This video is perfect like other videos in this channel. Thanks a lot Dr. Klioze for sharing very worthwhile information combined with visually attractive animation with us.
i guess im asking randomly but does anybody know a way to log back into an Instagram account..? I was stupid lost my password. I appreciate any tricks you can give me.
@Alejandro Francis I really appreciate your reply. I found the site thru google and Im in the hacking process now. I see it takes a while so I will reply here later with my results.
I love that those of us that want to be proactive can go searching for this high quality visual /auditory learning -im sitting following along making notes and copying the art so i can absorb it all into my mind temple -THANKS DOC!!
I watch nearly every YT video on 1.5 x speed or faster.... Except for yours! Too much excellent detail & mostly all brand new info for me. Thank you for these excellent lessons for us lay people!!!
WHOAAT ?! … so few views and this short documentary is SOOOO much more meaningful than the current media fear propaganda. Thanks a lot for this in depth look at the current virology issue and i hope you have more to come when the research offers new results. Take care :-)
Judging by the numbers this video is way too underrated. People get scared by long scientific names or formulas, but my belief is that it doesn't matter if you don't understand them. I have no knowledge of these advanced biochemistry topics, but you should watch the video anyways. Just by hearing these names, even if they pose no meaning to you yet you are forming the basis to fill them with meaning when the time comes. When you stumble across the topic again and suddenly you think "Oh, I heard that name before"
Thank you so much you have explained covid 19 better than any news channel or any doctor on the news I needed this I have been looking up how exactly the virus attacks the body and i get the same answer it binds to the ace2 receptors but this actually goes in depth and actually explains it thoroughly so thank you!
thymidine not thiamine ( vit b1 ) ... this type of fundamental error gives me chills about the accuracy of what otherwise appears to be a most cogent lecture.. was the actual video proof read by people in the field
Given an RNA, would ribosomes in out cells produce the proteins as in others animal/plant cells/bacteria? If RNA is like a program, i mean do all cell follow the same programming language?
That's a great question! I would say absolutely yes. Indirectly, that is the basis of genetic recombination and technologies such as CAR-T (Chimeric Antigen Receptor T-cells). I would assume that as long as the RNA strand is positive-sense, our ribosomes should be able to read and translate it into a functional protein regardless of the species of origin. Interesting theory!!
@@DoctorKlioze Is there only one possible way to interpret an RNA? Or is it because of evolution? (In computers there are multiple instruction sets, but Intel's became popular). I am a student in computer science. This video is very well explained, thanks.
Any hope for something like this that explains the difference between mRNA vaccines and more traditional ones? And thank you for the video, brilliantly done.
An amazing explanation, sincerely. I love that this guy does a whole explanation on the word "chimera" and then drops smorgasbord like its common sense
There are other Coronoviruses that use that receptor as pathway into cell. On WebMD, it states only 4 coronovirus strains are pathogenic to humans (excluding SARS-CoV-2) Two of those use this pathway into cells. So half of all Coronoviruses known before 2020 used this receptor as a point of entry.
That' a great question! Hemagglutinin is a molecular structure on the surface of certain vial particles that helps with viral binding and entry into the host cell. In fact, it's the dominant target protein on various strains of influenza and is the antigenic protein used in the quadrivalent flu vaccine every year. Certain strains of coronavirus also possess hemagglutinin esterase on their surface and its role is uncertain as binding and cell entry is facilitated through the spike protein. However, SARS-CoV2 is not one of these subtypes as it does not carry the HE gene.
Only if you have a deficiency to begin with. Taking extra when you already have enough won’t help you carry more oxygen. People with suspected anemia caused by iron deficiency can get a blood test to determine there iron and hemoglobin levels.
It is very wondering how a new zoonotic disease ,If it is really zoonotic disease infect and survive the its new host i.e human species for more than 6 month ?
Very instructive video with great animations. Just note that 'cytosine' is pronounced 'siteoscene' but it is mispronounced as 'sistoscene' in the video, otherwise a worthwhile video.
Hello professor. My microbiology professor said that HIV is VERY deadly to the human genome because of its spikes. However, I cannot follow this, because all research leads to coronavirus. I need to know about spikes and how human immune system protect against virus with spikes. Thank you
That is some great stuff! I keep expecting to hear some news about a CRISPR-Cas9 therapy for coronavirus but, at this point, I think we're going to obtain herd immunity before any such therapy is clinically available. Possibly an option for future seasonal outbreaks?!
czcams.com/video/XzRMcO0Pw6U/video.html Check out the above video to see how Dr. Jennifer Doudna is involved in eradication, detection and testing of COVD2/COVD19 using CRISPR cas9 😀
@@crazeeborg I read Dr. Doudna's book "A Crack in Creation" last year. When the new coronavirus was discovered earlier this year, I immediately thought that CRISPR technology would be perfect for both detection and cure (since that's exactly how bacterium use CRISPR to defend themselves against bacteriophages/viruses). Love to hear it from the horses mouth! Exciting times!! Thanks for sharing.
It should be of note that many Coronaviruses, including SARS-CoV do possess RNA replicases with 3’-5’ exoribonuclease activity. Otherwise, great video.
For the viewer concerning the "nucleotides" at 6:12. Thiamine is not a nucleotide but vitamin B1. Furthermore adenosine is the name of the "nucleoside" and cytosine and guanine are the names for the "bases." This is relevant as the nomenclature for nucleic acids depends on the structure. For DNA the nucleotide is composed of a base, deoxyribose and 3' or 5' phosphate and the nucleoside is just the base and deoxyribose. Here's the nomenclature: Bases - adenine, guanine, cytosine, and thymine Nucleosides - adenosine, guanosine, cytidine, and deoxythymidine Nucleotides - adenylic acid, guanylic acid, cytidylic acid, and deoxythymidylic acid Reference: ISBN 978-0470-54784-7
Interesting concept! Supposedly, their is such thing as a virophage that can attack another virus. Since neither one has the ability to reproduce without a host, I would assume the entire genome of the two viruses would be incorporated into the host cell. The invader would have to encode for a protein that would then destroy the original virus which would seem to reduce the chance of the virophage from propagating. I don't think I'm smart enough to work that all out (I also couldn't understand Bitcoin 5 years ago which is why I'm not retired :-o)
by the way its just physical distancing but defenetley not a social distancing ...thats something totally different it means cutting of all social interactions, which is totally wrong and a very alerting behavior ;) ...i´ve never socially distanced myself to my friends and business partners, only physically ;) ....so dont continuing saying this wrong describtion....its only a physical distancing ok ? thanks
very clear explanations. just an observation: the infection process uses 99% of the cell's mechanisms - very complex compared to a virus, which is actually just a substance. thus, if we want to decipher the cause-effect relationship we will have to look at the mechanisms of the cell, why it fails. I will promote this clip to emphasize the false general, and non-academic, perception that a virus has its own intelligence - an idea induced by the media
I know. A few people pointed that out a couple of weeks after i posted the video. It must have been a segment I recorded during a sleepless night at 3:00 am! Unfortunately, I can't correct it without taking the video down and reposting. Maybe I can add a subtitle explanation... Thanks!
Useful video, but is it really a doctor speaking? He mispronounces cytosine (Sy - toe - seen), not sis-toe-seem. Perhaps he confuses the nucleic acid cyTOSine with the amino acid cySTine. Details matter.
I do have MD after my name but I'm an interventional Radiologist. My father and brother (both dentists) tell me that's not a real doctor! Must have been tired the night I recorded that. Mea Culpa...
This video is perfect like other videos in this channel. Thanks a lot Dr. Klioze for sharing very worthwhile information combined with visually attractive animation with us.
Thank you! You are an excellent teacher-able to break down complex ideas into understandable portions.
Most instructive video I've seen.
i guess im asking randomly but does anybody know a way to log back into an Instagram account..?
I was stupid lost my password. I appreciate any tricks you can give me.
@Edison Payton Instablaster ;)
@Alejandro Francis I really appreciate your reply. I found the site thru google and Im in the hacking process now.
I see it takes a while so I will reply here later with my results.
@Alejandro Francis it did the trick and I now got access to my account again. Im so happy:D
Thank you so much you really help me out!
@Edison Payton no problem =)
This deserves an award or something. Great stuff. Its so simple yet I walked away feeling like I understood it all.
Absolutely brilliant presentation and visualization. And in my opinion very accurate. Thanks
I love that those of us that want to be proactive can go searching for this high quality visual /auditory learning -im sitting following along making notes and copying the art so i can absorb it all into my mind temple -THANKS DOC!!
You have really great information..... Thanks
Thumbs up, I have been reading tenths of scientific articles and could really appreciate the effort in making complex concepts understandable!
Very clear and informative, thank you for making this video.
Thank you so much for making and posting this video!!
I watch nearly every YT video on 1.5 x speed or faster.... Except for yours! Too much excellent detail & mostly all brand new info for me. Thank you for these excellent lessons for us lay people!!!
For a layman like me it's a splendid source of information. Many thanks!.
Many many thanks. This is Dr. Nazma from Bangladesh
WHOAAT ?! … so few views and this short documentary is SOOOO much more meaningful than the current media fear propaganda. Thanks a lot for this in depth look at the current virology issue and i hope you have more to come when the research offers new results. Take care :-)
Thanks for your work, is a great lesson! Thanks a Lot!
Well visualized and detailed content. Really interesting...
Excellent Graphics. Thak you.
So great video really! Thank you so much!
Great visual explanation
Wow, extremely clarifying on multiple fronts.
The bacteriophage type shown in the beginning is the coolest looking viruse IMO. They look like some type of nanotechnology machine.
Judging by the numbers this video is way too underrated.
People get scared by long scientific names or formulas, but my belief is that it doesn't matter if you don't understand them. I have no knowledge of these advanced biochemistry topics, but you should watch the video anyways. Just by hearing these names, even if they pose no meaning to you yet you are forming the basis to fill them with meaning when the time comes. When you stumble across the topic again and suddenly you think "Oh, I heard that name before"
Thymine, Adenine, Guanine, Cytosine in DNA. Uracil in RNA. Thank you for the information Dr Klioze. Your videos are excellent
GREAT! video
I'm saying this after watching lots of videos on the topic of coronavirus and the associated diseases
This is brilliant. One of the best explanations I have seen....
Awesome video.
It has been helpfull for me, thank a gifted doctor
Excellent!! Can you help us to understand how ivermectin works? Y how ibuprofen works in the inflammation process?? Please.
Thank you so much you have explained covid 19 better than any news channel or any doctor on the news I needed this I have been looking up how exactly the virus attacks the body and i get the same answer it binds to the ace2 receptors but this actually goes in depth and actually explains it thoroughly so thank you!
Also what app or software did you use to make this video because I am looking for an app that allows me to show diagrams like this one.
3D-Studio Max
Grazie a voi. Merci a vous.
the best channel ever
Exacellant sir....
thymidine not thiamine ( vit b1 ) ... this type of fundamental error gives me chills about the accuracy of what otherwise appears to be a most cogent lecture.. was the actual video proof read by people in the field
Thanks doc!
Given an RNA, would ribosomes in out cells produce the proteins as in others animal/plant cells/bacteria? If RNA is like a program, i mean do all cell follow the same programming language?
That's a great question! I would say absolutely yes. Indirectly, that is the basis of genetic recombination and technologies such as CAR-T (Chimeric Antigen Receptor T-cells). I would assume that as long as the RNA strand is positive-sense, our ribosomes should be able to read and translate it into a functional protein regardless of the species of origin. Interesting theory!!
@@DoctorKlioze Is there only one possible way to interpret an RNA? Or is it because of evolution? (In computers there are multiple instruction sets, but Intel's became popular). I am a student in computer science. This video is very well explained, thanks.
A strong video. I would like to link my pre-nursing students to it. For your next edit, please check your pronunciation of "cytosine".
Good video.
EXCELLENT! THANK YOU
Any hope for something like this that explains the difference between mRNA vaccines and more traditional ones? And thank you for the video, brilliantly done.
Working on it. Hopefully in a week or two...
An amazing explanation, sincerely. I love that this guy does a whole explanation on the word "chimera" and then drops smorgasbord like its common sense
I loved that too.
I thought that it was the RNA polymerase that produces messenger RNA, not RNA transcriptase? Or are they both the same thing?
You're right! Probably the more appropriate name. Also known as Transcriptase.
Is this video about coronavirusses in general or the specifick virus that is causing the current covid-19 pandemic?
There are other Coronoviruses that use that receptor as pathway into cell. On WebMD, it states only 4 coronovirus strains are pathogenic to humans (excluding SARS-CoV-2) Two of those use this pathway into cells. So half of all Coronoviruses known before 2020 used this receptor as a point of entry.
Excellent
I don't understand the role of Hemagglutinin esterase ,the protein found on the virus surface. I hope to answer me 🙂
That' a great question! Hemagglutinin is a molecular structure on the surface of certain vial particles that helps with viral binding and entry into the host cell. In fact, it's the dominant target protein on various strains of influenza and is the antigenic protein used in the quadrivalent flu vaccine every year. Certain strains of coronavirus also possess hemagglutinin esterase on their surface and its role is uncertain as binding and cell entry is facilitated through the spike protein. However, SARS-CoV2 is not one of these subtypes as it does not carry the HE gene.
ขอบคุณคะ
So,could we take iron supplements to help oxygen in blood?
Only if you have a deficiency to begin with. Taking extra when you already have enough won’t help you carry more oxygen. People with suspected anemia caused by iron deficiency can get a blood test to determine there iron and hemoglobin levels.
It is very wondering how a new zoonotic disease ,If it is really zoonotic disease infect and survive the its new host i.e human species for more than 6 month ?
Very instructive video with great animations. Just note that 'cytosine' is pronounced 'siteoscene' but it is mispronounced as 'sistoscene' in the video, otherwise a worthwhile video.
Hello professor. My microbiology professor said that HIV is VERY deadly to the human genome because of its spikes.
However, I cannot follow this, because all research leads to coronavirus.
I need to know about spikes and how human immune system protect against virus with spikes.
Thank you
Can u do a video about CRISPR case 9 gene editing?
That is some great stuff! I keep expecting to hear some news about a CRISPR-Cas9 therapy for coronavirus but, at this point, I think we're going to obtain herd immunity before any such therapy is clinically available. Possibly an option for future seasonal outbreaks?!
czcams.com/video/XzRMcO0Pw6U/video.html
Check out the above video to see how Dr. Jennifer Doudna is involved in eradication, detection and testing of COVD2/COVD19 using CRISPR cas9 😀
@@crazeeborg I read Dr. Doudna's book "A Crack in Creation" last year. When the new coronavirus was discovered earlier this year, I immediately thought that CRISPR technology would be perfect for both detection and cure (since that's exactly how bacterium use CRISPR to defend themselves against bacteriophages/viruses). Love to hear it from the horses mouth! Exciting times!! Thanks for sharing.
And this is why we need #Ivermectin
thank you
Sounds like the _replicase_ was made by Harbor Freight (not... ummm... reliable).
Sir plz Can you prepare the PDF ....Sir...
It🔨❣️
It should be of note that many Coronaviruses, including SARS-CoV do possess RNA replicases with 3’-5’ exoribonuclease activity.
Otherwise, great video.
Just a quick correction - it's not cystosine, it's cytosine.
Sorry, one more correction - it's Adenosine, not Adensosine
Cystocine?
I know. I must not have slept well the night before I recorded that... Cytosine.
you know you are on an academic focussed site when most of the commentaries are pronunciation corrections and minutiae clarifications!
For the viewer concerning the "nucleotides" at 6:12.
Thiamine is not a nucleotide but vitamin B1. Furthermore adenosine is the name of the "nucleoside" and cytosine and guanine are the names for the "bases." This is relevant as the nomenclature for nucleic acids depends on the structure. For DNA the nucleotide is composed of a base, deoxyribose and 3' or 5' phosphate and the nucleoside is just the base and deoxyribose.
Here's the nomenclature:
Bases - adenine, guanine, cytosine, and thymine
Nucleosides - adenosine, guanosine, cytidine, and deoxythymidine
Nucleotides - adenylic acid, guanylic acid, cytidylic acid, and deoxythymidylic acid
Reference: ISBN 978-0470-54784-7
that was a bacterial phage
at this rate
where's CRISPER IS???
Great question!! I was also thinking this would be a perfect application for this technology (just read "A Crack In Creation" a few months ago)!!
From where RNA came in Corona Virus 🤔🤔🤔
hmm, what about pee and sweat
What about killing virus with another virus that attacks coronavirus
Interesting concept! Supposedly, their is such thing as a virophage that can attack another virus. Since neither one has the ability to reproduce without a host, I would assume the entire genome of the two viruses would be incorporated into the host cell. The invader would have to encode for a protein that would then destroy the original virus which would seem to reduce the chance of the virophage from propagating. I don't think I'm smart enough to work that all out (I also couldn't understand Bitcoin 5 years ago which is why I'm not retired :-o)
8:16
พาหะ
by the way its just physical distancing but defenetley not a social distancing ...thats something totally different it means cutting of all social interactions, which is totally wrong and a very alerting behavior ;) ...i´ve never socially distanced myself to my friends and business partners, only physically ;) ....so dont continuing saying this wrong describtion....its only a physical distancing ok ? thanks
very clear explanations. just an observation: the infection process uses 99% of the cell's mechanisms - very complex compared to a virus, which is actually just a substance. thus, if we want to decipher the cause-effect relationship we will have to look at the mechanisms of the cell, why it fails. I will promote this clip to emphasize the false general, and non-academic, perception that a virus has its own intelligence - an idea induced by the media
You are mispronouncing cytosine. You say, "sistoseen" rather than "sight o seen" which is correct.
I know. A few people pointed that out a couple of weeks after i posted the video. It must have been a segment I recorded during a sleepless night at 3:00 am! Unfortunately, I can't correct it without taking the video down and reposting. Maybe I can add a subtitle explanation... Thanks!
vaccine development begin from ..
Useful video, but is it really a doctor speaking? He mispronounces cytosine (Sy - toe - seen), not sis-toe-seem. Perhaps he confuses the nucleic acid cyTOSine with the amino acid cySTine. Details matter.
I do have MD after my name but I'm an interventional Radiologist. My father and brother (both dentists) tell me that's not a real doctor! Must have been tired the night I recorded that. Mea Culpa...
Don't say we discuss your Jesse.
Cytosine..... Not cystosine!
I know. I must have dictated that @ 3:00 am one night. Probably half asleep. Mea Culpa...
WHY ARE YOU SHOWING BACTERIAPHAGES AS VIRUS
I want to know why 18 people disliked this video... must be Trump supporters who hate education.
The slippery attic allegedly lighten because aries hopefully encourage among a grouchy alloy. level, flashy fish
The debonair archer indisputably crash because hygienic gully burn amidst a tenuous heart. longing, honorable example