Pharmacology - ANTICOAGULANTS & ANTIPLATELET DRUGS (MADE EASY)
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- čas přidán 14. 06. 2024
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Anticoagulants, commonly referred to as blood thinners, are drugs that prevent or reduce coagulation of blood, prolonging the clotting time. Antiplatelet drugs, also known as a platelet aggregation inhibitors, decrease platelet aggregation and inhibit clot formation. These drugs play an important role in the treatment of various disorders such as myocardial infarction, thrombotic stroke and venous thromboembolism. This pharmacology lecture covers topics such as pathophysiology of blood clot formation and platelet function; activation, aggregation, cross-linking; ADP receptors, glycoprotein IIb/IIIa receptors, cyclooxygenase-1 (COX-1) enzyme, fibrinogen, fibrin mesh, coagulation cascade; intrinsic & extrinsic pathways, clotting factors, antithrombin, heparin induced thrombocytopenia, INR, plasmin, and plasminogen; mechanism of action of platelet inhibitors, anticoagulants, thrombolytic agents, and drugs used for treatment of bleeding. Drugs mentioned include; Aspirin, Clopidogrel, Ticagrelor, Ticlopidine, Prasugrel, Abciximab, Eptifibatide, Tirofiban, Heparin, low molecular weight heparins; Enoxaparin, Dalteparin, Protamine sulfate, Apixaban, Rivaroxaban, Univalent & Bivalent direct thrombin inhibitors; Argatroban, Dabigatran, Bivalirudin, Desirudin, Warfarin, Vitamin K, Alteplase, Reteplase, Tenecteplase, Urokinase, Streptokinase, Aminocaproic acid, Tranexamic acid.
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0:00 Platelet plug formation
2:04 Platelet aggregation inhibitors
5:34 Coagulation cascade
7:38 Anticoagulants
12:03 Warfarin
14:11 Thrombolytics
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Perfect
Update: an antidote for apixaban and rivaroxaban is now available: Andexanet alfa. Came out in 2018, one year after this video was uploaded.
thank you for information
Thanks 👍👍
Thank you
Also, Dabigatran has an antidote, Praxbind
Idarucizumab a monoclonal antibody
since i was pharmacy student i used to watch your videos before mid & final exams and it help me to remember things & make it easier
now i'm officially graduated pharmacist but still love watching your videos😅
so i want to say thank u so much for making pharmacology easier on me ❤️🧸
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I'm doing my b.pharm 3rd year right now.. Is there any scope for pharmacy after graduation????
Because, I don't see any scope in India as they are paying very low for the pharmacists.
It's nice to have a diagram of the cascade and then interject each drug class where it acts. Thank you! This is how all topics should be taught by all teachers!
this video is absolute gold. thank you so much for taking your time to make this, you deserve an award.
Please keep making those videos, it was organized, simple, and really straightforward. You just save my 5-hour listening to recording lectures. Thank you so much
This was perfect from beginning to end. Information logically categorized, great talking speed, use of graphics that helped anchor understanding... bless you for taking the time to make this!
First time seeing your videos, instantly subscribed. Looking forward to watching the rest of your videos through Pharmacology class!
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You are conveying little faster
And your slang make it us difficulty in understanding in some places
Coagulation cascade are the ones I found hardest at med school and it was a pain to revise when comes to finals then I forget about it. Now I'm preparing for core training exams and actually find this video more helpful than ever. I never understood this topic any clearer (I guess with more clinical experience it also helps to understand bit more). Thanks so much for making this video.
Amazing video. I have been struggling with this topic but this has made it very easy for me . Thank you.
I was struggling with this for hours then I found your video
This is the freaking best!
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WHO KNEW IT WAS THIS EASY!!! I can't thank you even for saving my life
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Great summary video! thanks for the post. It was very helpful. I like that you give examples of all the drugs in each class and their mechanisms with visuals. This helps to solidify the information for visual learners.
EXCELLENT - perfect for nursing students. Thanks for making this!
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Excellent video. Well organized, clear, and logically explained. Thank you!
I'm officially graduated pharmacist still love to watch ur videos , thanku so mch for making pharmacology easier
Excellent video! Covers everything. Really grateful to you for making this!😀
Oh my god! I was literally waiting for the upload of video on this topic. Sir, You make learning process in pharmacology so simple and easy to understand. I owe all my good marks to your lectures! Thanks a ton❤
Avneeta Swashna
This was the best video for the Hemostasis drugs!! Thank you!!! Perfect!!!!
The overall video was great. I would just like to note that the Mechanism of Action for Fondaparinux is incorrect. Fondaparinux actually binds to Anti-thrombin III and potentiates its selectivity and affinity for Xa. Fondaparinux is in fact Anti-thrombin III mediated which is what distinguishes it from the direct Xa inhibitors (ApiXAban, EdoXAban. RivaroXAban and BetriXAban) which are not Anti-thrombin 3 mediated.
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Thank you.
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Hi, Can you make video on Antiemetics..
And Thanks a lot for making the toughest topics of pharmacology EASIEST..!
Thank you for the great video! The reversal agents discovered after this video was made: for apixaban it’s andexanet alfa, and for dabigatran it’s idarucixumab.
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Buddy ... You are making things damn easy ... Thanks for making such a informative video ... combining all three classes of medications was good idea...
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I watched the first video from your channel 6 years ago when i was in semester one 1 trynna understand autonomic NS drugs.
and now I am doing my internship and wanted to revise.
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Exactly what I needed. Thanks
I am self studying some medical subjects without requisite chemistry and without other helpful pre medical information.
Despite the brain damage I got from this, your lecture has really helped me understand the activity of aspirin in coagulation.
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Beautiful explanation. Thank you!
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GREAT PRESENTATION .THANKS
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Life Saving Pharmacology Tutorials!
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I am not a doctor or pharmacist but after watching this video I understand each and everything about clotting.
bless you bro (Y) Thumbs up .
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Thank you sir for this video..
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Thanking you..
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Lots of helpful videos by speed pharmacology, thank u.
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Great explanation. Thank you
Perfect lecture for Anticoagulants and Antiplatelets
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Great video! Thank you!
Fantastic video on anticoagulants
just a quick errata; eloquis/(apixaban), xarelto (rivaroxaban) have an FDA approved reversal agent
"Andexxa, the first factor Xa inhibitor antidote indicated for patients treated with rivaroxaban (Xarelto) and apixaban (Eliquis), when reversal of anticoagulation is needed due to life-threatening or uncontrolled bleeding."
Even Dabigatra has an antidote: Idarucizumab
Thanks 🙏🏼 perfect video
thank you so much , u just saved my life