Lineweaver Burk plot

A typical curve of enzyme kinetics is a plot of a plot of velocity of reaction vs substrate concentration. As the substrate concentration increases the velocity of the reaction increases until it reaches a plateau, which is known as maximum reaction velocity or Vmax. The drawback of this graph is that the plateau region is not perfectly horizontal. Beacuse of this there is a error in the estimation of Vmax and Km. Hence the researchers started modifying the graphs to get better estimate of Vmax and Km. One of such graph is lineweaver burk plot.

[@rachael4775]

I remember watching this in university and I never forgot how helpful it was. Now 4 years later, I'm coming back to it in medical school

[@niatai9651]

Same!. Except for Pharmacy school

[@Lulu-uw1mj]

the video was posted 2 years ago...

[@rakshitasingh6574]

@@Lulu-uw1mj 😅

[@olaoluwaoyeniyi9948]

​@@Lulu-uw1mjsarcasm bro

[@blueflash3641]

hey what was your bsc in ?

[@theinkedaaila]

This is perfect to understand whatever the hell is this lineweaver burk plot...... just wow

[@Woogie9593]

*watching video after getting all lineweaver burke questions wrong*
"hence, lineweaver burke plot is one of the easiest graphs to understand enzyme inhibition"

[@alonzojonathan2553]

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I was stupid lost my account password. I would appreciate any assistance you can offer me!

[@dustinameer4343]

@Alonzo Jonathan instablaster =)

[@alonzojonathan2553]

@Dustin Ameer thanks so much for your reply. I found the site through google and Im in the hacking process now.
Looks like it's gonna take quite some time so I will get back to you later when my account password hopefully is recovered.

[@alonzojonathan2553]

@Dustin Ameer it did the trick and I finally got access to my account again. I'm so happy!
Thanks so much, you really help me out!

[@dustinameer4343]

@Alonzo Jonathan you are welcome xD

[@speci4list326]

I was procrastinating because this seemed really hard to understand. Thank you!

[@surbhisharma704]

Thank you so much for making it that simple for understanding in a better way

[@bobmogoboya1477]

Yoh!! im writting tomorrow and i thought i was gonna fail this burk plot and now i get it. Thank you!!!!

[@stellawanjiku4362]

Thanks, this made it so much easier to understand

[@heybriaannaa]

great video! thanks for sharing!

[@itzelhidalgo874]

Fantastic video!!
Thank you so much 😉

[@ayaahmedmahersayedabdelaal242]

This is so good. thank you!

[@MrCred_]

I thought this was hard u made it so easy thank u

[@elijahperry3454]

Lifesaver...thanks a bunch!

[@mckenseymiddleton9166]

that helped me a lot, thank you!

[@BioScienceClass]

More Videos on Lineweaver Burk plot: czcams.com/video/wAWYIGTRXQE/video.html

[@jyotsnaraut77]

I thought it's very hard
But seeing this video clear all the doubts thank you ❤️

[@Drift1]

Thank you! the mathematics explanation helped explained how Vmax and Km value changes can be infered from the Line - weever. I guess thats the point of it, make it simple to see changes.

[@katejbradshaw]

THIS video makes it all clear! THANK YOU!

[@nicolevillalon9737]

Quick and excellent explanation. Thank you!

[@malithaniman1730]

Helped a lot thanks

[@logitfau252]

thank u alot :) really helped me for my assignment :)

[@peerzadaabrar1800]

Very very Thankful to you. Jazakallahu Khair🤲.

[@nyikomhlarhimusic]

Awesome explanation. Thank you veeeery much 🙏🏿

[@mayryelll3822]

the only video that i understood thanks alot 😭🙏

[@jen-hungfang5437]

awesome channel!

[@kamariweaver1536]

What values on the plot are Vmax and what value is Km?

[@AA-kr1ci]

Explained to perfection !

[@gayatri5996]

Sometimes the easiest math seem difficult @ 2 o clock at night. Thanks for making it clear!

[@sanskritimishra7299]

This would help in my presentation ! ✌️

[@tylerdurden7903]

Great video

[@gatwiringera7567]

thank you very much. Understood!!!!!

[@oumaimaboughazala5706]

Thank you so much ,I understand it

[@asiaaaa]

awesome, thank you!!

[@mayryelll3822]

god this was soo easy thank you sm

[@preethimurugesh6722]

Simply superb

[@tukurummulkhairi9794]

Thanks a million times

[@harshithjagadeeswaran527]

Was really helpful.thanks 😊

[@linam4848]

Great stuff

[@easyochem]

This is a certified hood classic

[@rosekendi8590]

Thankyou easy to understand

[@ahmedshah6277]

You are not telling about what is meant by these values and how it changes with substrate concentration so its very hard for me to understsnd

[@MzPeregrine]

You are probably going save my exams today

[@alyssatipler6980]

I dont understand how you get the -1/km as the x intercept

[@gfkenya9926]

see
below from her post. Best to you.
"Nancy Barajas
1 month ago (edited)
At the x-intercept, the y-intercept is equal to zero. Using the lineweaver burk equation, you set 1/Vo equal to zero and solve for 1/[S] (x-int). This will give you -1/Km"

[@prakritipurushottam8427]

You got 1 subscriber today

[@user-bq5uw4uy1w]

so helpful! I’m an italian med student

[@jokebotter-vanelburg8590]

where does -1/Km come from?

[@nancybarajas4249]

At the x-intercept, the y-intercept is equal to zero. Using the lineweaver burk equation, you set 1/Vo equal to zero and solve for 1/[S] (x-int). This will give you -1/Km

[@JANVI_743]

@@nancybarajas4249 thank you, it was useful

[@abhishekrana5933]

Thank you from 🇮🇳

[@user-zj7rz5oi9b]

Plz
-1/km
From where coming???

[@Moye_moye03]

Thanks🙏

[@myra9250]

ThankYou.

[@munivet6685]

Excellent

[@abdullahshah7644]

outstanding

[@tarunkumarpalli7580]

How -1/km is come on negative side of x axis

[@vaishuu04]

Thank you!! It really helped!!!

[@prismaticseal2553]

I understand the how, not the why or what are any values

[@siddheshpathak9181]

But on X axis why do we take - 1/Km ?

[@krutarthshukla3067]

keeps bugging the hell out of me

[@paritiyasingh5342]

Since y=0, MX=-c. Then x= -c/m. Substitute values to get. X=-1/Km. Because Vmax get cancelled

[@Obamnaz]

@@paritiyasingh5342 Tanksss

[@abhi9973]

@@paritiyasingh5342 nice.thx

[@emilyi771]

Ty

[@AmberU]

Just maybe I’ll make it through biochemistry

[@anchalyadav3061]

Thanku

[@alhaeri1]

Legend

[@richardshane456]

Reverse hardware engineering use similar mythology to reverse engineer to find the answer incrementally by best guest trial and error feedback logic
a natural humanistic approach to solving a problem with the Mathematical mythology of trial and substitute to understand the trajectory spin of any reaction mathematically incrementally with finer granularity of the understanding of any process...
A common mistake with observation by maintaining a relative frame of data points that in reality are trajectory spin...
Although the graph inferring to the deduc enzyme reaction metric, belaboring the point of graphical representation for a finite metric that does not disclose the granular processes of the line depicted as the rate of change of velocity.
It would be interesting to observe the elementary particle processes of a enzymatic reaction...
Ty...very interesting
Good day

[@sebastianlerette9450]

🙏

[@confucheese]

Weemax

[@MuhammadAli-fj8qh]

1:51 I hate y=mx+c

[@arnepetric7333]

sef razjasnu

[@justicedauda6117]

❤😊😂

[@Blaskhartor]

Are you a man or a woman??

[@skellingtonmeteoryballoon]

IF we invert the equation.
Can vmax and km should be inverted to plot in the graph. Graph calculator is more than a convenience 🧮