Keeping up with the literature | Special discussion of Masking Evidence
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- čas přidán 3. 05. 2023
- Vinay Prasad, MD MPH; Physician & Professor
Hematologist/ Oncologist
Professor of Epidemiology, Biostatistics and Medicine
Author of 450+ Peer Reviewed papers, 2 Books, 2 Podcasts, 100+ op-eds.
If you want to contact me, do it here: www.vinayakkprasad.com/contact
Google Scholar: scholar.google.com/citations?...
Substack: vinayprasadmdmph.substack.com/
Podcast: podcasts.apple.com/us/podcast...
Personal Website: www.vinayakkprasad.com
Laboratory Website: www.vkprasadlab.com
Podcast Website: www.plenarysessionpodcast.com
Academic Publications: www.vinayakkprasad.com/papers
Follow me on:
Twitter @vprasadmdmph
"I have stock photos of myself in all emotional states." This is the most hilarious thing I've heard all year. I'm freaking dying over here 😂😂😂
😂😂😂
Lol, I bet it's for the thumbnails!
Me too!!! He’s not only a genius he’s hilarious 😂
Genius, hilarious, well spoken… VP is the total package!
Professor Prasad, I loved this discussion. I see why you're a teacher and how you can keep your students captivated.
I so enjoy hearing you in the classroom setting. You're
such a dynamic, engaging speaker with shrewd analyses. 👏
This video, specifically the second mask section, should have millions of views. A great depiction of the truth and what happened with masking during the government mandated lockdowns.
Thank you Dr. Prasad for your wisdom and insights.
Thank you for all of your videos!! You should testify in Canada’s National Citizens Inquiry on Covid. Your perspective would be valuable.
I am not in medicine at all, but enjoy your presentations, dear Sir!
Fantastic presentation, thank you for making freely available
Learned a ton from you over the past few years. Thank you!
Thanks for posting this. Like the idea of being able to learn something from every video and article that will help me be more analytical when presented with so-called 'facts'.
The level of scientific censorship and scientific fraud rarely comes to light, and unfortunately, a familiarity with the literature is of little assurance of an informed individual.
Excellent talk, thanks. For future recordings, you might want to have a mic in the audience and for the host. I couldn't hear the questions. For the most part i was able to figure out the essence of the question from the answer, but it was like dead space in the video.
Man, what a great fkn talk.
Entertaining and informative. Thank you!
Would be interesting to hear what Vinaj did before he was confident about how to do these deep critical reads of studies that often result in conclusion different from source article claims and popular press. Probably will be covered in the future "how to read" series
Well, there are many articles describing his stuffups; here's just a few.
Ref: Dr. Vinay Prasad: “Public Health’s (Mis)Truth Problem”
Ref: It Was Misinformation When I Said Vaccines Are 100% Effective at Preventing Bad Outcomes & Will End the Pandemic
does anyone remember the name of the substack on "how to read" a study? I'd like to subscribe.
He’s making money by keeping conspiracy going strong. How you all fall for his lies is very telling. Sounds like he gets paid by the word he is so eager to go against common sense. If you sneeze or cough infected droplets are travelling at speed into the space around you. It’s common sense and courtesy to keep your germs to yourself.
Keep up the excellent work
Very good video and talk. Cheers from kansas city
Love you Vinay!
Thank you. Excellent pedagogy.
I can't believe I listened through this, till the sweet end, and I am not even a scientist or doctor. It is that interesting.
Vp.
As always, you’re awesome!
Waiting for q0 part series
I love the shaved look!
Men always look better clean shaven. Younger and fresher. And we can seee the Handsome face.
😂
GREAT VIDEO! One key factor that shouldn’t be ignored is the goal of the study: to get a newly developed drug on the market. Doubtlessly, they’d prefer it became popular enough to compete with or even topple top drugs in its class. It’s part of the problem these days with research conducted by drug manufacturers. It’s all too easy to skew statistics to manufacture a desired in the interest of profit.
Thanks a lot for the great talk. Would you also share the slides of this talk ? Some parts of the slides are covered by the video. Thank you so much!
It's good you and Dr. Lyons-Weiler examined the Bangladesh study and pointed out the flaws. Valuable video overall. PS: Have you considered reaching out to RFK Jr. for a talk? I think you possess an open mind and the two of you could make good music together. Cheers.
Fantastic
Can anyone provide a glossary for this vid? For us non-doctors/statisticians.
I know nothing about medicine, but the Sacubitril trial breakdown almost made me pass out
Medscape sends out a ‘What your patient s are reading’ list/recap, weekly I think.
On the other hand, the person who signs up for the mask study in order to get free stuff, might specifically want free masks because they are worried about getting covid and will be hyper-vigilant about calling when they get a symptom.
No beard = younger and fresher.
I like the beard look more but that's just me
I love you dr privey
The ways in which mask usage was enforced was so absurd and inconsistent that it completely convinced me they were useless regardless of any of the evidence.
How many "mechanistic" studies of masks even consider the mechanics of INHALATION? It is completely irrelevant how much exhaled virus makes it into the environment if we are not inhaling particles of various sizes at the same rate. The fact is, larger, wet particles have low air drag compared to their mass, so they have significant inertia and are virtually lubricated against being drawn in when someone is inhaling. The finest particles have lots of air drag and their inertia is low, so they move along with air almost as if they were themselves a gas, which is where the word "AERosol" comes from. It is only the filtration of the finest particles that really matter, and masks are very poor at that.
Even an accurate assessment of the mask filtration of total inoculum in all particles sizes would be a "correct answer to the wrong question".
@@exilius333 How? The masks don't seem to do it.
I remember Vinay's friend Monica Ghandi suggesting a couple of years ago on the ZDogg show that just partially reducing viral load with masks could make a difference in severity of disease, so masking could make people get less sick but still get the full natural immunity benefit, but as I thought that through a bit, I thought that this would only make a difference in those whose immune systems were fast and responsive, the people who weren't going to get severely ill, anyway, and for those with poor immune response, just one lucky virus copy that started a replication avalanche would cause deep illness before the immune response. So, I think, if there's anything to Monica's theory, it's about helping those who don't really need the help, and failure to help those who really need it.
Anyone who doubts what I am saying about particle size/shape/weight can conduct experiments. If you know someone who smokes or vapes (or do so yourself), have the person gently exhale smoke so that it sits close to their face instead of blowing it far away in a narrow channel with velocity, and have them try to suck it back in when the next inhale. The smoke just sits there, like they didn't even inhale, because the only place that there is significant air velocity is right at the openings of the mouth or nose. Any smoke that is more than an inch from the orifice just acts like nothing is happening, even though the volume of inhaled air comes from an area with smoke in it. It takes TIME for particles to start moving at the speed of the air; the more air drag and the lower the mass, the quicker they reach the velocity of the air. Now, try it with a vacuum; surprise, surprise, not much better, even though the vaccum keeps drawing in air at high velocity and does not reverse, like inhalation. Take a water spritzer and spritz it into a beam of light in an otherwise darker room, and put the vacuum up to the visible droplets; again, droplets that are not in the very immediate vicinity of the mouth of the hose do not get drawn in.
Anyone trying to sell you the efficacy of masks based on visual demonstrations of EXHALED droplets either doesn't know what they are talking about, or they know what they are talking about but are trying to trick you. Yes, masks are very effective at catching largish droplets, but that is a solution that has little to do with actual transmission, which occurs mainly with the finest particles. Even an N95 glued to your face at the edges passed a significant amount of the finest droplets, and passes even more when the electrostatic properties of the mask diminish over time from oils and moisture.
❤
How do you explain the difference in number of covid cases between between red and blue states, where red states people are less likely to mask than in blue states?
Did his video that he made 3 months ago answer your question?
Is this an old video or did Vinay shave?
🤷I was wondering the same thing.
@@dedetudor. Kim Thayil gave him a cease and desist order.
@@johnsheehy4192 who?
Fasting is going to lower risk even more, as cancer is really a metabolic disease. Fasting and low carb will have a great effect to prevent this. Some of the many benefits of doing occasional extended fasting: Blood clotting is reduced and blood clots and arterial plaque are reabsorbed into the body. High blood pressure is lowered to normal levels very quickly while fasting. Fibrosis/scarring is reversed over time.
Stomach acid is reduced over time while fasting and can allow for the healing of treatment resistant ulcers, but some patients may need continued acid reducation medication while fasting.
Telomeres are lengthened and fasting also increases anti-aging Yamanaka factors.
Fasting reduces pain and anxiety by stimulating the endocannabinoid system in a similar way to CBD oil.
Fasting stimulates phagocytosis, the ingestion of bacteria, plaques and viruses by the immune system. It will also remove any 'foreign material' that is not supposed to be there.
Reflexes and short term memory are increased.
Fasts from 36-96 h actually INCREASE metabolic rate due to norepinephrine release!
After 72 hours or more fasted, your body recycles as much as 1/3 of all immune bodies and creates new ones, rejuvenating your entire immune system.
Fasting can help with MS, Depression, BPD, Autism and seizures.
Thymus is regenerated, which suppresses aging and renews the immune system. The thymus also plays a vital role in fighting cancer.
Weight loss from daily caloric restriction has 1/4 to 1/3 of the weight lost as lean tissue while many studies show fat loss from 36 h fasts without losing any lean tissue! The hunger hormone ghrelin also lowers with extended fasting and rises from dieting.
Blood sugar and insulin are lowered, allowing white blood cells to move more freely throughout the body and do their job. Some viruses activate glycolosis (the release of sugar in the body) and clinically it has been shown that decreasing glucose metabolism in the body weakens the influenza virus.
When you move out of MTOR your body shuts down the building blocks of the cell which are used to produce organelles and proteins. This means the mechanisms needed by viruses to replicate are by and large unavailable when you are in a deeply fasted state.
What breaks a fast? Anything with protein or carbohydrates in it will break a fast, though if the amount is tiny you will go back into ketosis very quickly. Most teas and herbs are OK. Most supplements and meds will either break ketosis directly or contain a filler that will. Many meds are dangerous to take while fasting.
Does fasting lower testosterone? No, it raises it when the fast is broken by increasing lutenizing hormone. Fasting also increases insulin sensitivity, which helps with muscle building.
Fasts of 36-96 will not affect short term female fertility or affect menstrual cycle. They also may increase long term fertility, especially in women with PCOS.
The hormone Leptin is an immunomodulator that keeps the body from attacking itself and obesity causes leptin resistance. Fasting very quickly reduces leptin resistance and leptin levels and one day of fasting can cut your leptin levels in half and gets your immune system working properly again!
Does the body preferentially prefer glucose as a fuel? No, except for brief periods of very intense exercise, your body mainly burns fats in the form of free fatty acids. Your brain also prefers to burn ketones at a rate of around 2.5 to 1 when they are available in equal quantity to glucose.
Fasting stimulates the AMPK complex and activates autophagy. Autophagy (literally self eating) will cause cells to recycle foreign matter such as viruses and kill cancerous and senescent cells. AMPK does many helpful things in the body including activating the body's antioxidant defenses.
Deep ketosis virtually eliminates chronic inflammation in the body. When not in ketosis, the brain can only burn carbohydrate, which produces a great deal of damaging ROS the brain has to deal with.
It increases mitochondrial function and repairs mitichondrial DNA, leading to improved ATP production and oxygen efficiency and thereby making cells better able to fight off infection. Increased mitochondrial function also has the added benefit of increasing your metabolism and cancer prevention!
When you fast, this stimulates apoptosis in senescent or genetically damaged cells, which destroys them. Senescent cells are responsible for many of the effects of aging and are a root cause of the development of cancer.
Fasting also releases BDNF and NGF in the blood which stimulates new nerve and brain cell growth. This can help a great deal with diseases like MS, peripheral neuropathy and Alzheimers.
Fasting also increases telomere length, negating some of the effects of aging at a cellular level.
A fasting mimicking diet for 3-5 days in a row also provides many of the same benefits as water fasting. FMD usually has 200-800 calories, under 18 g of protein and extremely low carbs.
Exogenous ketones can aid with fasting, making it easier in healthy people and allowing some people with specific issues to fast in spite of them without worrying as much about hypoglycemia.
Children, pregnant or nursing women should not fast for periods longer than 16 hours. People with pancreatic tumors or certain forms of hypoglycemia generally cannot fast at all. Type 1 diabetics can also fast but it is more complicated and should be approached with caution as it could lead to ketoacidosis. Those with Addison's disease may also be unable to fast without liberal use of exogenous ketones, depending on severity. If you experience extreme symptoms of some kind, especially dizziness then simply break the fast and seek advice.
Resources:
www.sciencedirect.com/science/article/pii/S1931312809002832
www.ncbi.nlm.nih.gov/pmc/articles/PMC5895342/
pubmed.ncbi.nlm.nih.gov/31890243/
www.ncbi.nlm.nih.gov/pubmed/10232622
pubmed.ncbi.nlm.nih.gov/31877297/
pubmed.ncbi.nlm.nih.gov/23707514/
clinical.diabetesjournals.org/content/36/3/217
pubmed.ncbi.nlm.nih.gov/27569118/
pubmed.ncbi.nlm.nih.gov/6859089/
www.ncbi.nlm.nih.gov/pmc/articles/PMC1779438/
pubmed.ncbi.nlm.nih.gov/2518860/
pubmed.ncbi.nlm.nih.gov/29727683/
www.nejm.org/doi/full/10.1056/NEJMc2001176
pubmed.ncbi.nlm.nih.gov/23408502/
www.ncbi.nlm.nih.gov/pmc/articles/PMC7607739/
www.ncbi.nlm.nih.gov/pubmed/23876457
www.cell.com/molecular-cell/fulltext/S1097-2765(18)30605-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1097276518306051%3Fshowall%3Dtrue
www.clinicaltrials.gov/ct2/show/NCT04375657
www.cell.com/cell-metabolism/abstract/S1550-4131(15)00224-7
www.ncbi.nlm.nih.gov/gene/25712
www.ncbi.nlm.nih.gov/pmc/articles/PMC7093158/
n.neurology.org/content/88/16_Supplement/P3.090
www.arcjournals.org/pdfs/ijrsb/v3-i11/7.pdf
www.amjmedsci.org/article/S0002-9629%2815%2900027-0/fulltext
pubmed.ncbi.nlm.nih.gov/20921964/
www.ncbi.nlm.nih.gov/pmc/articles/PMC6141719/
www.ncbi.nlm.nih.gov/pmc/articles/PMC6526871/
www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752/
www.collective-evolution.com/2017/05/16/study-shows-how-fasting-for-3-days-can-regenerate-your-entire-immune-system/
www.ncbi.nlm.nih.gov/pmc/articles/PMC2815756/
repository.upenn.edu/cgi/viewcontent.cgi?article=1537&context=edissertations
www.cell.com/cell/fulltext/S0092-8674(19)30849-9
www.ncbi.nlm.nih.gov/pubmed/25686106
faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2019.33.1_supplement.819.10
www.biorxiv.org/node/93305.full
www.ncbi.nlm.nih.gov/pubmed/10859646
pubmed.ncbi.nlm.nih.gov/21410865/
pubmed.ncbi.nlm.nih.gov/28235195/
www.ncbi.nlm.nih.gov/pubmed/24905167
www.health.harvard.edu/heart-health/abundance-of-fructose-not-good-for-the-liver-heart
pubmed.ncbi.nlm.nih.gov/20102774/
www.sciencedirect.com/science/article/pii/S0005272806000223
www.ncbi.nlm.nih.gov/pmc/articles/PMC1413655/
www.nia.nih.gov/news/research-intermittent-fasting-shows-health-benefits
medicalxpress.com/news/2022-10-treatment-pulmonary-fibrosis-focus-telomeres.html
www.ncbi.nlm.nih.gov/pmc/articles/PMC6407435/
pubmed.ncbi.nlm.nih.gov/7714088/
www.ncbi.nlm.nih.gov/pmc/articles/PMC8470960/
academic.oup.com/ajcn/article/81/1/69/4607679
pubmed.ncbi.nlm.nih.gov/25909219/
www.nejm.org/doi/full/10.1056/NEJMoa012908
pubmed.ncbi.nlm.nih.gov/15522942/
europepmc.org/article/MED/22402737?javascript_support=no
onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2265.2005.02288.x
www.ncbi.nlm.nih.gov/pmc/articles/PMC3017674/
This list compiled over years of research by the user known as Pottenger's Human on youtube but feel free to copy and paste this anywhere you like, no accreditation needed!
My channel which will always contain an updated version of this list of fasting benefits on the community tab. I also have playlists on fasting and health topics.
Great stuff! Thanks for taking the time to repost
@@josephshawa thank you!
Wow - very helpful. What would you recommend for a fasting schedule over a month?
@@livingroomc Ideally a 72-96 every month and a 36 every week. But if people did just one 72 h per year it would have a big impact on their health!
not a doctor and i don’t know anything about medical practice ethics soooo please forgive me. But… would not active placebo control be, like, lieing to your patient or something? I dunno how to feel about since I am no doctor, and power of suggestion to get over depression I see as a good from my own perspective
Come on please - I want to see what you got on parachutes!
Come on please - not this tired excuse as to why you don't need to provide the evidence masking does anything significant.
@@stevebryan2446I'm not the one that keeps bringing it up but I do plead guilty to feeding the fire. Ok so how about safety belts - is there anything on that?
@@olibertosoto5470 There actually are, I found one on Google in 5 seconds. Now, if you want to claim an intervention works, you need to provide the evidence. Sorry, dems da rulz.
@@olibertosoto5470 Well there is actual evidence that proves these things work so...
@@henryliciousTo be on the up and up I am interested in any trustworthy study with no aversion to observational studies - but it's likely I'll find a contradictory study to match. Trusting any study these past 3 years is imposible.
While I like seeing you face, could you please place your video next to your slides?
If we're going to do technical critiques, his shutter speed was too fast, too; that's why his motions were jumpy, and he had 8 fingers when he moved his hand quickly.
@john sheehy, your comment is entirely unnecessary. I'm not asking for minor improvements, large chunks of the slides are obscured. If he expects us to think critically about the data presented, we need to be able to see it.
Agree but this sort of thing might also be fixed by moving the face around the screen, sometimes can be done during post-editing. Depends how they recorded it.
@@jevandezande Where did I trivialize your critique? In your imagination, that's where.
An average interview framing usually places a subject in a medium closeup shot. With a focal length of less than 28mm, not only will you have to stand very close to the subject, but if the subject approaches the edges of the frame, it’s quite possible that barrel distortion or keystoning may happen to parts of their body. Facial features can become exaggerated, and that’s usually not desirable.
A Kallikantzaroi without beard!😁🤣😂
at least read the new papers. _JC
the difference between a democrat, a republican, and a decent human being -- a democrat uses central authority to enforce one contemporaneous opinion as the law of the land, a republican suggests local authorities should decide what's best in each area within the bill of rights, a decent human being believes information should be shared with everyone so each can make the right decision for himself and the incompetent under his guardianship...
So…a libertarian? They probably were the most correct in this whole debacle.
@@greglarson6293 a possibility, but not exclusively
“There is a lack of substantial evidence to support claims that facemasks protect either patient or surgeon from infectious contamination.” - Journal of the Royal Society of Medicine. :-)
Is there evidence that the abaluck study was biased, or do the numbers speak for themselves?
Enjoyed this talk
Maybe just ignore associative studies altogether until someone builds up an actual scientific study. There is so much noise in epidemiology you cant see the data because how thick the data is. Too many variables. The moment you ‘correct’ for ANYTHING you invalidate all the data.
I didn't hear them talk about putting patients on exercise. Even as placebo.
But it's not about the patient, is it.
Oh, it is. Its about how many deaths can be caused in the shortest amount of time. Decrease the surplus population.
Your process risks a healthy dose of recency bias. Just sayin. Checking the latest pubs in real time in the elevator?
The influence of drug companies and activists in the process has undermined medicine's credibility. IMHO, doctors need to push back, throw out the snakeoil salesmen, and return to "do no harm." Stick to using well-designed, critically reviewed, randomized studies.
Brah... Why you still talking about masks instead of the unexplained excess deaths?
The talk was about keeping up with literature in general. Very few medical papers are out relating to unexplained excess deaths, since no government wants to fund such research.
I think you can unravel it all through masks or natural immunity
Why chase shadows when you already have enough evidence in front of you
@@krishna-e-bera Exactly. Which is why we need independent doctors/sources to investigate it.
Excess deaths are no mystery -
COVID-19 is associated with higher subsequent mortality risk from heart disease and other causes (high impact)
Delay in emergency care (High impact during COVID-19 and influenza peaks)
Mortality displacement - People who otherwise may have died earlier had their systems been stressed by respiratory disease may now be succumbing to their underlying illnesses (Moderate impact, likely to reduce over time.)
Delay in routine care (Low to Moderate impact, likely to increase over time.)
@@gribbler1695 If this is true, then I would like to see VP post a video giving a detailed explanation including his thoughts on the issue. To my knowledge, he has not done so. He has only made jokes about the people pointing to their dead relatives and friends asking why. Actually suggesting that they are somehow crazy, and that no matter how many bodies pile up, that it's not actually evidence.