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Chris Masterjohn, PhD
United States
Registrace 11. 04. 2010
I combine my scientific expertise with out-of-the-box thinking to translate complex science into new, practical ideas that you can use to help yourself on your journey towards optimizing your health.
My mission is to synthesize what we have discovered in fields related to the practical biology of human health to help individuals optimize their nutrition around their most important genetic bottlenecks, leading to improved wellness, performance, and longevity.
I stand for free speech, bodily autonomy, and medical freedom.
I have a PhD in Nutritional Sciences and am not a medical doctor. Nothing on this site constitutes medical advice. Never use this information as a substitute for medical advice or as a reason to ignore the advice of your doctor. Always talk to your doctor before making health-related decisions.
My mission is to synthesize what we have discovered in fields related to the practical biology of human health to help individuals optimize their nutrition around their most important genetic bottlenecks, leading to improved wellness, performance, and longevity.
I stand for free speech, bodily autonomy, and medical freedom.
I have a PhD in Nutritional Sciences and am not a medical doctor. Nothing on this site constitutes medical advice. Never use this information as a substitute for medical advice or as a reason to ignore the advice of your doctor. Always talk to your doctor before making health-related decisions.
What Experts Aren’t Saying About D-Lactate: Groundbreaking Research
D-lactate is commonly stated to be exclusively a microbial metabolite.
This is found in assumptions within the medical literature for decades even when it was long-known to be false.
While D-lactate is indeed made by bacteria, D-lactate is also inarguably and irrefutably produced by human enzymes.
In this video, moreover, I will argue the following:
Microbial contribution to D-lactate in humans under normal circumstances is negligible.
I coin the term “the D-lactate shuttle” to describe a role for D-lactate that should eventually make its way into biochemistry textbooks alongside the malate-aspartate shuttle and the glycerol phosphate shuttle.
The D-lactate shuttle operates alongside these other shuttles to balance the priorities of conserving cytosolic NAD+, reducing cytosolic acidity, bypassing complex I, or generating ATP. It is uniquely useful as a shuttle when there is an absolute deficit of niacin or NAD(H).
D-lactate is an important contributor to gluconeogenesis that could account for up to 11% of it and rival an individual amino acid.
While D-lactate concentrations in human plasma are infinitesimal, when the downstream metabolism of D-lactate and L-lactate are blocked by genetic disorders, the concentrations of the two forms are similar in plasma. This contrasts wildly with the common claim that flux through D-lactate is “minuscule.” Most likely D-lactate is produced in considerable quantities in liver and kidney but is rarely secreted into plasma because doing so would risk neurotoxicity.
D-lactate should be taken seriously for its potential role in Parkinson’s and in neurological problems generally, for its role in diabetes, and for its extremely underappreciated roles in glycolysis, gluconeogenesis, and the respiratory chain.
Oxalate powerfully impairs D-lactate clearance, so D-lactate should be investigated as a potential link between oxalate and autism, and oxalate-lowering strategies should be seen as a way to improve D-lactate clearance and reduce its potential role in diabetes and neurological disorders.
See the sections on riboflavin, zinc manganese, and glutathione in Testing Nutritional Status: The Ultimate Cheat Sheet, as well as Does CoQ10 Deserve a Spot on Your Longevity Plan? and the How to Detox Manganese guide for managing the relevant nutrients.
Look forward to more Masterclass with Masterjohn Energy Metabolism lessons on the D-lactate shuttle in the context of the related shuttles and the roles of L-lactate coming soon.
Read the written version for live links and references:
chrismasterjohnphd.substack.com/p/d-lactate-groundbreaking-research
00:00 Introduction
02:30 Summary
06:15 Will Probiotics Give You Brain Fog?
08:55 Methylglyoxal at the Origins of Glycolysis
16:35 My Doctoral Dissertation: Physiological Roles of Methylglyoxal
33:48 A Brief History of D-Lactate
48:15 Is D-Lactate Production "Minuscule"?
57:21 Why D-Lactate Is So Low in the Blood
1:03:15 Is D-Lactate Mainly Produced by the Microbiome?
1:06:10 D-Lactate in Diabetes
1:07:30 The Physiological Purpose of D-Lactate
1:19:40 Introducing the D-Lactate Shuttle
1:27:12 Glycolysis starts acidic and ends alkaline, made possible by L-lactate and the malate-aspartate and glycerol phosphate shuttles.
1:35:30 The D-Lactate Shuttle Is Superior for NAD+ Conservation
1:38:18 Pros and Cons of the Three Shuttles
1:40:08 D-Lactate, Gluconeogenesis and the Malate and 2-Oxoacid Antiporters
1:40:49 Does Glyoxalase-III Spare the Brain?
1:46:10 Practical Considerations
1:48:27 The Bottom Line
Read the written version for live links and references:
chrismasterjohnphd.substack.com/p/d-lactate-groundbreaking-research
This is found in assumptions within the medical literature for decades even when it was long-known to be false.
While D-lactate is indeed made by bacteria, D-lactate is also inarguably and irrefutably produced by human enzymes.
In this video, moreover, I will argue the following:
Microbial contribution to D-lactate in humans under normal circumstances is negligible.
I coin the term “the D-lactate shuttle” to describe a role for D-lactate that should eventually make its way into biochemistry textbooks alongside the malate-aspartate shuttle and the glycerol phosphate shuttle.
The D-lactate shuttle operates alongside these other shuttles to balance the priorities of conserving cytosolic NAD+, reducing cytosolic acidity, bypassing complex I, or generating ATP. It is uniquely useful as a shuttle when there is an absolute deficit of niacin or NAD(H).
D-lactate is an important contributor to gluconeogenesis that could account for up to 11% of it and rival an individual amino acid.
While D-lactate concentrations in human plasma are infinitesimal, when the downstream metabolism of D-lactate and L-lactate are blocked by genetic disorders, the concentrations of the two forms are similar in plasma. This contrasts wildly with the common claim that flux through D-lactate is “minuscule.” Most likely D-lactate is produced in considerable quantities in liver and kidney but is rarely secreted into plasma because doing so would risk neurotoxicity.
D-lactate should be taken seriously for its potential role in Parkinson’s and in neurological problems generally, for its role in diabetes, and for its extremely underappreciated roles in glycolysis, gluconeogenesis, and the respiratory chain.
Oxalate powerfully impairs D-lactate clearance, so D-lactate should be investigated as a potential link between oxalate and autism, and oxalate-lowering strategies should be seen as a way to improve D-lactate clearance and reduce its potential role in diabetes and neurological disorders.
See the sections on riboflavin, zinc manganese, and glutathione in Testing Nutritional Status: The Ultimate Cheat Sheet, as well as Does CoQ10 Deserve a Spot on Your Longevity Plan? and the How to Detox Manganese guide for managing the relevant nutrients.
Look forward to more Masterclass with Masterjohn Energy Metabolism lessons on the D-lactate shuttle in the context of the related shuttles and the roles of L-lactate coming soon.
Read the written version for live links and references:
chrismasterjohnphd.substack.com/p/d-lactate-groundbreaking-research
00:00 Introduction
02:30 Summary
06:15 Will Probiotics Give You Brain Fog?
08:55 Methylglyoxal at the Origins of Glycolysis
16:35 My Doctoral Dissertation: Physiological Roles of Methylglyoxal
33:48 A Brief History of D-Lactate
48:15 Is D-Lactate Production "Minuscule"?
57:21 Why D-Lactate Is So Low in the Blood
1:03:15 Is D-Lactate Mainly Produced by the Microbiome?
1:06:10 D-Lactate in Diabetes
1:07:30 The Physiological Purpose of D-Lactate
1:19:40 Introducing the D-Lactate Shuttle
1:27:12 Glycolysis starts acidic and ends alkaline, made possible by L-lactate and the malate-aspartate and glycerol phosphate shuttles.
1:35:30 The D-Lactate Shuttle Is Superior for NAD+ Conservation
1:38:18 Pros and Cons of the Three Shuttles
1:40:08 D-Lactate, Gluconeogenesis and the Malate and 2-Oxoacid Antiporters
1:40:49 Does Glyoxalase-III Spare the Brain?
1:46:10 Practical Considerations
1:48:27 The Bottom Line
Read the written version for live links and references:
chrismasterjohnphd.substack.com/p/d-lactate-groundbreaking-research
zhlédnutí: 2 763
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The widespread claims in the nutrition and longevity spaces that there is no safe level of alcohol consumption are total nonsense. For the written version, with somewhat more technical detail and links to all the references, see chrismasterjohnphd.substack.com/p/alcohols-surprising-role-in-your 00:00 Overview 01:06 Why Alcohol Is a Macronutrient 02:17 Why Alcohol Is Not Uniquely Toxic Among the...
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zhlédnutí 3,2KPřed 9 měsíci
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Never Just Measure Glucose! The ONE Biomarker You're Missing
zhlédnutí 3,5KPřed 9 měsíci
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So basically MK4 is made by the body unless you have a deficiency in it You don't really need it understood
Robinson Carol Young Susan Walker Mary
Yes, it is crazy how much biotin they put in supplements. Too much for my system. I took some last year and it actually made my hair fall OUT when it was supposed to do the opposite. How much biotin should we take?
Well, I hope this works for someone....it did nothing for me.
Idk there is a study where hdb md1003 for 30 days improved disability from ms
I really like all the studies and scientific explanations that you put into the video. Ignore all the guys that want a quick answer so they can gamble on their health. You’re awesome. 👍
Why riboflavin in any form can cause mental irritability? I'm becoming really short fuse when taking it. Is it somehow connected with Mao-a and serotonin degradation? Isn't B2 is cofactor for MAO-A?
He is a drug addict vegan, full of estrogen.
Go on higher fat carnivore diet, stay away from stress, heavy workouts, marathon, cold showers, fasting, drugs, alcohol, watching corn with P and other none sense....etc, and you will recover.
I do like my beer. But the research in this video reminds me of all the research that said smoking was good for you.
Thank you for this video ❤
in my organic tests, byruvate is always elevated (one was in the orange zone and last time in the red). In both times, lactae was lower end of normal range. some branched amino acids catbolites are upper end of normal range and some in the high zone. Oxidative stress markers are elevated. For amino acids, taurine is elevated and methionine is in the orange zone. I am at loss of what is causing this ... everywhere I look it seems lactate should increase with byruvate but not my case. what does this mean?
Hi Chris, what does it mean if pyruvate is elevated but lactate is lower end of range?
Nice article! But why so much focus on d lactate when l lactate seems to play major role in sports/performance in general and d lactate is only metabolized in liver? So what is going on with gut producing lactate from fructose- The Gut Shields the Liver from Fructose-Induced Damage.
This is very valuable information to me. But Im no PhD. It would be super helpful if you could slow down and dumb it down just a little bit. Instead of naming diagnostic names of effects of things like eggs, etc, just name the symptoms. Super helpful video very grateful for glycine knowledge, just can't keep up with you and intemperate all your technical language. I get the just but need to understand the details better. Thank you so much for publishing this video. ❤
Would it make sense to have instead of restricting all calories, you restrict protein until say the evening where you have a high protein meal?
if you haven't yet you really need to get a audio interface and a good mic . this audio is horrible and this is good information and presented well
If someone has iron overload or oxalate overload then vitamin C supplementation will make it worse
i have a question my Ferririn level is 44 but my other iron labs are normal ive been researching and have found that for men and women the optimal ferritin level should begin at 70 Is this accurate and if so in my case should i take an iron supplement since my Ferritin was 44? Thanks
Lost credibility saying he only uses the 5 genes.. you clearly habe not watched him enough
Does folic acid end up on receptors that methylated folate normally uses? If so, which one gets in to the cell, and which does work that is more conducive to better health? Thanks.
So how do you fix this??
RDA = Ridicule Daily Amount. lmao
What about the French paradox? Basically, Alcohol combined with food is different, especially wine that has been fermented in an oak barrel. Look at the studies in the rabbit hole.
All alcohol is not the same!
I tried it once and got very bad uti pain
ketogenic is the worst diet for Gaba- learned the hard way
Thank you Chris!!!! You’re the first person I’ve heard that addresses liver toxicity remediation! Excellent video. I’m taking nicotinic acid to reduce lp (a). Did you address extended release NA as being effective in any other videos?
Q? So what makes him so accurate on "Perdicting" Peoples Death dwn to the month they Die ? & heard he's been very accurate due to his pervious job working for insurance Companys..
What if you're a menstruating man?
MTHFR according to Samuel L Jackson means MoTHer Fuck-R
Interesting! Very interesting.
I'm going to try putting it on my skin before using my red light. I added ascorbic acid until it turned clear and will add it to my lotion. I'm hoping and praying it will help my edema and plump up my skin. I've been drinking some this last week...2 drops but bumped it up to 6 drops. I'm starting low and slowly increasing it. I haven't noticed anything good or bad except greenish blue urine. If it raises my boood pressure, that will be okay. I usually have low blood pressure.
First, she said we had to get her blood sugar up and then you said keto diet was good for GABA. I thought you would have to cut out carbs wouldn’t that lower your blood sugar?
Long term Taking bh4 is safe? What about if phenylanine would be dcreased, after taking Bh4... Also phenylanine is lower as bh4
Long term Taking bh4 is safe? What about if phenylanine would be ceased, after taking Bh4...
What effect would lactoferrin have in someone with high hemoglobin and hematocrit levels?
Did you ever research into if there is a way to introduce / colonize oxalobacter into the gut microbiome?
Thanks sir...
YALL NEED TO GET TOWERS SERIOUSLY. PPL DONT KNOW WHAT 2 DO. U NEED TO ALSO TELL PPL WHAT 2 TAKE. BRECKA TELLS PPL EXACTLY WHAT 2 TAKE & U DONT
Is glycine alone enough? Should i stop folinic acid/b12?
MK7은 쓰레기입니까?
Hi Chris. Would you give this study any weight? Is it designed well enough to be taken seriosuly? Thank you www.ncbi.nlm.nih.gov/pmc/articles/PMC2854908/ Titled: MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate