How does your body process medicine? - Céline Valéry

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  • čas přidán 14. 05. 2017
  • View full lesson: ed.ted.com/lessons/how-does-yo...
    Have you ever wondered what happens to a painkiller, like ibuprofen, after you swallow it? Medicine that slides down your throat can help treat a headache, a sore back, or a throbbing sprained ankle. But how does it get where it needs to go in the first place? Céline Valéry explains how your body processes medicine.
    Lesson by Céline Valéry, animation by Daniel Gray.

Komentáře • 1,4K

  • @FizanAhmed
    @FizanAhmed Před 7 lety +6747

    Probably the best and simplest explanation of pharmacodynamics I've ever seen. Brilliant. Thanks.

    • @LadyEpsilon
      @LadyEpsilon Před 7 lety +62

      Fizan Ahmed ikr, I just took a pharmacology course and watching this is like a mini abstract

    • @WeArePharmers
      @WeArePharmers Před 7 lety +94

      Wouldn't this be considered more pharmacokinetics than pharmacodynamics?

    • @FizanAhmed
      @FizanAhmed Před 7 lety +45

      Not a pharmacologist, but pharmacokinetics is how the body affects the drugs (the liver enzymes turning the drugs into metabolites) whereas pharmacodynamics is how drugs affect the body (the mechanism of blocking pain) so I guess the video has a bit of both?

    • @WeArePharmers
      @WeArePharmers Před 7 lety +60

      I'm not a pharmacologist, but I am a pharmacist. What I remember from school is that pharmacokinetics involves the ADME processes (absorption, distribution, metabolism, excretion), whereas pharmacodynamics involves the mechanism of action.
      You are right that there is a brief mention of mechanism. However, the video focuses more on how the drug molecules move after ingestion and less on how the medicine works (i.e. COX-1 and COX-2 inhibition).
      ...and I've officially nerded out on CZcams XD

    • @FizanAhmed
      @FizanAhmed Před 7 lety +18

      WeArePharmers Yup, you really have nerded out but don't worry, you're in good company. Also, you're right. It does focus more on the pharmacokinetics side of it. Thanks.

  • @Naanisdabomb
    @Naanisdabomb Před 7 lety +6906

    Lmfao this was posted 44 seconds ago and someone already disliked it.... calm down bruh you haven't even watched the video 😂😂

    • @nel6745
      @nel6745 Před 7 lety +537

      savage hater XD

    • @boynedmaster
      @boynedmaster Před 7 lety +23

      e

    • @Jordan_Dossou
      @Jordan_Dossou Před 7 lety +149

      Senaca Gardipee lol frm there are just trolls that have nothing better to do...unless he tapped dislike by avciddmt4

    • @awekeningdragon7524
      @awekeningdragon7524 Před 7 lety +56

      Senaca Gardipee no he/she must have mistaken it for a fistbump button.

    • @AnupBhatt
      @AnupBhatt Před 7 lety +55

      These people would dislike nudes from Scarlett Johansson....grumpy cats or Ron Swansons :P :D

  • @Rukiachan05
    @Rukiachan05 Před 2 lety +1251

    So much respect for doctors, scientists, and just modern medicine for their contribution to the world 👏🏼

    • @hafeezhurrahmaan3162
      @hafeezhurrahmaan3162 Před 2 lety +54

      All praise to the lord who gave us this kinda intelligent complicated system in our body

    • @thetrollslayer3716
      @thetrollslayer3716 Před 2 lety +1

      And still we can't cure common cold. Greek and Herbal medicine are much more effective.

    • @musicmaniac257
      @musicmaniac257 Před 2 lety +1

      p7

    • @t-t2459
      @t-t2459 Před 2 lety +3

      @@musicmaniac257 maybe theres no direct treatment because of the many kinds of viruses that cause it

    • @AmidaNyorai48
      @AmidaNyorai48 Před 2 lety +1

      😯

  • @hollyleafwell2118
    @hollyleafwell2118 Před 7 lety +1648

    I learned way more in this 4 minute video than I did doing two years of biology in high school

  • @brunomiranda9100
    @brunomiranda9100 Před 7 lety +338

    I fucking love how you guys turn complex subjects like this into simple and interesting animated videos

    • @Jackgritty28
      @Jackgritty28 Před 2 lety +3

      Is it designed to cure a disease, read the instructions on the label, age and diet could be blame💊

  • @AbudBakri
    @AbudBakri Před 7 lety +3981

    My poor, poor liver

    • @miyo7376
      @miyo7376 Před 7 lety +79

      You seem to be in the comments of every science video on CZcams 😂. Great videos btw!

    • @aClovey
      @aClovey Před 7 lety +23

      I see you everywhere

    • @DanielHarris579
      @DanielHarris579 Před 7 lety +7

      Dr.StickFigure ubiquitous one

    • @ChrisPPotatoIDC
      @ChrisPPotatoIDC Před 7 lety +21

      ( ͡◉ ͜ʖ ͡◉) My poor, poor puss

    • @siddharth8184
      @siddharth8184 Před 7 lety +17

      you again

  • @KennethSee
    @KennethSee Před 4 lety +396

    Not a medical professional or student. Just a sick guy at home curious about how this works. Fantastically simple explanation. I'm sure there is more nuance I'm gonna miss but this answered my questions. Thanks for the video!

    • @reagan_ruth7117
      @reagan_ruth7117 Před 2 lety +1

      What are/was sick with?

    • @KennethSee
      @KennethSee Před 2 lety +8

      @@reagan_ruth7117 I had Covid back when it first started. Was a mean bugger lol.

    • @nickjunior9862
      @nickjunior9862 Před rokem +2

      @@KennethSee covid? bro i forgot it was a thing 3 years ago

    • @KennethSee
      @KennethSee Před rokem

      @@nickjunior9862 Yep! I got alpha while traveling in Asia during winter 2019. Laid me flat for like a week and a half haha

    • @danielscarfo3230
      @danielscarfo3230 Před rokem

      Me too 🤣🤣

  • @lyonheart501st
    @lyonheart501st Před 7 lety +579

    dude i didn't know my liver was a pachinko machine............

  • @thivaharanantharajah7864
    @thivaharanantharajah7864 Před 3 lety +34

    Has anyone got that feeling when they're stuck in the Ted Ed loop? LIke, it's so hard ignore a Ted Ed vid in your recommendations and when you click it and finish it, there's always another one waiting for you in the side column. I've already got 2 hours of watching Ted Ed alone... But anyways, thank you so much Ted Ed for answering so many of our biggest questions.

  • @QuaziIrtiza
    @QuaziIrtiza Před 7 lety +583

    My GCSE Biology exam is tomorrow, great video but I'm still panicking. Loved the animation.

  • @MountyDani13
    @MountyDani13 Před 7 lety +211

    This is honestly one of the best (and well explained/simple) videos I think I have ever watched. The animation is excellent and the narration is superb. I now understand how the body processes medicine more clearly now. Thank you.

  • @knocknockify
    @knocknockify Před 7 lety +410

    How does alcohol affects this process? I see warnings not to take medicines with alcohol

    • @42Fossy
      @42Fossy Před 7 lety +153

      knocknockify Alchohol is technically a poison, so while its in your system your liver is working like crazy. So it can't process your medicine at the same rate it would when you're sober and you could easily overdose.

    • @boynedmaster
      @boynedmaster Před 7 lety +17

      uh alcohol is actually a sin so idk

    • @42Fossy
      @42Fossy Před 7 lety +67

      How is alcohol a sin...? Jesus literally turned water into wine once.

    • @bennybateman9942
      @bennybateman9942 Před 7 lety +32

      knocknockify It depends on the drugs you're taking! Consuming alcohol with paracetamol, whose metabolites are toxic, for example, would result in even more toxicity to the liver. But in the case of hypnotic drugs like valium, its respiratory depression effect will be likely be multiplied if taking with alcohol, and that might be fatal. So tl;dr - Alcohol will make what's already bad worse ;)

    • @darksidecola4529
      @darksidecola4529 Před 7 lety +33

      Alcohol is processed in the liver the same way as medicine. Taking medicine while consuming alcohol can overwork and damage your liver.

  • @RAND882
    @RAND882 Před 7 lety +179

    I'm so thankful for this video! I Study medicine and had been trying to process a pharmacology lecture on this topic just now. SO glad I saw this before going to bed

    • @pauleleopoulos7969
      @pauleleopoulos7969 Před 5 lety

      rand kubaysi 9i9090

    • @amarsahu7137
      @amarsahu7137 Před 3 lety

      I am also thank you for the complete comments 😂

    • @jimmyvendor100
      @jimmyvendor100 Před 3 lety

      If you are interested in getting adderall, Percocet, oxycodone, Xanax visit our website/ buymedpharmacy.com

  • @Darsh0019
    @Darsh0019 Před 7 lety +819

    how about a video on how vaccination works?

    • @anonymous-oy4hr
      @anonymous-oy4hr Před 7 lety +79

      Darsh Jalan They introduce a weakened form of whatever illness the vaccine is for and your body's immune system learns how to fight it.

    • @Darsh0019
      @Darsh0019 Před 7 lety +52

      anonymous yeah but still it would be good to see a more detailed version of your answer. Thanks for that by the way:)

    • @anonymous-oy4hr
      @anonymous-oy4hr Před 7 lety +8

      Darsh Jalan No problem.

    • @ID1visor
      @ID1visor Před 7 lety +62

      It doesn't. *grabs popcorn*

    • @Darsh0019
      @Darsh0019 Před 7 lety +1

      D1visor so then how does it work?

  • @jimmybfmv9023
    @jimmybfmv9023 Před 2 lety +79

    Watching it as a pharmacy student, all I have to say is: great video for everyone to understand the basics! Well done guys 💯

  • @raajnishkdas2803
    @raajnishkdas2803 Před 4 lety +47

    This channel provides me with information that I didn't really seek for, but I'm grateful nonetheless to have known it now.

  • @JB-nj7nq
    @JB-nj7nq Před 7 lety +413

    can you do a video on how inuslin works? like when diabetics take shots? i think that'd be so cool ☺

    • @aniluluful
      @aniluluful Před 7 lety +5

      Jacob Braxton that would be fun to watch in a little animation

    • @1RolyPoly
      @1RolyPoly Před 7 lety +3

      along with a video about Celiac disease and how it affects the body when those allergens enter the body. that'd be interesting to see. 👍

    • @lexik4603
      @lexik4603 Před 7 lety +2

      Insulin video would be awesome! I have PCOS and insulin resistance and something about that area would be cool

    • @JoelAtico
      @JoelAtico Před 7 lety +23

      i read it muslim instead of insulin

    • @-CreamPied
      @-CreamPied Před 7 lety +1

      Watch "nucleus media diabetes" it might help you :)

  • @kawaiime4714
    @kawaiime4714 Před 6 lety +54

    Amazing explanation. No one ever said me my body goes through so much trouble for my life and I'm so ungrateful.
    Alhamdulillah ya Rab❤️

  • @hujan5005
    @hujan5005 Před 4 lety +19

    The visuals and the concise explanation with examples made it easy to understand even for the non-experts. It was great.

  • @danielf986
    @danielf986 Před 2 lety +3

    The animation, the music, her voice is so soothing! Amazing job!

  • @MemeApocalypse
    @MemeApocalypse Před 7 lety +95

    I *LOVE* this animation

  • @oldlogin3383
    @oldlogin3383 Před 4 lety +3

    This is one of the best explanatory animations I've seen on anything. Great job.

  • @scottzvidzo5564
    @scottzvidzo5564 Před rokem +1

    This is why I love animated , simplified stuff for complex subjects like these , everybody gets it.

  • @woojungsaeko2062
    @woojungsaeko2062 Před 2 lety +1

    I'm a pharmacy student, n won't go away without watching it even though I've already studied about it

  • @TMicxd
    @TMicxd Před 7 lety +6

    Thank you for the explanation and the illustration. They're very clear and informative.

  • @anthonydecapite959
    @anthonydecapite959 Před 2 lety +8

    I’ve been wondering this forever. How amazing! A very well made video.

  • @azzyup4790
    @azzyup4790 Před 5 měsíci +1

    I find it fascinating the people who created this and proved it worked and be able to explain it step by step

  • @OmkaR-lg2nt
    @OmkaR-lg2nt Před 4 lety +11

    Watching this with a sore throat, imagining how will the medicines help me out

  • @mohammedal-hammadi5085
    @mohammedal-hammadi5085 Před 5 lety +4

    I was searching for this information for several days and I have found it here, thank you so much 😊

  • @LondenPeirce
    @LondenPeirce Před rokem +5

    I have so much respect for all of the medical professionals who save lives and educate their patients every day! God Bless them all!

  • @mahimaaggarwal6015
    @mahimaaggarwal6015 Před 6 lety +10

    It was the simplest explanation of medicine reaction I have ever seen....and probably indelible as well....thank you so much

  • @shaunaaaah
    @shaunaaaah Před 7 lety +6

    Thankyou so much, I've been on medication for my epilepsy for years and it felt like magic. Which I wasn't particularly thrilled with for something so important, so it's nice to know how it works.

  • @roderickmendoza3185
    @roderickmendoza3185 Před 7 lety +10

    that was very informative and simple. Ted Ed you've done it again

  • @hdog9046
    @hdog9046 Před 7 lety +3

    This was something I have always wondered about, thanks for providing an answer!

  • @Acetronomy
    @Acetronomy Před 2 lety

    The animation makes this so much easier to understand, thank you!

  • @Wolf-hd1hr
    @Wolf-hd1hr Před 5 lety +2

    By far,the best channel on CZcams.Every concept,every video gives you something new to learn and cherish

    • @thelanister96
      @thelanister96 Před rokem

      Calm down its not the best channel you are so childish i bet when you see people open a door you are amaze and in awe 😂

  • @woocheongan1437
    @woocheongan1437 Před rokem +3

    Really good explanation, explained the pharmacodynamics in an easy to understand way. During this special period, countless medical workers and scientists have made significant contributions to the world. worthy of respect

  • @laf1493
    @laf1493 Před 3 lety +25

    I don't know if I'm the only one but the reason I'm watching this it's because I sprained my ankle and I took an Advil pill and now I'm watching this to see what it's doing in my body

  • @filipinoarchmage5793
    @filipinoarchmage5793 Před 3 lety

    The fantastic animation made it super easy for me to understand how medicines work.

  • @QueenTheOG
    @QueenTheOG Před 3 lety +4

    Omg i love this, this video popped up just when I needed a simple pharmacokinetic video to study with 😩

  • @linneawestberg6435
    @linneawestberg6435 Před 7 lety +8

    what a lovely animation

  • @davidlloyd3116
    @davidlloyd3116 Před 2 lety +6

    Absolutely brilliant animation. I worked in pharmaceutical industry all my life. Still learned something!

  • @izzybelisle3550
    @izzybelisle3550 Před 6 lety +1

    this video is so beautifully made and the music is peaceful

  • @ThanhTruongNguyen1909
    @ThanhTruongNguyen1909 Před měsícem

    One of TED-Ed's the best illustrations, despite its simplicity. Thanks to everyone who's behind this great educational channel.

  • @kshitij_
    @kshitij_ Před 7 lety +9

    This is very helpful. And love ur animation concept

  • @jerrie1533
    @jerrie1533 Před 7 lety +21

    And now I know, the inside of my liver looks like an arcade game. Thanks Ted-Ed, for sharing your wisdom.

  • @theknockoutladysaint23
    @theknockoutladysaint23 Před 11 měsíci

    Short, simple and informative. I love it.

  • @kenbobca
    @kenbobca Před 7 lety +2

    Very good video. Thank you for explaining the process.

  • @Yarshy.
    @Yarshy. Před 7 lety +4

    Such an exciting time to go into healthcare, I hope personalized medicine comes to fruition in the UK and helps us care for patients better as early as possible! :)

  • @ShAmOxO
    @ShAmOxO Před 4 lety +9

    The way the animator truly represented the amazingly well-oganized incredible machine the human body is was just sublime to me.

  • @durpyrainbowp8405
    @durpyrainbowp8405 Před 5 lety

    Whoever drew every scene of this video. IT LOOKS SO AMAZING!!! BRAVO!👏👏👏👏👏👏👏👏👏❤️❤️❤️

  • @itsmeee7
    @itsmeee7 Před 4 lety +1

    This was very well done, very well explained. Thx!

  • @angelliripalda1203
    @angelliripalda1203 Před 2 lety +3

    watching this as i am on antibiotics every 8 hours, want to know what happens then. thank you! been learning a lot from ted! :)

  • @advancedchemistr
    @advancedchemistr Před 6 lety +4

    Great information and animations

  • @blackswanmotion
    @blackswanmotion Před 2 lety

    Beautifully animated and explained.

  • @hakeemcanonio3840
    @hakeemcanonio3840 Před 5 lety

    Thank you! Very informative and concise video.
    More power!

  • @Baldoxxx4000
    @Baldoxxx4000 Před 7 lety +7

    The animation and music is an amazing art on its own....

  • @tsukitohoshi5934
    @tsukitohoshi5934 Před 7 lety +32

    The Music Is like Im Going on a mall...

  • @michaelcarlos7605
    @michaelcarlos7605 Před 3 lety

    Thanks for the simple presentation

  • @animationpoint4621
    @animationpoint4621 Před 7 lety

    So easy to understand explained!

  • @Wolfy-Edits
    @Wolfy-Edits Před rokem +3

    3:22 I don't think Slenderman needs a painkiller

  • @rtyankeedoodle
    @rtyankeedoodle Před 7 lety +5

    love the animation

  • @kii44malec
    @kii44malec Před 7 lety +1

    Found this video extremely useful and satisfying. Thank you

  • @SugoiGaming.
    @SugoiGaming. Před 4 lety

    Extremely well done animation and explanation

  • @hello0959
    @hello0959 Před 7 lety +9

    Whoa. I loved the animation on this video!,

  • @thenaynaycat
    @thenaynaycat Před 7 lety +58

    What about drugs that affect your brain like to help ADD? (Ex: Concerta)

    • @chloeandjasminecraft9257
      @chloeandjasminecraft9257 Před 7 lety

      thenaynaycat it's slow release and has a tougher inner shell so it dissolves in the system slower

    • @emilysewell3464
      @emilysewell3464 Před 7 lety +7

      Those affect the levels of neurotransmitters during synaptic transmission. eg, people with depression generally have low serotonin levels meaning a low rate of fire for that neuron and so by blocking the selective re uptake molecules that reabsorb serotonin using SSRIs (selective serotonin re uptake inhibitors), the concentration increases and reverses the low serotonin levels, and in turn some of the symptoms. For ADD, adderal and other drugs can be used that block different re uptake molecules that are associated with Dopamine which helps with motivation and concentration.

    • @Pwner-ng3rl
      @Pwner-ng3rl Před 7 lety +7

      thenaynaycat it's better if you don't take it

    • @Albinojackal
      @Albinojackal Před 7 lety +1

      Pwner 1775 lol no

    • @albertvala1333
      @albertvala1333 Před 7 lety

      Gluten does it! celiac.com

  • @ullhastaiyde
    @ullhastaiyde Před 2 lety +1

    This specific topic was something which I was waiting for since ages. Thanks

  • @sandeeppawar8521
    @sandeeppawar8521 Před 6 lety

    Very nicely explained, thank you

  • @Vanderlyle1987
    @Vanderlyle1987 Před 7 lety +6

    the animation on this reminds me of the pinball/countdown cartoon from Seasame Street.

  • @shortvideo9092
    @shortvideo9092 Před 3 lety +9

    Dear people that' reading this, we don't know each other but I wish you all the best in life don't ever blam yourself, accept things and a key for happy life.....

  • @aniruddhabarahate3178
    @aniruddhabarahate3178 Před 7 lety

    Its just grt to get this Simplified Version of this Complex Cycle

  • @Reviewsanphamcuasovang

    I really didn't know that until now, until I watched your video, it's great, thank you for sharing.

  • @longwoolcoat2266
    @longwoolcoat2266 Před 7 lety +4

    Holy fuck this animtion is amazing

  • @nathanricketts2415
    @nathanricketts2415 Před 7 lety +12

    2D has probably learned more about his life watching this than he will in his entire life-time.

  • @theghostkiki1765
    @theghostkiki1765 Před 2 lety

    Explanation was amazing. Thank you!

  • @4ppl3Tr335
    @4ppl3Tr335 Před rokem +1

    Special thanks for your fantastic work!👏

  • @dek5775
    @dek5775 Před 5 lety +6

    0:14 it all happened to me when you just said them.

  • @xiazenchen5551
    @xiazenchen5551 Před 7 lety +14

    Pictures are so cute!😆

  • @Geekypedagogy
    @Geekypedagogy Před 2 lety

    The details and the design in our body is a masterpiece

  • @NitinSharma-bt8yj
    @NitinSharma-bt8yj Před 4 lety +1

    Amazing, fantastic, good job, thanks for the knowledge....

  • @jaydenhpiano5600
    @jaydenhpiano5600 Před 7 lety +16

    Am I the only one who ACTUALLY *ENJOYS* the taste of medicine???

  • @chetangupta5
    @chetangupta5 Před 7 lety +3

    As far as I know , the APIs of Ibuprofen molecule converting to inactive metabolites is termed as 1st pass metabolism. But why some molecule gets converted to inactive while some escape?. How the molecules manage to escape 1st pass metabolism in liver?

  • @chinmaysharma3658
    @chinmaysharma3658 Před 4 lety

    Appreciate TED-ED for this sharing this video.

  • @revahirhama
    @revahirhama Před 2 lety

    Clear explanation .thanks for the wonderful effort on this video

  • @RIFLQ
    @RIFLQ Před 5 lety +3

    Make a video on how good bacteria fights bad bacteria

  • @_22wind53
    @_22wind53 Před 5 lety +12

    I'm having a migraine then i took one pill of paracetamol then I went to sleep,I don't know either with my sleep or that pill that stop myself from the pain.

    • @mrendyman4824
      @mrendyman4824 Před 4 lety

      Naddy Kim u rare

    • @mulliganstew72
      @mulliganstew72 Před 4 lety +1

      Naddy Kim both! But Sleep is king! PS-sorry you have migraines. I have them too, chronically. Therefore I sleep my life away :(

    • @aleena3819
      @aleena3819 Před 3 lety

      @@mulliganstew72 how do you get rid of chronic migraine?

    • @mulliganstew72
      @mulliganstew72 Před 3 lety

      Aleena there is no cure at the moment. Different people have different reactions to some of the “potentially helpful” drugs on the market and some have had great success changing small things like dietary changes or adding yoga to the routine (I can’t help but wonder if they had through chronic migraines or just tension headaches Simply because I haven’t been that lucky). It sucks. I take triptans, lay in the dark hoping to sleep it off. .. & life passes by. Ugh Fingers crossed they come up with something and I am sorry to hear you have them too.

    • @jimmyvendor100
      @jimmyvendor100 Před 3 lety

      If you are interested in getting adderall, Percocet, oxycodone, Xanax visit our website/ buymedpharmacy.com

  • @user-ru3dh5zk5u
    @user-ru3dh5zk5u Před 4 lety

    the intelligible illustration of the video is totally amazing,I cannot find other who is better than ted's

  • @carline_fc
    @carline_fc Před 5 lety

    I love the visualization of this video!

  • @changedname_8970
    @changedname_8970 Před 4 lety +5

    3:40 I can see that happening

  • @shrek4438
    @shrek4438 Před 7 lety +3

    This was a very nicely animated :)

  • @LLLadySSS
    @LLLadySSS Před 6 lety +1

    I've always wondered where does the medicine knows where to go. Fascinating.

  • @fatyymashahzad8175
    @fatyymashahzad8175 Před 4 lety +2

    DAMN. THIS WAS ONE OF THE BEST VIDEOS BY TEDEX

  • @videoloops1
    @videoloops1 Před 5 lety +16

    And that's why the doctor recommends you to rest after taking the medicine! The lesser the heart rate, slower the blood will flow through the liver in a given time and therefore slower it will remove the medicine out of your body increasing it's effectiveness.
    Eureka!!

  • @wissamalhourani2291
    @wissamalhourani2291 Před 5 lety +4

    dude, i was so scared of taking pills and stuff, it feels like putting poisen or unknown chemicals into your body, but now i know its not that bad, thanks.

  • @eefundemonkey
    @eefundemonkey Před 7 lety

    another great video and knowledge TED-ed! thank you!

  • @anujchhabra3660
    @anujchhabra3660 Před 7 lety +4

    very nyc animation. i study medicine. wish they taught us this way

  • @turtleextra4128
    @turtleextra4128 Před 7 lety +17

    But when that 2 hours is up *the pain oh the pain*

  • @sahil3863
    @sahil3863 Před 4 lety +3

    That means painkillers are just stopping symptoms temporarily, not curing the actual problem,

  • @DarthCoco
    @DarthCoco Před rokem

    Now this is a worthy explanation, worth my time.

  • @tuanz8009
    @tuanz8009 Před 3 lety +3

    Does medicine affect in your body permanently or it will go away after a few days?