Listen to what he says about not being dogmatic. I went Carnivore and it fixed several of my symptoms.....for about 4 months. Then, I suffered from several vitamin deffiencies. Carnivore can definetley be a tool, but if you get well enough that your activity goes up, your newly found energy demands will likely require vitamin supplementation.
Not exactly nose to tail but my diet includes: oysters, sardines, liver and recently kidney. When I buy a whole chicken, I do eat everything, including skin and bones.@@hussainhaider2818
Most carnivore people like Dr. Berry make sure to take enough salt and electrolytes. During the summer I might have 2 LMNT or key nutrient electrolytes have many micronutrients and 40 to 50 cents a day. I have been strict carnivore and get tested by my Doctor every other month and other than one time I ate muscles and oysters 3 days in 1 week I had low B1 and felt like I took 2 grams of Niacin. There is thalamse in bi-valves that stop absorption of b1☮️
I’ve come to agree with you on this, but I also think exogenous hormones have their place. Most men do not want to be dependent on TRT injections, myself included. Your zinc protocol was one of the few things to help… also, oddly, extra virgin olive oil (of all things). But I still struggled with the mental and physical effects of low testosterone. The last straw was breaking my leg falling in the kitchen and learning that I had osteoporosis… in my 30’s! TRT worked fantastically for this. I also had mitral valve regurgitation which went away (and I have reason to believe it was due to TRT, but that’s less certain). TRT makes sense in cases of low bone density, when you can’t risk staying low for much longer. It’s also good for muscle wasting. I had quite low muscle mass, although that was less of an issue. But for someone who has muscle wasting due to disease, TRT makes a lot of sense. That’s another possible exception to your rule… when low testosterone is caused by chronic disease that is poorly controlled. At that point TRT can be considered appropriate palliative care (and is probably underutilized, imho). But you are correct, hormones do not just spontaneously become deficient (except in older women, but that’s a different story). I’m sure you also won’t be surprised when I mention that TRT was an incomplete resolution for my issues with social anxiety and confidence (which I have come to find respond most to reductions in inflammation). Moreover when I was recently forced to stop TRT, and my testosterone plummeted to that of a woman’s, I felt surprisingly ok (I was really expecting the worst!). Having low testosterone since puberty, it might be the case that TRT just flipped a switch. I also note that inflammation can both cause low testosterone, plus low testosterone can cause inflammation. So it could be a self-reinforcing cycle, like the psychological causes you mention. Also I believe I had low protein intake previously, which I did not fix until I was on TRT. Same with selenium deficiency, which is one of the anti-inflammatories to help the most with my social anxiety, independent of testosterone level. As you suggest, I also found that excess selenium is as bad as deficiency in my experience (I later found research to support this finding, with both low and high selenium being bad for mood). If you ever have the time, it would be really helpful to have a practical guide for men with low testosterone, who want to exhaust all possible avenues before getting on TRT (which many if not most would like to avoid). I’ve tried to help guys online as best I can, but I wouldn’t even know where to begin with the genetic stuff. And even with the more straightforward parts, it would be really helpful to have everything in one place. Frankly, I don’t blame men who just throw up their hands the minute healthy lifestyles and a multivitamin don’t work. But there is so little good information out there.
osteoporosis and low T can both be driven by high IL6. have you had your IL6 measured? a diet that you think of as healthy or anti inflammatory might not be good enough for example if you have really strong IL6 genetics.
@@FreedomFox1 IL6 is one of the body's main inflammatory (stress response) signals. all kinds of stress cause it to be produced, and from the initial point it can spread throughout the body and, if persistently high, can damage any of the body's tissues. i would guess that common causes of persistent elevation of IL6 include eating too frequently (IL6 roughly doubles for several hours while digesting each meal), eating too much starch or sugar (to the point of developing metabolic syndrome, which also roughly doubles IL6 secretion), and not sleeping well enough. other things that induce IL6 include infection, injury (to joint, bone, skin, etc), psychological or social stress, and even physical exercise (though scientists often hypothesize that the IL6 induced by exercise is not harmful as by other causes). there are various foods and supplements that can reduce secretion of inflammatory cytokines including IL6, maybe Chris Masterjohn has made a video about them, i'm not sure. also, level of IL6 production can vary substantially from person to person, maybe by as much as a factor of 4x, mainly as a result of genetics.
The section on "How to approach hormones" is fine until I get to the very abrupt ending, which brings you back to the title of the video. How adamant are you that we shouldn't "argue with our brain"? Should we at no point use hormones for general health? What about things in our environment that "argue with our brain", that have hormonal effects, psychosomatic effects, that interfere with our glands etc...? Deficiencies are paramount. But if the system is geared for stress, inflamed and overly permeable it's much harder to tell it "things are all right" just by feeding it well because it's more vulnerable.
I don’t want to give up and take the hormones (Progesterone) but I am still stumped as to why my monthly period hits me so hard as estrogen levels go up and only progesterone gives me relief. I know that progesterone helps the body hold onto copper, and zinc helps the body make progesterone. I take copper and try to add zinc but it immediately results in copper deficiency symptoms again. I guess I will try B6 as the unpleasant high estrogen symptoms seem to be mostly low gut Diamine Oxidase levels and I know it should help support progesterone and DAO.
I would read up on ceruloplasmin as it relates to copper. It's very confusing for most people because there's a big difference between available copper in the body for biological processes versus excessive copper levels that cause oxidation. If you're not producing enough ceruloplasmin, your body can't utilize copper for cellular function and then the excess copper becomes oxidative to bodily tissues. You can literally be too high in Copper while simultaneously not being able to efficiently utilize the copper in your body.
Thanks Brian. This definitely was the case for me and vitamin A for ceruloplasmin and niacin for uric acid have definitely improved my copper transport. Riboflavin helps with ATP which also keeps copper moving. None of the other supplements suggested for ceruloplasmin have helped. Progesterone seems to help with copper utilization and retention but I want to help my body make it naturally. I used to have a condition called Interstitial Cystitis and whenever I got pregnant it would go into complete remission when my progesterone levels and DAO levels rose. But my progesterone was never high enough to prevent bleeding during pregnancy and miscarriage scares.@@brianwnc8168
There is a basic key here that seems to be often overlooked: focus on supplying the nutrients that provide the raw materials FIRST, focus on supplying the nutrients needed for signaling SECOND. I often see people go straight to the signaling part of the equation while skipping over requirements for raw building blocks. For example, it’s very popular to supplement B vitamins without paying any attention to iodine. This is such a simple, obvious principle that it strikes me as one of those “hidden in plain sight” kind of things. To Chris’ point about paying more attention to your own body than to studies, it also occurs to me that reading study data can contribute to this “cart before the horse” effect of prioritizing signaling at the expense of raw materials - I’m thinking of studies in Japan showing that the TTFD form of thiamine can dramatically improve neurological signaling in the gut - no one who quotes these studies bothers to mention that they were done on a population - i.e. the Japanese - who are already replete with iodine.
What a gangster. Appreciate all your info. On a separate note: thoughts on Dr. Layne’s newest video on seed oils? Can’t seem to reconcile your genius with his wisdom.
This is most likely why I find a lot of my clients report that they are unable to increase their thyroid medication - they just don't have the energy stores to support the increase. They often feel worse when they increase, even slowly. Or develop new issues like jitteriness. (I don't prescribe meds but I do see a lot of people on thyroid meds who look like they are under-dosed).
I loved the explanation. But I get tired of this audio quickly and hesitate to send it to others. Please let me help you with this, I won't charge you for it. I messaged before and not sure if you saw this. I think it wouldn't be hard to fix.
Extremely well explained. Thanks Chris! Question, though: Even if current levels are normal, would it make sense to increase testosterone, DHEA, and pregnenolone with endogenous hormones for longevity reasons?
Some people think that there is such thing as "contrarian biochemistry" which means when you take hormones you deplete micronutrients that are needed for synthesis of that hormone. Basically that taking hormones will work, but long term they will ruin your body.. So it is better to only supply the body with raw materials to make all the hormones it needs and if you want anabolic hormones you need to lower stress of any kind. Give the body plenty of rest, good calories with all the micronutrients. That is a good strategy. Just taking hormones and not addressing anything else doesn't look like a good idea long term..
When I was quite unwell 15 years ago I had some kind of virus and it kicked off all sorts of weird symptoms, including my thyroid. I had stabbing thyroid pain, but my antibodies were never elevated (only ANA - I do have other autoimmune issues). Selenium fixed that stabbing pain in only a few days - pretty amazing how your body can give you clear signals if we are able to listen and figure it out. I only occasionally get that pain now and it tells me I need to get back on to supporting my antioxidant capacity.
I've been on injectable biologics (20 years) at a frequency of 12 weeks but get blood work every 8 weeks. This gives me a unique perpective. Looking at yearly trends of Liver, Kidney and Thyroid funciton over time, I can see that they all suffer in correlation to the efficacy of the injection and inflammatory symptoms. I eat 2 brazil nuts per day and supplement with Lugol's drops, plus Manganese, Molybdenum, MSM, Taurine and all of the Methylation protocol supplements.
@@mitochondria_uncoupler Wolff-Chaikoff effect is just a deregulation in the Iodine transporter, in the presence of an over abundance of Iodine. The same type of regulation happens in many other of the cells enzymes. The goal in Iodine supplementaion isn't to get more than is required. The goal is to get enough. I don't consume Iodized table salt but I do consume oysters and sardines. I don't go overboard on the drops.
@@rdance3 how much is ‘enough’ is my question. Because 200 mcg is the RDI, and over a few milligrams is W-C territory iirc. Iodine is pretty easy to get through diet / small amounts of added kelp granules. At that point, the health of the liver (where the bulk of conversion of t4 to t3) should be more of a focus (selenium helps conversion) in my opinion, as well as things like magnesium, zinc, copper, b vitamins, etc.
Excellent information, Very well presented. It would help me with understanding The complexities and interdependence Of the overall picture if you could Provide some diagrams showing Interdependency of the salient parts. 👍👍👍👍👍😊😊😊🤔🤔
Would you ever consider going on a bodybuilding podcast? With Dr Todd Lee or Paul at anabolic bodybuilding, vigorous steve. It would be so epic im meeting them at the Olympia Im telling them to contact you!
What about when the hormones are exogenous/xeno? Couldn't they not push the metabolism and physiology in such direction that we could say it was definitely unwanted?
If a man is diagnosed with RA (Rheumatoid Arthritis) he has a 65% chance he will have low testosterone levels. Are you suggesting that there is a treatment (not a prevention, but after a diagnosis) for an autoimmune disease, such as RA and thus prevent the secondary effect of hypogonadism? (low T). I understand that MTHFR defects have an effect on autoimmune diseases.
@@meggi8048 some type of regular fasting (eating less frequently) and at least a few days of keto each week. 5htp and lipoic acid perhaps every day. maybe soy or soy isoflavones a few times a week. generally, antioxidant super foods like flavonoids and other phenolics suppress IL6.
Some one please point me in the direction of where Chris indicates age related “extra” nutrients needed. What does a 40 year old need that his 20 year old self doesn’t have problems with.
Listen to what he says about not being dogmatic. I went Carnivore and it fixed several of my symptoms.....for about 4 months. Then, I suffered from several vitamin deffiencies. Carnivore can definetley be a tool, but if you get well enough that your activity goes up, your newly found energy demands will likely require vitamin supplementation.
Exact same thing happened to me! Carnivore was great… until it wasn’t. But it is a helpful tool.
We’re you eating nose to tail? All the organs?
Not exactly nose to tail but my diet includes: oysters, sardines, liver and recently kidney. When I buy a whole chicken, I do eat everything, including skin and bones.@@hussainhaider2818
Most carnivore people like Dr. Berry make sure to take enough salt and electrolytes. During the summer I might have 2 LMNT or key nutrient electrolytes have many micronutrients and 40 to 50 cents a day. I have been strict carnivore and get tested by my Doctor every other month and other than one time I ate muscles and oysters 3 days in 1 week I had low B1 and felt like I took 2 grams of Niacin. There is thalamse in bi-valves that stop absorption of b1☮️
I’ve come to agree with you on this, but I also think exogenous hormones have their place. Most men do not want to be dependent on TRT injections, myself included. Your zinc protocol was one of the few things to help… also, oddly, extra virgin olive oil (of all things). But I still struggled with the mental and physical effects of low testosterone. The last straw was breaking my leg falling in the kitchen and learning that I had osteoporosis… in my 30’s! TRT worked fantastically for this. I also had mitral valve regurgitation which went away (and I have reason to believe it was due to TRT, but that’s less certain). TRT makes sense in cases of low bone density, when you can’t risk staying low for much longer. It’s also good for muscle wasting. I had quite low muscle mass, although that was less of an issue. But for someone who has muscle wasting due to disease, TRT makes a lot of sense. That’s another possible exception to your rule… when low testosterone is caused by chronic disease that is poorly controlled. At that point TRT can be considered appropriate palliative care (and is probably underutilized, imho).
But you are correct, hormones do not just spontaneously become deficient (except in older women, but that’s a different story). I’m sure you also won’t be surprised when I mention that TRT was an incomplete resolution for my issues with social anxiety and confidence (which I have come to find respond most to reductions in inflammation). Moreover when I was recently forced to stop TRT, and my testosterone plummeted to that of a woman’s, I felt surprisingly ok (I was really expecting the worst!).
Having low testosterone since puberty, it might be the case that TRT just flipped a switch. I also note that inflammation can both cause low testosterone, plus low testosterone can cause inflammation. So it could be a self-reinforcing cycle, like the psychological causes you mention. Also I believe I had low protein intake previously, which I did not fix until I was on TRT. Same with selenium deficiency, which is one of the anti-inflammatories to help the most with my social anxiety, independent of testosterone level. As you suggest, I also found that excess selenium is as bad as deficiency in my experience (I later found research to support this finding, with both low and high selenium being bad for mood).
If you ever have the time, it would be really helpful to have a practical guide for men with low testosterone, who want to exhaust all possible avenues before getting on TRT (which many if not most would like to avoid). I’ve tried to help guys online as best I can, but I wouldn’t even know where to begin with the genetic stuff. And even with the more straightforward parts, it would be really helpful to have everything in one place. Frankly, I don’t blame men who just throw up their hands the minute healthy lifestyles and a multivitamin don’t work. But there is so little good information out there.
osteoporosis and low T can both be driven by high IL6. have you had your IL6 measured? a diet that you think of as healthy or anti inflammatory might not be good enough for example if you have really strong IL6 genetics.
@@tohopes I have not had IL6 tested. What would cause elevated levels?
@@FreedomFox1
IL6 is one of the body's main inflammatory (stress response) signals. all kinds of stress cause it to be produced, and from the initial point it can spread throughout the body and, if persistently high, can damage any of the body's tissues. i would guess that common causes of persistent elevation of IL6 include eating too frequently (IL6 roughly doubles for several hours while digesting each meal), eating too much starch or sugar (to the point of developing metabolic syndrome, which also roughly doubles IL6 secretion), and not sleeping well enough. other things that induce IL6 include infection, injury (to joint, bone, skin, etc), psychological or social stress, and even physical exercise (though scientists often hypothesize that the IL6 induced by exercise is not harmful as by other causes). there are various foods and supplements that can reduce secretion of inflammatory cytokines including IL6, maybe Chris Masterjohn has made a video about them, i'm not sure. also, level of IL6 production can vary substantially from person to person, maybe by as much as a factor of 4x, mainly as a result of genetics.
The section on "How to approach hormones" is fine until I get to the very abrupt ending, which brings you back to the title of the video.
How adamant are you that we shouldn't "argue with our brain"? Should we at no point use hormones for general health? What about things in our environment that "argue with our brain", that have hormonal effects, psychosomatic effects, that interfere with our glands etc...?
Deficiencies are paramount. But if the system is geared for stress, inflamed and overly permeable it's much harder to tell it "things are all right" just by feeding it well because it's more vulnerable.
I don’t want to give up and take the hormones (Progesterone) but I am still stumped as to why my monthly period hits me so hard as estrogen levels go up and only progesterone gives me relief. I know that progesterone helps the body hold onto copper, and zinc helps the body make progesterone. I take copper and try to add zinc but it immediately results in copper deficiency symptoms again. I guess I will try B6 as the unpleasant high estrogen symptoms seem to be mostly low gut Diamine Oxidase levels and I know it should help support progesterone and DAO.
I would read up on ceruloplasmin as it relates to copper. It's very confusing for most people because there's a big difference between available copper in the body for biological processes versus excessive copper levels that cause oxidation. If you're not producing enough ceruloplasmin, your body can't utilize copper for cellular function and then the excess copper becomes oxidative to bodily tissues. You can literally be too high in Copper while simultaneously not being able to efficiently utilize the copper in your body.
Thanks Brian. This definitely was the case for me and vitamin A for ceruloplasmin and niacin for uric acid have definitely improved my copper transport. Riboflavin helps with ATP which also keeps copper moving. None of the other supplements suggested for ceruloplasmin have helped. Progesterone seems to help with copper utilization and retention but I want to help my body make it naturally. I used to have a condition called Interstitial Cystitis and whenever I got pregnant it would go into complete remission when my progesterone levels and DAO levels rose. But my progesterone was never high enough to prevent bleeding during pregnancy and miscarriage scares.@@brianwnc8168
Love the complexity here! This is the furthest thing from other casually "reductionist" videos I've seen in a great while! Keep it up!
Thank you! For both the truth and the emphatic way in which you share it. It is important for people to understand this.
There is a basic key here that seems to be often overlooked: focus on supplying the nutrients that provide the raw materials FIRST, focus on supplying the nutrients needed for signaling SECOND. I often see people go straight to the signaling part of the equation while skipping over requirements for raw building blocks. For example, it’s very popular to supplement B vitamins without paying any attention to iodine. This is such a simple, obvious principle that it strikes me as one of those “hidden in plain sight” kind of things. To Chris’ point about paying more attention to your own body than to studies, it also occurs to me that reading study data can contribute to this “cart before the horse” effect of prioritizing signaling at the expense of raw materials - I’m thinking of studies in Japan showing that the TTFD form of thiamine can dramatically improve neurological signaling in the gut - no one who quotes these studies bothers to mention that they were done on a population - i.e. the Japanese - who are already replete with iodine.
What a gangster. Appreciate all your info.
On a separate note: thoughts on Dr. Layne’s newest video on seed oils? Can’t seem to reconcile your genius with his wisdom.
This is most likely why I find a lot of my clients report that they are unable to increase their thyroid medication - they just don't have the energy stores to support the increase. They often feel worse when they increase, even slowly. Or develop new issues like jitteriness. (I don't prescribe meds but I do see a lot of people on thyroid meds who look like they are under-dosed).
I loved the explanation. But I get tired of this audio quickly and hesitate to send it to others. Please let me help you with this, I won't charge you for it. I messaged before and not sure if you saw this. I think it wouldn't be hard to fix.
Extremely well explained. Thanks Chris! Question, though: Even if current levels are normal, would it make sense to increase testosterone, DHEA, and pregnenolone with endogenous hormones for longevity reasons?
Some people think that there is such thing as "contrarian biochemistry" which means when you take hormones you deplete micronutrients that are needed for synthesis of that hormone. Basically that taking hormones will work, but long term they will ruin your body.. So it is better to only supply the body with raw materials to make all the hormones it needs and if you want anabolic hormones you need to lower stress of any kind. Give the body plenty of rest, good calories with all the micronutrients. That is a good strategy. Just taking hormones and not addressing anything else doesn't look like a good idea long term..
@jirihutecka9020 I am afraid you nailed it. Was hoping for a different answer but you are most likely right. Well explained, too.
When I was quite unwell 15 years ago I had some kind of virus and it kicked off all sorts of weird symptoms, including my thyroid. I had stabbing thyroid pain, but my antibodies were never elevated (only ANA - I do have other autoimmune issues). Selenium fixed that stabbing pain in only a few days - pretty amazing how your body can give you clear signals if we are able to listen and figure it out. I only occasionally get that pain now and it tells me I need to get back on to supporting my antioxidant capacity.
I've been on injectable biologics (20 years) at a frequency of 12 weeks but get blood work every 8 weeks. This gives me a unique perpective. Looking at yearly trends of Liver, Kidney and Thyroid funciton over time, I can see that they all suffer in correlation to the efficacy of the injection and inflammatory symptoms. I eat 2 brazil nuts per day and supplement with Lugol's drops, plus Manganese, Molybdenum, MSM, Taurine and all of the Methylation protocol supplements.
What do you think about Lugol’s iodine counterintuitively lowering thyroid activity via the Wolff-Chaikoff effect?
@@mitochondria_uncoupler Wolff-Chaikoff effect is just a deregulation in the Iodine transporter, in the presence of an over abundance of Iodine. The same type of regulation happens in many other of the cells enzymes. The goal in Iodine supplementaion isn't to get more than is required. The goal is to get enough. I don't consume Iodized table salt but I do consume oysters and sardines. I don't go overboard on the drops.
@@rdance3 how much is ‘enough’ is my question. Because 200 mcg is the RDI, and over a few milligrams is W-C territory iirc. Iodine is pretty easy to get through diet / small amounts of added kelp granules. At that point, the health of the liver (where the bulk of conversion of t4 to t3) should be more of a focus (selenium helps conversion) in my opinion, as well as things like magnesium, zinc, copper, b vitamins, etc.
I take 6 drops every other day. I measure my neck once a month. I add two drops for every .25" that my neck grows above 16". @@mitochondria_uncoupler
Excellent information,
Very well presented.
It would help me with understanding
The complexities and interdependence
Of the overall picture if you could
Provide some diagrams showing
Interdependency of the salient parts.
👍👍👍👍👍😊😊😊🤔🤔
Not asking for individual attendance, just an observation that may help elevate viewer understanding.
Thanks for your work.
8-)
Would you ever consider going on a bodybuilding podcast? With Dr Todd Lee or Paul at anabolic bodybuilding, vigorous steve. It would be so epic im meeting them at the Olympia Im telling them to contact you!
What about chronic inflammation severe enough that it affects organs and glands?
what exactly could cause that? did you look into astaxanthin?
You are a living encyclopedia🤩
What about when the hormones are exogenous/xeno? Couldn't they not push the metabolism and physiology in such direction that we could say it was definitely unwanted?
Chris what is the protocol to get the genome sequencing and finding metabolic issues there? Do you have link that describes this?
If a man is diagnosed with RA (Rheumatoid Arthritis) he has a 65% chance he will have low testosterone levels. Are you suggesting that there is a treatment (not a prevention, but after a diagnosis) for an autoimmune disease, such as RA and thus prevent the secondary effect of hypogonadism? (low T). I understand that MTHFR defects have an effect on autoimmune diseases.
high IL6 drives RA and also substantially lowers T. there are many diet and or supplement things you could do to keep IL6 lower.
@@tohopes what are those diet and supplements to keep IL6 lower?
@@meggi8048 some type of regular fasting (eating less frequently) and at least a few days of keto each week. 5htp and lipoic acid perhaps every day. maybe soy or soy isoflavones a few times a week. generally, antioxidant super foods like flavonoids and other phenolics suppress IL6.
so what is the best way to optimize, fix methlaytion pathways remove stress and take things to optimize hormone production, like b6?
If too much GABA can create shortness of breathe then taking too much b6 could lead to that also?
If you have high levels in the blood, definitely. B6 toxicity is no joke.
Thanks
Some one please point me in the direction of where Chris indicates age related “extra” nutrients needed. What does a 40 year old need that his 20 year old self doesn’t have problems with.
U go
10:00!?