This is HUGE: Statins, Death Risk & LDL Myth? - Ep 77
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- čas přidán 12. 03. 2024
- Is everything we are taught about cholesterol a lie? Imagine a world where the very medications prescribed to save us from heart disease are, in fact, doing more harm than good. In this episode I dive into a this study that might just turn the tables on conventional wisdom.
I'm looking at this study from Zhou et al (doi.org/10.1186/s12916-024-03...) which used data from the UK Biobank study, and it's causing quite a stir on platforms like Reddit. This extensive research, involving over 110,000 participants, may just challenge long-held beliefs about LDL cholesterol and its role in heart disease. But as we peel back the layers, we uncover a narrative even more compelling than LDL's innocence: the potential peril of statins and cholesterol-lowering medications.
Statins, the go-to solution for cholesterol management, are under the microscope. Could these widely prescribed drugs be linked to an increased risk of death, overshadowing their supposed cardiovascular benefits?
Join me as I question the status quo, armed with evidence and a critical eye. This episode is not just a discussion-it's a call to rethink everything we've been taught about cholesterol, heart health and medications.
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Welcome to The Meat Medic Podcast. I'm your host Dr Suresh Khirwadkar. I'm a GP and Lifestyle Physician and I'm a practicing carnivore. I've had great success myself and with patients by following a carnivore diet, and want to spread the word about how to achieve optimal health through diet, nutrition and lifestyle changes.
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Would you take a statin?
No. I personally know several people around 50 years old who developed dementia right after starting statins and lost their jobs because they could no longer function at even a minimal level at work.
Never!
Definitely not!
I take statins. When I started taking them I got diabetes. Now im in a mess.
Knowing everything I know now, no, never for primary prevention, and probably not secondary either, but that's a slightly different story. I haven't looked closely at the study yet but I assume this is for primary prevention. I've had "high" LDL since my first test at about 20, and have a chronic back injury that's constantly been in repair mode since I was 13, so it makes perfect sense to me. At 59 I care more that I got the high blood pressure under control and off of those meds and reversed pre-diabetes. Those are the numbers that scared me.
My hubby, age 80, was having trouble finding words. I kept telling him to tell his cardiologist, as it was getting worse and worse. He finally did and the cardiologist took him off his statins. Almost immediately his verbal ability improved. Also his aches and pains decreased. I was amazed as how quickly his symptoms improved.
It would not surprise me if statin lowering medication increases mortality in some circumstances. The body sometimes increases high LDL for a reason - could it be that interfering with this mechanism causes the body to compensate in a different way which is more harmful than without this intervention? Don't know but it does seem to be a smart thing to try to work out why LDL is high in the first place rather than medicating it straight away.
There is also a game theory aspect that most docs I know do not consider, which is that the most healthy diet for you is the diet you can and will follow long term - not some theoretical diet that you won't follow. E.g. if the only way for you to maintain a lean body mass and metabolic health is carnivore this is the healthiest for you. If carnivore would increase your LDL and even if this would increase your "risk" for CVD, the overall health benefit is still likely to be overwhelmingly positive (if it allows you to improve obvious health markers).
Fascinating and interesting the nuances, twists and turns in this saga.
Thank you.
I always look forward to your videos 😊
Glad you like them!
Thank you for this review.
My aunt had a mild heart attack in December last year. She has one stent since then. She is on a few meds (daily) since then, statin is one of them. We have noticed a marked decline in her memory. It’s concerning . Recently, her legs got swollen, which might be a different reason altogether. I don’t know what else is happening with her body. All this statin hype is really worrying.
Memory issues and muscle pain are two big side effects of statins because it kills cells. Cholesterol is in every cell wall and is a big part of the brain. Statins for secondary benefit do seem to help, but the thinking is because of it's anti-inflammatory effect. There are much better ways to get inflammation down, like a keto diet.
As someone with familial hypercholesterolemia, I've been taking statins for a few years. I haven't noticed any side effects, and even with the statin my cholesterol is still slightly on the high side. However, I do agonise about whether they do more harm than good. It seems to depend on who you ask.
The figure 3 charts seems to show which risk factors when controlled help reduce the category of mortality identified. Is this the ncorrect way to read these charts: when a participant has none of the risks above cholesterol lowering meds, then cholesterol lowering is the most important factor.
I'm confused though whether the chart says taking such meds is a risk factor or that taking them is an intervention that controls a risk.
Thank you Excellent 🎉❤
I stopped my statins due to severe side effects. I started taking them after a heart attack.
This study is clearly about diabetic patients, which I am not. Does this translate to similar findings in people who are merely overweight, and have heart disease? And yes, I know it's all observational. As are nearly all of the studies supporting statins.
I have a physical next week, and my cholesterol is creeping up.
No medications or supplements here and hope to never be on any. Thx for your analyses. 👏
2.5 mml is 45 mg for those in the US. That's insane. I don't see how this obsession doesn't start killing people.
yeah it causes so many problems being so low
@@Themeatmedic That would make for an interesting video, talking about the dangers of going so unnaturally low.
2.5 mmol/L is 96.67 mg/dL which I guess is the older recommendation to have LDL-C under 100 mg/dL.
@@techadsr Hm. I tried 2 different calculators and get 45 (I made a typo on the op, now corrected).
But you do need to read the actual data. And get your own opinions also and what are the actual cases.
If I get time, I’ll try and look but it would be much easier for Nina or Bart to look at this.
At 22 mins I see you falling for the vegan trap
I think you are reading the charts wrong. It’s association, not causal. So those on hypertension drugs will also have high blood pressure so will be higher on the charts. If those people were not on the drugs they would be at even higher risk. I agree it’s a weird study though.
Absolutely, but why do you have people with hypertension? Caused by plaques? Supposedly caused by cholesterols ? But why? I must admit some people have a genetic disposition for high cholesterol that little can be done for except cholesterol control. But otherwise my view is cholesterol is caused by our junk food diet which causes inflammation/high insulin eventually the rise in cholesterol is the bodies defence agains this.
@@mrofnocnon I highly encourage you to look up what cholesterol actually is and what it does in our bodies. What are it's functions? Because it's not what you think. The demonizing of it is a fascinating, and disturbing, history lesson. It's in every cell wall, it's a big part of our brain (which is why memory problems and dementia are big side effects of statins, along with muscle pain because they are killing cells), among other important things. If you could snap your fingers and have all of it removed from your body you would immediately drop dead. It's life vital. Look up Ancel Keys and his Diet-Heart hypothesis. It's been repeatedly debunked. In fact, the studies show that it's the opposite of what we've been told, higher cholesterol is actually protective against all cause mortality. And it has nothing to do with high blood pressure. High carb, high sugar diets do. Many people, myself included, have lowered our blood pressure back to normal and gotten off the meds by eating a low carb diet. I lowered mine first by removing wheat from my diet, then improved it even more on low carb.
Off topic request: I would like to see you do a video on the recent trend among carnivore influencers to assert that sun exposure does not cause skin cancer. I am no expert but I find this incredulous to the highest degree as well as dangerous and irresponsible. I know in your practkce you deal with skin cancer, so I would like to hear what you have to say about this, either way.
Well, let's think about this filtered through common sense, how did our ancestors, who evolved under the Savannah sun, escape skin cancer?
I would be insulting your intelligence to presume you cant figure out what is wrong with that question. Ridiculous on so many levels, like the one carnivore doctor who asked me, " how can the life giving sun possibly harm you." Common sense indeed.
@@MohseenLala Why do you assume they didn't get sunburned and skin cancer? I've been keto for a few years now, but some of these "ancestor" assumptions are ridiculous and assume they didn't have any issues. With a simple common sense search, violà, found the history of sun screen. www.ncbi.nlm.nih.gov/pmc/articles/PMC8682817/
this dr is a nut