Overall good video, except: LPS is located in gram-negative bacterias and not in gram-positive. LTA is located in gram-positive bacterias and not in gram-negative.
LPS is in Gram (-ve) not Gram (+ve), and LTA is in Gram (+ve) not Gram (-ve). This should be fixed by now, this could affect someone's grade. I don't mean this in a rude way by the way, I just mean PLEASE fix this so that it doesn't confuse anyone and result in them getting a lower mark.
I cannot thank you enough for this video. I have been struggling to understand TLRs. My textbook did not go into depth about them and my instructor just confused me when it came to them. Thank you thank you thank you!!!!!
In case any one trying to remember thier individual function , TLR 2 gram +ve bacteria LTA(two lines in plus sign) TLR 4 opposite =gram negative bacteria LPS remember TLR 3 and 7 together: 3 for double stranded viral RNA, 7 single stranded viral RNA TLR5 - Five for Flagellin TLR 9-nine for nucleic acid =DNA
Armando, Karin Kolbe is right, peptidoglycan cell wall is huge for Gram positive bacteria and is the outermost "layer" of said bacteria. LPS is only on gram negative bacteria as far as I understand it. So you are right as far as what the TLR recognizes, but I think you got the "+" and "-" signs mixed up. Thanks for all the videos!
Your drawings are amazing!! I searched through your Facebook to find this specific lesson and no luck :( Can you please post it if you still have it? Thanks again for your superb lectures!
Your Präsentations are very helpful but there is sometimes minor error. Example you exchanged the peptidoglaycan of gram +ve and gram -ve bacteria's. Lipopolysaccharide (LPS), which also called endotoxin, is found exclusively in Gram-negative bacteria, while lipoteichoic acid (LTA) is specific to Gram-positive bacteria.
I love all this and it is truly interesting to me but, I just dont know how it is possible to remember every name for every protein that does this and that etc. HOW??????
Video is tooooooooooooooooooooooooooo nice!!!! :) Psst ! IF I'M NOT WRONG - Lipoteichoic acid (LTA) is a major constituent of the cell wall of Gram-positive bacteria (and not Gram negative as You mentioned it). But to err is Human!! :) Hope You don't mind me pointing the mistake out.
Good video overall but at about 4:21, you said that you skipped TLR6 among others and that TLR6 is found in the endosome. That's not true - it's found in the cell surface membrane.
Overall good video, except:
LPS is located in gram-negative bacterias and not in gram-positive.
LTA is located in gram-positive bacterias and not in gram-negative.
Yeah this is what I was pondering about!
It’s gram negative bacteria. The video is correct
@@faresyaziji5791 The video is not correct at this point. He says TLR-4 gram-positive, but it is gram-negative (LPS)
Right
True, thanks for mentioning that
LPS is in Gram (-ve) not Gram (+ve), and LTA is in Gram (+ve) not Gram (-ve). This should be fixed by now, this could affect someone's grade. I don't mean this in a rude way by the way, I just mean PLEASE fix this so that it doesn't confuse anyone and result in them getting a lower mark.
Glad I opened the comment section
This guy deserves all the recognition he has received, these videos are amazing, I wish I could make something half as good as this guys stuff.
you already did ;) by the way I like your videos so much!
I cannot thank you enough for this video. I have been struggling to understand TLRs. My textbook did not go into depth about them and my instructor just confused me when it came to them. Thank you thank you thank you!!!!!
In case any one trying to remember thier individual function ,
TLR 2 gram +ve bacteria LTA(two lines in plus sign)
TLR 4 opposite =gram negative bacteria LPS
remember TLR 3 and 7 together: 3 for double stranded viral RNA, 7 single stranded viral RNA
TLR5 - Five for Flagellin
TLR 9-nine for nucleic acid =DNA
Thanks so much for doing these videos! you don't know how much they have helped me! thanks a ton~
Loving your videos! They are getting me through med school!
CCNM 2018 Breaking New Ground how's med school? Love to learn from people's experiences.
@@saulloll8547 its hard
It's easy
Thank you so much and it is very useful for me. May I suggest to talk more about NF-kB and pro-inflammatory cytokines?
Great! Thank you. very clear and concise.
Thank you a lot for a bright and legible overview.
hi ! amazing video as usual,please add it to the immunology video series ,you're awesome ! thanks !
Great page! Extremely helpful
Great job, Armando!
Awesome animated lesson. I like it very much.
You are just amazing,I love you Armando ❤️
Armando, Karin Kolbe is right, peptidoglycan cell wall is huge for Gram positive bacteria and is the outermost "layer" of said bacteria. LPS is only on gram negative bacteria as far as I understand it. So you are right as far as what the TLR recognizes, but I think you got the "+" and "-" signs mixed up. Thanks for all the videos!
Hey Ivan, Yes you are right, its a mistake. Didn't realise it when I was doing the video! cheers
Armando Hasudungan wait what? where's the mistake?
Armando Hasudungan Thanks I was a bit confused too
@@armandohasudungan hi. First of all, thanks for tutorial. What do you do with your papers after filming?
Fantastic video of TLRs, Armando.
Great explanation, thank you very much.
Pretty good your video, I've undesrtood very well about this topic, thank`s you
this is really helpful
thank you
Loved it. Thanks so much.
Armando you are the best! Thank you!
I really did enjoy the vidéo Thank you ❤
amazing work
great presentation. I like it.
Good description, thanks
Thank you very much. It was very useful.
In single word you are GREAT
You have severely reduced the 'Toll' this topic was having on me. Great diagrams btw.
such a nice video. thank you
I really wish to buy the pdf image of this but I cant find it on your website, please advise. Thanks!
Your drawings are amazing!! I searched through your Facebook to find this specific lesson and no luck :( Can you please post it if you still have it? Thanks again for your superb lectures!
So nice to find u : )
Perfect video! Help me very much!
Ty so much
Thank you so. Much
U are brilliant 💖
Thank you
God bless your soul.
Thank you so much for the amazing explanation!
Any chance to get this drawing? Couldn't find it on fb..
There is one mistake. TLR4 is for gram (-) negative bacteria.
Very nice explation ,new subscriber
Your Präsentations are very helpful but there is sometimes minor error. Example you exchanged the peptidoglaycan of gram +ve and gram -ve bacteria's. Lipopolysaccharide (LPS), which also called endotoxin, is found exclusively in Gram-negative bacteria, while lipoteichoic acid (LTA) is specific to Gram-positive bacteria.
Gram positive's do not have LPL's(it is in gram -) they have teichoic and lipoteichoic acids
Good video
I love all this and it is truly interesting to me but, I just dont know how it is possible to remember every name for every protein that does this and that etc. HOW??????
I feel your pain...
Nucleus has a double membrane, not a simple one as we can find in the plasmatic membrane
what's the difference between TCR or BCR and Toll Like Receptor?
What about the transcription of genes that make co-stimulating molecules such as CD80 and CD86??
TLR 4 Gram neg bacteria since it recognizes Lipopolysaccharide.
TLR 2 for Gram pos bacteria since it recognizes peptidoglycans and lipoproteins
such amazing our body
TLR receptors are localized on both Extracellular & Endosomal membranes.
Hello, could I ask what the red strand represents on CpG? Thank you
Lipopolysaccharide (LPS) are on Gram negative Bacteria. This is recognized by the TLR-4 recptor
A small correction. Lipopolysaccharides are found on gram-negative bacteria, while LTA is found on gram-positive bacteria!
Video is tooooooooooooooooooooooooooo nice!!!! :)
Psst ! IF I'M NOT WRONG - Lipoteichoic acid (LTA) is a major constituent of the cell wall of Gram-positive bacteria (and not Gram negative as You mentioned it). But to err is Human!! :) Hope You don't mind me pointing the mistake out.
Exactly my thought!
Eduardrssl Thanks for confirming!! :)
Can anyone please tell me where do the toll like receptors come from in the first place? Like where did they evolve from? How are they synthesized?
I like your style!!! Great info and drawings.
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Which of these pathways result in fever?
are toll like receptors,TL3 and TL7 present in ALL cells?
good info, needs volume....
3:39, TLR5 doesn't dimerise? it does!
correct me if m wrong. please
look here: www.ncbi.nlm.nih.gov/pmc/articles/PMC3727914/ seems that TLR5 does dimerize
What is the meaning of toll-like? Why we call these receptors as toll-like? Thank you.
whats the difference between toll like receptors and the PRR ( pattern recognation receptor) ??? plz answer me
+Imene Bda there are different types of PRRs , among them the toll like receptors
How can we get that image?
anyone else notice that Armando was high af in this video
listen to how much slower he talks compared to his other videos
Thanks, good description.
TLR4 = gramnegative (LPS) , not grampositive
This tol reseptort Can bé found in all type of celles or juste the immunologique cells
I thought nfkb produces Il1, Il6 ?
Correction: TLRs are not only extracellular/plasma membrane-bound!
Hi dear, LTA is on Gram (+) not Gram (-)
Which molecule(s) is/are NOT normally induced by TLR signaling (TLR=Toll‐Like Receptor)?
A. TNF‐alpha
B. IL‐1
C. iNOS
D. IL‐6
E. IL‐4
IL 4 because it is released by Th cells to activate B cells ?
@@karthininageshwaran7143 bro i needed this answer 4 years ago for an exam haha thanks for answering 😁
good
Good video overall but at about 4:21, you said that you skipped TLR6 among others and that TLR6 is found in the endosome. That's not true - it's found in the cell surface membrane.
LPS : Gram-negative
3:22 Gram negative not positive
Update from 2024 there are 13 TLR now , hope it helps
You say that TLR - 4 recognise the lipopolysacharide LPS in Gram +ve .
Wrong because the LPS found in Gram -ve 👍👍👍❤❤❤❤
Your my best teachers 😍
LPS are on the cell wall of gram negative
If you ever think to leave youtube, do not complain if a stranger hits you in the street...that will be me jajajaja! Thanks!!!
I am very confused. Why does TLR 2 and 6 form a dimer to detect the same things as the dimer of 1 and 2?
Also shouldn't you mention that triacylated lipoproteins are detected for the 1 and 2 dimer, however for 2 and 6 diacylated lipoproteins are detected?
where did u get that info??
It doesn't. TLR1/2 and TLR2/6 recognize different types of lipoproteins (triacylated and diacylated, respectively).
Love u
LPS is for gram negative Bacteria... Please correct it!
How could the arn bé found out the virus cell !?
Can you quickly explain, in layman's terms, what a TLR-7 agonist is? Thanks.
Emmanuel Nogueira it detects viral genomes single stranded RNA
big liiiiiiike & thaaaaaaaaaaanks
This isn’t right according to my microbiology book.
TLR 2 = G+ (PEPTIDOGLYCAN, LIPOTECHOIC ADIC)
TLR4 = G- (LIPID A)
3,7,8,9 = NUCLEIC ACIDS
TLR10 stimulation suppresses the TLR2 responce via the production of il-1ra
Are you half indonesian?
You have switched Gram- with Gram+
Toll like receptors recognize gram negative bacteria not positive
it doesnt help when scientists call it il 18 and il 1B esp if you're writing it out lol great vid btw
TLR4 supposed to be gram negative
WOW
it's leviosa no leviosaah: it´s kappa-b no kb
TLR 4 for gram negative Lipopolysaccaride
TLR5 do dimerize, dont they?
they do! I read that in kuby and now cross checked on google too.
TLR 7 & Herpes & SarsCov19 . . . . . . . . . . . . . . . . . . . .. . . . . Help
please subtitles in portuguese-BR PLEASE!!!!!!!!!!!!