023 - Inflammation causes depression
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- čas přidán 30. 06. 2024
- It is a little-known fact that chronic inflammation causes depressed mood. I want to show you where in the brain this occurs, and why it makes no sense to tell someone with FM, ME/CFS, GWI, MCAS, or other chronic conditions that they "are just depressed". - Jarred Younger
- Věda a technologie
Hello everyone! A quick note - the audio drops for a second a few times. That is my "pop" filter set too high. Someday, I will have all this audio and video stuff figured out! Thanks for being patient with it. :-) Jarred Younger
Ah it's ok.. it happens what's more important is the info you give us. I appreciate so much.
Hi Jarred, thanks for your fantastic work! Giving us hope is so important as keeps us hanging on
There’s an interesting study I just read. It’s not about ME/CFS, However it’s interesting that a new autoimmune disease has possibly been discovered, suggests to me more are yet to be found. And an also interesting is these antibodies are apparently crossing the blood brain barrier.
Maybe ME/CFS has yet to show us a similar autoimmune issue
I couldn’t post the link here, so to read the article go to Medscape look up:
‘Form of B12 Deficiency in CNS May Be New Autoimmune Disease’
@@youngerlab infuenza killed more people world wide than both world wars combined. I had influenza at 7 months into my first of two pregnancies, very early on in 1977
Being that ill does not equate with 'knowing' to stay home and rest. It certainly though, does mean being completely prone, inable (not unable), and utterly helpless.
A little louder for the healthcare professionals in the back of the room. Just in case they missed this. Thank you for the video!
Yeah we may need to scream it
Ha, yes. You know I give medical talks when I can and try to share the information that way as well. I hope all is going well! - Jarred Younger
The only thing I found, by accident, that resolved my depression and anxiety was changing my diet. I had white knuckled my way through most of my life with debilitating depression and it just disappeared like a switch was flipped. I was just stunned. Figure out what foods are causing inflammation, remove them and see how much better you can feel. This is the first time I've heard a scientist/doctor directly relate depression to inflammation. Fascinating...
Great! I appreciate you mentioned it. I responded to a comment below and said that diet should be one of the first things to investigate when dealing with potential chronic inflammatory issues. An inflammatory gut can migrate to an inflammatory body, and finally to an inflammatory brain. I'm so glad you found a way to effectively treat these conditions! - Jarred Younger
I am finally realizing that although I suffer from depression I am so much worse because of my chronic inflammation. Anxiety is also a greater symptom that my inflammation causes. I have fibromyalgia, mast cell activation syndrome, hEDS, and depression.
Do you have muscle pain daily nurologist says my fybromyalgia us migraine in the body I have heds now diagnosed autism ADHD this causes mcas
@@Truerealism747 I have pain most days. I used to have headaches every day but that stopped when all the other symptoms got worse 7 years ago. I also have had to cut almost all foods from my diet. It’s been rough trying to get the inflammation in my brain under control. I can deal with pain but the overwhelming depression and anxiety are much harder to deal with. Most medications have stopped working for me. I’m at the end of my rope trying to heal myself. The medical community has been little to no help. 😩
Swap the depression diagnosis with a rare type of bipolar spectrum disorder and you have just described my life.
Oh and add GI symptoms suspected to be Chron's disease.
@@dotcassilles1488 I am truly sorry that you are dealing with this. It’s not easy being us. Invisible illnesses are especially hard.
The challenge isn’t so much as solving the depression but stopping the gaslighting of consistently putting the cart before the horse… the depression is cause vs symptom… and we need to keep at finding the inflammation cause and solving the inflammation, if possible. But that just doesn’t seem to resonate for most in the medical psychological arena 😢
Thank you for sharing this valuable information...especially for those of us that have been depressed for years with fibro, CFS, systemic inflammation... no one has ever explained this to me the way you did in the 40 years of being diagnosed with fibromyalgia ❤😂🎉...thank you!!! 🎉🎉🎉
I’m sharing this with my ME groups. Thank you. I KNEW I get down in PEM state. Now I know why. I ‘fight’ my way through it with gratitude as I find that’s a key to happiness for me. And remind myself it’s the illness not me pulling me down. Thank you
Very wise words and an invaluable reminder to others!
Thanks for sharing! I'm glad it was helpful! - Jarred Younger
I think 'Cytokine Induced Sickness Response' is my new self-appointed diagnosis. It captures my experience these days. I used to be classic fibromyalgia but through many interventions I'm no longer in fibro pain. I changed my diet, healed my gut, started LDN, rewired my nervous system out of chronic stress and suppressed pesky herpes 2 years ago and put most of my symptoms into remission for almost 2 years (no depression was SO GOOD!). But recently I've been flaring some days with all the symptoms Dr. Younger listed. So I know my inflammation is out of control again. I'm doing SO MUCH to manage it (sleep, no stress, diet, saunas, PEA, SPMs etc etc) but it's not working well enough for me to be able to work. Some days I can only sit at home alone and do nothing, other days I can function perfectly normally. SO frustrating. Argh!
Thanks again for all you do Dr. Younger. Love these weekly videos.
Thank you. I'm glad you have found some ways to mitigate the severity of the condition. There are many ideas (most highly experimental) on how to further help, and more are popping up all the time. I hope you can find some answers through the videos! - Jarred Younger
Anyone that has been severely sick, specially if they see no end to it(can't afford to get treatment, don't know the cause, etc) then they will be depressed. The depression is amplified by our system which treats people as chattle rather than human beings. If a person is in constant pain, for example, they will 100% start thinking about suicide. It isn't because they are depressed, it is because they are sick. If a person gets sick but then gets demolished financially then they will become depressed. It isn't because they are depressed but because they are financially broke.
Depression is an EFFECT *not* a cause. Anyone that claims otherwise is a moron and a dangerous one if they actually work in the medical field. It's not rocket science. It's like saying "I stubbed my toe because it was bleeding". There are lots of humans that are extremely ignorant and get cause and effect backwards(this is why a balanced education is so important and especially mathematical and scientific knowledge). I think humanity is just starting to move out of the dark ages. So many people are now able to educate themselves that it is bringing a new level of awareness that could never exist without the internet and computers. Many of the beliefs of the past are starting to dissolve because enough people can see through them. Unfortunately this also creates a lot of chaos because as of yet there is nothing replacing the void that is being created(but the void enables something new to come along eventually).
Thanks for saying all that. Yes, I agree that depression is often a "symptom" that something is wrong, rather than a condition itself. - Jarred Younger
Thank you for stating clearly that it's an expected outcome from inflammation 👍🏼
Can brain inflammation cause panic attacks, OCD symptoms, and phobias? Do the cytokines in the brain you described affect/inflame the amygdala? Do benzodiazepines reduce brain inflammation? Some people with CFS report relief in “crashes” and pem with benzodiazepines. Thank you again for your work.
This psychiatrist thinks that benzos can calm mast cells and reduce inflammation. At about the 25 min mark she says so m.czcams.com/video/8NMvXD3JPJA/video.html&pp=ygUeUHN5Y2hvbG9naWNhbCBzeW1wdG9tcyBvZiBtY2Fz
Hi. Yes, brain inflammation can cause all those anxiety-type problems. Because the pathway is different (e.g., the amygdala, like you mentioned), I am doing a separate video on how brain inflammation causes anxiety. Yes it is true that benzos dock on microglia and calm brain inflammation. They can do so quite effectively in some cases. However, I have to mention that benzos have a high risk of dependence and, if used too much, can make the original problem even worse over time. I think they are seductive drugs because they can work so well and so quickly. A discussion to have with a doctor for sure, but I would just suggest that they be used sparingly and tracked to make sure their usage isn't being increased. - Jarred Younger
@@bjornolson21 what about the substantial risks of using benzos more than a few times or 2-4 weeks, rarely longer?
Why are they not suggesting or trying fasting? I’ve dealt with Hashimotos for 30+ years, RA 10 years, and psoriasis. Discovered a few years ago that fasting is the quickest and best way to reduce inflammation.
It is a good idea, just outside of my area. It is ideal if autoimmune conditions like you mentioned can be managed with diet. It would be interesting to track C-reactive protein before and during the diet change. My *guess* would be you would see a reduction of CRP with the fasting that would predict the positive effects. Thanks for sharing! - Jarred Younger
I've only recently started to track "anhedonia" seperately as a symptom.
It's more specific than "depression" and to me feels almost always directly related to physical states of my body.
Yeah I like to use specific concepts as much as possible, because terms like depression and fatigue get thrown around by everyone, and they can mean very different things person to person. - Jarred Younger
It would be helpful to understand depression from inflammation also could induce anxiety. I suspect that many patients may be wrongly diagnosed with GAD (General anxiety disorder).
Yep you are right. I will do an anxiety video soon. The anxiety pathways are different from the depression ones, so I am keeping that one separate. - Jarred Younger
@@youngerlab Great, thanks ❤️
My severe depression was caused by bad gut bacteria, cured with antibiotics thanks to a Chinese doctor. She asked me about my diet first thing. I told her that five foods were behind it. I also told her that I had developed asthma attacks after eating eggs, something that had never happened before. She figured out it was due to bad gut bacteria and gave me three couses of antibiotics. I am now cured. Out of a 1-10, it was a 50. I can now eat whatever I want.
Do u know what antibiotics?
@@giakolou2876 Doxycycline was one. I forgot the other two.
Bacteria "poop" toxins and when you have too much "bad bacteria" they can overload your system with toxins that cause all kinds of issues in terms of moods, health issues, etc. Basically they are poisoning the body. Obviously lactose issues is a typical one but that is gas. The toxins can cause gastrointestinal issues such as ulcers, polips, etc which can go on to further create issues.
Because our food supply is so full of antibiotics(which can cause our gut bacteria to become resistant), chemicals(which can throw our system out of whack), diseases, etc a lot of people are having these types of issues more than ever before.
In the past the food supply was rather healthy. People typically got sick from certain types of jobs such as mining(heavy metal poisoning, lung diseases, etc), textiles(chemical), etc. But it was isolated to those jobs. Now everyone is getting diseases due to our food supply being the way it is(all about maximizing profits rather than health).
I get excruciating depression that doesn't respond to my usual meds 12 hours before other signs of a virus show up (headaches, congestion, exhaustion). Like clockwork. I have told various medical and psych professionals this and they don't know what to do with it, even if they believe me. Giving this to my dr. Thank you for explaining so "medically." At least I know I'm not crazy.
Wow! When I started LDN (on the right ultra low dose for me) the first thing I noticed was that I was happier. Other signs of improvement took more time to notice. Please keep the information coming!
Great! I am working on alternative forms of LDN that will hopefully work even better. We will get it all figured out. - Jarred Younger
DBS is still considered quite a risky procedure… as in, unpredictable loss of various brain functions (not only but significantly potentially sequoia cognitive losses). You acknowledge this. To your credit. I’ve never heard of a surgeon who dies research on DBS (implanting electrical stimulation lines through brain tissue) ask a patient in (research) on depression during surgery if they feel “HAPPY.” Maybe someone among these researchers asks that question. Depression is not lack of “happiness,”….).
*Edit: the typos are obvious. I can’t correct them immediately, unfortunately, but I think anyone can understand. (I hope this is exhaustion, in me, and nothing else!).,
Thank you for the work you do - even more so thank you for educating laymen about current research.
A big and much too familiar one for me.
I have had anxiety with bouts of depression for as long as I can remember. After getting ME\CFS I do become depressed sometimes because of the illness. I also noticed depression that comes with flares/post exertional malaise. It comes on much more suddenly than depression usually does for me. And when the flare is over, it’s gone. It can make me feel really hopeless and helpless, but if I remind myself that it’s just the inflammation in my brain, I can make it through.
That all makes sense. We really have to figure out the PEM. There are many people who could manage the tonic CFS just fine if we could just knock out or substantially minimize the PEM unpredictability. - Jarred Younger
Kudos, Dr. Younger. I sent this to my brother in law who is a psychiatrist, and a my sister who is a licensed mental health practitioner . Being older they seemed to look at the world as everything is a neurotransmitter. The anti-inflammatory/antioxidant approach has worked well in me for pain, fatigue, and my mood. I am hoping to find how to take them in a minimum amount and still receive the benefits.
Yes, I think the role of NT's and neurons have been exaggerated in many conditions -- with recent research showing other cells such as microglia being even more important. Since microglia are the ones in charge of pruning and maintaining neurons, we have missed the target completely for decades because scientists thought microglia were just simple "glue" for neurons (where the name glia comes from). The scientists know better now, but no drugs have made it to conventional medical use. - Jarred Younger
That makes me wonder how we ended up in a world where people are spreading disease everywhere and even get aggressive towards you when you are trying to protect yourself from their illness.
What are you talking about who can go to a grocery store and catch a cold life ain’t peachy
It is difficult to see from the outside whether people walk around with Covid, the flu, a common cold or allergies. So the only thing you can do basically to assume that it can be Covid or the flu (which can both floor you for weeks, so that you lose weeks of income).
Yeah I see what you are saying. The problem is that the "retreat to the house" phase doesn't start until the brain has been alerted to a significant problem. That is usually a few days after the person has contracted the illness. So when people feel fine or just a little off, the sickness behaviors haven't kicked in. The problem is that they may already be contagious then. It is when the brain interprets an issue that behavior changes. But that takes a bit when the pathogen is in the peripheral system. For many bacterial or viral pathogens, the marker of systemic alert is the simple body temperature. As fever increases, people become much less likely to want to walk around and socialize with people. So, the system is far from perfect. - Jarred Younger
When can I buy a nightcap I can wear during sleep that magically calms chronic brain inflammation induced psychological and cognitive symptoms during the day?
There is a large, wide-open market waiting for that product. - Jarred Younger
When I started LDN, my depression vanished almost immediately. It was substantially more powerful than the antidepressant I was already taking.
That is great! - Jarred Younger
This video is enlightening 👍
Perhaps a nutrient dense anti-inflammatory diet will fix it. Then, maintain along with a low stress lifestyle. This is what helped me 2 years ago. It only took 2 months to get rid of a plethora of symptoms that stemmed from inflammation caused by being overworked and eating a bad diet for 1 year.
This is so inspiring to hear! Can you recommend any books or resources about ant inflammatory diet or other tips?
Carnivore/keto diet really alleviated all those nasty signs & symptoms pretty much ❤😂
Why are perhaps laughing about it? If one needs more protein there is protein etc. If it has to do what actually recommended to others well then that is entirely different topic and looking up those research papers is paramount to truly knowing what the squeaky clean truth is. So that is all I have to say about that so called fad diet. What is discussed here is the backbone of our metabolism and not the sales, science and not the pseudoscience, the recognition to change when we were wrong and carryon. To be allowed as patients and or drs to change our autonomy. 😊
Incredible such a precise description.
'We knew about this for quite a while'.
I wish more medics knew about this.
You didn't mentioned CIRS (chronic inflammation response syndrome) but for what i understand is almost the same. (Sometimes they talk about cytokine storm).
The problem is that without healing the cause (mold or lime desease others) it wont be cured.
I think that the intervention is amnice experiment but its certainly not a fix. Its not healing the inflamantin its just a patch to trick the brain.
As in cirs, the inflamantion could have a huge effect on the rest of the organs. You might feel happier but youre still getting your organs damaged.
Its also dubious, reminds me to ren & stimpy happy hat.
Thank you. It is really helpful to have a specialist (medical model person) validate the effects of these illnesses. Even though people with these illnesses will have an idea this is what is happening, few people understand nor believe them. Thanks again ❤
You're welcome! Thanks for saying that. - Jarred Younger
After a gout attac, and taking anti inflammatory diclofenac for that i feld significant better all the way...
thank you for your work
Hi esteemed doctor. Could all of this also be linked to undiagnosed gluten sensitivity or celiac disease? I have read several posts on Reddit from patients about cases of severe mental confusion, cognitive impairment, ADHD, depression, migraines, neuropathy, ataxia improving after a gluten-free diet. It appears to be due to the immune response to tTg6 antibodies present in the nervous system even in the absence of usual markers of celiac disease. Unfortunately, there are few laboratories that can measure it. Professor Marios Hadjivassiliou of the University of Sheffield is a proponent of this theory and has written several articles about it. I'd like to have your opinion. Kind Regards
gluten worsens me, gluten free does not end all troubles/symptoms. enough tho to stay gluten free.
Thank you!!
just an update; my remission after LSD is now lasting without any added re-dosing. i dosed 4 times total over a month and one microdose. definitely an antiinflammatory/antidepressive effect partially responsible.
Thanks for mentioning it. We are working with psilocybin (macro dose), but have not started an LSD trial. After I determine how the psilocybin works for fibromyalgia, we may trial LSD. My graduate student just collected information from people who used LSD (and other chemicals) for fibromyalgia pain, and there were several interesting experiences shared with us. My colleague Peter Hendriks has the approvals to do these types of studies. - Jarred Younger
@@youngerlab I would love to offer my experience more in detail if Peter Hendriks is interested because I have cross examined a lot of my symptoms between a lot of varied treatments, and i have a very detailed memory of the moment where I felt like my body slipped into it's present functioning state, and what I personally did to allow it to happen, I believe there is a reflexive/functional aspect that was allowed to start working normally again. my experience of the "chain having fallen off the gears" has been fully resolved, I can exercise and dont have to pace at all, the POTS and dysautonomia is totally gone even under strenuous exercise.
@@youngerlab I know of 3 cases of long COVID in remission after the subject self-medicated with a psychedelic (a single dose DMT in 2 cases and several doses of psilocybin in 1, which has since been published).
This is wild! I think I've seen it used for Parkinson's, but had no idea about using it for depression, or that there was a region of the brain that did this!
And would this make depression particularly medication resistant? At least for the normal anti-depressant meds?
Yep, same approach, different location. If it weren't so risky, we would probably be using it for all kinds of chronic conditions. - Jarred Younger
@@darthmeowry I don't think the DBS would make oral anti-depressant meds less effective, but I haven't seen data specifically on that question. - Jarred Younger
could you look into the potential therapeutic use of intravenous ketamine infusion for fibromyalgia and neuroinflammation?
I was just thinking that I'd love to know if Dr Younger has anything to share regarding ketamine
Starting Catamine e next week
Yes I added it to the list of videos to make. Ketamine is *almost* conventional care in pain clinics -- many will do IV ketamine for fibromyalgia. It does a good job of reducing central nervous system sensitivity to counter fibromyalgia hypersensitivity. I haven't used it in a trial myself, though. - Jarred Younger
@@youngerlabdoes sublingual ketamine treatment work for fibromyalgia. I have found a clinic that will do this but don’t do IV infusion but am not sure if it will work this way. Do you have any knowledge about this?
@@youngerlabMany times I feel that my head is too painfully large to be allowed to get on a bus or even think of what I was taught, even misspellings in 3 languages and it is actually embarrassing. It is embarrassing to have condescending physicians and a tremendous amount of medicine sensitivities and be believed by I know that it is not made up and criteria for Wellca re, State care etc is intertwined 😂Thank you for caring!
I remember in a previous video that you said LDN reduced inflammation generally. Do you think that LDN should be tried in general patients exhibiting depression, even if they are not known to have a chronic condition such as ME/CFS etc?
I see an earlier comment below that might support this approach...
Yes I think that should be tested. I thought someone at Harvard was testing that idea (maybe David Mischoulon?) but I haven't talked to him in a while. I would hypothesize that LDN works best for those with inflammatory-induced depression, but it would be a nice development if it ended up having broader actions across other types of depression. - Jarred Younger
My inflammation numbers were down.. on blood test . I’m still having migraines/vertigo with weather pressure changes and fibromyalgia pain. …..
I only get depression when vertigo/migraines are triggered w/weather. Is there supplements or something I can take to help?
Q10 magnesium acetyltel carnitine foe a few I have fybromyalgia CFS heds autism ADHD are you hypermobile Dr Sarah myhill Dr teilbuam.list minerals fir it they help fatigue but pain worst symptom
Hmmm I'm not sure about this one. I haven't investigated migraines and vertigo. We do have an interesting weather paper coming out and I will talk about it as soon as it is published. It sounds like you are describing something like Meniere's disease. Depression is very common when these individuals have barometric vertigo. I assumed it was due to changing pressure in the eustachian tubes and not really an inflammatory thing, but I admit I have never looked into it closely. So I don't know for sure, but it sounds like handling that aspect of the problem will take you in a direction other than inflammatory. - Jarred Younger
2:25 Where can I read more about this process of inducing depressed moods in healthy individuals?
I've long thought of the Neurotoxin used by the "Scarecrow" in the Batman franchise as a fitting description to some of my experiences with anxiety/panic states that can be directly linked to and provoked by histamine load e.g. or acute infections or in recovery from a concussion.
I have often thought: I wish I could help him or her understand!
If only there were a way to have them experience what I am experiencing without doing any longterm damage to them…
It sounds like you may have found a way?
When‘s the product release party? 😉
You can search for any study where a human is given lipopolysaccharide (or endotoxin). A dosage of 0.4ng/kg is pretty light and a dosage of 4ng/kg would be pretty rough on the person. Very high dosages can cause delirium that may be what you are describing, but I don't do high dosages, and I think very few other groups push the dosages that high. Some groups use vaccines to induce an acute inflammatory response, but I think the LPS/endotoxin approach is the cleanest. You can search via google or even better in pubmed.gov - Jarred Younger
I'm surprised you didn't mention the external TCS or Transcranial magnetic stimulation. It cured my years of chronic depression and worsening depression from peripheral neuropathy. It certainly seems to be a step first before having brain surgery to use leads that stick out of your cranium.
I've been suffering for over 10 years from peripheral neuropathy and depression and I'm also considering TCS. Is TCS the same as Transcranial Magnetic Stimulation? There's a clinic on the west coast that I'm considering. Would you mind telling me which clinic treated you with TCS? Did the TCS also help with your neuropathy?
@@dannya965 Hi. I'm in Central California so you need to search in your area for a clinic. I was referred to one by my Psychiatrist. I had significant depression and anxiety for nearly 30 years. Yes. Trans Cranial Magnetic stimulation is it. It cured my depression. It did nothing for peripheral neuropathy. Good luck.
@@dannya965 Hi. Yes, it is TCM or transcranial magnetic stimulation. It cured my depression after 34 treatments (that is standard amount). No help with peripheral neuropathy pain. Search your area for a clinic, usually referred by a psychiatrist. Good Luck.
Yep great point. TMS is powerful. I like the protocol targeting the left dorsolateral prefrontal cortex to indirectly hit the subgenual ACC. I didn't mention it because it can't directly reach the sgACC, but I will be doing a video soon on all the neuromodulatory approaches currently being used and the things being developed. More soon! - Jarred Younger
I have BPD, pyroluria, and the MTHFR gene mutation, and I've found that restricting all inflammatory foods dramatically improves my conditions. Inflammatory foods also cause me stomach issues, which lead to
depression, and my physical pain is dramatically lowered too.
I'm glad you found some things that help! I think the anti-inflammatory diet makes great sense, though I don't do diet studies myself. One of my colleagues (Robert Sorge) does these studies and would say diet is critically important in managing chronic pain. - Jarred Younger
Try a ketogenic diet. A recent french study cured 45% of bipolar disorder by going keto in just 12 weeks. 40% reduced their meds. Berberine will lower lps bacteria and helps lower inflammation. Exogenous ketones and mct oil will help as well. NAC and glycine will restore glutathione to youthful levels in just 4 weeks. Apigenin and quercetin will spare NAD by lower cd38 and inflammation.
When you induce inflammation have you done a Cytokine blood panel to see which markers are elevated? Is inflammatory depression visible in any blood markers?
Following
Following
www.ncbi.nlm.nih.gov/pmc/articles/PMC7327519/#:~:text=Direct%20evidence%20of%20inflammation%20in,(TNF%CE%B1)%2C%20and%20reductions%20in
@@matthiusantonin2652
Thank you...very interesting study..
Thanks Jarred...
A very informative, important and valuable video!
Your work and particularly your efforts and kindness are a godsend..
We appreciate it all immensely.
Share what audio tools you're using, how you're using them, another branch on the growing tree of social media, thx for sharing info on inflame.
Video on GH5, audio on Shure C1000S running through Audacity. Mixed in Premiere Pro. - Jarred Younger
Dr. Younger, I suspect that chronic EBV and Lyme disease have been caused my fatigue and mood problems. C19 seems to have made matters worse. Dexamethasone seemed to help but is not a viable long term treatment. It seems like treating endemic diseases would be helpful.
I agree that dexamethasone helping is a pretty good sign there is a chronic inflammatory issue. It is possible to focus on EBV and Lyme Disease by doing titers on good days and bad days to see which pathogen flares with the bad times. There are companies that do this kind of work. I guess the issue is what to do even if the pathogen is identified. It is possible valacyclovir could be used for EBV, and a course of antibiotics for the Lyme Disease. I agree sometimes there is a recalcitrant pathogen, but I think in other times there is a hypersensitized inflammatory system left behind after a major immune insult. The treatments for those two scenarios will be very different. But me and others are working from both angles. - Jarred Younger
Wow, this confirms what I've experienced myself for years, a strong relationship between depression, lack of motivation, pain and inflammation. I find that if I'm depressed and in pain and take 200mg celebrex at night, I feel great the next day - no depression and very motivated.
Likewise I find that I often have pain and depression occurring simultaneously and taking slow release tramadol at night completely sorts me out for days afterwards.
It makes a lot of sense for celebrex to help with many cases of depression. COX-2 is a major culprit in the maintenance of depression and celebrex is one of the best inhibitors of that enzyme. The relationship you identified strongly hints at inflammatory depression. - Jarred Younger
Do you know what an elevated transforming growth factor beta1 means?
Also, is it possible that some antidepressants such as fluoxetine have some anti inflammatory effects? I was looking into it and it seems like that and the snri venlafaxine may have anti inflammatory effects
TGF-b1 has dozens of possible causes across many body systems, so the test itself doesn't indicate anything in particular. If I had elevated TGF-b1 on two separate tests (at least 3 months apart), I would start going down the list of possible causes and ruling them out.
You are absolutely right about the anti-inflammatory action of many anti-depressants. It is my position that many people get better on these meds because of the anti-inflammatory action, rather than the serotonin, norepinephrine, etc. increases. It seems that only a small percentage of sufferers have a true deficit of those neurotransmitters. - Jarred Younger
Thanks for the reply
By chance, would an infared vielight that fits over the head help with the brain inflammation and depression? I have a Vielight, used it for about 3 months after brain surgery... but stopped after the initial response helped but seemed to slow down. If i would've continued for 6 -12 months could it have helped the depression/andehonia?
Should I try? ❤
It is an intriguing approach, but I haven't used that device, so I can't vouch for its brain penetration. I see they used the preferred wavelength, but I would have to dig deeper to see if everything else looks right. There is some scientific evidence that exposing a region near the front of the brain with near infrared light can reduce depression, but I don't know enough to make a recommendation on this one. - Jarred Younger
Bingo!
Have you looked into Irlen Syndrome at all?
All I can say is it helps me cognitively a lot to wear my Irlen filtered glasses. Especially when reading text, reading music, looking at a piano keyboard, screens, driving…
It's outside of my area, but interesting condition. I think about it in the context of stroke, but I don't know much about it. I bet people have it and dont realize what it is. - Jarred Younger
If this mechanism is at play, will serum IL1-beta and TNF-alpha be elevated?
Hi. Not necessarily - it depends on whether the inflammatory driver is in the body, or starts in the brain. A large percentage of cases will have a peripheral inflammatory driver so those cytokine elevations should be observable. In other cases, the problem is pathologic microglia activity and the cytokines are being produced directly in the brain. In that case, they may be observable only by doing a lumbar puncture. - Jarred Younger
Could Long Co-v Anosmia (and subsequent Depression) be a result of Neuro inflammation? Could you kindly do a video on this
Yes, I will. SARS-CoV-2 can enter the brain by traveling olfactory nerves at the top of the nose. The first brain area to be reached after the olfactory bulb in the olfactory cortex. My colleague Ayushe Sharma just published a paper showing neuroinflammation in the olfactory system. - Jarred Younger
🙏
Can it cause severe anhedonia and mecfs?
Yes to both of those. I'll be talking in future videos on possible ways to treat problems with that brain region. - Jarred Younger
So doesn't Transcranial Magnetic Stimulation, which is another treatment for depression, target a different area of the brain? In light of what you mentioned, why does that work?
TMS works along the principle of the brain halves counter-balancing each others activity, so you actually target the area that is overactive, to inhibit it so that it comes in balance with the opposite side. you target different areas depending on symptoms.
@arasharfa The way it was described to be was that the region being stimulated by the TMS treatment is underactive in depressed individuals, and stimulating it increases activity and strengthens connections which happens to alleviate depression.
I'm wondering if there is any kind of unique relationship between the TMS targeted region and the one Dr Younger mentioned.
@@rdan721 the way I was described by the people giving me TMS was that the overactivity in one lobe causes under activity in the other corresponding lobe so to increase that you inhibit the activity of the overactive part since each brain half inhibits each others activity.
Great question, I will talk about TMS soon. I should have mentioned it in this video. TMS should always be tried before deep brain stimulation. There is a region on the outer surface of the brain that has a connection to the sgACC. So, TMS can be used to indirectly alter the sgACC activity. - Jarred Younger
I can't find the link to the NST video..
It was his video two weeks ago.
It should pop up in the last few seconds of this video - it is the square that comes up on the left side. - Jarred Younger
I suspect everyone knows what I'm about to point out but vitamin D and fish oil (which has vitamin D) can help both with brain inflammation and depression. Please be aware that fish oil will thin the blood. Please report to your doctor if you want to take fish oil. The blood thinning quality may interfere with mediations and you may need to temporarily stop if having a surgery, or dental work.
what if we have depression have comes from C-ptsd and yes chronic pain.. I mean I don't think drilling holes in someone's head to to abuse and trauma is a thing one would want to do b/c of neglect and abuse..
Yes I think that is one example where the deep brain stimulation may not be the optimal approach. Right now, only a small percentage of those with depression have the option of doing DBS. I am focusing on less invasive ways to do the same thing that will (hopefully) work in a larger group. - Jarred Younger
First 🙌🥳
The keto or carnivore diet will greatly reduce or eliminate inflammation.
Did you have success with one of these?
@@FantasticDrums My girlfriend, who has fibromyalgia, has had success with both. Don’t expect to reduce pain and inflammation to zero, but those diets have helped more than anything else she has tried
I agree one of the first things to investigate is the diet. Considering our diet is what we exposure our system to every day, it isn't strange to assume it can be a critical factor in our health. Many people have inflammatory issues that originate from gut issues. - Jarred Younger
Absolutely, worked very good especially carnivore, unfortunately for me as a skinny person i lost too much weight on it to stay healthy so i needed to go back eating carbs and all...
@@mmm365 You can maintain a very high-calorie intake on a keto or carnivore diet by consuming high levels of fats. I was on a keto diet for a short period and consumed around 3000 calories.
I thought it is interesting about how we will stay away when sick. Addiction will drive a person into isolation and it is true that person is dangerous for the rest of society. Thank you for sharing your knowledge. We can get better.❤️🩹
Omega 3
...but what causes the inflammation..?
Stress food air magnetic fields bad sleep
@@Truerealism747also chronic infections both bacterial and viral…
Benzos
Autoimmune disease. I have MDD, Ankylosing Spondylitis and just spent 3 horrid months with, at best assessment, Polymyalgia Rheumatica.
sugar, alcohol, processed food, omega 6
And carnivore heal it😊