Two Main MTHFR Variants Explained: MTHFR C677T and MTHFR A1298C
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- čas přidán 4. 04. 2024
- Discussing the two main MTHFR variations and our personal experiences with them in my recent podcast with Karalynne Call @just.ingredients.podcast
The two main MTHFR variants are MTHFR C677T and A1298C.
These MTHFR variants are also called MTHFR mutations, MTHFR polymorphisms, MTHFR SNPs.
Want to learn more about the MTHFR gene and 7 other really important ones? Read Dr. Lynch's book, Dirty Genes:
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Homozygous MTHFR C677T plus folate transport mutations. Interesting about dying in utero. My mother nearly lost me early in pregnancy (in 1955) and she was confined to her bed for most of the pregnancy. I always thought, given all of the homozygous mutations I have and various health issues, that I wasn't meant to survive. It's been a really difficult life. No one knew that I needed extra nutritional support. And yes, I'm autistic/ADHD as well.
❤❤❤
I have the same mutation and have autism too. I’m blown away.
The motherfu$@er Jean is what it needs to be called. It sucks !
So I got tested and I'm 1298cc. I have two variants . So I'm assuming I got one copy from each parent. Still trying to figure this out n just found this out at age 54. Explains a lot for me though. I do have your book dirty genes.
I have the C677T type, which is homozygous. I had a serous angle closure glaucoma attack and temporarily lost my vision. Studies show that low folate and high homocysteine are implicated in glaucoma. At the time I was just divorced and I was struggling with living situation and was sleep deprived. I got emotionally triggered and it happened. All is well now and I am supporting MTHFR, but would like to do more with Seeking Health supplements.
Thank you.
I like this new videos you are posting, thank you. I would like to see the whole interview.
Im blown away because I literally have this gene mutation with autism, adhd and a few other diagnoses.
Those disorders are mainly caused by methylation and neurotransmitter issues (in simple terms).
@@Paul-hu1ht Yes
we would love to see the full interview...
🎯 Key Takeaways for quick navigation:
00:28 *🧬 There are 676 known genetic variations of MTHFR, but only two are commonly discussed.*
01:49 *🤚 Most genetic variations have little impact on gene function, similar to different hand shapes affecting catching ability.*
02:45 *🧬 MTHFR variants alter enzyme shape, affecting methyl folate production; 677 and 1298 are the most discussed.*
04:08 *📉 Variants at position 677 reduce methyl folate production by 60-70% with two thymidines, 20% with one.*
05:02 *🧬 Variant at position 1298 affects SAMe binding, possibly slowing enzyme function by 20%.*
07:21 *🤰 Medical interventions during pregnancy can increase prevalence of MTHFR variants, impacting offspring's health.*
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Wow
Thank you!
Never thought about it this way, although I always wondered about the mathematics of transferring more insufficient variants to the next generation. Thanks Ben!
Dr Lynch, ur Awesome, thanks for continuing education of this, especially as I’m Just discovering it ! As I research this, and figure out finances for supplements and test,, I’d also like to know your thoughts on the Methylene Blue micro dosing, per say, that is also very interesting, and how it may or not be connected. Thank You Sir !
Dr. Ben Lynch, I have both C677T and A1298C like you. Trying to to work out what's going on with my health and what I'll need to do!
Same. I am wondering what % reduction we have with this combination?
Just found out my daughter has hyperhomocysteinemia according her genome, C677T homozygous. So my question is why would a low protein low meat diet be recommended? I’ve read that meat will raise her methionine, but it also the source of the B vitamins she needs. What kind of protein is ok then?
Homozygous MTHFR C677T plus folate transport mutations. My folate levels were bordering on the levels that can cause megaloblastic anemia. I'd been unable to take folate, even crumbs (tried for a couple of years), without serious side effects. Then I stumbled onto some magnesium I could handle, and when I addressed that issue, suddenly I could take folate and avert that one health crisis. I have to take 400mg daily or I get hangnails very quickly (a sign of a folate deficiency)... missing just 3 in a week will result in this sign. Had them my whole life and could never figure out why my fingers were always painfully peeling like that.
the info you shared about hangnails is very interesting. I did the 23andme swab 10 years ago & then had MTHFR tested thru bloodwork. I have 2 SNPs, one 677 & one 1298. I have had weak fingernails all my life (now 70) & some issues w hangnails. I would be interested in the form of magnesium that you now take as there are at least 10 forms. You mentioned about anemia, well……my hemoglobin & hematocrit are too high but my ferritin is ok??? Any ideas are welcome😊
My 3x4 genetics report says I have 1298A>C result AC. So no idea if that is different that what you are discussing. I wish there was a standard for these terms/variants. Same for in your book and you say GST/GPX and yet I have GSTM1 snips, GSTP1, GSTO2, GPX1, GSTP1. All very confusing unfortunately and also understandably.
hi dr ben do you think the mthfr gene is more predominate in european people rather than hispanic or other ethinic people thanks
I have the E429A per genetic testing but i don't see too much info online when i try to research it. My genetic testing does indicate I can take Methl B vitamins to counteract.
My genetic testing also revealed I tested high for severe combined immunodeficiency disease. The reason I did this testing on my own was because of my family history of cryptogentnic Liver disease and autoimmune diseases. I lost my mom, aunt, uncle, grandmother to this Liver disease without any answers. I was sick a lot as a kid with multiple uti's, sicknesses, lung infections. Fast forward I've been diagnosed with stage 2 liver fibrosis and 5 autoimmune diseases. My uncle has crohns and other issues but is still alive on my mom's side. The problem is I can't get any of my Dr's to do the genetic testing or even listen to the fact that I did.
Umm... Would the left hand be considered the standard blueprint in use?
Dr. Lynch, is it theoretically possible that high estrogen due to the MTHFR polymorphism causes Pubertas precox, thanks, Dr. dent med Goran Bras?
not familiar - haven't looked into it
Hey Doc, have you ever weighed in on using creatine to bring down homocystine levels? Asking for a friend.
In theory, it should work but I don't have evidence. If one already has sufficient creatine levels, then taking more won't help. Phosphatidylcholine may help instead as that also is a big homocysteine producer during the production of it. I'd look into Homocysteine Nutrients or Optimal PC.
@@DrBenLynchIs Creatine measured in a standard blood panel? My homocysteine runs high (currently around 15). I have taken Homocystex Plus off and on for several years but can’t get it down to around 7. Looking for answers.
Have you tried TMG?
Can you take TMG Betaine if you have either one of these genes?
you dont supplement based on SNPs - you supplement based on need. SNPs identify vulnerabilities - they don't dictate them.
The answer is yes you can. Track homocysteine with blood tests. Aim for about 7 or 8. Also methyl B vitamins help as well especially B12.
@@chrismyers9951 thank you 😊
I am homozygous for 3667, I tried TMG and it helps with anxiety. I started getting some ringing in the ears.
Why would supplementation during pregnancy make someone more susceptible to genetic variations?
He is saying that the supplementations are what is allowing the babies to survive to term, but because they already have the variations they will struggle with the downsides of them through life. They would have otherwise most likely not survived to term without the supplementation support.
@@tinad6812My neighbor had never heard of MTHFR……her daughter had 10 miscarriages & finally had 2 kiddos that are now teenagers.
Why not just take DMG or TMG both methyl donors to process folate if you have the mutation? DMG has 2 methyl donors, TMG has 3. DMG has even been documented to help with autism. Research DMG's history it's an interesting supplement.
Not everyone can tolerate them - they are hard core. Remember, it’s about the sum total of SNPs, not just any one in particular
*promo sm*
wow-that was new to me - kind of Darwins theory how the population going to get more and more sick by every generation etc