Richard Miller: The Science Behind Longevity & How To Increase Lifespan | Episode 13
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- čas přidán 6. 08. 2024
- How far along is the science of longevity, and are there already proven methods that can increase your lifespan? In this episode, Richard Miller and Joe discuss the massive strides that are happening in the longevity space, and Richard shares the six compounds that have very promising research backing their benefit in improving life expectancy!
Richard talks about the problem with certain scientific studies and gives his thoughts on the controversial calorie restriction & longevity debate.
They talk about all kinds of drugs, including rapamycin, acarbose, resveratrol, and more, and discuss the one OTC supplement that has positive effects on lifespan!
Richard Miller is a Professor of Pathology at the University of Michigan, and Director of the Michigan Glenn Center on Aging. He got his MD and PhD at Yale, did postdoctoral work at Harvard and Sloan-Kettering, and was on the faculty at Boston University until his move to Michigan in 1990.
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• SelfDecode: bit.ly/3CKztjE
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Dr.Richard Miller:
• Website: www.richmillerlab.com/ - Věda a technologie
What surprised you the most about this episode of The Joe Cohen Show?
I was surprised by the difference between effects in male and female mice. However what I enjoyed most of all was this truly fascinating and approachable professor who has decided not to go down the route of prioritising commercial interests but is focusing on data and proven results. What an impressive human being he is.
I think Richard and his research deserves more attention: but because there is so many scientists who overinflate their research by saying things like "We cured Alzheimer / cancer / heart attack in mice", his results may not convince people
BTW, differences between female and male mice can be because estrogen and testosterone affect metabolic pathways
Thanks for covering this Joe. Many people are already using these drugs (and discussing pros and cons of different longevity drugs) on our site. Most people (87% from our last poll) plan to continue using them.
As far as 17-alpha estradiol production, does DIM have any effect on this process? Can you convert estrogen into 17-alpha via DIM?
I love richard. Get him often on your show
Fantastic, thank you both.
Will be continuing my calorie restriction + NMN/resveratrol regimen from my 50% increase in athletic performance over the last year, but will always keep Dr. Miller's observations in mind on lifespan.
What's NMN?
Thanks, this was an interesting interview, and I am pleased that you discussed the issue of senescent research driven by profit motives. Joe, your side of the audio was badly distorted, I'm sure you can avoid that in the future.
Wil they try combination of rapamycin + acarbose + 17 alfa estradiol + protandim + glycine?
resveratrol has lengthened the lifespan of countless short lived species. It also lengthens the lifespan of shorter lived mice strains. Longer lived rodents need fasting to increase NAD+ so resveratrol can work. NAD+ increasing interventions should also allow resveratrol to work. Aging in longer lived animals reduces NAD+ levels affecting the function of resveratrol adversely.
Translation of the closed captions...lol. I believe "nerf two" and "nerve to" actually refer to the Nrf2 transcription factor in cells. Activating Nrf2 turns on the body's detox mechanisms and helps create some anti-oxidants. I'm no doctor, but I know a bit about Nrf2 and take a sulforaphane supplement to activate it (*or you make broccoli sprout smoothies - with some mustard seed). But - yes- activating Nrf2 is huge
Totally agree nrf2 stimulation is something the ITP needs to research further Protandim when tested increased lifespan which is a nrf2 inducer but sulforaphane is much more potent than Protandim so you would probably see a greater effect they definitely need to test sulforaphane.
And the one OTC supplement? Is metformin discussed?
OTC supplements: Astaxanthin (12% in male mice, Protandim (8% male mice), glycine (6% male mice, 4% female mice).
Metformin isn't discussed here but he talked in other videos that it was 8% in male mice (but -1% for maximum lifespan) and 0% in female mice
Is 17-alpha estradiol available to the public?
There is no way to get 17-alpha estradiol, it's not a drug, it's just a chemical compound.
But I want to know where to get it too.
Only from lab supply businesses, and you have to work in a lab. But people are using it and reporting on it on our site.
Even if available it would do really nothing .
@@sleepsmartsmashstress740 how are you so sure about that?
Can someone please list the 6 compounds discussed
I know right. It's so clickbaity. I don't want to watch the whole video. I wish he'd timestamp the video by topic like other biohackers do.
I write from memory so these are not exact numbers:
Male mice:
1. Acarbose + rapamycin: +29% (when started at 1/3 lifespan), +10% (when started at 2/3 of mice lifespan)
2. rapamycin: +18%
3. Acarbose: 10-20% (20% when started early)
3. Astaxanthin: +12%
4. 17 alfa estradiol: +17%
5. Protandim: +8%
6. Glycine: +6%
Female mice:
1. Acarbose + rapamycin: +22% (when started at 1/3 lifespan), +10% when started 2/3 lifespan
2. Rapamycin: +18%
3. Acarbose: +6%
4. Glycine: +4%
5. Captopril: +4%
Famous supplements that didn't extend lifespan:
- nicotinamide riboside
- fisetin
- resveratol
- curcumin
- 60 different drugs/ supplements
He didn't talk here much about exact effect of drugs here - there is youtube movie from month ago where he talked more about these drugs and what is mechanism
@@Lucas90ab I thought the Astaxanthin results haven’t been published yet? I know you said you were going by memory but how accurate is the 12% number?
@@lv1985aa You can check it by entering "Richard A Miller" in youtube search. I am 95% sure that it was 12% median lifespan for male mice but it was not significant for maximum lifespan (10% of the longest lived mice lived about only 3% longer). Also it increased female lifespan by 3% but it wasn't statistically significant
Dr. Richard Miller starts discussing these compounds at 6:48
Wwwwoooowwwww!!!! So Plant Heavy KETO for me & drop some more weight.
Glutencancer