Dust mite allergens in the human GI tract: a potential contributor to intestinal barrier dysfunction
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- čas přidán 16. 05. 2016
- Read the full paper here: gut.bmj.com/content/65/5/757.long
To cite: Tulic MK, Vivinus-Nebot M, Rekima A et al. Presence of commensal house dust mite allergen in human gastrointestinal tract: a potential contributor to intestinal barrier dysfunction.
Background
Abnormal gut barrier function is the basis of gut inflammatory disease. It is known that house dust mite aero-allergens induce inflammation in respiratory mucosa. We have recently reported allergen from Dermatophagoides pteronyssinus to be present in rodent gut.
Objective
To examine whether Der p1 is present in human gut and to assess its effect on gut barrier function and inflammation.
Design
Colonic biopsies, gut fluid, serum and stool were collected from healthy adults during endoscopy. Der p1 was measured by ELISA. Effect of HDM was assessed on gut permeability, tight-junction and mucin expression, and cytokine production, in presence or absence of cysteine protease inhibitors or serine protease inhibitors. In vivo effect of HDM was examined in mice given oral HDM or protease-neutralised HDM. Role of HDM in low-grade inflammation was studied in patients with IBS.
Results
HDM Der p1 was detected in the human gut. In colonic biopsies from healthy patients, HDM increased epithelial permeability, reduced expression of tight-junction proteins and mucus barrier. These effects were associated with increased TNF-α and IL-10 production and were abolished by cysteine-protease inhibitor. HDM effects did not require Th2 immunity. Results were confirmed in vivo in mice. In patients with IBS, HDM further deteriorated gut barrier function, induced TNF-α but failed to induce IL-10 secretion.
Conclusions
HDM, a ubiquitous environmental factor, is present in the human gut where it directly affects gut function through its proteolytic activity. HDM may be an important trigger of gut dysfunction and warrants further investigation.
Another Wow here! I have had dust mite allergy (diagnosed with skin prick test) and gut problems for 30 years. Diarrhea on waking most mornings. Need antihistamines to sleep, itchy roof of mouth. Colonoscopy showed intestinal wall thickening but docs had no idea what caused it. Never considered these two were linked but the evidence is undeniable. I have started my enquires about immunotherapy.
Did not understand anything and did not learn anything. I hope the 3 scientists who heard it learned something.
Hi, I used 3rd generation oral cephalosporins and got prone to dust allergy severely and had an overall decline of my body energy level. The disturbance of gut flora leads to unidentified truths. Gut health is really important and so to limit the extensive use and prescription of broad spectrum antibiotics.
Why is this allergy is not considered as very harmful disease
I got too much troubled by dust mites I really frustrated man!
Same it really made my life bad through out my middle school and high school years
@@iitian9015 make sure to renovate ur walls and floor to concrete u will have less problem with dust mites
100% correct that dust mites cause the problem of gut...
I think, the research is absolutely correct those whose attacks in IBS. I also support your opinion.
Can you please help me figure out a natural treatment for this?
Interesting video. I too have digestive issues & severe dust mite allergies. If i understand this video correctly....you're saying one probably caused the other. Ok.
What's the treatment???????????????
Good hygiene for health, clean the house often, do not have a dog or cat at home where you live. Therefore in Islam it is not allowed to have a dog at home, Dogs also have giant microbes in addition, which are deadly for humans. And not least shower often if you don't wash your bottom after toilet visits.
Ivermectin
Background music is annoying.
well that is an outstanding report ladies
She didn't give a pertinent answer. No specific answer.
What did I just watch exactly ?
what is the treatment please
When I wake up I cough up a lot of thick white and translucent mucous, so much, could it be due to inhaling dust mite waste while I sleep?
That's covid-19 bro, are you still alive ??
Yeah me too for a while. Could be allergy associated with dust mites
@@AceofDlamonds yes it could i also have dust mites allergy
If dust mites get in the gut, can they produce inflammation which mimics flares of chrons disease??
The captions for this video are so off! It's hard to hear what they are saying in English because of the accents and the closed captions are no where near what is being said.
Same here. I understood basically nothing. I only got that there might be a link between IBS and dust mites.
Wow!!! Now it makes since. I’ve always had stomach issues. I was shown to test pos for dust mite allergies. I was also diagnosed with IBS. What are treatments against this? Really I can handle the IBS, it’s normal to me to go to the restroom 2/3 times daily. It’s the sinus drainage that’s hardest on me.
Vitamin D help it
Yep. Vitamin d helped my nasal congestion. But allergy bed covers helped the most
Door mats and kalins have lot if dust mites . Dust mites and Cockroaches are common causes of respiratory, dermal( skin ) and gut allergic inflammation. Prevention of these by reducing exposure is the important.
What treatment does dust mites have in the scalp in Australia nothing shown
I need to know!!! 😢
I am very allergic to dust mites ,and I also have a dx of irritable bowel ,I wonder if I get the allergy from the dust mites in my gut,but how I treated with antisthamins?
hi! thanks for interest... this work is preliminary but you may try to get desensitised by subcutaneous route?...
WeThePrimitives: your not the only one I have asthma and dust mite allergy and I find some days I have a small touch of diarrhoea.
If you are allergic to those critters if you want to just about elenate those we can show you how , you can't get rid of them because we are always feeding them
If you want a solution to the problem let us know and we will show you a solution
Joe Sayers - I was told there isn’t one. That dust mites are everywhere. Only certain pillow case and covers that help a small %
well work best video
I love the second ladies voice she sounds like someone talking in a sci fi Movie ;) Very nice :) & I love how smart you are :)
Thank you. That is very sweet and I will take it as a complement
But….you offer no treatment for ppl who suffer from it 🧐😢🙄‼️
Awesome info
The music makes this video unwatchable.😞😮💨 I'll find the information elsewhere, I guess.
Very much tutorial. Thank you
Good science!
And pretty researchers ;P
Wi la melesiya❤❤❤❤
Umm, what?
Huh?
I feel carpets with fibers should be banned unexceptable in apartment homes , get rid of all kinds of mite's and germs, especially in hot climate conditions.
Couldn’t understand a word
same
Me too.
Irritating, jittery, ghastly music. It is not necessary.
The difficult accent takes 100% highly focused attention - we don’t need the extra irritation of the “music”.
Ewwwwww. They’re in your gut too⁉️