Type III hypersensitivity (immune complex mediated) - causes, symptoms & pathology

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  • čas přidán 4. 07. 2024
  • What is Type III hypersensitivity? Type III hypersensitivity describes when antigen-antibody complexes deposit in the blood vessels and cause subsequent inflammation and tissue damage. Find our full video library only on Osmosis: osms.it/more.
    Join millions of current and future clinicians who learn by Osmosis, along with hundreds of universities around the world who partner with Osmosis from Elseiver to make medical and health education more engaging and efficient. We have unparalleled tools and materials to prepare you for success in school, on your board exams, and as a future clinician. Sign up for a free trial at osms.it/more. If you're interested in exploring an institutional partnership, visit osmosis.org/educators to request a personalized demo.
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    © 2024 Elsevier. All rights reserved.

Komentáře • 127

  • @Ryoko48
    @Ryoko48 Před 5 lety +394

    I've watched a few of your videos, now everytime I refer to cell degranulation, I have a visual image of a cartoon cell vomiting out granules and enzymes hahahaha. Your illustrations are great

  • @LiquidSwords007
    @LiquidSwords007 Před 4 lety +108

    The best thing about this video is that there is special emphasis on the difference between type 2 and type 3, something that confused me a lot

  • @josesolorzano2669
    @josesolorzano2669 Před 5 lety +63

    "not to play with snakes" that part killed me XD I love these videos so much

  • @osmosis
    @osmosis  Před 5 lety +94

    Hi everyone, we've updated this video to correct a minor error.

  • @syedsaber9666
    @syedsaber9666 Před rokem +16

    3 major differences btw type 2 and type 3
    *Cell surface bound and atigen ab complement system with soluble antigen
    *complement proteins are synthesize in small amount in 2 and in large amount in 3
    *clinical symptoms corresponds to tissue on interacting with antibody in type 2 and in type 3 it is due to deposition of immune comples (ag ab )

  • @ikramzz701
    @ikramzz701 Před 5 lety +94

    7min more interesting than 1hour and half spent with my teacher in the medical school.

  • @minatsukinana2761
    @minatsukinana2761 Před 4 lety +19

    Cant thank you enough *-* I always start with your videos before i read my lectures 💜

  • @bettinafratto1472
    @bettinafratto1472 Před 3 lety +16

    Quick informative and to the point. Great examples and great stress on the differences b/n II and III types. Thank you

  • @cacarew544
    @cacarew544 Před 5 lety +6

    Thank u so much. It helps me to have a clearer picture of hypersensitivity

  • @dhuhachouchen6145
    @dhuhachouchen6145 Před 3 lety +2

    thank youuuuu your videos made my life as a medical student much easier and fun

  • @gomotsegangngwako6762
    @gomotsegangngwako6762 Před rokem +4

    Detailed yet brief, its brilliant. I watched videos on the three types of hypersensitivity except type 4, can you please direct me to it if its available.

  • @dayhanaaldave2193
    @dayhanaaldave2193 Před 4 lety

    I really love this, no se me da mucho el ingles, pero sus videos son realmente buenos, todo esta super entendible. Thanks youuu💜

  • @guljafari3269
    @guljafari3269 Před 4 lety +2

    thank you very helpful everytime

  • @34jayalakshmi36
    @34jayalakshmi36 Před 5 lety +10

    You r the reason for me to study path...pls upload all pathalogy video

  • @radhekrishna_lifeline_thak6809

    I LOVE YOU OSMOSIS.... FROM INDIA.. 😀😃😃💟💟💟💟

  • @emanuele2398
    @emanuele2398 Před 3 lety

    Amazing thank you!

  • @Be1smaht
    @Be1smaht Před 3 lety

    That was great as usual

  • @melylacheb
    @melylacheb Před 8 měsíci +5

    Life savior as always 🤩✨. I will pass my immunology test this week and u litterally resuled a 1 h lecture in 7 minutes sucessfully 🎉

    • @osmosis
      @osmosis  Před 8 měsíci

      We hope it went well! 🙏🏼

  • @elladaye2100
    @elladaye2100 Před 2 lety +3

    Such a great video to understand these hypersensitivities

    • @osmosis
      @osmosis  Před 2 lety

      Glad you think so, Ella! 😊

  • @user-um1fe2fd6b
    @user-um1fe2fd6b Před 2 lety

    Amazing expalantion
    Thank youu really !!

  • @akanshawadekar7430
    @akanshawadekar7430 Před 3 lety

    Thank you so much

  • @nouhahassam3667
    @nouhahassam3667 Před 3 lety +1

    I love you guys , thanks for making it easy and interesting

    • @osmosis
      @osmosis  Před 3 lety +2

      Thanks for watching! 🥰🥰🥰

  • @miranmuslem
    @miranmuslem Před 10 měsíci +1

    Thank you for the amazing video!

    • @osmosis
      @osmosis  Před 10 měsíci +1

      🤓🩺 🙌🏼

  • @zoechang7528
    @zoechang7528 Před 2 lety

    So clear and easy to remember with cute image

  • @allaboutmovies4821
    @allaboutmovies4821 Před 3 lety +5

    "Which ultimately teaches a person not to play with snakes" that had me laughing thank you guys.

  • @arinarakhteenko579
    @arinarakhteenko579 Před 2 lety

    You’ve made awesome videos thank you so much!!

    • @osmosis
      @osmosis  Před 2 lety

      Glad you like them! 🙌🏼

  • @abdurrehmantayyab9785
    @abdurrehmantayyab9785 Před rokem +2

    Very good explanation. Sorry to say but i didn't find type 4 hypersensitivity reaction.

  • @enoch9019
    @enoch9019 Před 5 lety +7

    The unsung heroes of CZcams🙏🏾🙏🏾🙏🏾

  • @Taypha1914
    @Taypha1914 Před 3 lety

    Your the GOAT my bro

  • @user-rz6xn4nn2s
    @user-rz6xn4nn2s Před 5 lety +1

    Awesome in awesome way

  • @nargismalik6293
    @nargismalik6293 Před 2 lety

    Thank you for the amazing videos

    • @osmosis
      @osmosis  Před 2 lety

      Always our pleasure. Nargis! 🙌🏼

  • @zubairkkkakar296
    @zubairkkkakar296 Před 2 lety

    Very good explanation has been given in this way, it is understandable by explaining ..very nice video very well understood

    • @osmosis
      @osmosis  Před 2 lety

      Glad you liked it! 😊

  • @alexandrerebmann203
    @alexandrerebmann203 Před rokem

    Amazing video thank you so much

    • @osmosis
      @osmosis  Před rokem

      Always our pleasure, Alexandre! ❤️

  • @lilmamasofly9111
    @lilmamasofly9111 Před 4 lety

    Awesome!

  • @sumitrajpurohit7657
    @sumitrajpurohit7657 Před 2 lety

    Thanks....love from BHARAT ( INDIA)

  • @rashamohammad2170
    @rashamohammad2170 Před 3 lety

    informative 🍁

  • @malathali8658
    @malathali8658 Před 3 lety

    عاشت ايدكم

  • @safalechkhab609
    @safalechkhab609 Před 2 lety

    thank u so much that was helpful

    • @osmosis
      @osmosis  Před 2 lety

      You're welcome, Safa! 🙌🏼

  • @robertvega5467
    @robertvega5467 Před 3 lety +2

    una cosa que haria que muchas nos suscribieramos es que cuando estemos en su plataforma tambien podamos poner subtitulos en español

  • @sachitpatil9061
    @sachitpatil9061 Před 3 lety

    Perfect

  • @jadkousa294
    @jadkousa294 Před rokem +1

    Thanks mate, just saved my ass for my upcoming exam xx

    • @osmosis
      @osmosis  Před rokem

      Glad to help, Jad! 😊

  • @ibrahimmohammed6385
    @ibrahimmohammed6385 Před 4 lety +2

    U the man

  • @zakayomsigwa2826
    @zakayomsigwa2826 Před 2 lety

    I have already subscribed . Thanks, much love from TZ. 🙏🙏🙏🙏🙏

    • @osmosis
      @osmosis  Před 2 lety +1

      Thanks for the sub, Zakayo!

  • @jinuannasabu1242
    @jinuannasabu1242 Před 4 měsíci

    Pls upload type IV

  • @Kyujinie
    @Kyujinie Před 2 lety

    thank u so much

    • @osmosis
      @osmosis  Před 2 lety

      You're welcome, Alex! 😊

  • @Nothing-es5nk
    @Nothing-es5nk Před 4 lety

    Awesome

  • @alaaadel8900
    @alaaadel8900 Před 2 lety +3

    *اللَّهُمَّ صَلِّ عَلَى سَيِّدِنَا مُحَمَّدٍ نُورِ الْأَنْوَارِ وَسِرِّ الْأَسْرَارِ وَسَيِّدِ الْأَبْرَارِ، وَزَيْنِ الُمرْسَلِينَ الْأَخْيَارِ وَأَكْرَمِ مَنْ أَظْلَمَ عَلَيْهِ اللَّيْلُ وَأَشْرَقَ عَلَيْهِ النَّهَارُ، وَعَدَدَ مَا نَزَلَ مِنْ أَوَّلِ الدُّنْيَا إِلَى آخِرِهَا مِنْ قَطْرِ الْأَمْطَارِ ،وَعَدَدَ مَا نَبَتَ مِنْ أَوَّلِ الدُّنْيَا إِلَى آخِرِهَا مِنَ النَّبَاتِ وَالْأَشْجَارِ صَلَاةً دَائِمَةً بِدَوَامِ مُلْكِ اللَّـهِ الْوَاحِدِ الْقَهَّارِ.**اللهم صل على سيدنا محمد وعلى اله وصحبه وسلم تسليما كثيرا عدد خلقك و رضا نفسك وزنة عرشك ومداد كلماتك و عدد ما كان وعدد ما سيكون وعدد الحركات والسكون.*

  • @mdzahikhalid404
    @mdzahikhalid404 Před 5 lety +2

    Nice lecture.u already mention in early vedeos hyper 1 , hyper 2 hyper 3....i am from india....hyderabad

  • @susanahernandez6893
    @susanahernandez6893 Před 3 měsíci

    The differences between type 2 and 3, are: complement proteins are synthesize in small amount in 2 and in large amount in 3, clinical symptoms corresponds to tissue on interacting with antibody in type 2 and in type 3 it is due to deposition of immune comples (ag ab ). And the inmune complexes get in the blood vessel, depending in different features: the size of the inmune complexes, the isotype of the Ig, characteristics of the blood flow, the quantity of the inmune complexes and the antigen load (which is possitive).

  • @deffousiheb5031
    @deffousiheb5031 Před rokem

    hi ... first i want to say thank you for your explications .... they'r awsome ... but i have a question .... opsonines will bind to immune complexe or endothelial cells or both ??

  • @Lina-hi5ji
    @Lina-hi5ji Před 5 lety +3

    Thank you Osmosis. Love from Peru

  • @115afreen3
    @115afreen3 Před 5 lety +26

    Don't play with the same snake twice 🐍🐍

  • @zamraabdi3561
    @zamraabdi3561 Před 5 lety

    I love u keeep going is the only channel that i'm easy to understand the videos 😍😍😍😍😘😘😘😘

  • @ShahzaibAli-og6st
    @ShahzaibAli-og6st Před rokem

    Good

    • @osmosis
      @osmosis  Před rokem

      Thanks, Shahzaib! 🙏🏼

  • @amylouise3789
    @amylouise3789 Před 8 měsíci

    I am unfortunately suffering from arthritis due to a type III reaction.
    Is there any way to reverse the reaction? I’m about 15 months post the initial onset/reaction to Plavix but still have joint pain!

  • @mohamudabdulkadir7215
    @mohamudabdulkadir7215 Před 5 lety +1

    Hi osmosis , why aren't u grouping videos systemic wise at your channel anymore ? Like all videos of CVS in one place and so on.... infectious diseases at one place .
    This will make reaching videos on the same system easier

    • @osmosis
      @osmosis  Před 5 lety

      Hi Mohamud, thanks for the interest! Check out our playlists here: osms.it/playlist. These playlists include all of our video content, including complete coverage of physiology and pathophysiology. Many of these videos are not available on CZcams.

    • @Ur1z13l
      @Ur1z13l Před 5 lety

      Not cool removing functionality from CZcams intentionally so people can pay up.

    • @osmosis
      @osmosis  Před 5 lety +2

      All of the videos we have published on CZcams are also free to watch on Osmosis.org!

  • @shards8300
    @shards8300 Před 3 lety +2

    life saver of med and dent students

    • @osmosis
      @osmosis  Před 3 lety

      Glad to be of help! 😊

  • @dr.manishadeol6561
    @dr.manishadeol6561 Před 5 lety

    Can u plz tell me about ur osmosis prime?

  • @ditodewantoros04
    @ditodewantoros04 Před 5 lety +1

    Sry may i ask, why does neutrofil cant fagocyte immune complex? Thx.

  • @user-jz2nx6xt3t
    @user-jz2nx6xt3t Před 3 lety

    You mentioned in your previous video about type two hypersensitivity that the antigen antibody complexes are formed!! 😕 if someone can clarify to me i’ll be thankful

    • @doofenshmirtz4474
      @doofenshmirtz4474 Před 3 lety +2

      in type 3 hypersensitivity antibodies (IgG/IgM) attach to soluble antigens forming immune complexes that are circulant in the blood. however, in type 2 hypersensitivity tissular/cellular antigens.
      So in both hypersensitivities, there is the formation of antibody-antigen complexes, except un HS3 the complexes are circulant in the blood (immune complexes).
      I hope I helped a little, English isn't my first language x)

    • @user-jz2nx6xt3t
      @user-jz2nx6xt3t Před 3 lety +1

      Ha Thor
      Yeah you helped alot ❤️
      I need to go over my notes again so i can gather it all .. thanks🙏🏻
      (English is not my first language either.. lol )

  • @nouhahassam3667
    @nouhahassam3667 Před 3 lety

    what do you mean by saying that complement levels help you to know about the progress of the pathology

    • @user-jj1nm4sx6w
      @user-jj1nm4sx6w Před 2 lety

      I know that the complement system levels help in classifying an autoimmune disease as lupus Erythematous

  • @EMTako
    @EMTako Před 2 lety +1

    Most important lesson, don’t play with snakes. Lolz

  • @penelopelambson9128
    @penelopelambson9128 Před 4 lety

    Need a hard copy of this.

  • @user-my8ps8iu2h
    @user-my8ps8iu2h Před 5 měsíci

    I can't find Type IV hypersensitivity
    Can you diresy me to the link?

  • @farazahmadnoor6840
    @farazahmadnoor6840 Před rokem

    @osmosis... Plz check why this video isn't playable

    • @osmosis
      @osmosis  Před rokem

      Hi Faraz! If you're having issues with our videos, kindly contact support@osmosis.org so that our team can better assist you. 🙏🏼

  • @foxykira2005
    @foxykira2005 Před rokem

    You're website is down?

    • @osmosis
      @osmosis  Před rokem +1

      Hi! We don't get to regularly check our comments here but you may send us an email (support@osmosis.org) anytime and our team will be glad to assist you with your concerns. 🙏🏼

  • @anabyakhan160
    @anabyakhan160 Před 2 lety +1

    Which ultimately teach the person not to play with snakes 😂😂😂😂😂 that was good

  • @richardprah1159
    @richardprah1159 Před rokem

    Great Video. But i have a question for you.
    Please you made a statement at 4:09-4-11 minute that DNA is cationic.
    I only Know of DNA being anionic from the peripheral phosphate groups. So why did you made that statement that DNA is cationic? And for that case of me knowing DNA is anionic, there would be repulsion between it and the anionic basement membranes.
    Can you clarify what actually makes the dna bind to the basement membrane even though both are anionic. What really happens. I need an answer for this please

  • @sweetta2596
    @sweetta2596 Před 2 lety

    I just graded 30%/100 cuz of this video. I told to teacher that serum sickness can cause of snake, and he said that "serum sickness causing of snake is impossible. It's other reaction of snake toxicity, u're so wrong." :( guys which one is right ? pls respond me

  • @doctorjunaid3924
    @doctorjunaid3924 Před rokem

    The post streptococcus glomerulonephritis comes under type 3 hs but my question is in this condition antigen is already bound to cells of kidney,shouldn’t it be considered as type 2 bec like u said immune complexes are not considered if antigen is bound to cells .?Anyone has answer

    • @muhammadmuaziqbal
      @muhammadmuaziqbal Před rokem

      Antibody is bound to streptococcal antigens and the complex get deposited in the glomeruli. It is not type 2 because streptococcal antigen is not bound to kidney cell, it is a soluble antigen in blood, which later gets deposited. That's my understanding. Correct me if I'm wrong..

  • @user-gn2un1de9n
    @user-gn2un1de9n Před 5 měsíci

    From where i get this notes ??????????

    • @osmosis
      @osmosis  Před 4 měsíci

      Hi! We have high-yield notes that you can access over at osmosis.org 😊

  • @fadiwassouf739
    @fadiwassouf739 Před 11 měsíci +1

    Moral of the story: don't play with snakes

  • @76sohamingavale42
    @76sohamingavale42 Před rokem

    Full form of PAN anyone???

  • @lucian6257
    @lucian6257 Před rokem

    Where is type4?🥺

  • @mewmannamwem6087
    @mewmannamwem6087 Před 3 lety

    Bro... my university's "homework giver" sucks .... !@#$ .... why i dont have teachers like this :/

  • @Arendt-Foucault
    @Arendt-Foucault Před 4 lety

    Hahahahaha.. which will ultimately teach a person NOT TO PALY a SNAKE 🤣

  • @mahesm2604
    @mahesm2604 Před 5 lety

    There is no playlist ???😐😐😐

    • @osmosis
      @osmosis  Před 5 lety

      Hi Human, thanks for the interest! Check out our playlists here: osms.it/playlist. These playlists include all of our high-yield content, not just the videos available on CZcams.

    • @mahesm2604
      @mahesm2604 Před 5 lety

      Thank you so much 😊😊😊

  • @happypaul7966
    @happypaul7966 Před 2 lety

    serum sickness usmle

  • @suriosha
    @suriosha Před 2 lety

    ♥️

  • @ahmedhesham2096
    @ahmedhesham2096 Před 2 lety

    Don't play with snakes, noted

  • @Everydayimmoonwalkin
    @Everydayimmoonwalkin Před rokem

    Pls don’t tell me type 4 needs that subscription thing

  • @user-jj1nm4sx6w
    @user-jj1nm4sx6w Před 2 lety

    This video is so incomplete and somethings are not explained good ..

    • @osmosis
      @osmosis  Před 2 lety

      Hi! Thanks for your feedback. We'd love to hear more from you as to how we can improve our content. If you can, please get in touch with support@osmosis.org 🙏🏼

  • @adamstonebraker5532
    @adamstonebraker5532 Před 5 měsíci

    yo dawg, I heard you like antibodies, so we put antibodies on your antibodies! -Xzibit on serum sickness, probably

  • @khuziwesithole6719
    @khuziwesithole6719 Před rokem

    Why do the cells look so evil😂😂😂😂😂😂

  • @nablesbenarous9682
    @nablesbenarous9682 Před 6 měsíci

    🇩🇿🇩🇿🇩🇿🇩🇿

  • @blackyme2889
    @blackyme2889 Před 3 lety

    which will teach a person not to play with snikes 😂😂😂

  • @MusicIsMyLife31x
    @MusicIsMyLife31x Před rokem

    no type 4? T__T ahh

  • @bluemoon78296
    @bluemoon78296 Před rokem

    Please speak slower

    • @osmosis
      @osmosis  Před rokem

      Sorry about this, Sandra. You may adjust the playback speed of the video by clicking in the cog icon/settings button on the lower part of the video player. 🙏🏼

  • @jinsu0504
    @jinsu0504 Před rokem

    text goes on and on 40 pages of gibberish and this guy explains the whole chapter and then some more in just 7 minutes... sigh.

    • @osmosis
      @osmosis  Před rokem

      We hope that our video was able to help, Matthew! 🙏🏼

  • @ghassanauf8103
    @ghassanauf8103 Před 4 lety

    Try to read your lecture slowly , the best way to learn is teaching , and you’re teaching nothing

  • @leena02nu76
    @leena02nu76 Před rokem

    sounds like Type 4 doesn’t exist to him🥲