Introduction to RANKL | RANK | OPG Signaling Pathway

Lesson on the RANKL / RANK / OPG Signaling Pathway: Purpose and Mechanism. The RANKL-RANK-OPG Signaling pathway is an important pathway in bone remodelling and is important in various osteopathies such as osteoporosis. Osteoblasts are bone forming cells, which express and release the protein RANK ligand (RANKL) and osteoprotegerin (OPG). RANK ligand binds to the RANK receptor, which is located on bone absorbing cells known as osteoclasts. RANK ligand binding to RANK receptor leads to the differentiation and activation of osteoclasts. Activation of osteoclasts enables them to reabsorb bone to ensure bone remodelling occurs.
Hey everyone. In this lesson you will learn about the RANKL-RANK-OPG Signaling Pathway, its purpose in bone remodelling, and the various downstream signaling targets of the pathway, including PI3K-AKT signaling, JNK signaling, and NFKB signaling.
I hope you find this video helpful. If you do, please like and subscribe to keep up-to-date on my newest videos.
JJ
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
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Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
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Thanks for watching! If you found this video helpful, please like and subscribe!
JJ

[@theronlauren411]

I am a pharmacy student with a background in molecular biology. Your content is so comprehensive and detailed that every time I have a question or consideration, it gets addressed within the next few seconds of the video. Thank you, this is excellent.

[@sercibosvb8341]

Came across this video through Google. I am a Brazilian family doctor. During my private review of Denosumab as a whole I learned about your channel. My first experience with it made me become a fan. It will become along with Medscape my source of study. Your archive is vast and the way you go through the subjet makes learning as easy as learning math with a good teacher. Thanks.

[@bunclip]

Very nice and clear explanation of the RANK and RANKL mechanism. Thank you so much ❤❤❤❤❤

[@xhuljanoshehu4399]

Great video!
simple, clear! Thank you!

[@sujatapanthi83]

Important steps in pathway
2:29
3:00
3:44
4:28
4:55
7:13

[@mohamedgadelkarim7968]

Nice explanation! Good job!

[@lorenaml]

Thanks for this explanation!!!

[@ondrejpetrka1283]

Great explanation! thank u

[@halimcremer]

omg! thank you!!!

[@mahuubao]

Excellent ... well done ...

[@sarahsahibqran2198]

Thank you so much, this is so amazing please keep the great videos coming

[@CCzhang-xz6kf]

wonderful！！！

[@usmanshami5604]

very well explained

[@edwardmaximus5439]

Never would've thought osteoblast/clas went through a complex process of bone remodeling

[@abdulrahmanomar3443]

Will... now u know.
go and thank them for the great job they're doing

[@dr.durmohammadlashari6037]

very informative video

[@donarnold8268]

Thank You!

[@jjmedicine]

You're very welcome! Glad you liked it :)

[@rhondamaza8598]

I just had a patient with hard bright white super thick bone from Prolia. I can see why some could get the necrosis instead though.

[@touseefbeig915]

Nice Sir

[@mdneha1432]

Thank you so much 😊

[@jjmedicine]

You're welcome 😊

[@ChristopherDobson-dt9km]

Thanks for a great talk. Is there any paradox between the anti-bone resorptive action of osteoprogerin and its putative anti-calcification effects in blood vessel walls?

[@world1923]

Super explanation

[@jjmedicine]

Glad you liked it

[@rudramadhabmohanty3822]

JNK ,fos, jun these are the death promoting pathway ,how they are involved in cell differentiation?

[@n4nn3rss]

how did they figure out all this stuff. medicine is such a meme I love it

[@brigettetreloar717]

what type of receptor is RANK?

[@kamrankhan-en1if]

Is this osteoporosis cascade pls?

[@rewantharwat2095]

Yes