...and I haven't been to see a dr in nearly 10 years. I am planning to add resveratrol and nmn to my supplement regimen, but I am still researching which supplier to go with. I also plan to start getting annual blood testing so I can have that feedback to add to my box of tools. I am looking forward to 100 years!
I dont understand - you turn away from the medical establishment but are ok taking all these supplements...? Why can we not have normal (healthy) diets?
@@avi2125 It's called research, do some! You can do your own research instead of relying on a corrupt doctor who's owned by big pharma to hold your hand and feed you prescription meds that cause more problems than they solve. I've taken control of my own health and it has paid off!
Unless you grow your own food or buy only expensive organic products, it is impossible to get all the nutrients you need from food. The quality and nutritional value of mass produced food has been plummeting for years.
Dr. Chatterjee, you asked for tips and ideas for living a long and happy life. The Japanese have a concept called Ikigai, meaning to find a purpose in life that brings satisfaction and happiness. For me, it's daily practice of yoga (preferably hot yoga), meditation, being in nature, volunteering and giving back to the community, and surrounding yourself with few good friends and love. Teaching yoga has further elevated me to a new level of satisfaction and challenge.
Dr Rangan you nailed it in this amazing interview with prof. David. Asking the right questions gave us a chance to receive massive important information.
What a revolutionary interview, absolutely mind blowing. David's vision and passion shone through in every word he said besides loads of intelligence. I was teary on occasions esp when David's spoke about loneliness and the importance of having a family, his optimism and simplicity is inspirational.And Dr. Ranjan asked such intelligent questions.....I am truly speechless at the content and the way this interview has been conducted. Thank you both. Namaste!
Family would only be a distraction from loneliness, not a solution to it.
Long live chairman Mao!
Here's a humble theory...
I took my Rottie to the vet for his annual check-up, and the vet said he is in incredible shape, but he could stand to lose a couple pounds. I cut back his food by 25%, and what happened next seems to conform with what Sinclair says.
The dog eats outside, and in response to a decrease in his daily meat supply, he began eating grass and greens like a starving goat.
In other words, the dog's natural response appeared to be to supplement his diet to get a feeling of satiation with huge amounts of greens.
Dr. Sinclair says our bodies' responses to starvation are millions or even billions of years old. If a meat-eating animal's natural response to "starvation" is to eat mass amounts of greens, could it not be that after millions of years, our bodies have been taught that getting greens is associated with a shortage of food, and thereby stimulates the production of the stress hormones that prolong life?
To put it another way, the greens stimulate the hormones and the "healthy" content of the greens is less a factor than the body interpreting that we have turned to greens as a sign that things are not going well on the food front.
Eating greens is genetically a signal of bad times ahead.
Just a thought.
Very interesting!
No one can reverse aging, rather we can reverse what we have been eating. It's what we eat that helps to stop aging, or what we indulge in. I am 69 now and people are shocked when I tell them because they always say I look 45 years old.
People say the same thing about my mom. I'd love to see her look like in her early twenties though. 60 year olds looking like in their 40s are too common where I'm from.
@@leibnitz0030810 Where are you from?
@@MrBl3ki Australia but originally the Philippines
@@leibnitz0030810 Which ones are you talking about, though? Asians look younger than other people on average, and Australia is a first world country with moderate climate, so I'm not surprised if people look younger there either.
@leibnitz0030810 you Philipinos NEVER look old. Lol. U never age.
Absolutely fantastic interview. You asked all the questions I’ve had in my head. You are a credit to your profession. I wish you were my doctor.
Great comment, I completely agree!
How refreshing to hear someone giving sound advice and not preaching or telling you what to do!!!
I have been doing clinical trials for about 31 years I would love to be part of your clinical trials considering that I am legally blind in one eye and have low vision in the other but I have already been implementing some of the fasting intermittent and have been doing my own clinical trials and have seen amazing results just from what I have been doing thank you so much for this video God bless you both stay safe everyone in Jesus name
Aging is not a piece of a cake that you can just ignore. Especially for us women, we tend to look more stressed and weaker as we age. But as science is getting more advanced nowadays, it’s now possible to slow the aging process. Thanks to Dr. Sinclair's podcasts and interviews about the benefits of NMN supplement. It's been my 3rd month now of taking NMN by Vitruvin Nutrition, and I could say that my health has improved a lot. I used to have a poor cardio, but now it's regulated and I feel renewed everyday as my energy level is through the roof! It makes me workout daily.
especially for us women.
I think women age waaaay better than men on average
What i like about Dr.Sinclaire is that he always give straight forward answers in all his conversations.
@DrRanganChatterjee and @DavidSinclair Thank you so much for making your cutting edge expert knowledge available. You guys invest countless hours of your very expensive time to freely educate anybody interested in advancing the wellbeing of the human race, and you do it just for the sake of it, with no personal financial gain. Will this time of free education ever end? I don't know, but I feel priviledged to live it now, and eternally grateful to you for it.
I've seen 3 or so interviews with David, but this one is by far the best! Great subject-specific as well as personal questions!
The most important interview I have ever experienced! It is a lengthy video but worth every second for its powerful message and practical ways to drastically improve your life! A must watch interview.. thank you for sharing this knowledge.
Insanely good interview. Dr David Sinclair is wonderful. Imagine being those guys painting behind him and hearing this - your mind would be absolutely blown!
I'm so into David's message now. I've been a 20 year proponent of Dr. Sears' zone diet and other teachings (Omega/Fish Oil - Anti Inflamation). I've now been fasting for 3 months, and am practicing exaclty what he is: I fast 18-19 hours, have all of my calories between 6 and 10pm. I feel excellent all day long. My big frustration: I've always very much trusted Dr. Sears, but he strongly argues against intermittent fasting! I need a live debate between Dr. Sears and David Sinclair - MAKE IT HAPPEN! :) - Thanks for posting this.
This podcast was an answer to prayer this morning. Thank you.
Amen.
Yes I eat two meals a day I am 79 years old feel great I eat at 2 pm And again at 7 pm practice hit exercise 4 times a week also strength train the same
Eating less and less frequently is such a pleasure for me. I almost never have a full belly, and if I accidentally do eat too much I immediately walk until I feel better. You should enjoy many hours of pleasant hunger per day. It’s incredibly liberating to realize this, but it does take practice. Just keep at it.
How much do you weigh
Thank you for this awesome interview. I’m definitely going to read his book. I’m vegan since 5 yrs now and 3 months ago started on my raw whole plants no gluten, no sugar, no alcohol journey. (I may include some red wine after this interview). I recently completed my 1st ever water only fast (5days) then green juice fast, green smoothies, and now back on to raw whole plants. Just need to get more active with some out of breath type of exercise, and I’m on route to my healthiest life staring in my mid fifties, wish I’d started decades ago! Feeling vibrant and stopped what was the onset of painful arthritis in my hands in just the first few weeks! Highly recommended it!
Thank you 🙏🏽 David for your work.
That’s amazing! I’m so happy for you.
@@princessstephanie7387 thank you so much ☺️ I highly recommend it!
Vegans age faster than chronic smokers ... Please have a look at "Vegans - The Epitome of malnourishment" here on CZcams.
@@chrisatwill9330 These vegans r not eating a balance healthy vegans diet, thats why. Hv u seen many vegans Body builders ? Incredible well build strong lean healthy body!! Meat is Toxic to human body n blood, like eating anomals Carcases !!
What did you do to stop the pain of arthritis in your hands, please let me know. The fasting?
The mind’s influence on the body is huge. In societies that believe in magic whether as curse or healing the individuals respond to the rituals accordingly because they believe in it
I eat one meal a day plus a snack. I also started walking everyday and exercise my upper body with two pound weights as I walk. I have only been exercising for two weeks and I feel much stronger with better brain clarity.
So many out there talk about health and fitness but just don't look healthy. They look stressed out, puffy, wrinkly, etc. They may mean well, but have addictions, habits, and things they simply overlook, or honestly have misconceptions about. Dr. Sinclair definitely looks like he has reversed his aging since his first Joe Rogan appearance. He is walking the walk. I would listen!
Absolutely the best interview of Sinclair. Great job!
Dr. Rangan you are changing the world and you are exquisite in bringing extraordinary humans like yourself to the world. Thank YOU!
Great show. I learned a lot. I will try to change my life. I just 'love' the current medical approach: "come see me when your sick". It's time to change the approach from reactive to predictive and proactive. Keep it up in changing our minds!
I like the futuristic doctor's visit: very streamlined, with technology removing the guesswork & adding more concrete data to go by. Also, getting doctors trained in nutritional & lifestyle skills they can then pass on to their patients. Some of the plant-based diet docs have had problems with pushback from the meat & dairy industries, however, so that will have to be dealt with.
Best conversation with D.Sinclair I have heard so far!
Fantastic interview. Well done. David Sinclair, thank you so much for your interest in well being on every level. You've become my most recent, favorite teacher. Rock on
👍🏼
I just cannot believe anyone would attack David Sinclair because of the nature of his work, humanity should be grateful 😮
I absolutely love this guy he talks so much sense everybody needs to live this way there would be no need for medication. I’m 53 years old got a 2 daughters one 28 one 26 and a sim at 23 everyone can’t believe they my daughters we get took for sisters. I’ve been fasting for about 6 year now sailed through menopause as well
One of the best interviews I have watched. Thanks so much, Dr Rangan, for giving us this amazing ew research from Dr Sinclair.
Very THOUGHTFUL conversation keep going mr DAVID and DR CHATERJEE 🙏🙏
Damn, this man is 52 yrs.old ???? He looks to be in his twenties !!! No grey hair and no wrinkles !!!! He and his colleagues are definitely on to something I think it is revolutionary ! I've read Dr. Sinclair's book on telemores and it is fascinating science with proven age markers ! I only wish I was younger than 74 because I believe the future of aging and preventing ALL diseases is before us now ! May God speed their research to help all of mankind !
I got to say that I switched from eating your almost normal three meals a day. Basically, often skipped breakfast but I still would eat something small or drink something that would break a fast. Fast. I went right into doing a 20-hour intermittent fasting window and I also worked from the AM till the p.m. in a restaurant. Which absolutely did add a little bit extra difficulty. But it was only really difficult from the last 2 hours of the window while I'm smelling all this food being cooked. As far as lack of energy, I had absolutely no lack of energy. I had more energy. And I actually started this while I was working 12 hours a day outside in the southwest Florida heat. And I was working in a restaurant. The one thing I had going for me though is eating. Just a dinner was relatively what I did already. I just had to get strict with not allowing any snacks or sodas in such things. Luckily I like tea so it was easily replaced by matcha green tea and English breakfast black tea. It really wasn't that hard though and in about 6 months I lost 70 lb. Now this is because I was doing the physical labor I was doing at work coupled with an hour routine at the gym every day. I didn't drop all that just fasting. But I did all that without ever noticing a decrease in energy. In fact there was an absolute increase in energy. My sleep and rest got a million times better. The trick was to take a wide range of things that I enjoy eating and basically set out a buffet for myself at the end of every night. This made it so much easier to have a buffet of food to choose from and snack at once. My eating window took effect. This way it mentally satiated me.
*"Very little is needed to make a happy life; it is all within yourself, in your way of thinking." - Marcus Aurelius*
Is this automatic or are we watching the same videos?
Happy and sad are artificial constructs not real. Figment of your imagination. That is irrelevant to the longevity debate.
@@sleepsmartsmashstress740 exactly. Seems lots of people love a good quote 🙄
"He who fart in church, sit in his own pew"
This was fascinating, brilliant interview and loved finding out all about David Sinclair, what an intelligent and lovely man with so much wisdom to give.
Haha ya sure. Resveratrol is proven not to work almost 15 years ago now but he persists with it. Silly. Rapamycin is the only proven anti aging molecule.
Show us the evidence for your vicious claim.
@@davidbarrett8348 Do your research. Google is your friend.
I’ve done this since I was like 17, without knowing about this, or with any intention of it. Now I understand why everyone who knows/knew me back then are so often surprised about my appearance. They say I’ve never changed!
How old are you?
Thank you very much for this podcast! I'm 76 and although I don't really look much younger but I'm very healthy and am very active as well. You're an inspiration!
A great interview, I've listened to many of Dr. Sinclair's talks and this is the first time he's actually been asked the questions I care the most about.
Please share with us, what's your question?
He just hasn’t talked much about ‘level 3’ on the aging ladder that much. Much of his interviews focus on levels 1 & 2. Nice to hear him speak about level 3.
I eat one meal a day on a keto diet and it's amazing. I disagree with their stance on keto being a high protein diet. Actually, keto is about primarily consuming healthy fats and reducing sugar, which they agree with, and done the right way keto is not a high protein diet.
I also think that a persons mind can control many abilities in our bodies . For example as a child I was often sick or had colds etc . But because I disliked that "sick feeling" so much I think that I was able to program my physical body/mind to refuse to accept it. Being able to control your own mind and "mind set " was something I was able to subconsciously control because I did not like being sick. To this very day I can not remember being " sick " from a common cold , I programmed my self to not need a covid 19 shot , etc . For some reason my body automatically was fasting and I never even knew I was doing it. I do enjoy staying active without even realizing I do it. Perhaps it is part genetic .Soon I will be 57 years old and work with teenagers that act or preform in their life like they are in their forties. I do not think I am " special " . I actually damage my body a lot or this planet does it for me. But my mind does not accept what I do to it. I watched only 46 minutes of this video and believe in the " science " behind your research . If you ask me how long I want to live my answer is probably 80 physical years . I think that we as a human race are destroying ourselves and the planet at the same time we are trying to fix the problems , because many of our implemented institutions that society sets in place are programmed by those very thought patterns . As a race we seem to weaken our will to even want to see any further down the line in the future. I am not a negative person. I enjoy many things. Mentally , physically and spiritually. It is a planned obsolescence . Whether or not we build it or live it . Our diet has a lot to do with it too. Our produce , meat and everything and anything we put into our body is getting worse . That includes music , air quality , the cell phone connected to every hand when I see strangers walking down the street, our water and oceans . Sorry this comment was so long. Take care and keep up the good work.
can you program your mind to use paragraphs? it'd be a lot cooler if you did.
At the age of thirty five, I was going down hill fast, my hair was falling out, skin rashes on my face, very toxic body, my doctor did all kinds of tests, so may colon cleanses, No energy-laughed at by so many guys as I passed by. I have this cleanse, all plant uncooked foods, foods, fruit and veggies nothing cooked, roasted, toasted etc…….terrible colon and intestinal problems. Nothing my specialist could correct. I had a list of all the foods I needed to start eating. Transformed within one week I saw amazing results -I stayed on this cleanse for six and felt wonderful, number one people I worked with thought I had hip surgery. So I said have you been working with me this last month-Yes they said, so where did I get the time to have have a surgery and heal! I had more energy then all the young people around me at work. My energy was very high - I did grow and sprouts everyday. I went to see my specialist a year later, after an upper GI and Lower tests and was shocked -he said, I have never seen such healthy organs!! Now 78I’ve always be told how healthy I looked with very nice complexion. Exercise was my next. I took up an exercise routine three days a week, Modern Bally Bar work for 3 years. I need more, I looked into weight training. Great it was working very well, I went from there to body building- loved it, I needed to eat a protein to build up muscle my protein was fish and have alts hated meat. Then entered into competing and went from a light weight to a middle weight the next year, took 2nd place at 43. I decided to attended a program to maintain a healthy Skin alongside a healthy body. Then I opened up a Full Day Spa. Me ex asked me to help him , he couldn’t do the three day fast…….I used to look a girls great looking fit body. And as she turned around, she looked about 60 years old, but her body looked a young healthy fit body. I need to repeat some of the healthy ..
Nice conversation! At around 1h (1:01:00) there is an interesting question being asked to which I don’t feel the answer really nails is. The general advice towards fighting sarcopenia is to increase the protein intake, to which David agrees, but then he recommends eating protein with low amounts of leucine (and low MTOR therefor). This is where I get puzzled, as the literature at the moment does seem to suggest leucine is required in order to stimulate muscle protein sintesis, otherwise it does not happen. There is of course leucine in plants, that’s not the contradiction, but how to reduce leucine and still build muscle is not really explained.
Christian Andreica - you are correct.
Nevermind that the question about protein for muscle mass was not addressed factually, either.
Unfortunately, Dr. S appears to be mTOR phobic. (Sounds to me like he'd like to eliminate it altogether bc of his belief that mTOR promotes growth, and therefore 'aging', as well.
Anyhow, his answer to Dr. Rangan's questions about (where do you get your protein to help with muscle mass)....he gave the standard, misleading, IMO... vegan answer - plant protein! All plants contain protein!
(True on the face of it, but look deeper and we find that leucine (being the key that unlocks mTOR) is not sufficiently high enuf to stimulate muscle protein synthesis. E.g., under 2.5g Leucine in a ONE meal 'event', and the mTOR switch remains OFF.
Nevermind the fact that most plant 'protein' is lacking in bioavailability, compared to animal protein
Add to this the fact that we need to increase our protein intake (quality... i.e. animal protein), as we age just to try to keep up with the 1-2% loss/year of muscle mass after the age of 25.
AND... that muscles also slowly lose the ability to synthesize protein as we age.
Granted, intense exercise - specifically 'lifting' also helps to stimulates mTOR.
In my view, though, we need both - higher (animal) protein intake and a good weight-lifting program to stave off sarcopenia and bone loss as we age.
I am 64 and cycle 450km per week & can easily do 200km & have done 400km as a single ride. My diet is similar to David Sinclair's & my improvement in life generally is a joy. What amazes me about the sedentary comforts of Western Life is that people struggle to do 2 hours of moderate effort per week. The few Times that I've had medical checkups, my Doctors have wanted to admit me for my resting pulse of 46. Medical institutions have forgotten what normal good health is. I work as a Nurse and patients with BP's of 130/80 are considered "normal". The Health field has compromised on the basic health guidelines, as an example: 10,000 steps per day is a poor health parameter.
WOW
Você está exagerando nos exercícios...
My grandma is 94 and my grandad is 96. They have never over eaten and only really eaten whole foods. Though they grew up on beef dripping and lard they ate plenty of vegetables. My grandma has no problems including no arthritis! Both have their sharp minds. My grandads body has let him down but that’s more to do with him being super fit throughout his life and injuries because of it.
Same my gma and gpa grew up eating lard in england and lots of fats but they dont over eat. My gpa has eaten a lot of sweets too but just in moderation and theyve both lived till 90. Health is detiriating now because of age and my gma smoked but still! Amazing to live that long and they were great until they turned late 80’s/90
The beef and lard is actually loaded with vitamins and good fats so contrary to popular belief that was likely helpful
How can you eat lots of sweets in moderation 😅
So beautiful how Dr. Sinclair lit up when discussing his daughter Alex. Just priceless!
Ordered the book today and took my first resveratrol capsule, feeling better, at 41 , have diabetes and a-fib , I hope to get some good results from this therapy.
NO! Did you not hear him in the interview. Solve the resveratrol in yoghurt or olive oil mate. Or else no absorption.
@@unholyquail4560 yes I heard about the yogurt , and the absorption ,thanks.
Feel super wired after this though like , after many coffees , mine is a 250.
@@michalarkalion Honestly I do feel that you should not just rely on this routine. Like Sinclair said the hormetic stimulus of resveratrol and the NAD+ increase of NMN is both tier 3. Adapting his diet alone (plant based mediterranian) will have the highest impact in the short and long run. Hé is far from the only one suggesting it for healthspan. Like Dean Ornish, Colin Cambell, Valter Longo, Michael Greger, Neal Barnard.... All also recommended this way of eating with huge proof of positive health effects and restoration of health.
@@unholyquail4560 agreed, and believe me i am following most of the other suggestions here, Mediterranean, and intermittent fasting, and metformin, aspirin, etc, etc. don’t have nmn, yet, I am not sure which to choose from on the web. Local health store did not carry.
Are you following the diet and the supplementation ?
@@michalarkalion I do take NMN from time to time (after stressfull periods where I couldn't maintain a proper diet and exersize routine). I get it from "donotage". Which are up to the European supplement standards and quality control. Which is the highest standard we have on the globe. So you know what is in it, is really in it.
Funny enough Sinclair has been moving towards my routine more and more (see his instragram post about Serena Poon), so I feel like he is following my diet now? haha. I am fully plant based (Whole Food Plant based diet based on the Broad study in 2017, The China study, Blue zone studies and the work of Neil Barnard, Colin Cambell and Michael Greger). So no animal products no refined products, nothing that adds more damage than repair really. Also I keep my fats to around 20% and protein around 40-50 grams based on my weights and muscle mass.
I supplement with B12, Vit D and Omega 3 EPA 125 + DHA 250 algea oil. With it I use creatine monohydrate in my yoghurt because it is really demanding on your body to make it yourself. The diet is so good in glucose control I do not need metformine in my opinion. Furthermore I make sure my diet has a hyper nourishment element to it. I get all Recommended daily intake and more of vitamine and minerals after Bruce Ames his triage theory suggesting RDA only keeps your primary usage in check but does not lend itself to support secondary and tertiary systems (already proven in Vit D and Vitamine K).
With it I make sure I get enough sulphoraphane (100 gram of brocoli sprouts) for a better NRF2 function. With it 100 gram of blueberries for the (low) therapeutical dosage of Quercitin and 12 grams of dried parsley for the therapeutical dosage (based on weight) for Fisetin. Just blend it up and drink it with some avocado for the oleic acid and flax seed for more omega 3 and voilá!. No supplements required it is all found in nature and absorbed well.
1:10:17 supplements
Greetings Dr. Sinclair,
I am 65 y/o, and I have learned a bit about your work and life experience, in relation to longevity via your CZcams videos and reading your Lifespan book.
The following is not a critique or reflection of what you are, what you announce and do.
I ventured, w/o consulting w/my PCP, naively and not well informed, I admit, to explore the effects of NMN (1,000 mg), combined with NR 500, Quercetin, and Ashwagandha on me, for 1-2 months and recently ended up in the ER of my local hospital to find out that, what I thought was an ulcer in my stomach, turned out to be pancreatitis. Fortunately, although it was a painful experience, it did not pass the inflammation phase. I have, of course, stopped taking these supplements. I just want your audience to be wiser than I regarding experimenting w/o medical supervision. Thank you, and I wish you well in your life.
All my life i ate minimally i had a lot of energy and stamina i only ate when i was hungry.
However, i now have hypothyroidism AND THE BIG ISSUE from my experience for ME IS eating fresh whole food from local sources. Moving exercising drinking clean fresh water dont eat late at night.
Do what he said eat a small hot bowl of soup w/fresh ingredients. Cut condiments and sugars starches refined foods repmace with herbs and spices.
Dont eat much past 3pm i never could truly hit that but i made it my aim so i would eat as early as possible. I COULDNT EAT EARLY IN MORNING but instead more like a brunch.
I ate eggs or peanut butter something with that type of protein added high vitamin type veggies/fruit.
I infused my water mainly drank teas and water. When i lived that way i was so healthy and i even had extra time in my day for some reason.
I was more creative, clear minded, full of energy the list is endless it covers every issue. If i lived like that continually id bet id never have had a thyroid issue.
I lost 70 lbs that year and toned up and completely changed physically. I sped walked 5 miles a day + floor exercises or the gymn or road my mountain bike 5miles.
Before this diet type (i made up myself), i ate once a day but huge amounts and it was pizza, cheesy breads n butter fast food joints like mcd's big macs. I would feel like i was poisoned after i ate.
Id feel like it was in my veins or something and id get weak lethargic exhausted. I had a very unhealthy bringing most of my life.
Not fed most of the time...i worked for food as a child, yup blond hair blue eyes only child in the usa worked with immigrants, got picked up and rode in a bus to a field of okra and picked okra.
Or id have to dig clams sell painted religious plaques or ate from trash or even work in a barber shop to buy a jar of peanut butter n loaf of bread for supper. Dont judge.
I know the way i ate when on my diet was correct for me because i felt like a child again and i used to always feel lethargic and poisoned, sickly.
One more important thing. After you eat get up and move not exercise but go do dishes or walk around the block casually.
Dont over eat, small portions and waiting chew well take a few seconds between bites, eat slow, drink water with a meal.
Gobbling not chewing over eating sugary carbinated drinks or milk are heavy gassy bloating and mess up digestion. Its all common sense.
Adjust the diet youre used to thats the easiest way to get results and continue to adjust until you know its proper!
I found this Dr to be so real & honest, a great ability to lecturer & relate to people, no Asperger syndrome in this scientist, great spouse & father
Hope to see him in the millennium
One of the best interviews with David Sinclair...Thank you..
It seems to me though that when it comes to future predictions of how much lifespan can be extended he can not speak freely in public..I m sure privetly he expects much more..
Definitely. He talks down immortality hopes etc
Noticed the same thing. He completely side-stepped the maximum longevity question.
My mom used to walk a lot, no, she was one of those people who didn't take sunscreen seriously, so she'd skip it...always. she didn't do workouts but as I mentioned she'd WALK A LOT everyday, she ate normally, no restrictions. She died from metastasized bone cancer at the age of 58. She looked 36 even when she was battling cancer. What I mean is, genetic plays a huge role. Nurses at hospital would ask questions like..."Are you pregnant, miss?" To then realize she was almost 60 and their jaw would drop amazed at how young a beautiful she looked, she didn't even look like she was on stage 4 cancer.
Control over aging is definitely a worthy aspiration. But this guy looks very much to be his age ( I understand it to be 54 currently). So it seems that his research has a way to go befor any reverence has been earned by Mr Sinclair.
MY MAN... You win CZcams for having the absolute MOST ads squeezed into your show. While I was trying to listen to this interview while multitasking - there were 5 different ad interruptions in a matter of 14 minutes. I appreciate your need to monetize but I can't even get to the content without getting inundated with ADs.
So much so that while multi-tasking I ended up 30 minutes into a freaking ad/commerical. I now know EVERYTHING I need to know about TAAS - Transportation As A Service - it's still going and appears to be only halfway through LOL.
So what did I learn? More about an ad than anything you had to say. Good thing I already follow David Sinclair and the many other CZcamsrs w/ high quality interviews who don't inundate and ruin their content with so.many.freakin.ads.
If you go into your advertisement management tool and uncheck all the boxes, you'll get only the standard two adverts at the beginning of each show.
@@SuzanneU Really? That’s awesome! I had no idea I could change the settings!
I enjoy fasting now after 6 months. It saves money snd time as well. It helps the body regenerate cells better. Cancer cells starve to death too.
But you shouldn't eat less, just in a shorter time window. You're only going to slow down your metabolism by eating less. I'm talking about IF.
Last year I had a health check my bio age was 2 years older. But this year the test turned out I am 8 years younger meaning my fasting helped reverse my age by 10 years!!
@@benkim2016 what type of fasting do you do, to get such amazing results?
@@benkim2016 Yes!
Dear Doctor... if I may... it seems more like reversing the effects of AGING ....not AGE..... i do believe in Sinclair... control of eating habits is the simple part of a solution that many people feel unable to adhere to...
Excellent interview David has a humble personality and share his knowledge in language that lay person can follow Thanks for asking wonderful questions
Even if most people don't believe longevity, they should still support it coz in fact we just have one life after all. Living up to a hundred and being still healthy is beyond priceless. I'm up for Dr. Sinclair's NMN supplementation. It's hard to prove something if you don't experience it yourself. Thanks to Vitruvin Health supplementation, I'll never have to worry about aging and the age-linked illnesses.
how do you know we only have one life?
So thankful I found this conversation! Bravo, gentlemen! PLEASE keep doing what you do?!
I am forever 27 🥰🥰🥰
I'd like to believe that I manifested this together with millions who want to feel, look and be our best knowing that life can offer more and something better in every now. The world is evolving. Exciting times ahead! 😎
I have listened to David's talks before but I am very impressed by how it is done in this channel!
Amazing... this way of eating is exactly what I do. I have tea in the morning ...then just dinner. Once a week ...I don't eat at all.
pls can you sum up this 2 hours video fot us?
@@goodvibrations6 so someone should watch the 2hrs video and sum it up for you?????
How did you all survive in school????
I'm guessing someone does your job????? Weird ..
@@clarkclarke she already seen it, she want watch to sum it up for me. and its up to her kindness. if not, its ok.
Do you get hungry on your non food day?
You got the same channels as me,, try America uncovered, he is funny and informative
I love listening to your interviews because you always have the most thoughtful questions! The guests clearly feel the same. You're awesome, thank you!!
Why don't you cut to the chase and just tell him that you'd like to sleep with him, better direct.
@@otherone1234 wow mate, you've got some issues huh?
@@CherylsBirds nah just bugging you hahaa
Just turned 20 last 4 months and listening to this. Thanks for the info✨🙏😘
I'm 63, have eaten pretty healthy and worked out my whole life, but also a Gulf War vet, unfortunately I have had three joint replacements since age 52, but I carry on and will try to improve where I can, no medications either.
This has to be the best interview with Sinclair I have ever seen. Well done and thank you Dr Chatterjee!
I love Dr. Sinclair!! He is always so beautifully optimistic!!🙏🏽❤️✌🏽
God loves you so, W Balingit, hoping you’re healthy and vibrant when you’re 120 or beyond, whatever you shoot for, and still contribute to society.
@@keynes70 Thank you so much for all your kindness!!! May God bless you and your family!!!🙏🏽❤️
When he said he got attached to his yeast cultures, I fell in love.
I am great example of the version you talking about. I frozen my age at 23 years young. I'm keep going and I do my best.
Dr. Sinclair is a very special person. If I'll buy his book to begin his treatments.