Warfarin | The blood 🩸 thinner | Hematology & Pharmacology
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- čas přidán 7. 06. 2024
- Warfarin (anticoaulant) | Hematology & Pharmacology. Warfarin is an anticoagulant that inhibits the epoxide reductase enzyme which prevents the activation of vitamin K. Therefore, Warfarin inhibits the gamma carboxylation (gamma-glutamyl carboxylase) of the coagulation factors II, VII, IX, IX (2,7,9,10) as well as Protein C, Protein S, and Protein Z.
Heparin is an anticoagulant that stimulates antithrombin III (ATIII) which then inhibits coagulation factors VII, IX, X, XI, XII, as well as thrombin. This leads to prevention of thrombus formation (anticoagulation)...Heparin is used for ICU anticoagulation...Adverse effects of heparin includes bleeding, Heparin-induced thrombocytopenia (HIT), and osteoporosis.
Anticoaulants are chemicals that inhibit blood coagulation (secondary hemostasis).
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Vitamin K Deficiency | Hemorrhagic Disease of the Newborn or Vitamin K dependent bleeding (VKDB) is a bleeding disorder that occurs due to deficiency of vitamin K.
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Coagulation Tests (PT, aPTT, TT, Fibrinogen, Mixing Studies,..etc).
The coagulation factors are divided into 3 coagulation groups | Fibrinogen group, Prothrombin group, and Contact Group..
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Platelet count is one of the lab tests used by a doctor or a hematologist to assess whether your platelet number is normal, low (thrombocytopenia) or high (thrombocytosis).
Bleeding 🩸 time (BT) is another test for platelet function.
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hi great video really helps make sense of alot. could you please do a video on warfarin dosinf with INR monitoring and dosing when INR monitoring is not available ?
Is the bioavailability 100% , due to high plasma protein binding effect of warfarin. So that the unbound amount only undergoes the changes
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Why mointer PT yet warfarin inhibit 9,10,2,7 factor?
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Do not take warfarin if you cannot take it on time every day. Warfarin increases your risk of severe or fatal bleeding, especially if you have certain medical conditions, if you are 65 or older, or if you have had a stroke, or bleeding in your stomach or intestines.👍
The risk of warfarin induced necrosis kinda scares me too, even if it isnt the most common of side effects. I personally wouldnt take it myself just because of that, theres plenty of other blood thinners out there
what happen if a male on warfarin and he had sex and noticed discharge with little blood during intercourse?
You sure about aspirin and warfarin contraindication?
There are exceptions to every rule!
7:05 warfarin is in vivo
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INR is Same in Pakistan too☹️
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11:45
The way you said CHINA, I see what you did there lol
Warfarin in vivo not in vitro..
What about INR in Pakistan
😅