006 - Simple blood tests to detect inflammation
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- čas přidán 3. 03. 2024
- I get asked quite often how someone can find out if they have chronic inflammation. Here are 8 blood tests that your physician can order. If the test results show abnormalities, it is possible that your chronic pain, fatigue, or cognitive issues are due to sustained inflammation.
- Věda a technologie
You are a blessing. The real deal. Not bought and sold like most....Super super appreciate you!
The tests are first the two most important ones. CRP, and ESR, and the remaining 6 are, SAA, plasma viscosity, ferritin, fibrinogen, interleukin 6 and tumor
necrosis factor
You completely made my day with this video! It's something that needs to get shared with providers. I started tracking my blood values because my guess was there was some inflammation going on. Unfortunately doctors didn't feel my markers for ESR and CRP were extreme enough. Higher than they should be but not high enough. I had a lot of symptoms though. Some of the lab companies have "inflammation packages" you can order on your own which is what I did. It's fascinating to look at the various test values and look for patterns once you have enough data. For fibromyalgia, we really need to encourage the providers to run blood tests instead of only relying on the WPI. Thanks again for the video!!
Thanks for saying! Yes I think we have to dig in more and figure out the importance of values in this grey zone, especially since most FM and ME/CFS individuals I test are in that exact spot. Those "mildly elevated" values are meaningful. - Jarred Younger
Just want to send out my continued appreciation for not only what you are doing but in communicating the pertinent issues publicly. It keeps us hopeful. Cheers.
As always, very informative and easy to understand.when I listened to Dr. younger present in 2019 ,at the NIH during Advocacy week, I knew he was the researcher giving Fibromyalgia and CFS patients hope.
4blood tests:
HOMA-IR, HBAIC, AA/EPA Ratio, TGL/HDL ratio.
Great work Jarred. Patient education is the way to go, thank you. Thinking of empowering, with a Pareto mindset as well as inexpensive (auto) testing. Serum Vit D levels, possibly you can do a separate dedicated video, it is a quick win, clinically relevant in autoimmunity, inexpensive, both test as well as supplementation. I would assume long lasting inflammation in autoimmunity drains Vit D reserves. The vitamin is protective against autoimmune triggers, reduces incidence as well as severity, shown in different studies.
Thanks! As you have probably seen as well, the Vit D levels are low in over 75% of the FM and ME/CFS individuals we screen (with about 25% of those having severely depleted Vit D). Undoubtedly there are many people struggling with chronic pain and fatigue who just need to get their Vit D or B12 levels raised. - Jarred Younger
@@youngerlab yes, especially considering these come with no negative effects if you avoid over supplementation, which is hard to do in the first place, and you can always test your status. Low Vit D is surely an issue in autoimmunity in general. I have yet to meet a person who did not present with low vit D at diagnosis of autoimmunity, which includes myself.
Thank you so much for your work and information! I would also add the affordable at-home dry blood spot omega6:3 ratio-test, where the AA/EPA-ratio shows a lot of the chronic inflammation in the body the last 4 months. The Norwegian laboratory VITAS has analyzed almost 1 300 000 test from all over the world now.
I love your accessible / understandable approach to your info videos 💙🙏🏼💙
Thank you
Thanks! - Jarred Younger
Thank You Dr. Younger. So very appreciated. I'm sharing this to my local support groups to spread the valuable information.
Wonderful info 🎉 thank you 🎉 very helpful 🎉
Thank you for your work!
Thank you Dr. Younger.
Dr. Younger - thank you for this information. In your studies, have you observed that people who have ME/CFS have high markers on either/both the hs-CRP and the ESR blood tests?
Yes, both -- but I see the most consistent abnormal elevations in CRP. We will probably put out a CRP and ME/CFS paper later this year. I haven't run the calculations, but it is looking like average CRP is around 0.5mg/L for healthy individuals, and around 6.0mg/L for ME/CFS. I don't know if all the labs are finding the same thing, but the difference is very clear in the people we test. - Jarred Younger
So interesting! Thank you!
Each time I attend the ER, they order a CRO but recently refuse to take the ESR which they consider non-spevific. It is always elevated unlike the CRP which is consistently normal.
I was really excited to find your CZcams channel. I was bitten by a spider(s) in Mexico, exposed to EB through my brother, and 3:22 contracted campylobacter, all in a relatively short period. Over the years since I have been diagnosed with psoriasis, psoriatic arthritis and cancer. I received treatment at UAB that included chemo, radiation and surgery. If my chronic fatigue wasn't bad enough before, it is near overwhelming now. I just saw a video by a medical doctor who also practices functional or naturopathic medicine. He had interesting info on glutathione. I did acquire a TENS/EMS unit with the intent to try vagus nerve stimulation but I haven't mastered exactly how to do it yet. Thanks for your work in this area. It's liberating and validating to hear from someone who is doing more than questioning a patient's sanity
I forgot to add the fibro diagnosed by a rheumatologist. It was the initial diagnosis in this journey. And I had reactive arthritis after the campylobacter infection.
@@bcwbarbThanks for your story and sorry to learn you have these maladies!
Thank you!!! 🙏
Great topic!
😭I’m telling my doctors that internal shingles are causing my problems. Yet they refuse to even consider that. After labs results return ok. They shrug their shoulders and say I don’t have anything for you. 😭😭😭The pain is real, debilitating and disabling. can’t wait to retire and move to a place that I can slowly regain my health.
My CRP has always been normal but ESR remains elevated. ED docs call the ESR too non-specific yet I have a myriad of autoimmune issues.
Great videos. Thank you sir. Are you able tp touch on the symptoms too im any of your vidoes please ?
Very informative video. Thank you! 👍I have had polymyalgia rheumatica for about six years with multiple treatments with prednisolone 15 mg weaning to zero with reoccurrences. Lately rheumatologist included leflunomide and it seems to be working which enables cessation of prednisolone. Just for readers' information, my CRP doesn't really indicate the degree of inflammation but the ESR does when we run them in parallel. As well, in the last three or four years I have developed what I suspect is CFS/ME with profound fatigue (but not sleepiness). I will be following your work to help elucidate my malady because this condition being new is hard to diagnose even for experienced generalists. Thanks for your great information!
Thank you 😊
I'm glad you could watch it! - Jarred Younger
I have long COVID since 2021 and I tried to travel to florida beginning of April and ended up in the ER with extensive clotting
My c reactive protein was 21 which was high
I’m having a reaction to ivermectin and LDN over the first few weeks
So discouraged!
Thank you so much for such informative video!
I'm just curious what markers could be a reflection of inflammation caused by chronic viral/bacterial activity (which many of CFS patients have).
For instance I have extreme fatigue and chronic EBV/CMV activity but hs-CRP, ESR, IL-6, ferritin and TNF alpha are in normal ranges.
Thank you. In my experience inflammation from foods as the most common cause of RLS and at least one of these tests should be part of a regular health check as it could be the key to stopping many chronic diseases fefore they do any permanent damage.
Are you saying inflammation from foods is a different test? If so, what is the best test for food inflammation?
@@royrogers495 Where did you get that idea? I'm just saying that food is the most common cause of inflammation, especialy given the standard American diet, high in processed foods.
Thank you for your work Dr. Younger! 💚
If you have inflammation in the spinal cord or brain, as observed in autopsies of seriously ill ME/CFS patients, would you also see this inflammation using normal markers such as CRP or would you have to look at the protein in the spinal fluid, for example?
And would it also be possible to see inflammation in the spinal cord tissue through blood tests or would you have to get tissue samples?
Good question because for years my csf(cerebral spinal fluid) was tested and it was when my PSA became severe and it was showing there too. Headaches are serious and I think that most of the time they are not associated with an inflammatory disease when I personally have seen evidence showing that it is affected and I am also a patient, my comment was earlier and I am completely disabled.
I have had hs crp done for years and that test alone costs me usually over $100. Insurance doesn’t cover it.
What say you about the hypothesis of impaired lymphatic drainage & interstitial inflammatory stasis?
I find it quite compelling as I've felt myself surprising (transitory) positive effects on my mood and mind abd overall energy right after lymphatic massage of head and shoulders.
what type of blood test need to inflamation i feel something very weird happen to my body like my heart beat like very weak and super fast like i almost die sometimes even i workout everyday i visit heart doctor take echocardiogram there is no problem i dont know what to do
I see CPR and ESR normal in most Lyme patients. Any comments?
What say you about the blood serum marker Rantes aka CCL5?
My Rantes value was strongly elevanted before a NICO jaw excavation surgery.
Dropped to normal after surgery.
Now elevated again 2 years after the NICO surgery.
My hsCRP is above 10. Keep me in mind. Current UAB patient.
Would you please explain brain fog? Is brain fog inflammation of the brain?
Dear Dr. Younger, wonderful talk! could you help elaborate how EDR predicts the response rate of LDN?
I wish I could attach a pic. But in my fibromyalgia studies, those with ESRs around 15mm/hr have a 20% reduction of pain with LDN, ESRs around 30mm/hr have pain reduction of about 30% on LDN, and ESRs closer to 60mm/hr have a 50% reduction of pain with LDN. There are plenty of exceptions, but those are the general means. And I have run these analyses only in fibromyalgia participants. - Jarred Younger
@@youngerlab Very cooool
Hi, what could it mean if your CRP is 1 but you have a high WBC?
Thanks for the information, that’s really helpful. I was wondering about what you said about ESR, that a high number seems to predict that someone might not react well to LDN? Am I understanding that correctly? Does it reason to say that if someone did have a high ESR, and found ways to reduce it to a normal or low number, would they be more likely to respond positively to LDN?
Hello! I may have phrased that statement awkwardly. I was trying to say that individuals with high ESR are more likely to respond well to LDN. It seems that LDN works particularly well in people who have evidence of sustained inflammation. - Jarred Younger
@@youngerlab Thank you for the clarification, that is really interesting
I've recently discovered through a series of blood tests performed in the hospital that I had Sepsis. The labs taken show markers and that's how the 6 kidney surgeons decided to perform an immediate ureteroscopy and lithotripsy. I lived to share this story with you, but still have the side effects. What do you suggest I do now? Do I see a hematologist?
I am wondering why my son would have an 11.2 for his CRP, but only a six for his ESR. I would have expected the ESR to be high, as well. He has been having some trouble with his liver, and his ALT was also high. I am guessing that the high CRP is because of his liver issues and being overweight. Still, surprised that the ESR was not higher.
Can you cover ferritin and how it is an acute phase reactant that increases during inflammation? I strongly suspect depleted ferritin levels to be a driving factor in my chronic fatigue; however I can’t get an accurate result bc my results are elevated due to inflammation. Women are very prone to low ferritin from pregnancy childbirth and menstruation. Thank you!
I wanted to add that the current reference range for “normal” ferritin is very wide and doctors aren’t helpful. Low ferritin can cause many unpleasant symptoms
That is a great point about ferritin that I should have made in the video. Thanks for bringing it up. In some of the tests I mentioned, lower is always better. But ferritin and fibrinogen are exceptions where too low can be bad as well because they are involved in processes besides inflammation. Ferritin is critical for iron utilization and low ferritin is a problem for many people. As you noted, in individuals with significant inflammation, ferritin tests stop being useful screens for anemia. And there are some individuals who have inflammation-induced anemia. The related tests like transferrin and direct assessment of iron can help, but I do not think there is a clear marker of inflammatory anemia. The diagnoses need to be pieced together from many sources of info. - Jarred Younger
Hi I’d love to be a guinea pig! Chronic inflammation for decades. I’m a patient at UAB.
So what do we do if any of those labs are elevated? My hs-crp was 1.6 when last checked. STRONG family history of alzheimer's disease, my father died with it yesterday morning and i keep having to tell my uncle because he keeps forgetting. How do I mitigate inflammation?
How about the chronic poisoning from the government and corpse orations?
D-Dimer test for inflammation?
Fibromyalgia. My child esinophilic esophagus. So fed up
I have post Covid and have IL-6 and TNF very high. Any insights why?
Probably Mast cell activation syndrome (MCAS).
IL-6 and TNF are two of over 1050 different types of mediators that Mast cells can produce and release, where a large part of them are inflammatory.
There are also other immune cells that can release IL-6 and TNF.
From BBC. Long Covid triggered our MCAS, but doctors didn't believe us
From National Institutes of Health (NIH).
Mast cell activation symptoms are prevalent in Long-COVID
Mast cell activation syndrome and the link with long COVID
Mast cell activation is associated with post‐acute COVID‐19 syndrome
Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome
Immunological dysfunction and mast cell activation syndrome in long COVID
My CRP is 30 and my sed rate is 58, just fyi - ya, I'm concerned!
Ok
During my 2nd acute infection my CRP was up to 35 😢
You probably felt quite poorly then! 35mg/L is not unusual for a flu or similar viral infection. Bacterial infections can take it well over 100mg/L. When I see over 20mg/L in my lab, it is usually an acute infection of some sort. In those cases, I just give them a couple of weeks and we re-test. - Jarred Younger
How do you test for auto-antibodies in the CSF? My neurologist suspects that I have an auto-immune condition triggered by by a covid infection resulting in lingering symptoms. But this requires a spinal puncture to investigate. Is there any blood test that could be done first (or instead) that could be used to rule this out before going to the more invasive procedure?
GPCR antibodies Test. Available in Germany. Send it there
Ok
@@alias701 How does this differ from the standard ANA (anti-nuclear antibody) blood test? My neurologist says this blood test tells you nothing about what's happening in the CSF, i.e. the blood test could come back negative but it doersn't mean that autoantibodies don't exist in the CSF.
Hot breath
Nhs ask for test your having a laugh