Platelet Plug Formation | Platelet Mediated Hemostasis

Hemostasis or haemostasis is a process which causes bleeding to stop, meaning to keep blood within a damaged blood vessel (the opposite of hemostasis is hemorrhage). It is the first stage of wound healing. This involves coagulation, blood changing from a liquid to a gel. Intact blood vessels are central to moderating blood's tendency to form clots. The endothelial cells of intact vessels prevent blood clotting with a heparin-like molecule and thrombomodulin and prevent platelet aggregation with nitric oxide and prostacyclin. When endothelial injury occurs, the endothelial cells stop secretion of coagulation and aggregation inhibitors and instead secrete von Willebrand factor which initiate the maintenance of hemostasis after injury. Hemostasis has three major steps: 1) vasoconstriction, 2) temporary blockage of a break by a platelet plug, and 3) blood coagulation, or formation of a fibrin clot. These processes seal the hole until tissues are repaired.
Platelet plug formation- Platelets adhere to damaged endothelium to form a platelet plug (primary hemostasis) and then degranulate. This process is regulated through thromboregulation. Plug formation is activated by a glycoprotein called Von Willebrand factor (vWF), which is found in plasma. Platelets play one of major roles in the hemostatic process. When platelets come across the injured endothelium cells, they change shape, release granules and ultimately become ‘sticky’. Platelets express certain receptors, some of which are used for the adhesion of platelets to collagen. When platelets are activated, they express glycoprotein receptors that interact with other platelets, producing aggregation and adhesion. Platelets release cytoplasmic granules such as adenosine diphosphate (ADP), serotonin and thromboxane A2. Adenosine diphosphate (ADP) attracts more platelets to the affected area, serotonin is a vasoconstrictor and thromboxane A2 assists in platelet aggregation, vasoconstriction and degranulation. As more chemicals are released more platelets stick and release their chemicals; creating a platelet plug and continuing the process in a positive feedback loop. Platelets alone are responsible for stopping the bleeding of unnoticed wear and tear of our skin on a daily basis. This is referred to as primary hemostasis.

[@ahmetkeyan3346]

i think my brain is not enough to understand this

[@ummehabiba5557]

Thank you sir, for uploading this video.

[@simpleaverage9772]

respect brother, thank you

[@rittenbrake1613]

Excellent video, Thank you so much.

[@hussainbiology]

Thanks Beth for appreciation..Glad to know that it helps

[@karanjoshi2662]

hey can you do genes cip/kip and INK4a cell cycle inhibitors please.

[@bilalsheikh6853]

Well explained gud work thanks for upload ☺

[@hussainbiology]

Thanks Bilal for appreciation...
glad to know that it helps

[@ramchandrasuthar2848]

Nice Analysis
Brother

[@hussainbiology]

thanks for appreciation...

[@zainabmustafa378]

Well explained

[@hussainbiology]

thanks for appreciation...Glad to know that it helps ✌️

[@shashwatafouzder5237]

For further reference which book should be studied in this topic sir?

[@bokugakirada6599]

Great video sir

[@hussainbiology]

Thanks for appreciation.. Glad to know that it helps ✌️

[@bokugakirada6599]

@@hussainbiology glad to know you are soo humble,that you reply everyone

[@hussainbiology]

Will reply always in the same way..... ♥️

[@bokugakirada6599]

@@hussainbiology you have my respect sir🙏🙏

[@sahilsm4052]

Bai
Plz upload a lecture on systamatics 11th Class

[@chinyegarumamah]

Please do a video on clot formation

[@hussainbiology]

okay

[@nishatfatima2091]

I want homeostasis sir please........🙏

[@hussainbiology]

You know currently i am working on Translation series then after i will take this into consideration

[@zeeshan-o7]

Thanks sir...sir are u from Kashmir

[@hussainbiology]

Most welcome... Yes i am from KASHMIR

[@zeeshan-o7]

@@hussainbiology sir from where if u don't mind...u have amazing skills of teacher ...I put my medical book (gyton) aside to sort out all doubts by ur video's ..much love

[@hussainbiology]

@@zeeshan-o7 I am from Baramulla.... And thanks for ur love and support

[@shahedshahrearsani352]

Vascular spasm

[@mistermarlega2941]

Yar.. ap P or F sai krlo.. buht ajeeb lgtaa suny mai

[@tanu6464]

😃😃😃😃😃😃