Hypersensitivity Type II (Cytotoxic reaction) - causes, pathophysiology, complement system

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"Hypersensitivity Type II also known as cytotoxic hypersensitivity reaction is where antibodies produced bind directly to antigens on the surface of a membrane and then activate the complement response. Complement response involves circulating proteins that when activated lead to an inflammatory response against a target.
An example of hypersensitivity II reaction are antibodies mounted against drugs such as penicillin, hydrochlorothiazide and quinones that in rare cases can bind on to the surface of some cells subsequently activating the complement response. Antibodies can also be made that target some bacteria but accidentally cross react with human cells and then activate complement. Another good example is antibodies being formed against Rh+ RBC in a Rh - person.
In order for the antibodies to be made in the first place, there must be a first contact."
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Thank you armando! For all the videos you made, all the knowledge you spread! It is amazing what you have accomplished over the years! Keep making these amazing videos, and keep educating us 👍🔥

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The way u explain ,make me feel the subject and thanks for saving me from breaking my head bcoz of subject

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i m here only to tell you dont even dare to delete any video from your channel.
i m in 1st year....
i know my study will get easier than ever before
1 request- can you provide your extraordinary diagram in the sheet so we can download it
btw love from india

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believe me you will need those videos ...i'm intern now and i still use them

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Thank you for the precise presentation

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A lot of love from INDIA ,sir awesome teaching style,

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Thanks Armando, from Iraq, wherever you now like my comment

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Sir please also do adrenergic receptors...plx do it as soon as possible...

[@ammaraahmad167]

This was amazing! Thank you

[@TheASMRMedic]

This was very helpful, thank you.

[@eltiobry3859]

Lovely resume, thank you very much, it helps to better imagine the complement system.

[@abijeyarajan2173]

Best video for type 2 hypersensitivity reactions. Thanks for making this video with clear explanations 😄

[@microbiologyeasynotes]

This is very informative. Thank you Armando

[@nooralmaamari9486]

thank you so much for your amazing videos, but is the PDF for this video uploaded in website? and if it is not can you upload it please

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Thank you

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Praise Kek, another Armando video 🙏🏽

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Thanks for the lecture! That was fantastic!!

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You are my saver in med school thank you very very much 💕💕💕

[@vivekrakha5295]

Very well explained

[@himalaydebsourav]

Everytime i see yur video, my expression is like 😮

[@drnur9137]

C3 convertase is produced in alternative pathway right

[@nourhouda2289]

thank you it's very helpful

[@rayleenfischer7736]

Did anyone notice the penicillin misspelling change at 6:35?

[@AnujKaushal]

Thanks!

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Thnak u

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Thanks so much 💛

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i wish i could put 10000000000000 billion thumbs up or this video

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Thanks a lot.. 😍

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Jazak ALLAH ❤️🌺

[@OmarAli-py3pq]

It’s the first video that mentions type 2 H.S cause sensitization then attack in same exposure so it is tissue specific not organ specific 🧐🧐

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Hi ...Armando.😀

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God bless u 😇😇😇

[@ameeralbaghdadi9798]

There is mistake
Rheumatic heart disease is type 3 and not type 2 HR
Please correct it

[@drmxl91]

Google it

[@amindelna5863]

U were supposed to explain type II hypersensitivity and u linked it with complement system hence your made the topic complex.

[@samserozan1063]

His hands ;_;

[@emmanuelsarpong3385]

Thank you

[@samserozan1063]

His hands ;_;