David Sinclair | Why We Age and Why We Don't Have To | Talks at Google
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- čas přidán 20. 05. 2024
- David Sinclair, professor of genetics at Harvard Medical School, discusses his new book "Lifespan", which distills his cutting-edge research findings on the biological processes underpinning aging. Sinclair describes lifestyle hacks we can undertake now to combat aging, as well as future scientific breakthroughs that promise to slow down-and even reverse-the aging process.
Moderated by: Sam Phippen
Get the book: goo.gle/2LXCd2P
❤️🎉 Eat healthy, do exercise, take vitamin tabs and sleep well. That's what I've done and it's my 90th birthday next week. 😊
A very happy birthday to you!
No Vodka?
Congratulations. Live long and prosper!
Happy birthday you . What all supplements you have been taking ?
Food and walking are the keys to health.
I’ve watched many lectures. The common message is fast regularly, walk often, have good friendships, and avoid simple carbs.
Excellent Greg!! That boils it down to a usable life style without being confused
with so many messages, and messengers.
Avoid carbs is bullshit. The biggest example is that the longest living people on earth (living in the blue zones) eat many carbs. We have to distinguish between Refined sugar (which you should definitely avoid) and complex carbohydrates, that the body needs to digest, these carbs have low glycemic index.
Many healthy foods like whole grains, legumes, fruits, and even vegetables have a big amount carbs, and to avoid carbs, we would have to avoid those foods, and essentially avoid important nutrients like vitamins, minerals, and disease-fighting phytochemicals.
I highly recommend a video called: „Deconstructing the Paleo Diet“, that talk touches on the carb myth.
@@SchgurmTewehr Look at Asian population 50 years ago...Especially India they lived on so called low GI carbs... I think I don't have to elaborate more on that... Carbs are futile
@@SchgurmTewehr It’s a pity the science disagrees with you. Carbs are totally unnecessary and too much too often leads you to insulin resistance, which leads to metabolic disease.
@@snowflake5204
No, you shouldn’t elaborate from epidemiology.
I just gave an example, but we shouldn’t elaborate from epidemiology - it just gives us a clue what to look at.
David Sinclair's talk in 2250: "Why We Don't Age and Why We Have To."
and he looks exactly the same... imagine
I agree!
Go back! I want to be monke!
david pushes covID govt narrative
😆
What's more amazing he isn't reading off a script!
that is because he had this speech memorized since 200 years ago
@@danielmanahan692 you have
By
This is how it sounds when an expert speaks. Unfortunately in society today we hide our experts under mountains of Grant proposals while we let the clowns with no practical competency to speak of run the world. Occasional breakthroughs of transcendent, species-level imperatives like this one (plus the institution known as Elon Musk) are exceptions defining the rule.
@@josephkellum2083 Yes. It’s a shame anyone will need to be “amazed” by a highly trained academic. There are lots of them out there but we’re in an anti-intellectual culture where dumbing down is the rule and intellect is often mocked and derided to make the intellectually lazy feel better about themselves. Watch out as this could result in a moron becoming president.
It was very natural
Interesting the comment on fasting. When I was a child I had quite severe asthma and eczema. The nail on my left hand index finger was buckled with a cakey something underneath it. My sister used to tease me... I'd never get married with those hands... lol.. kids. At age 11 I decided to fast once a week. Missed breakfast and lunch, just took a thermos with hot water with lemon and honey in it to school every Monday. Had a cabbage and carrot salad with a light lemon and oil dressing and then cooked non starchy vegetables around 4pm when I got home from school. By the end of the year I had no asthma or eczema and my fingernail had grown normal like the others.
very good experience. great remedy for asthma.
@@R.R.Brahma ….it's all for body integrity in general.
Whaaa? Good for you.
How could you at this young age be so wiser? Fews people are awake enough to even see they have body to take care of, just leave it para some known dr out there.
Wow. I am impressed, really. You're 11 then and yet you've done fasting?!
Good for you👏👏
and he finished with a bang... "you've gotta take some risks, not everything will work, when they fail just keep going, you'll eventually get there if you focus on a dream" !
Thanks so much David, you are a great help to me and being healthy and for looking forward ⏩ to live healthier and longer. Congratulations for all the good works you have made.
Hi David, just want to let you know I have followed your videos for the past few years. When I looked back during my prime years (~ 30 yrs old), my work schedule was irregular, therefore, I only ate a maximum twice per day, sometimes even once per day. On top of that, I was an avid racket sports enthusiast. Played sports every other day, (quite intensive), and never stopped. Now, I am 50 yrs old, and still continue to play badminton (extremely intensive - advanced/pro level) every other day consistently, and only eat a maximum twice per day, most of the time eat once per day, with light snacks. All my friends and new people I met, still thinks I look around 30 yrs old. It seems like my aging halted considerably ever since I started eating less meals, and got into intensive sport when I was 30 yrs old. When I see some of my friends that are the same age as I am now, they all starting to have grey hair, and wrinkle skin, early stage conditions (weight gain, diabetes, high blood, cholesterol, etc.). Ironically, I weighed around 130 lbs when I was 30 yrs old, but now my weight has been averaging 120 lbs for the last 20 years, with an average BMI of 20.5. I notice it's a bit weird when my surroundings are aging much faster than I am. Therefore, when I saw your videos, I noticed there is a similar pattern that I have been on the right track for the last few decades.
A fascinating book. Much of it way over my head but he explains everything well. Everyone should read Lifespan. I'm 78 so I can't stay young but maybe I can stay old a little longer.
He looks younger than his age...
one of secrets to living to 100 is proper food, toxic one gets stores in our bodies for years and years and eventually coming up and some for of diseases, natural food (and not all) can help you live longer. Feel free to read some articles about that - but be aware there's lot of noise in it - false theories etc. try to verify elsewhere everything you read about it
@@orchidpearlwhite732 Botox and filler helps.
Well, if SENS and Aubrey de Grey are right, you'll not just be living old longer, you'll be reversing your age to become young again!
Just live a fulfilled life, if you are content with the life you have live it wouldn't matter if you die tomorrow, next month, or next year.
In our lifetime ..please Professor!!!! No pressure 😬 I’m hopeful ✌️✌️⚡️
Same here 🤸
Keep in mind that others are also working on this. The “partial cellular reprogramming” seems promising.
I really hope David achieves something great with his but imho what is really hopeful is the growing number of biotechnology companies investing in this field. If the science can continue showing it can be done there could be a huge acceleration of progress in the years to come.
I’ve been using a formula based on his research for a little over 2 years. So much has improved!!
Don't just be hopeful, Margics 🙂 because hope is not enough when action can be done: Donate in favor of the anti-aging research as much as you can, even just €1 per month like me (I'm still poor and I can't afford more).
You can donate to the SENS Research Foundation here, for example:
www.sens.org/get-involved/donate/
This dude is so onto something. 65 and fitter than ever in my life. Feels like I am getting younger by the day.
Are you taking 1g of reservatrol/day?
I'm almost 69 and been following Dr. Sinclair's program for about a year, including taking a gram of NMN a day, and the results have been fantastic. I really do feel as though I am aging in reverse. I have more energy than I have ever had in my life.
Where can you get this?
@@ElonizuMuskamoto I get it from Amazon. But in my experience, I don't feel much effect unless I exercise. When I take NMN, the more I exercise, the more I want to exercise.
How did you found MNN
@@lourdesmartin6602 I searched on Amazon. A lot of brands were too expensive but the Livemax brand in multiple bottle packages came out to a dollar a day or less.
What is mnm?
Big fan of David Sinclair. I hope he gets all he wants (funding etc) to keep researching and tie up the lose ends faster.
Yeah, but if you were a billionaire, would you fund him substantially and graciously?
@@ogungou9 100%. I most definitely want to live a long healthy life plus I have a personal vendetta with diseases. Cancer killed my mom in her 40s. I know this is not directly about cancer but who knows where his researches will lead us. Preventions and Cures maybe.
Kirk Buchanan I’m with you; if back him 100% too if I had the money 💰
Pharma will lock the door to public success. If will be a very private success
Ogun Gou I'm still young so I'm gonna go get the money for funding
50-year-old dude that looks 20 and talks about living forever? I'm all ears
ask your doctor for better glasses, he is old the face is not everything what decide about age
@@softrek His clothes are 20 like my socks are 20 like I'm 30 years older than my college physics student. No, make that 35 older...
@@drbonesshow1 are you a jew?
Softreck Softreck Mueller is not even close to being a Jewish name
@@ytyt3922 they are changing names like you pants
I really find this topic very interesting. Dr. David Sinclair discusses and explains it very well that can be fully understood. Thanks for sharing us your knowledge.
Thank you for your very coherent speaking and knowledge. Very interesting concept and will look forward to reading your book when it comes out. You are helping the world vision with wonderful material. Brilliant
Thank you David Sinclair, the most fantastic talk ever listened to!
A real genuine human being...really someone to look upto.
I thank "Talks at Google" for sharing all these novel talks worldwide instead of keeping these closed-door. Now I can sit in my study room and learn about some cutting-edge developments from the other side of the world. Thank you!
My mom has Parkinson's and dimentia, and I'm very depressive person. I hope that his research someday leads us to healthy lives.
thank you David Sinclair you have helped me and countless others with science based information, my best to you and all from manhattan, nyc !
This has been an excellent and informative talk. Thank you!
This man is awesome. Dedicated his life to science and ageing
. . . when somebody makes a living out of ageing . . .
His youth secret might be that he dedicated (donated) his life (some 50 years) to ageing and became a teenager. Worth a try!
Thank you so much for this important informational breakthrough.
I like his cautious approach and the audience questions are fantastic also sleep is the fountain of youth.
Amazing listening to Dr. David Sinclair, its mind blowing, Wishing him Success in all the funding etc.
Just accepting ageing as inevitable seems blind. I am certain that there is at least one way to become immortal. Probably more than one way... Keep going Mr Sinclair.
We won't be immortal. But if we can be healthy and productive for longer maybe Social Security won't go bankrupt.
death is inevitable, fear of death is not, Humans are curious to want to everything except death and what beyond death.
@@MrManny075 If we were created by some kind of good force, then there should be a way for us to avoid all suffering to be fair. That would include watching yourself decay in the mirror by a process we call ageing.
@@NeoFrontierTechnologies no such thing if
Hope one of theme not beeing zombies
Wow. This is amazing, hopeful information. How strange anyone could give this video a "dislike"?!
This guy is a legend - been watching him for a year now. Really interesting stuff!
Check out his interviews from around 6-12 months ago, frown lines, nasty wrinkles that looked like a road map- Now, gone and he seemingly cannot move parts of his face...Stroke? No, BOTOX!
Rumor has it that he had Christian Slater lookalike surgery...
That only works on mice
Lol it takes a year for him to get to the point!
@@lyndenmanning8669 you are absolutely right. He looks like he's 50 or more. I just looked at his close up photos on google. He has so many wrinkles especially around his eyes.
David Sinclair is an Australian who has opened up his Harvard lab research, in a totally transparent fashion, to give hope to millions of people when their otherwise was nothing. I have been taking Niagen now for 4 months and the difference is amazing. Thank you Aussie, you are indeed the most incredible and amazing legend. :)
The health promises of boosting an important metabolic molecule may be clouded by its possible role in promoting cancer-cell growth.
www.scientificamerican.com/article/cancer-research-points-to-key-unknowns-about-popular-antiaging-supplements/
SIRTs are involved in many important biological processes and play a critical role in cancer initiation, promotion, and progression.
Dual Tumor Suppressor and Tumor Promoter Action of Sirtuins in Determining Malignant Phenotype.
www.ncbi.nlm.nih.gov/pmc/articles/PMC6363704/
Dipartimento di Medicina di Precisione, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy (2019)
"SIRT1 is involved in the initiation, promotion, and progression of several malignant tumors including prostate cancer (Jung-Hynes et al., 2009), breast cancer (Jin et al., 2018), lung cancer (Han et al., 2013), leukemia (Chen and Bhatia, 2013), colon cancer (Lin and Fang, 2013), melanoma (Ohanna et al., 2014), and ovarian and gastric cancer (Han et al., 2013; Shuang et al., 2015)."
So how is it going, three years later? Also, which NMN exactly do you consume?
Once again, science has cured every illness known to mice..
hahaaa good one!
🤣😂🤣😂
Extremely helpful, yes.
Cute pic
Of mice and men......
A very well-spoken scientist. Thank you, Dr David Sinclair.
Dr. Sinclair ,
You are a great inspiration for me and many people who believes that medicine has to be changed with a new ways to treat patients.
Thank you, David! This is a Great and Promising Research!!!
I love that naturally, I have seemingly gotten younger. My doctor recently said I have the physiology of a 17-year old and I am older than David Sinclair. I used to need glasses to read, but now I don't (no surgery or any other thing), my hair was thinner and now it's thicker. My sleep has gotten better in a huge way. I have more energy now than I did as a teen. I healed every issue that I had physically and emotionally. I have no pain, none of the pain I used to have. I am stronger as well. My changes were all about the inner guidance I receive. Thank you, David. This is a fascinating subject. I actually teach a class on age reversal so people look and feel more and more youthful, etc. Thank you!
So what do you do?
@@ShroomGill join her class (pay $999) to find out!
What s the name of the pills you are taking ..?
@@almamunoz5276 None. It's all endogenous. I do take some vitamins but if I take them or not this happens because of natural things I do at home. Does that help?
@@ShroomGill I teach people true mastery over life, and I teach how to look and feel younger. I have 2 podcasts also and am an actress and a speaker, and have written 3 books. What do you do?
We all get old yes and age but being 50 and living what you love, being passionate about life is great!! 💘
This guy is 50.... It seems like his methods are legit
OPEN MIND Wow and he’s white??? Would never guessed 50! Black don’t crack
@@samsun01 ehhh what
yeah, but the speech sounds like an intro to a new zombie apocalypse
@@cryptoshi9636 And yet white people live on average 10 years longer than black people in the usa lol
the size of his ears says hes about 50, cant stop your ears from growing
Shannon's information theory and epigenetics in the one talk - very very cool! This is amazing theory!
The world watching you with a hope.. U r just doing a great job Dr. David Sinclair.. The idea is just awesome.. Hope you get success..
Caloric restriction is something I've heard from Michio Kaku over 20 years ago when he was on Coast to Coast AM with Art Bell. I think this method of prolonging aging has obviously been studied and practiced for many decades, if not, centuries and millennia in the form of fasting.
The most beneficial of the whole talk: hunger. Fasting for 2 and 3 days in a row is not bad. Your body is forced to kill old cells and create new cells. This is fact. I practice fasting 1, 2, 3 days of fasting and only drink water at least once a week. At least once a week. A regular week I will fast 3 time at one fast-whole-day per fast. Other times I will fast 2 days in a row in that week up to 3 days. I've fasted up to 6 days, but it's very difficult only because of habits, not really from hunger, but the habit of reaching for that thing I love to eat. Cutting sugar is the MOST difficult for me. I can say that I have not had milk in about 10 years. I stopped drinking soda years ago, diet soda about 4 years now ( I fell for that diet food/drink trick which is lethal on the body's health ). I have only stopped eating meat about a year now. And besides sugar, cheese if also a hard habit to break. Sugar and cheese, my problem areas. Eating for fun and taste is the basis of all get-together's, all things fun, involves stuffing the face full of horrible chemically treated dead-food sold as "edible food".
Hello! It feels that you are describing me! 😊After reading the book Paul C. Bragg "The miracle of fasting", I was 19 at that time, but I was so impressed that I have made a decision to give it a try and to see how it actually works in reality. I started with 3 days fasting (that was a mistake, because I never done that in my life...) , I thought that I will faint a couple times, but I survived and then I tryed slowly to come back to the regular eating, it was really hard not to overeat. It's really a challenge. Right now I am 48 and I have decided to do a regular 36 hours fasting once a week and I feel great! I have so much energy and I don't feel hungry at all. Going for 3 days fasting the next week, will see how is going to work. The hardest part is the cold when your metabolism is slowing down. I am trying to be more active then, to walk more, I wish that I could work out, but it's not good while you are fasting. I can't do only with the water for the same reason, so I take a tea, green tea is good especially if you have headaches while fasting, but water is essential. I drink min 2 liters per day anyways, so while fasting is even more.
Yes, cutting sugar is the hardest part, I don't use any white sugar while ago, but a honey or maple syrup is still on my list, otherwise I have no energy, my blood pressure becomes much lower while fasting, otherwise it's perfect. I don't use any coffee for 3 years now, it was hard, because it's usual to drink so much coffee at work here is Sweden and it's very strong coffee. It took around six month until I could walk away from a coffee shop without just enjoying the smell like an ex smoker who enjoys another person smoking beside. Now coffee beans smells horrible to me, like something burned and unpleasant.
Cheese was another challenge of mine, before I got lactose intolerant 4 years ago I use to eat it every single day, maybe that's why... 🤔 I don't see another reason, once my body just said: okay, honey, enough is enough, your cheese intake in this life is just finished... 🙄😏
Otherwise I am quite good with my diet, trying to eat as much organic fruits and vegetables as I can. Beans and lentils are good meat replacement. I still need some fish (mostly wild salmon or herring ) as a protein and vit D provider, but meat intake I have limited very much lately, I still enjoy some turkey breast sometimes, but like only once a week or less often. I hope I am on a good path. I workout regularly for 10 years now, I love to move all the time. I think that I will be fine, I got good genes as well, my mom is 73, she still don't need glasses just while she is writing something, almost no grey hair whatsoever, amazing memory (I wish I would have that!) she is growing her own natural food in the village, moving a lot, excercising every day. My dad died a few years ago, but he also had a terrible diet, nobody could change his habits, not even my mom, may rest he in piece. 😟
I am trying my best here, I never smoked, never used any alcohol in my life, the last and most difficult one is to cut completely a drug called SUGAR. The longest time I survived without any sugar whatsoever was for 6 weeks... 😏 It was a hell, just because my daughter likes to bake sweets. 🍰🍮🍪 I felt much better though, it's nothing to compare, it really takes a lot of power of will, as an addiction is 10 times stronger than to cocain... 😒 If I can do it, so do you! Good luck and stay healthy people! 🍀
that s amazing I am happy for you . I hope I can succeed too
Is cheese that bad for you? Cut yourself some slack and enjoy some cheese.
For very different reasons, NAD+ has also attracted a wave of attention from cancer researchers. Recent studies suggest that cancer cells of many types depend on NAD+ to sustain their rapid growth and that cutting off the NAD+ supply could be an effective strategy for killing certain cancers. The data from these studies paint a more complicated picture of NAD+ and raise new questions about the diverse ways taking an NAD+-boosting supplement might influence health. “It might still slow down the aging part, but it might fuel the cancer part,” says Versha Banerji, a clinician-scientist at the University of Manitoba. “We just need to figure out more about the biology of both of those processes, to figure out how we can make people age well and also not get cancer.” This is just a fellow up to my previous post. Interesting that most sites are ignoring the possibilities of its effects on cancer.
Don't keep this a secret folks. The best way to help Dr. Sinclair is to share the knowledge and get more people involved. Everything new needs a go through a period of acceptance from the establishment. The faster we get over the hump the better for everyone.
Copyrights make money
Such wonderful information. Thanks to Dr Sinclair.
Thank you David! U and ur team are amazing! I bought ur book!
Love love love! Thanks for sharing your insights!
What an incredible talk. These discoveries are beyond exciting.
there are so many factors involved in anti aging. I try to do my best and tackle it from many angles. Im sure im doing a lot of things right because strangers comment ay how good my skin look and think Im younger than my biological age. The fact is you need a lot of money to cover all bases. first and foremost get rid of excess stress. no pill or drink will counter the effect of excess stress. the people in the most stressful jobs are the ones who age the fastest.
I wish google[X] offer this guy the fund and facilities to speed up his research progress
@anders damin acording to aubrey de grey calico is a waste of money
@anders damin of course, ive been looking at all of this for like 5 years now. Aubrey says that they're doing basic research on how metabolism works and how to slow it down, he thinks that its a dead end that will eventually lead nowhere, since (acording to him) we cant tweak metabolism, and we have to treat damage directly. However, i hope sinclair and steve hovard are right about their epigenetics theory as the source of all damage. That would be a huge leap foward.
Aubrey actually says that metabolism is far too complex to be helpful to us now. Eventually, yes, we will crack metabolism, but it could be a century from now or whatever.
The fact that Calico has been at this for six years with huge funding and has produced absolutely nothing or has publicized nothing tells me everything I need to know. I hope I'm wrong though.
@@squamish4244 maybe an AGI could decipher metabolism sooner than we think
This man is a Genius. And he looks so youthful
He is simply a well trained scientist who sees the benefit of this endeavor. And there are many others like him.
If I could stop aging at 25 years old then I'd definitely wanna live at least 200 years.
The intro is kind of obscure and dark but half way through it, the whole speech really brightens up.
11:53 The metaphore is mixed. The Genome is the underlying code, the Software. The Epigenome is the Operating System, that is the Base Code that interprets and actions the Software's instructions.
thank you Dr. David sinclair
I am 68 and eat one meal a day, usually after 8pm, for most of my adult life and don't feel hungry
also stopped drinking soda at 19 after a Mountain Dew binge for a few weeks one summer was making me feel ill
same weight as I was at 20, no belly fat, some of the work I do daily is quite physical which takes care of my exercise
have not been ill in going on 20 years, take no medications, not even an oral antibiotic in 45 years
I am low sugar (dark brown sugar in coffee only) .. ZERO high-fructose corn syrup
whole milk, butter, cheeses nearly every meal, about a dozen eggs a week, lot's of fatty beef, fish about once a week, and quality hot Italian sausage as a treat,
Chicken thighs for 3-4 meals about every 2 weeks, rye bread .. lot's of Broccoli (with onion, butter and cheddar), beans, red onion, garlic, .. cumin and turmeric as spices
I DO! I WANT TO LIVE FOR 1000 YEARS OR MORE! Can you imagine all the amazing discoveries and achievements you normally wouldn't get to witness? I want to live long enough to see humanity create a Star Trek like society. Where people choose to do things because they want to, not because they have to. And I want to explore the universe in a star ship. That would be so amazing!
I don't give a damn what they discover, but I guarantee you WILL NOT live to 1000 year, you won't even live to 200 years.
I agree!! Check out Dr. Aubrey De Grey also. And Calico.
You could always ask to come back.
I am happy to find someone else who wants to live 1000 years! So many negative people hate this world, hate life, have given up on humanity, and look forward to some fantasized after life. I love this life and want to explore it, change the world for the better, and be alive for centuries!
@Ray J. marxism
As much backlash as he’s probably encountered, I pray that never stops what he’s trying to bring to light. If you ever need a nurse to help in research or testing, I give myself to this.
I see what you're doing.... trying to outlive us, huh? 😂
Quick your hired,run to Atlanta wearing no clothes in the middle of winter, packing meals not necessary and do it at night when you wont be exposed to the Sun and no cheating by stopping at any convenience stores to use their microwave,and when you get here will have a nice cold shower waiting and a bowl of hot soup of onions ,cabbage and carrots
I wish more people had your attitude Kelly. It amazes me that there are so many initiatives out there for every stupid thing under the sun but only a tiny fraction is put into age research.
I think I know you, you said your a nurse!!! Don't you live in Oregon
We literally have nothing to lose trying to find elixir of youth, we may as well die trying.
I myself am not really phased by dying. I dont wanna be old god damn it lol.
Excellent Information.You are ahead of the curve and will give millions of people hope. You have information for Doctors and Scientists that will make the world a better place. A+ Retired College Professor.
He did his own podcast for a year. Worth a listen for sure.
Excellent Talk!!!
A great creative idea has found the secret of aging, Look forward to see the human studies...Thank you so much!
Thanks a lot to David Sinclair for his amazing work.
Fantastic! Thank you so much for devoting yourself to solving this important issue. If we can age without falling victim to dementia and disease, what a quantum leap that will be for mankind. May GOD guides you in your search for the answers.
How interesting a pursuit! His book is very appealing; what a brilliant man is Dr. Sinclair. This is one of the foremost concerns of mankind historically, although there is such a massive amount biological information related to this line of inquiry. We are fortunate to have such a brilliant young man in our culture.
Public have not get time or peace to read a book, but this video you could save and use for its excellent content. Thank you Mr Sinclair..
Thank you for bringing my role model onto your talks.
He's the most important person in the world right now.
Yes david is the most valuable person
under any other time or circumstance I should never have been able to understand this and it should have been so over my head! amazing! Cool, exciting, and WOW.
Excellent presentation!!
29:56 what an amazing observation!
I love ❤️ this guy! So intelligent and his voice is so genuine and soothing. Thank you for this wealth of information.
Fasting is a crucial part of life. I'm not talking about lent, or Persian fast for part of the year, but fasting for 1 whole day, 2 days, and 3 days, on a very regular basis. And no sugar, sugar is lethal.
Thank you Dr David for your great and usefull talks ! 💛
This sounds awesome and gives me hope since I was recently diagnosed with glaucoma.
CBD will help glaucoma.
This guy is amazing and he looks so healthy for his age!
Botox?
@@tf2368 He explains what he takes on the joe rogan podcast.
Suggestion is he does botox
Botox isn't everything. You still ha e to eat right and sleep properly excersize etc
This is the most exciting talk I've heard in a long time... I hope more work gets done in this field. Most diseases are byproduct of aging and if you stop aging you stop those diseases too.
Actually you do have to age even if u take those shot like what David said that can reverse age by decades. He use a word ‘reset’ so it’s like u age and you reverse it so diseases will be created while aging, we can not stop aging but scientists are trying to reset it.
I don’t know if you’ve been keeping up on the research, but over the last three years since you commented, David and people like him have made huge progress
@@Crescent-IVI’m new to all of this but could you elaborate on the progress that’s been made?
Easy pass as 30. Amazing !!!! I think you are on the right track doc !!!! BRAVO !
Amazing knowledge Thank you Dr Davd 🥰
Can’t wait to be in Boston , thousands of miles away now
Fabulous work David Sinclair. I hope the cure for glaucoma nerve damage comes while I am still alive as I have lost permanent vision in one of my eyes. My life has become different. I send you many blessings in your life and for your continued wonderful discoveries. Much love, Desiree.xx
Historically, 'self-experimentation' has been a thing.
Including several Noble Prize winners.
Just a thought in passing. ;)
this bit about, "It is all happening all at once in the same moment" is true at the core of it all.
It's difficult to evaluate something with no visible consequences, but the research points to a positive outcome. It's probably best to utilize while you're under physical duress. This product has met my expectations in that it has made me feel more energetic in the morning and throughout the day since I started using it. I'll keep taking Vitruvin Health Anti-aging supplement since it keeps me energetic throughout the day.
I was doing a lot of the stuff from the book before that and this January I've decided to decrease the meat intake (maybe half of what I usually consumed) and started supplementing NMN and K2. I don't know if I'll live longer, my Horvath clock tests will show that with time, but damn I feel so good that it's worth it even without a lifespan increase.
Just drop the fucking meat
What NMN are you taking? Looking at amazon but not sure about them.
Buy the Book, Read it. Took me years to get the information in this book together for myself.
What is the name of the book?
Big fan. I welcome all his study on biological science and reverse ageing.
I'm 42 and I feel as if I'm only just finding myself, but the physical signs of decay are already apparent in my body. It's mostly cosmetic, but even still it's your body doing something with itself that you can't control, and that's never a good thing. Human life as we know it is far too short, and 70-80 years or so just isn't enough for me. A couple of hundred years would be nice, but 500 would be even better.
I'd even settle for a workaround. If I could grow a clone of myself then mature it for 20 years, then transfer my consciousness to it then that would be fine too. Do that every 60 years or so and bingo - immortality (sort of). It's not as if the Universe doesn't have the space. Infinity is pretty big.
"It's not as if the Universe doesn't have the space."
Thanos would disagree with you. 😉
I completely agree with you.
However, the physical appearance ("cosmetic") is a very important component for psychological well-being, needless to lie.
And in any case the appearance reflects the functionality, as always happens in biology. "Aging Looks Are Not Just a Matter of Aesthetics": www.leafscience.org/aging-more-than-aesthetics/
it's hard to believe that googlers and whoever else is reading comments here would up vote such stupidity. For starters - if you will be able to 'upload' your personality / mind to the brain of another person (which will never happen, it's just a weird pipe dream of fiction literature) - this action means that you have to 'wipe out' the mind of that 20 yrs old clone which is in other words equivalent to a CRIME OF MURDER. Think for a second- how that person (clone) would feel if he/she learns that their only purpose in life is being body double for some schmuck, who will wipe their mind / memory /soul, if you like- just to replace it with theirs, lol.. beyond ridiculous..
I did the NAD+ IV drip at age 39-40 about ten months ago and it was very powerful. My mental acuity increased, soreness in my muscles and joints decreased, inflammation decreased and I gained strength, flexibility and mild gains in agility. The process literally 'purified' my body (you can imagine what the purification was like ;)
So yes, I am 40 when I look in the mirror but I don't feel it. I go every three months now.
You can take the pills too, or the powder, both are sold on Amazon or you can order them from a naturopath who does NAD drips...they aren't as effective as the drips but they ARE effective. Ideally, you should purchase tablets that you can dissolve under the tongue, as that maximizes absorption into the bloodstream.
I also do hot yoga and hit the gym. I'm probably as fit and strong as I've ever been. So 42 is nothing to fear these days, although it does take some serious contemplation and maybe a mid-life crisis to realize that.
Another thing that is often neglected is the mind. We have piled on 20 years of adult shit, caution, bitterness, anxiety, neuroses etc. that we lacked when our minds were young. In a phrase, life has kicked our asses.
Therefore, it is important to explore potential brain technologies to basically function as meditation on steroids, such as neurofeedback (I use NeurOptimal) to calm the chattering mind and remove layers of trauma. This device has the potential to make us feel psychologically younger when we were bulletproof while retaining the wisdom of experience. Many other devices are coming out or are already out. Ask me if you want to know more :)
What about the clone? It's a separate human, unless we found a way to harvest bodies without brains. Also there a dis
Wow, this is amazing!
I read about Dr. Sinclair's book "Why We Age, and Why We Don't Have To," very educative. There's no point increasing lifespan without health span. The goal should be to live longer while staying young and healthy. People who say they don't want to live forever should still support this because you can always change your mind later but not if you're already dead. I have been saying this... longevity is our choice! If we want to sustain our health, we have to do something about it! This will start by knowing what supplies our body needs. Start by eating a balanced diet, quit vices, exercise regularly and take an NMN supplement. It's my 7th month taking the NMN by Vitruvin already. It's cost-effective, and I can tell that what I hear from the feedbacks online aligns as well to my experience.
Couldn't agree more
Are there any side effects of nmn?
I agree that eating right, getting enough sleep, taking vitamin supplements, exercising and not abusing our bodies (avoiding toxic things like alcohol, smoking, drugs) and you will live longer!!!
Great talk! I'm reading his book right now, it is quite fascinating.
Mathieu G how'd you get hold of it? Couldn't find it anywhere
@@unknownchannel3141 Amazon has it, reading the digital version
Soham Sadhukhan I purchased mine at Costco and I’m enjoying it.
I'll be turning 50 this May.
I quit sleeping well several years ago and I believe that not sleeping properly 0-4 hours nightly has amped up my aging process. I have had very little energy for 7-8 years now
When I find enough energy to exercise, it takes several days to revover and if I get my heart rates up to high, it takes awhile to come back down to normal. I have yet to found the key to my poor sleep, but
I would do just about anything to find the key to unlock that pathway.
You can use ‘Tru Niagen’ it works! You will sleep better but also look younger, I’m way younger than 50 but I noticed that my skin looks way younger since I’m using this product.
It is very good to hear your talk on aging. I will get your book 'Lifespan'
Eyes opening👏👏👏👏
Excellent Talk
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Google ~
I just want to say thank you to David Sinclair. I have been taking NMN and its like night and day energy wise.
For how long have you being taking it?
Which brand?
I could certainly use more energy.
JUST FOUND THIS CHANNEL AM IMPRESSED RIGHT AWAY TO THIS GENIUS SCIENTIST DAVID SINCLAIR
Nothing genius about him. He seems very practical which is way more important than being a genius.
Now that I am a founder of a major IT company, I am looking for ways to live long and enjoy my soon to be incoming wealth. So here I am and am so happy to have found this very intelligent scientist working at Harvard explaining in simple terms what is involved in prolonging one's life in an enjoyable fashion. Yes, this man should be protected and encouraged to continue his research. I, for one, will be more than happy to contribute to this cause.
👍👍👍🏽
Buy a thousand copies of his book and give them to your well educated friends. This will trigger an avalanche of inquiry that will result in increased funding of Dr. Sinclair's very expensive research.😇
Awesome Talk. I love the idea of being able to reset an individual's physical body back to an operation of the previous 10 years. I've thought about this concept myself over the years and have tried to implement a solution via Low carb eating, raw vegetables, no sugar, daily low impact exercise, B vitamins, hydration and other supplements (natural & synthetic). I have always dreamed about telomere extension since I thought that was the primary solution to extending life but now after this talk and previous ones I've seen and heard from David Sinclair, I now see that there's far more going on in our cells that will lead to healthy longevity. I'll continue to follow his research so I can continue to have a good understanding of these exciting discoveries.
Hi what supplements do you take?
@@irumkhan3381 The list is extensive. You may have to narrow your question up a little, such as "what supplements do (I) take for longevity, or focus, or daily regiment."
The real problem with all of this research into the biochemistry of aging is that we are living in a world grossly contaminated with thousands of chemicals known to be harmful to human beings. With the dumping of human trash in the oceans and burying it in the ground, this toxic chemical contamination problem will only increase exponentially as the world population increases. Ask yourself this question: What happened to all the nuclear fallout that resulted from above ground nuclear testing on this planet from 1945 to 1963??😇
When I talk about this kind of thing to friends, many say "well I wouldn't want to live forever", or "I don't want to live 500 years". My answer is simple, do you want to live until next week? Do you want to see the next walking dead episode or whatever? And they all say yes. So I explain whether it's now or 100, 500, 1000 years from now, it's always just living until tomorrow or next week.
But is that going to result in a more meaningful life for the average person ? Even if people had all the time in the world, they will never be able to do all the things they wanted to do, and even if they do it again and again is that going to result in a similar experience to the first time ? I don't think so. At some point the law of diminishing returns is going to kick in and you are going to end up with people looking to suicide to relieve themselves of unending boredom.
Loo Eli good thing for the gene poole
@anders damin true, good point.
With the realization that death is a rarity and that you and the tree will likely always be there, I can imagine it is going to be hell on earth for a lot of people.
no not really, u will get to a point you will say I have had enough thank you, even for a tomorrow and its true
Sinclair looks almost exactly like a younger version of Christian Slater who, coincidentally, is the same age.
For Sinclair's twin mouse, the first who came to my mind is Christopher Nolan, who is also roughly the same calendar age ...while looking more than a decade older.
Why was I saying the same thing
Hahahaha totally!
Thank you! Couldn't think of who he looked like haha 🤣
@@dahawk8574 Looks nothing like Noland.
Dear Professor Sinclair, dear scientist and esteemed man!
Although your concept of fasting, which is not new, but has been here at least for two thousand years, is trustworthy, you never mention how to manage craving for food. How can I fast if my appetite craves for delicious meals and takes over mind?
I watched my mother shrink and not be able to walk more than a few yards without getting out of breath as she went into her late seventies. Now watching my parents in law fall apart slowly and get frail. Ageing sucks. It has made me determined to be one of the outliers that run marathons (slowly) in their nineties. Starting in my sixties and building muscle to go into old age with a good muscle base, sprinting twice a week, walking and swimming. Just started skipping meals until 11.30 am. Started NMN supplements two weeks ago and from the first day I can tell you it really works. My body runs warmer, my energy and mental clarity is much better, and after months of grinding slow weight loss, my diet is finally working and the pounds are dropping off. I am effortlessly faster on my runs. It’s crazy.
Not sure I’ll take the Metformin/Berberine as I do so much exercise. Jury seems to be out on Resveratrol for similar reasons but the NMN is effective and does not block the effects of exercise. I think most of us who start it find you have to be older to feel it as your NAD levels are fine until around 50.
Sinclair doesn’t think the jury is out on resveratrol. He takes 1 gm per day. I think the known research and safety profile are almost astounding. If I could take only 1 it would be resveratrol. But I take more than 1.
Be careful about losing too much weight. It's actually better going into 'old age' with a few extra pounds for much needed energy when your appetite begins to falter....and you eat less and less and less. 😇
Where’s the supplements to buy
What NMN supplements do you take?