Pentose Phosphate Pathway - Regulation, Purpose and Importance in Human Health
Vložit
- čas přidán 6. 04. 2017
- Video lesson on the pentose phosphate pathway (hexose monophosphate shunt), the purpose of the pathway and the importance in human health.
Hey guys! In this lesson, I talk to you guys about the pentose phosphate pathway, what the purpose of the pathway is, how the pathway is regulated, and why the pathway is so important in human health and some health conditions that can arise from problems in the pathway.
If you found this video helpful, please like and subscribe for more lessons like this one! :)
Subscribe for more free medical lessons / @jjmedicine
Please help support this channel and future lessons by becoming a patron (and get some cool stuff) ➜ / jjmedicine
-------------------------------------------------------------------------------------------------------------
Try Audible and Get A Free Audiobook (great for studying some topics!)
www.amazon.com/dp/B00NB86OYE/...
For books and more information on these topics
www.amazon.com/shop/jjmedicine
Follow me on Twitter! ➜ / jj_medicine
Come join me on Facebook! ➜ / jj-medicine-1006426481...
Start your own website with BlueHost ➜ www.bluehost.com/track/jjmedi...
Check out the best tool to help grow your CZcams channel (it’s helped me!)
www.tubebuddy.com/jjmedicine
-------------------------------------------------------------------------------------------------------------
Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
• Medical Terminology - ...
Fatty Acid Synthesis Pathway:
• Fatty Acid Synthesis P...
Wnt/B Catenin Signaling Pathway:
• Wnt/β-Catenin Signalin...
Upper vs. Lower Motor Neuron Lesions:
• Upper and Lower Motor ...
Lesson on the Purine Synthesis and Salvage Pathway:
• Purine Synthesis and S...
Gastrulation | Formation of Germ Layers:
• Gastrulation | Formati...
Introductory lesson on Autophagy (Macroautophagy):
• Autophagy | Macroautop...
Infectious Disease Playlist
• Infectious Diseases
Dermatology Playlist
• Dermatology
Pharmacology Playlist
• Pharmacology
Hematology Playlist
• Hematology
Rheumatology Playlist
• Rheumatology
Endocrinology Playlist
• Endocrinology
Nephrology Playlist
• Nephrology
----------------------------------------------------------------------------------------------------
**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
----------------------------------------------------------------------------------------------------
Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ
Brief summary:
PPP drives the formation of reducing agent, NADPH (used in fatty acid synthesis), and pentose sugars which are used for glycolysis and nucleic acid synthesis.
Glucose-6-phosphate, catalysed by enzyme glucose-6-phosphate dehydrogenase, reduces NADP+ into NADPH. The final net result of this oxidative branch pathway is ribulose-5-phosphate and 2 NADPH molecules.
Ribulose-5-phosphate can get converted into xylulose-5-phosphate which is further converted into fructose-6-phosphate. Fructose-6-phosphate is utilised in glycolysis where glucose is broken down into pyruvate to generate ATP.
Ribose-5-phosphate is also used for the production of PRPP which determines pyramidine and purine nucleotide synthesis.
This process mainly occurs in the liver and adipose tissues where NADPH can be utilised to donate electrons required for fatty acid synthesis.
PPP is regulated by the activity of glucose-6-phosphate dehydrogenase where NADPH can allosterically inhibit its activity at high concentrations.
Amazing video. Clear, concise, and easy to understand. Thank you!
Thanks so much for your videos! It's really helpful to have as an extra resource.
Great video. Super helpful for my Biochem class, cheers and keep up the good work
thanks! relating the mechanism to its purpose in the bigger picture is really helpful.
not a medicine student but a biotechnology student and wow bro you always save me in the
last minute. you're heavenly sent
👌
Beautifully concise and informative.
Saved my night god bless... it was soooo helpfull
This makes biochem so much more bearable. Thanks!
hopefully ill feel the same one day
You're a legend man. Thanks a lot
Very interesting and understanding. Thank you!
Absolutely love your way of teaching!!❤❤
You did justice to this video. Thank you so much!
You're the best. Thank you, very easy to understand.
it was helpful, thank you so much
Love the video.brief and helpful thnx
Very helpful! Thank you.
Great lecture!
thank you so much. It is so clear.
Thank you bro. Very helpful!
I think it would be much easier to follow along if you also presented the chemical structures of the starting materials, intermediates and products. I think this would help with understanding, vs just cramming. Thank you for your videos.
U rock! thanks for the video
Very helpful !!! Thanks a lot... 👍
This makes biochemistry much easier to understand.
Thank you ... Have a great day
thanks you.very informative class.
Thanks so Much ...you saved My day sir
Thank you for this ❤️🤍
thank you sir!
Explanation is 2 good❤️
Thank you JJ for all your amazing videos!! It would be great if you could do a lesson on the areas of the brain that lack a blood-brain barrier (I think circumventricular organs.. hypothalamus, etc.). A lot of people I ask at my university do not know much about the areas of the brain that lack a BBB and their physiological functions. I would love to learn more myself on this topic and it would be much appreciated if you were able to make a video. Thank you either way!
Babies with high and prolonged jaundice do not have the BBB and within the first week of their lives, they can go from being born perfectly healthy to severely brain damaged. Kernicterus, sadly destroys a child. The mothers of these children say they can't even look at their baby's first days, and most have PTSD from the disaster. Women go home and THEN the jaundice hits, some doctors even downplay it. This is not part of newborn testing in most of United States.
This really helped me with my class 11th finale exams thank u 😁
thank you jj
I have Mediterranean variant; I have almost no g6pd. Every time I have surgery, I go into hemolytic anemia. It is X recessive, but due to lyonization, someone like I, can be very fragile and react with the slightest oxidative stressor. I was just in the hospital requiring transfusions because I pet a dog that had just gotten the flea and tick ointment administered on their neck.
Clinically so relevant... Thank you
Excellent
Thanks!
thanks a lot
Thank you for your effort it’s really helpful & simple✨ but why don’t you involve the remaining of the non oxidative part of the pathway
Thank you for reading, and giving me the chance to comment 😊
You are the best
Kia bt hai bhai
Nice explaination.Can you tell me by which enzyme Glucono -1,5- lactone 6P was converted into 6- phosphogluconate ?
Lactonase
@@JackeelG more precisely 6-Phosphogluconolactonase
Hahaha
From G-6-PO4 (g6pd) - 6phophogluconolactone (GLUCONOLACTONE HYDROLASE) - 6phosphogluconate (6phosphogluconate dehydrogenase) - Ribulose-5-PO4........
Thanks very interesting. I'm just wondering if you can explain why the supplement d-ribose which works on the PPP pathway is used to increase ATP as apposed to just glycolysis.
ppp occurs in the cytosol of the cell
Those in Africa have the A- variant, which is very mild.
Gluc-G-6-PO4-(g6pd)-6phosphogluconolactone (gluconolactone hydrolase) - 6phosphogluconate (6phosphogluconate dh) - Ribulose5PO4 (ribulose-5-PO4-3-epimerase) - xylulose-5-PO4 (transketolase) - ribose-5-PO4
Where did you got your source?
helpfull for usmle
a question; is the reaction at which Fructose-6-Phosphate , erythrose-4-phosphte and xylulose-5-phosphate part of the cycle or it ends where you finished it?
btw amazing video! You helped me alot sir
all 3 pentose sugars are converted back to hexoses after non oxidative phase. 6 molecules of pentose are converted to 5 molecules of hexoses.
Are you sure that xylulose 5 phosphate can be converted to fructose 6 phosphate? i think its incorrect
fantastic video, that ad in the middle killed my flow though :-/
If you pay for Premium you wont have ads...best investment ever ;)
Nice but how does it prevent oxidative stress
by making glutathione that converts h202 into h2o
Why is it called anabolic rather than catabolic 6 carbon glucose is converting into 5 carbon
💗💗💗
8:23: Glutathione = GLU-TA-THIONE
It’s not really clear I mean the picture quality
Hjk
you are so confused on teaching- guys go to NINJA NERD instead
This makes biochemistry much easier to understand.