DHT blockers, testosterone & the relationship with hair loss | Parsa Mohebi, MD

If you are experiencing hair loss and need a consultation, we have a resource on the website where you can find a doctor by location: ishrs.org/find-a-doctor/
In this video, Dr. Parsa Mohebi explains the relationship between Testosterone, dihydrotestosterone (DHT) and hair loss. DHT is a potent androgenic hormone derived from testosterone that plays a key role in the development and maintenance of male sexual characteristics and is also associated with various physiological processes in both males and females.
DHT is linked to hair loss because it binds to hair follicles, leading to their gradual miniaturization and shortened growth cycles, ultimately resulting in the thinning and eventual loss of hair in individuals genetically predisposed to this process, especially in conditions like androgenetic alopecia (male-pattern baldness and female-pattern baldness).
Note: Herbal DHT blockers haven’t been proven to be as effective as Finasteride. So it is always best to discuss this with your doctor.

[@Jim-oc3sp]

I've been taking dutasteride for 14 months and I'm still losing ground. I've also been taking oral minoxidil at 5 mg during the same time frame. So does that mean my body is simply making too much DHT and is overpowering Dut?

[@skepticthegreat979]

Dutasteride combined with oral Minoxidil is the gold standard to stop hair loss.
How many milligrams of DUT are you taking, and how often?
The max dose is 2.5mg per day. At that dosage, 90+% of serum DHT is inhibited... It would be very unlikely that you would still lose ground at that point.
If however, you are EXTREMELY sensitive to DHT or even Testosterone alone, you may also need a topical antiandrogen, like ALFATRADIOL.
In that setting, you will have done everything you possibly can to at least halt your hair loss.

[@Jim-oc3sp]

@@skepticthegreat979 I only take .5mg so might need to consider going up to 2.5mg. But I know that Dut (and Fin) can increase testosterone so could be counter-productive. Regarding a topical antiandrogen, I'm not familar with alfatradiol but I will look into it. Does that have more research and better outcomes than Pyrallutamide and/or RU?

[@Jim-oc3sp]

@@skepticthegreat979 .5/day but might need more. I've been interested in topical antiandrogens such as Pyrl or Dut but since not sold in US, haven't taken that step. Isn't Afatradiol a 5 alpha reductase inhibitor?

[@tbg750]

Cap.

[@vikrantthakur5136]

Why

[@stevencamp1]

Type shi 😭