N-Acetylcysteine (NAC) in Schizophrenia and Bipolar Disorder- Prof Michael Berk
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- čas přidán 14. 12. 2016
- Professor Michael Berk is currently an NHMRC Senior Principal Research Fellow and is Alfred Deakin Chair of Psychiatry at Deakin University and Barwon Health, where he heads the IMPACT Strategic Research Centre. He also is an Honorary Professorial Research Fellow in the Department of Psychiatry, the Florey Institute for Neuroscience and Mental Health, and Orygen Youth Health at Melbourne University, as well as in the School of Public Health and Preventive Medicine at Monash University. His major interests are in the discovery and implementation of novel therapies, and risk factors and prevention of psychiatric disorders.
Professor Berk starts this section of the presentation by discussing a study that looked at the effects of NAC on Schizophrenia.
Take-home Points
• NAC showed a statistically significant reduction of negative symptoms in Schizophrenia but no effect on positive symptoms. N-acetyl cysteine treatment also was associated with an improvement in akathisia.
• NAC demonstrated large effect sizes across the range of Bipolar symptoms; from depression to functioning, to quality of life, etc.
• In the maintenance study, There were no significant between-group differences in recurrence or symptomatic outcomes during the maintenance phase of the trial; however, these findings may be confounded by limitations.
• In another study, it was revealed that NAC was suggestive of producing higher rates of remission for Mania, compared to a placebo.
• NAC may be useful as an adjunctive treatment in Major Depression in Bipolar Disorder.
Full article: psychscenehub.com/video/nac-s...
I have been giving nac to my son who has severe schizophrenia and has been in and out of the hospital for years. I saw a difference in him within 30 minutes after giving him 1000 mg. He's calmer and happier and hasn't had as many angry outbursts in the week's since.
Thank you for sharing.
Was there a follow up study?
@beastmode4617 hi dear, can you please give more details about how he's doing now? Also more on his illness. Am having really difficulty with my 31st yr old sister who refuses to listen to everyone and is having anger issues. She thinks everything is against her and she's being observed
NAC is an amazing compound I've used for almost a decade for a variety of reasons. It's very scary to see the FDA and Amazon trying to prevent people from buying it.
The FDA banned it because it's safe and effective and May potentially cut into the profits of big pharma.
I am seeing it available on Amazon.
But ur body is of steroids not nac
Thanks. The voices in my head advised me to take 600mg NAC daily. I haven't heard them since.
are u on any Aps?
Hahahah
Lmao, nice
You should let the world know. Spread your word so that people like you can take your example to consume it.
lolz
I was diagnosed with amphedime induced psychosis no longer a user, NAC has definitely normalised my thinking as well as my lungs capacity. I was also a heavy smoker no longer smoke either.
Thank you for sharing 🙏🏼
Did you give up smoking because of NAC, or was it just pure will power?
As a nurse who had a brother with Schizophrenia ( he’s gone now) I would love if this worked for the people who suffer from this disorder. 🙏 I pray it’s a breakthrough. My brother had no life here. He must in the next world ❤️
So sorry to hear. It has some evidence as augmentation but not on its own or in treating serious illness. Hopefully there will be better breakthroughs for schizophrenia in the future. Take care and sorry for your loss.
Ÿ⁶pppp
the FDA should be shut down and its leaders sent to prison
I highly recommend the documentary "Making a Killing the Untold Story of Psychotropic Drugging."
Produced by the church of Scientology, a large organized controlled opposition operation
Good presentation! This is definitely a promising compound.! Thanks for the video mate.!👍
Staring using NAC since 5 days ago and let me say you than I feel incredible, in 12 years drinking alcohol first time than I get the desire to stop drinking at all :) and I also loose 5kg in one week I really put effort at gym since months of inactivity
Thank you, this is quite interesting.
NAC is good for mild catatonia. I myself have it. It reduces impulsivity thus can slightly improve working memory too. Reduces the urge to respond to OCD and other false urges. It also reduces muscle stiffness thus may be useful for Parkinson's disease and in other neurodegenerative conditions.
Thank you for sharing
Is NAC safe to take alongside various mood stabilisers commonly used for both bipolar and schizophrenia. Such as Quitiepine?
In theory yes but one has to discuss this with their doctor to ensure it’s an individualised decision.
Unfortunately the FDA decided to ban this supplement. A cowardly shame.
they ain't cowards they makin bank!
@Fat Goy Slim it isn’t banned
It’s not banned! lol
If it's banned , it's working
Ebay sells it...
What do you think intrinsically leads to a defficiency of this amino acid? Lack of sleep? Born like this?
Can you tell me why NAC is not being administered to treat
COVI-19 illness esp. Acute Respiratory Distress Syndrome (ARDS)
Trials underway clinicaltrials.gov/ct2/show/NCT04374461
@@PsychiatrySimplified any results on this?
Thank the government for stepping in.
It’s banned now , since your Gov wants total control
@@Malitubee NAC is not off the market. Only off Amazon marketplace. This was a corporate decision, not a government decision.
the graph shown in 7:10 the graph says in the NAC section that remission is much higher, isn't this bad?
No it's good. Remission from manic symptoms was greater in NAC group.
After a four month long course of accutane, I found myself having horrible adhd. I lost my job, I can’t focus the same as before. Did some research found out it could be due to oxidative stress from accutane that induced the adhd.
I have been on adderall 10 mg for 2 weeks and found improvement but upon reading how adderall can cause neurotoxicity. I Stopped treatment. Now I have to deal with this adhd, and am trying to self-medicate using NAC, l theanine, l tyrosine, GABA, and cod liver oil.
My hopes are that I can reduce the oxidative stress from the accutane course and get my mental health back, my adhd was never this bad and was manageable prior to going on accutane, had straight As before hand. So if this works it will be amazing.
Anyone have any comments, or ideas about this?
While we can't provide medical advice - some general thoughts. Stimulants such as dexamphetamine and methylphenidate are safe when prescribed at the appropriate dose. There is an inverted U shape curve where too high a dose can be excitotoxic. Any symptoms of ADHD should also have a thorough medical screen to rule out other disorders. There are also non-stimulants and alpha agonists in the treatment of ADHD. Furthermore, long-acting stimulants are more likely to mimic the rhythmic dopamine release of the brain. psychscenehub.com/psychinsights/diagnosis-and-management-of-adult-adhd/
PsychScene Hub what about stimulants on a therapeutic dose do you think this can cause aging? I heard adderall caused aging and my adhd gets really bad to impact my quality of life but I care a lot about my skin and don’t want aging 😭but I do need the adhd help that’s for sure
Valeria Bustos I would recommend having a discussion with a psychiatrist or your doctor about this. There is no evidence of stimulants ’causing’ ageing or accelerating the ageing process.
@@valeriabustos4100 B COMPLEX, VIT D, AND VIT B5...
@@valeriabustos4100 Vitamin A, MSM Sulfur, Essential Fatty Acids.
N=1 helps my depression after about 2 weeks of daily dosing. After about 2 weeks not taking it comes back (pretty badly)
Thanks for sharing
Are you sure you aren't perhaps self medicating something like unnaturally high baseline levels of glutamate or something like that? Do you ever get so anxious that your brain feels like it is almost fizzing? It might be more of an anxiety disorder causing you to feel depressed but I could be wrong!
Is this help to people with tricotilomania?
A study showed that - N-acetylcysteine demonstrated statistically significant reductions in trichotillomania symptoms. No adverse events occurred in the N-acetylcysteine group, and N-acetylcysteine was well tolerated. Pharmacologic modulation of the glutamate system may prove to be useful in the control of a range of compulsive behaviors.
What is rhe name of this product where to buy?
You can ask your local pharmacist.
If many goes to approve the reality of using NAC business may go down. After finding new disease to humankind banning NAC will be reviewed.
Not every psychotic patient is the same type. I know some Patienten with schizoaffective disorder. There it's easier.
They all had muscles cramps, slight headaches, problems with sleep and an unwiling loss of weight before their psychotic episodes. But the maniac and psychotic symptomes we're the only seen by doctors. But if you start to give them magnesium when the sleep problems begin, then they never get psychotic...
There's an easy explanation: magnesium ist the co-factor of COMT-enzyme, then adrenaline, noradrenaline, dopamin one after the other can't be built down. All exceeds. Then the Body Takes another way by serotonine, too. That's causing the maniac symptoms.
At the end the dopamine is still too much and the psychosis starts.
Caffein makes all worse in this Case because it's built down the same way.
So is magnesium good or bad for psychiatric disorders?
Sorry I didn’t understand your explanation
@@WildImgination for a certain Type, it's good. I listed the Symptoms, when it can Help and the causal chain
I have bipolar II. I take NAC twice daily 500-600mg a dose. Seems to be helpful at balancing the highs and the lows.
But if I take 1200mg at once, it can swing me into more manic
Interesting . Thanks for sharing
Did you say 1000mg once a day?
Do you mean the doses of NAC. There is a range. Doses in OCD for example have been trialled at 2-4 gms ( 2000-4000mgs). Taking NAC and doses should be discussed with a medical professional especially if higher doses are used. The pharmacist can also provide information. Ps not medical advice
You can buy NAC from eBay
Placebo effect could be a real possibility with this one.Maybe the inclusion of ADHD in the enriched phase might work.
@The mRNA jab Is the mark of the beast It's not the mark of the beast, sunday worship is. satan's sabbath. saturday is the day God commanded us to worship. They will soon force sunday worship under pain of death.
@@randallcatz3429 what the fuck is wrong with you hahahaha you're insane
Nah.
Any medicine for long use will not be effective and sometime it may lead to a new type of trouble.
gives me nausea. always...
Hypolaristic they told me to take it with protein, might help...
Brand may be the problem. Not all NAC is equal. Look for ingredients validated by a third party laboratory for identity, potency and purity.