Reverse aging could save my aging relatives from dying of old age and myself too. This will give me more financial freedom and long-term support too. I can have relationship later because I don't have money yet.
Ah, my 20s have been a bummer of poverty and one crappy situation after another. I think of the lost time and have hard time concentrating. If human ageing happened a quarter more slowly I think I could just tolerate it and see it as part of some intangible non-book based education, but I'm 30 now and it seems down the toilet. I wanna make up for lost time and have a good life. Maybe get the income to start of family and have a happy family with a modest income in time.
Sure, if you've had work done on your brain, accomplishments might feel like cheating, but we don't feel like cheaters when a vaccine stopped us from getting hepatitis. I'm sure sickle cell patients won't feel like cheaters when their bone marry starts making healthy blood.
Methylation is just one of many ways we age. It is a big one, but it does nothing for accumulations: DNA damage, Glucosepane and other crosslinks, Transthyretin Amyloid and other amyloids, Lipofuscin, and others. Because mice don't actually live that long, they don't build up as many accumulations. It is easier to see how methylation pattern reversal can replace things that are depleted during aging like telomeres, elastin, stem cells, thalamus volume, skin secretions, cartilage, muscle, bone density, even hair, I suppose.
@@NaNa-rx3dv How, in theory, reversing methylation patterns would result in increase in depleted things. There is absolutely no reason to think it would not. We undergo methylation aging. All it does is make some genes more active and others less active. The amounts of these proteins define a lot about our age. The accumulations, though, are "aging" too. No reason they will not continue to cause issues. In some ways we would be young, in other ways we would be old. Of course, this is "in theory." We don't know how to do this to a whole person well. Well enough to experiment on humans ethically. Lot of little steps. Small parts first, like the retina. People likely would still die at 115 or 125, because of the accumulations. But they may look like teenagers with age spots, and be stuck in wheelchairs for years before death, possibly decades. Their minds may still be reasonably sharp, vision and hearing just fine. Organ replacement might be the trick, but that would be expensive even if cloned or pig organs.
@@NaNa-rx3dvearth biology among mammals, of which, mice are mammals, the biological functionality is fairly standardized among our mammalian group. This is why we experiment on mice, they are so chemically and structurally similar to us as to be one of the most convenient analogues to us that exist. Obviously mice experiments aren't perfectly analogous, but it is so close given our genetic sequence similarities as to create a reasonable assurance of experimental cohesion.
Wow this is very encouraging. I've been listening to this hype for the last 25 years. Stem cells were all the rage in 1999, 2000. Embryonic stem cells were going to revolutionize medicine. Then Yamanaka discovered pluripotent stem cells in 2006, he won the Nobel Peace prize for in 2012... It's 2024 heading into 2025. Where are all the treatments? Where are all the results at clinic? Why are we still using 50-year-old cutting surgeries like trabeculectomy? Sometimes I think these doctors and scientists are full of $#@+. For all our sakes, I hope I'm wrong. But somehow, 10 to 15 years from now, I think they'll be talking about how they're still 10 to 15 years away...
It's not bullshit This is a recent scientific discovery that confirms the aging process that can be reversed at least in cells and then Dr. David Sinclair and his scientist friends will reverse the organs and the human brain
@js_es209 How is this bs what evidence can you prove that this is actually bullshit This is science it's the study of the physical world through experimentation testing theories with evidence obtained Do you not know what that is?
@skyhavender Describe and provide precisely how this is bullshit 3 2 1 go provide evidence science is literally about the study of the physical word expreametion through observation testing therapies of evidence obtained Stop being a hater fuck off
Needs to offer this to everyone asap….👍
Time to test these technique on humans!
Great video! I share your enthusiasm for Dr. Sinclair's work.
hi i like david sinclair too do you know about the chemical combos that they found for eternal youth
What a wonderful news! Thank you. Hope it could fix CNV for myopia patients!
Curing blindness 🙏
Big up David Sinclair, man. 👏
THIS IS FANTASTIC NEWS ! ! !
This is truly amazing and promising news, thank you so much for sharing!👍🙏🙏🙏
Fascinating! Hope this research will lead to real treatment in humans very soon. Thank you for sharing this information.🙏
i want to cure ageing so i can save family pets and elderly relitives hope it happens sooner than later
Reverse aging could save my aging relatives from dying of old age and myself too. This will give me more financial freedom and long-term support too. I can have relationship later because I don't have money yet.
Wowww
Ah, my 20s have been a bummer of poverty and one crappy situation after another. I think of the lost time and have hard time concentrating. If human ageing happened a quarter more slowly I think I could just tolerate it and see it as part of some intangible non-book based education, but I'm 30 now and it seems down the toilet. I wanna make up for lost time and have a good life. Maybe get the income to start of family and have a happy family with a modest income in time.
Sure, if you've had work done on your brain, accomplishments might feel like cheating, but we don't feel like cheaters when a vaccine stopped us from getting hepatitis. I'm sure sickle cell patients won't feel like cheaters when their bone marry starts making healthy blood.
You think this could reverse my dry eyes too? 😢
Thanks! Feeling hopeful and happy.
NB.My mother has crossed 70 .
I became legally blind from pituitary surgery i hope this one will work so i can drive again 50 yo man
You can use cloths drying racks too. Saves money and raises humity too.
When will it be available to the public?
Good News wow
Does this means glaucoma is one of them?
Methylation is just one of many ways we age. It is a big one, but it does nothing for accumulations: DNA damage, Glucosepane and other crosslinks, Transthyretin Amyloid and other amyloids, Lipofuscin, and others. Because mice don't actually live that long, they don't build up as many accumulations. It is easier to see how methylation pattern reversal can replace things that are depleted during aging like telomeres, elastin, stem cells, thalamus volume, skin secretions, cartilage, muscle, bone density, even hair, I suppose.
You mean it's easier to see hpw it reverses skin and cartilage changes in mice not humans
@@NaNa-rx3dv How, in theory, reversing methylation patterns would result in increase in depleted things. There is absolutely no reason to think it would not. We undergo methylation aging. All it does is make some genes more active and others less active. The amounts of these proteins define a lot about our age. The accumulations, though, are "aging" too. No reason they will not continue to cause issues. In some ways we would be young, in other ways we would be old. Of course, this is "in theory." We don't know how to do this to a whole person well. Well enough to experiment on humans ethically. Lot of little steps. Small parts first, like the retina.
People likely would still die at 115 or 125, because of the accumulations. But they may look like teenagers with age spots, and be stuck in wheelchairs for years before death, possibly decades. Their minds may still be reasonably sharp, vision and hearing just fine. Organ replacement might be the trick, but that would be expensive even if cloned or pig organs.
@@NaNa-rx3dvearth biology among mammals, of which, mice are mammals, the biological functionality is fairly standardized among our mammalian group. This is why we experiment on mice, they are so chemically and structurally similar to us as to be one of the most convenient analogues to us that exist. Obviously mice experiments aren't perfectly analogous, but it is so close given our genetic sequence similarities as to create a reasonable assurance of experimental cohesion.
I wonder if this would do anything for CRAO?
we kept getting such news since 10 years now yet nothing came out lol
CAN YOU MAKE SOME VIDEO ABOUT HUMAN EYE RESEARCH IN SPACE ? TUAN DUONG MD MPH
Sign me up…..!!! The pension companies won’t be happy…. Drawing my pension for 180 years
You live for 180 years im guessing pensions wont kick in until 150 make sure you like your job…. Lol
So how do I sign up for you to do to me what they have done to the mice by making them 70 percent younger?
Cool
More promising research from late last year- including efficacy in non-human primates with human trials slated for early 2025.
It could be a therapy vector for tinnitus, ohh, and I want to live to be 100...
AI should help with processing and compiling the data.
Wow this is very encouraging. I've been listening to this hype for the last 25 years. Stem cells were all the rage in 1999, 2000. Embryonic stem cells were going to revolutionize medicine. Then Yamanaka discovered pluripotent stem cells in 2006, he won the Nobel Peace prize for in 2012... It's 2024 heading into 2025. Where are all the treatments? Where are all the results at clinic? Why are we still using 50-year-old cutting surgeries like trabeculectomy? Sometimes I think these doctors and scientists are full of $#@+. For all our sakes, I hope I'm wrong. But somehow, 10 to 15 years from now, I think they'll be talking about how they're still 10 to 15 years away...
when blind people will get this cure asking for mother..if anyone know about it pls say it
Kieth Richard’s!!! 5029 yrs old genetically….
Great video Doctor! 👍
Thanks to the mouse, who suffered to help us understand this. 😢
Three blind mice, three blind mice. 🐁 🐁 🐁
See how they run, see how they run.😅
Did you ever see such a sight in your life as uuuh 2 blind mice? 😊🎉
I wonder what impact this tech would have on Parkinson's.
Steven Tyler and Mick Jagger are still around. I think they've done enough drugs and alcohol, no?
Poor little squeakers.
What a load of bs
It's not bullshit This is a recent scientific discovery that confirms the aging process that can be reversed at least in cells and then Dr. David Sinclair and his scientist friends will reverse the organs and the human brain
@js_es209 How is this bs what evidence can you prove that this is actually bullshit This is science it's the study of the physical world through experimentation testing theories with evidence obtained Do you not know what that is?
Totally incorrect
This is bullshit. 😂😂
@skyhavender Describe and provide precisely how this is bullshit 3 2 1 go provide evidence science is literally about the study of the physical word expreametion through observation testing therapies of evidence obtained Stop being a hater fuck off
Why the lie about Red Meat. The joke is you!