The Most Discussed Question in ANS Pharmacology: How Does Norepinephrine Cause REFLEX Bradycardia?
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- čas přidán 23. 09. 2022
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Why Norepinephrine Causes Reflex Bradycardia:
The norepinephrine does not have β2 activity, which tends to decrease blood pressure. So with unopposed α action, there is a marked rise in blood pressure. This rise in blood pressure, reflexively inhibits the heart, leading to bradycardia.
Dr Vipul Navadiya
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Awesome! Thank you!
reallly great explanation!
Thanks! really good content.
Well explained.Thanks a lot.
Baro receptor in brain stimulated to protect heart from Over stimulation of NE. Reflex action activate Parasympathetic neuron (M2) agonist at heart which reduce heart rate producing reflex bradycardia.
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Great Video!
I was legit confused.thankyou so much
Very well explained
Much appreciated❤😊
wow this is really amazing Thanks a lot
Should have used Phenylephrine as an example instead of Norepinephrine. Since it is alpha 1 and alpha 2 stimulation without beta receptor stimulation, the reflex bradycardia is significant. With Norepinephrine, the beta 1 activity usually negates the bradycardia or at least minimizes it.
But that will not explain how norepinephrine produces reflex bradycardia in spite of having β1 action. So, taking norepinephrine addresses both.
@@NonstopNeuron I get what you’re saying but I disagree. If you’re trying to explain reflex bradycardia then phenylephrine does so better. My opinion. But appreciate the content.
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