Revealing the Hidden Causes of Autoimmune Diseases
Vložit
- čas přidán 12. 09. 2024
- Question: How to Find the Root Cause of Autoimmunity?
Short Answer: Autoimmune conditions are likely driven by deficiencies of vitamins A and D, which contribute to post-infectious autoimmunity by compromising the rhythmic rise and fall of myeloid-derived suppressor cells (MDSCs), and to autoimmunity regardless of infections through impaired suppression of Th17 helper T cells. More broadly, infections and tissue damage are the most likely drivers of autoimmunity onset. However, energy metabolism governs everything through the second law of thermodynamics, which holds that energy must be used to prevent everything from randomly mixing, and this includes randomly mixing the immune defense against pathogens with immune attacks on the host. In this example, we discuss how a respiratory chain disorder would compromise absorption and distribution of zinc and compromise the oxidation of NADH to NAD+, and how both of these would interact with a genetic impairment in acetaldehyde dehydrogenase to prevent the activation of vitamin A to retinoic acid. Autoimmunity thus results as one of many symptoms of vitamin A deficiency driven not by lack of vitamin A, but rather by impaired activation of vitamin A, secondary to impaired energy metabolism.
This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link:
chrismasterjoh...
In that batch of free episodes you will also find the answer to this question:
Can NAC hurt your gut health?
Why Would Vitamin C Cause Joint Pain, Muscle Pain, and Brain Fog?
If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up:
chrismasterjoh...
Learn more about the Masterpass here:
chrismasterjoh...
This snippet is from the May 13, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:
*GLA to lower hydroxyhaemopyrrolin-2-one?
*When would I use the StrateGene and Genova Methylation Panel for nutritional testing?
*Energy metabolism as a root cause of gut issues?
*Nutrition for skin healing?
*Nutrition for hypnic jerks?
*Suggestions for snoring or sleep apnea?
*Nutrition to protect against restaurant meals?
*What is the cause of crusty eyes in the morning?
*What causes brain fog?
*How much oxalate should one eat each day?
*Should I be concerned about low alkaline phosphatase?
*What nutrients give tall children to short parents?
*Energy metabolism impairment mimicking Wilson's disease.
*Can taking digestive enzymes reduce our own production?
*Rapid-fire response to non-winners from the question contest.
Here’s a link to the full AMA: chrismasterjoh...
For more information, visit www.chrismaste...
The answer to this would change my life!!
Yes, this is my experience. Told I had the autoimmune condition Interstitial cystitis. Only recovered when vitamin A began being activated to retinoic acid.
How did you get this to
happen
So I began taking flush niacin 250 mg 3 times a day at meals. It is a cofactor for acetaldehyde dehydrogenase (NAD) which along with helping the body detox acetaldehyde also converts retinol to retinoic acid. When I didn’t take niacin taking vitamin A had no positive effects and only caused severe bone pain. When I took it with niacin it wasn’t painful at all and began slowly healing the lining of my bladder and gut/colon. There is a study out of Columbia University showing that they have found that retinoic acid restores the bladders lining in interstitial cystitis. Of course none of the doctors I was shuffled around to made any mention of this.@@benvowler6448
Yeah what activates vitamin A
Edit it’s zinc according to the video
@@Valoric for me it wasn’t zinc it was niacin. NAD is the cofactor to convert retinol to retinoic acid via acetaldehyde dehydrogenase.
Interesting because professor Malone lee doesn't believe IC is a real condition.
When I first sought the care of my rheumatologist, I made the comment that when I'm sick, I actually feel better. I actually found an article that echo'd my experiences. She stated that this is common with autoimmunity. I've been on biologics for 20 years now. They definetly help but they are not perfect. I often theorize ways to introduce pathogens that help act as a "sacrifcial immune buffer". Maybe a pill formed probiotic that contains weakened pathogens that can break through the leaky gutt in the tight junctions, that is common in many people who suffer.
What about Dr. Naviaux cell danger response? Also the idea that it’s not random, that the body has turned on a state of protecting the cell and in that process we have all these uncomfortable symptoms but the body doesn’t care about how we feel because it’s goal is to keep us alive. The problem he says is that the body gets stuck in a state of cell danger response (CDR) and it can be hard to switch it off. He figured out the purinergic drug suramin could help with this. The pilot study they did on autistic children at UCSD is exciting! He thinks this theory could also apply to all autoimmune conditions and new viruses. We don’t want to wait for a drug if we can turn of the cell danger response with the right tools. Your thoughts on CDR and how we can do this?
Those growing up where theres enough sun until they are mid teenagers have much less of autoimmune diseases.
In Finland they tried giving babies a little more of vitamin D. That reduced the frequency of MS substantially.
We have noticed the differences in allergies and asthma depending on sun exposure.
Some MD:s are sucessfully treating autoimmune diseases with very high doses of vitamin D.
What this indicates is that the immune system needs vitamin D especially when it's developing.
It seen like it cannot fully be recovered later, when grown up, if an autoimmun diseas already has developed.
Unfortunately, there's some extraordinary resistance against doing research on vitamin D with doses giving blood levels of 25(OH)D of at least 50 ng/ml, where the immune system effects are fully gained.
As a person who uses biologics at a 12 week frequency, I have swung from high energy/low inflammation to the complete opposite. The correlation is so tight, it's hard to determine which comes first. In my amature studies of metabolic pathways, I often see that certain enzymes are inhibited by immune markers like IL6, TNF etc...This correlation is the bane of my existance. It's like the "chicke and the egg". Sometimes I feel that my low energy is the product of my inflammation and other this I'm of the opinion that my inflammation is the cause of poor nutrient absorption.
The million dollar question
pretty complicated chris .. but i got the idea finally.. thanks genius.
EPI - Lucy Mailing metnioned recently she sees a lot of undiagnosed celiac being a cause of this. Also when I researched it, SIBO is linked to EPI.
nice! vit a is key.
I know a few with autoimmune diseases, such as artrit, asthma, and MS.
None of them show any sign of energy deficency. There's probably nothing wrong with their ATP production.
Is that really a main cause of autoimmune diseases?
He didn't mentioned creatine. That should be important for using the ATP efficiently.
What test did he metion at the end?
I got alcohol and caffeine intolerance after I became toxic in B6. Is there anything that's helped your clients with that?
Yeah, take all the b vitamins except b6 (take only a tiny bit to not totally tank your levels). Your b6 will go down in 3-4 weeks. Monitor using blood tests.
Take it in the P5P form
I was B6 caffeine and alcohol intolerant. The solution was flush niacin to correct a block at acetaldehyde dehydrogenase. Later added iodine and folic acid. This will increase progesterone levels so you no longer experience negative effects from B6.
@@maschoff69
Yes, the P5P form of B6 seems to be the only form that can be dosed safely. The other forms (whuch is in almost every multivitamin) have such a narrow range between what we need and what's toxic that it can't be safely dosed!
The B6 metabolites stays in the body for a number of days. So if you take a high dose daily, it can accumulate. One research paper recommended to take 100 mg once a week to avoid that accumulation. Most other B vitamins doesn't have this problem and can therefore be taken daily.
riboflavin, should i use free instead of riboflavin 5'-phosphate if i put it on my skin with DMSO since it needs to be converted in intestines? thank you
autism is also believed to be an auto-immune issue. Antibodies attacking the brain. In child, I wonder how complicated it would be to erase that immune pattern that their parents caused them (usually their brains are attacked in the womb already) - not easy in kids, immune in children acts differnetly compared to an adult - fasting is dangerous in children for example - not enough food for immune cells, immunoglubulins in digestive tract may get lowered etc.
It's being treated with high doses of folinic acid, and in some cases a steroid like dexamethasone.
It's a developmental issue, not autoimmune. Too many catecholamines and excitotoxicity not enough Dopamine, Serotonin, and GABA.
@@StarHarvestOfficial I mean we have papers with attacking antibodies. I mean scientific literature on how the brain is being attacked in mothers womb because the mother's diet's are crap (no fiber, no greens, no whole food, so the immune cells go nutcase - or the same from pollution,
vaccines can dip the balance but not necessarily in every case).
If interested in scientific literature, let me know, maybe I can forward titles if not links here.
Better yet, just do your research :)
And surely catecholamine imbalance can be a result of the inflammatory cascades.
@@0626love it's not necessarily diet. Mothers can have the same attacking antibodies robbing them of folate, then the baby also has attacking antibodies and brain suffering from a lack of folate.
Chris can you say your opinion on ttfd suplement and generally about high dosing b1 for some time taking in account that most people have high carb diets for whole life so it would bring their b1 to normal?
I would be careful. I took too much b1 compared to b2 and I got cracks on the corner of my lips. B2 is really needed for the electron transport chain. Chris has a video entitled, "Your MTHFR is just a riboflavin deficiency." Check it out!
Entropy does not increase at a constant immutable rate. You do control that rate. Efficiency of a mechanism is related to that. There is a limit to that efficiency dictated by 2nd law\entropy.
Not really a constructive approach to pathologies, more a distraction. Metabolism specifics you use well.
How do u determine a respiring chain disorder
Thank you.
Could someone please explain how to fix energy metabolism?
lol @ screwdriver example 😂😂😂🤣
Fix the gut infection first has been my reality, at least once. What's is your perspective?
I'm not getting something here. These people are not in a bedridden, debilitated or vegetative state, are they? They do create some energy. Why doesn't getting a good amount of rest helping them? How does a moment by moment sort of restricted capacity of the respiratory chain in the now become a bottle-neck over the long term also? If ATP is metabolic currency, why is there never enough spare change to redirect, so that at some point those issues are addressed? It's not like over-training makes one autoimmune, isn't it? Anyone?
I can tell ya exercise triggers autoimmune. I was sent in to do some PT. They had me doing mostly low level stuff. Then they had me doing a bike for 20 minutes. The first day holding the handle bars never felt anything while pedaling. The second day at the bike, like 7 minutes in started feeling real funny in the hands. I thought I was just gripping to hard. That evening notice puffiness around the knuckles. Third day on the bike full explosion, could watch the swelling all over my hands and writs. The PT guy was so scared he said don't come back till you have a doctors note. LOL Now here I am by 11am I'm falling asleep, I live in the desert 80 to 120 degrees and I'm still running my heater beside me to stay warm, low energy. No doctors seem to be of any use, they just say take the drugs, but I have arthritis nodules of the lungs, which mean no meds for me by my lung doctor. I just want a way to make this better. If vitamin A is the issue I'll eat liver all day long if I have to, but not going to like it!. Stuff is nasty tasting though!
@@lisathompson5500I used to hate liver with a vengeance. Then I tried making liver pate and after a few days I actually started craving the stuff. Tastes great with some sourdough bread. Oysters are great too. I just get the really cheap small ones and swallow them whole with some lime and Tabasco. I make sure at least once or twice a day I eat some of these essential foods.
And get enough sun exposure and grounding/earthing plus really work on good deep regular sleep. No screens after 8pm and a completely dark bedroom.
My problem turned out to be low stomach acid. Now I am on Betaine HCL capsules and feel better every day. I just wasn't able to digest fats and proteins properly.
@@lisathompson5500 I don't know what to say, but, maybe stearic acid could help with new mitochondria.
Elivated insulin.
Your body and I would add, your mind is in a state of cognitive dissonance.
for most auto-immune conditions, just do green smoothies and some seeds and nuts for omega-3 for few months. Then add other foods back in.
Surely, energy governs all, but all those phytos and minerals and vitamins from there, wihtout the excess crap, is what directs the energy metabolism the way we need
Those are high oxolate
😏
Grassfed grass-finished beef
@@debbicornell1 therefore good for growing nice healthy Oxalobacter formigenes colonies and more. DO you understand oxalate-scare is a pseudo-science.
It only matters to very few. And why use the highest oxalate-containig greens, use komatsuna instead of spinach etc.
@@maschoff69 Doesn't work. High meat is only useful when the gut is totally ruined (then meat-only for some time makes sense - later trying to add healthier stuff - I mean for long term health you wouldn't get signals for in short term).
People please don't ruin your guts in the first place.