L.J. Amaral, M.S., R.D., CSO | Implementing Metabolic Therapy for Cancer | The Metabolic Link Ep.7
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- čas přidán 6. 03. 2023
- On this week’s episode of The Metabolic Link, we’re sitting down with Oncology Dietitian, L.J. Amaral for a fascinating conversation that explores implementing metabolic therapy, such as the ketogenic diet, within oncology. In this episode, we dive into why she started using metabolic therapy for cancer, how she implements it with patients at Cedars-Sinai, and the kind of results she’s seen in using it. We also cover some of the most difficult obstacles in starting a ketogenic diet in the face of a cancer diagnosis, and how Amaral helps patients overcome such challenges.
L.J. Amaral, M.S., R.D., CSO, is a Clinical Research Dietitian who is board certified in oncology nutrition. She works at the Cedars Sinai Cancer Institute in Los Angeles, CA. She is involved in many clinical trials looking at diet/lifestyle within cancer, such as researching the efficacy of the Ketogenic Diet as an adjunct to standard of care therapy for CNS malignancies. Amaral specializes in cancer nutrition for cancer prevention, during treatment, for survivorship, in therapeutic Ketogenic diets and in oncology nutrition research and hosts Nourishing Nutrition Kitchen weekly on social media where she makes easy, cancer fighting recipes.
Over the years, L.J. Amaral has worked alongside Cedars-Sinai Neurooncologist Dr. Jethro Hu on clinical trials exploring the safety and utility of the ketogenic diet in brain cancer. If you’d like to learn more about their research, we’re offering a complimentary access to Dr. Jethro Hu’s lecture entitled “The Ketogenic Diet for Brain Tumors: A Phase 1 Trial and Beyond” for a limited time (available March 7th - 12th, 2023).
Sign-up to watch Dr. Hu's full presentation for free here: www.eventbrite.com/e/55616832...
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Professor/Dr. Thomas Seyfried has been doing massive research and leading the charge in this area. He's quite brilliant.
I agree. Dr. Seyfried does have procedures and results and has shown the cause of cancer growth in 100% of cancers. Many people think they're on keto but aren't. He developed the GKI to measure if a person is actually in keto. I would curious what the people speaking in this video think.
Keto for treating cancer has been around a long time, dr. Bosworth used it for her mom and she has a ratio of glucose to ketones that you want to achieve. Dr. Siegfried has been talking glutamine blockers and keto. Others are talking about the need to keep insulin low to limit growth factor. These are all somewhat related.
Reducing MITOCHONDRIAL IRON POOL ( inner membrane) May Stop CANCEROGENESIS, through improving Epitelial abd ESTROMAL INSULIN RESISTANCE, REDUCING ONCOGENE MTOR. IRON LOAD IN MITOCHONDRIA CAUSE CANCER, A MITOCHONDRIAL, NOT NUCLEAR DISEASES.
Wondering why you are not working with Prof Thomas Seyfried?
wondering the same thing
Probably cause Seyfried is trying to replace the standard of care that is killing people with complete metabolic treatment.
Seems they are working to improve and lessen the harm of chemo and radiation by diet changes only, which misses the depth of metabolic treatment of cancer.
Both will converge eventually, but Seyfried is way ahead of these guys in his understanding of cancer and root causes.
My thoughts also.
The source and font of knowledge for ketogenic approach and the biochemical explanation of why it is effective for cancer is Dr Thomas Seyfried. He has unlocked the pathway of how it can work via his extensive work on mitochondria. Dieticians and nutrition experts seem to be limited in where they access their information. Seyfried has a track record and has published papers for 9 years or more. Dig deeper for answers. I am a lung cancer survivor, 8 years. I found all my information via u tube, especially Seyfrieds papers on ‘Cancer as a metabolic disease’ this should be essential reading for dieticians. I am merely a 78 year old housewife, lucky to be educated in a system that valued critical thinking.
@@Unsensitivechemo is barbaric
No mention of the researcher Professor Thomas Seyfried of Boston College who has done and published a lot on this subject over the last 30 years. Little to no mention of the 2 tumour foods i.e. glucose and glutamine but still poisoning the patient with chemotherapy and or X-ray radiation as per the standard of care (I do appreciate that autonomy is not permitted when it comes to the standard of care).
Cancer metabolism can use glutamine when glucose is restricted. To restrict glutamine as cancer fuel, the following natural extracts can be effective : curcumin, EGCG, quercetin and berberine.
@timespasttelevision and it's somewhat toxic too
@@charmainekirk1512 but way more effective as a glutamine antagonist than we know.
Fix the diet early by eliminating vegetable/seed oils and other factors to preserve mitochondrial health, and these are unnecessary.
@Times Past Television and 1125$
@Times Past Television ...yes! Any idea where and how to obtain this?
Professor Thomas Seyfried is the mastermind behind metabolic oncology!
Prof Thomas Seyfried in Boston has already done 40 years of testing on this. 40 yrs! So you sound clueless. How don't you know about his 40 yrs of testing on diet & cancer & especially KETO. And if you are clueless almost all Cancer sites must be the same. And SeyFried went to all those big Cancer Hospitals and he says all ignored him over the yrs. Very very odd.
What a kind and caring person . She is exactly what we all need for a physician. Wish she was here in Boston.
Thank you ladies 💖🍀💖🍀
What is missing is this - cancer metabolism can use glutamine when glucose is restricted. To restrict that, the following natural extracts can be effective : curcumin, EGCG, quercetin and berberine.
Yes so true. Also Garlic, alpha lipoic acid, IV vitamin C, Hydroxy citrate, ashwaghanda, tocotrienols, Vitamin k2 mk4, medicinal mushrooms and Cinnamon all seem to be beneficial too.
I learn more from the comments sections than the videos most times. cancer patients are the most well read, most informed most educated on their own disease. I know all about dr. Seyfried. I also knew about ashwagandha root and that is what I've considered using. but my oncologist's insist that ashwagandha root interferes with the estrogen suppressing drug that I am on that I should not use it because it raises testosterone, or something like that. so it's nice to have another list of about 10 things to try. thank you for that.🎉
and then to go kill the cancer you must eat broccoli and all the cruciferous vegetables you can find. I wonder if vitamin b17 also could deliver a killing blow to cancer. because we are unable to get the DON we need.
just nailed it .thank you .please write more option i can give to my father lung cancer patient, any dose recommendation.????? pls share more glutamine inhibitors
Ashwagandha and ginseng are worth considering as extras; and also CBD / hemp seed oil@@komalchaudhary16
Professor Dr. Thomas Seyfried has been doing this research for over 30 years- and they don't even mention him and his massive amount work done on this topic. Sorry had to move back to more info from Dr. Seyfried studies!!!!
Agree
My husband, 49 yo, was diagnosed in May 2023 with Glioblastoma Multi Formme. Like you said… everything was normal, he has a seizure at work and MRI shows tumor. Crainiotomy 5 days later diagnosed GBM. Our life has been turned upside down. He is doing conventional treatment alongside Metabolic therapy with a RD. Thank you for sharing this interview.
I wish you and your husband all the best, I know it can be a very trying time.
My mother, 92, diabetic, decided to try the low carb, almost keto, during palliative radiation treatment for metastatic squamous cell carcinoma in the trigeminal nerve. Radiation ended but we continued the new lifestyle.
She is doing fine, A1C is 4.8, diabetes is in remission.
Cancer is probably still there but no pain.
Brain and thought process seem to be improving with theuse of MCT twice a day.
I would recommend for others, even as a preventative lifestyle.
We do go off the regimen about once a month for a big meal with family and friends, and it takes two or three days to get back on track.
I was also diagnosed with GBM in September 2023. Operated and undergoing Chemotherapy these days. 3 more months to go. I am taking my normal diet sans Sugar. Any advice or instructions for me. We can share info and help. Thank You
Great talk, learned a lot, keep it coming!
Please contact professor Thomas Seyfried and look at his research.
Excellent discussion, LJ and Victoria. Thank you both so much.
A new idea? Otto Warburg thought of it in 1929 I believe...... He just didn't have the Glutamine cycle worked out.
Thomas Seyfried.
Do you have the references L J Amaral mentioned in her talk?
Is the use of supplements necessary while using the 3:1 Or 4:1 keto therapeutic diet?
I’m a breast cancer patient that has had success with nutrition and treating my stage 4 cancer. I have only gotten into ketosis through fasting. I eat plant based and I’m afraid to add animal products back in. How can I test my cancer to find out what fuels it? When you talk about ketogenic diet how much if it is animal products? Do you rest insulin while on keto diet?
I would love to participate in a study if there is one coming up.
@@user-xh6bo6bc9p very useful information . Thank you .
me 2 . apreciate if you can inform me when you find some study. im from philippines, its far though
Stick with what’s working for you, thanks for sharing your story I hope they respond to your question.
Be careful of the vegetables that are oxalates it can damage your body to control the cancer. preferable go keto introducing high fat foots. natural, grass fed meats, salmon, sardines and believe me it is safe. just don´t consume sugar and carbs. stick with it as long as you can. make it your life for now on. gl
Why the reluctance to use animal products?
I am intrigued by how to more efficiently suppress inflammation while on a metabolic protocol (off label meds, high dose vitamin C 25gr.3 X/week and 3-5 water only fasting? When during or right after the fasting does is the HBOT needs to be done?? Is EBOO (although it's 10X more expensive) better than HBOT ? Thanks.
This is interesting in general but if anyone I know ever gets cancer it'll really be good to know
You're amazing you spoke for 40 minutes without giving any helpful info
Absolutely.
I couldn't find any very low carb snacks for an elderly person who has no chewing.
The best I found was sugarless meat sticks, but they were too hard to chew.
Cauliflower crackers, also too hard.
So we had to stick to unsweetened almond milk with collagen powder and MCT powder stirred in.
Snacks are not needed!!! Stop believing if they tell you to eat anything prepackaged processed!!!
IMO it is an inconclusive conversation.
We who have Cancer need Compromised Profesionals.
Not just "Educational Pourpouses"
We need Real Professionals who we could ask for a Consult and take us to healing.
Almost 30 minutes of self congratulation (so brave, so clever, so wonderful) before they even get around to discussing fat:cho/prot ratios. And stop telling folks how HARD it is.
True! They need to tell us what exactly to do, but they keep generalizing things. So, we know we have to do x, y and z, but then whatever it is, it's either hard to get or they're not really being specific. Drives me nuts.@@cassieoz1702
What are Pourpouses? I cannot find a definition.
You adopting Dr Seyfrieds work.?
What are the obstacles to getting more uptake of this promising approach to cancer treatment?
I find their conversation irrelevant when they have not even mentioned in Thomas, Seyfried, Boston University!
Furthermore, it scares me when every other sentence has to end in RIGHT- it makes me feel like they had to convince themselves what they’re saying is correct!
Question for the Dr:
Is it policy or are you required to implement SOC "with" keto/fasting?
Or in some cases, could you administer Keto/fasting "without" necessarily resorting to the SOC? IOW, are you beholden to using radiation/chemo/operations, due to your physician's license?
According to Prof Seyfried glutamine is the elephant in the room.
Do anyone know how to control glutamine, Prof Seyfried talks about a drug called DON, but he also said it is difficult to get?
@@Bilge-Tekin czcams.com/video/g4EY9WWuSR8/video.html
According to him there's more than one.
@@Bilge-Tekin Watch more of his videos. He talks about pulsing with EGCG and other supplements. Not the same as DON, but worth trying.
@@Bilge-Tekin Cancer metabolism can use glutamine when glucose is restricted. To restrict glutamine as cancer fuel, the following natural extracts can be effective : curcumin, EGCG, quercetin and berberine.
@@BeijingBuzzz-China-Travel do you have any recommendations for doses? Also, are they pulsed?
Thank you
3 days water Fasting alongside the Ketogenic diet in a week is good. (Berberine: as supplement for Glutamine blocking / Boswellia Serrata Extract: For glucose-lowering effect / CoQ10 reduces glioblastoma growth and infiltration through proteome remodeling and inhibition of angiogenesis and inflammation)
Also 1000 mg per day medical cannabis oil CBD:THC (2:1) for Glioblastoma
How do i get to work with you?
Talk, talk without specific advice. Please watch Dr Seyfried or Dr Jason Fung.
I have von Hippel-lindau syndrome, among other things I have some renal carcinomas. Do you think that these metabolic therapies may be suitable for my tumors?. Thanks a lot!!!
According to Dr Seyfried, yes. Since the common basis for all cancer is metabolic dysfunction.
Stop eating sugar/carbs! Find out about DON a drug that blocks glutamine. Dr Sayfried is the leading authority on the push pulse therapy.
The three questions that need to be asked to your doctors, your oncologists, your clinic, are:⠀
⠀
1. Is the proposed treatment based on the Somatic Mutation Theory of cancer or the Mitochondria Metabolic Theory of cancer?⠀
⠀
2. Will the proposed treatment be able to reduce the availability of glucose and glutamine, the two fuels that are driving the disregulated growth of cancer?⠀
⠀
3. Will the proposed treatment target the cancer cells while enhancing the health and vitality of the person's normal cells and tissues?⠀
#drthomasseyfried #thewarburgeffect #cancer #tumor #cure #mitochondria #pancreaticcancer
@Times Past Television Absolutely yes!!! Dr. Thomas Seyfried's research is vital. The powers that be ignore him, and it's sad. In their "ignorance" the moguls of mutation theory leave behind a wake of suffering, of lives wasted away to near nothingness. History will be harsh with these modern-day haters of the scientific method.
@Times Past Television
Sadly, it's too late for both of my parents, and the woman I was married to. The "standard of care" didn't serve them well, but the hospitals got paid.
@Times Past Television broken bones? See a doctor. Disease prevention? Stay away from the doctor. Above all, most important, is faith in the Almighty. Always pray, always reach out to Him. Give Him the chance to intercede as He sees fit. And give charity to Dr. Seyfried's cancer research.
The tripod of an armed patient or family member is knowledge (real science), faith/prayer only to the one God, and charity to nursing homes and/or Dr. Seyfried's cancer research.
@Times Past Television and also:statines for reduce cholesterol ,because statines block the link 1 in the chain transport of electron of the reaction oxidative phosphorilation in the mitochondria
Ah if you come in to a doctors office like that I’d suggest the following to the patient:
1) come in to the office right after a 30 day water only fast
2) be in therapeutic ketosis (GKI=1or2) and adopting a ketogenic diet for the rest of your life regardless what the doc says
3) by doing this you show you’re willing to walk the walk, not just talk the talk and that will also show you’re willing to save yourself if the doctor will not.
Oh and you have PhD Valter Longo who has also done decades of testing on this. So why do you have to do what has been done already? Dr Jason Fung wrote the Cancer Code long ago on this very thing! How can't you people not know if all these Experts that have worked decades on this and write books on the subject. Shame on you to be so out of touch. My God!
So how do i get in touch to
This. I have glioblastoma
They have been developing a successful protocol for glioblastomas. He is a researcher at Boston College.
Sorry about your health issues but thumbs up for making an effort for metabolic therapy.
It works.
Even if you just go one month eating only small servings of raw leaves and raw leaf juices. Wheat grass juice powder seems to be helpful.
They encourage adding some vinegar, olive oil, saurkraut, and salt.
These will help your internal organs.
Hope you are able to get better soon.
Saddly, most people are mostly on their own with this, unless you manage to get in on a clinical trial.
But cancers can't eat raw leaves, that would be a good start.
If you need warm food, try cabbage (small amount of cabbage, cooked cabbage has carbs)and zucchini soup. Flavor with plenty of parsley or cilantro, or natural herbs of your choice. Leeks, chives, oregano, anise, fennel,...
Life can be fun even with simple foods.
It's just a couple of months of extreme restriction, and soon your body will start healing.
For protein, one small can of sardines twice a week, or a couple of tablespoons of canned salmon in your salad.
Keep it simple.
Some people are able to eat an egg without feeding the cancer.
That is enough food.
Keeps the human alive.
The cancer will shrink and eventually go into remission.
Small amount of coconut oil should be ok, but be careful, some cancers can find strength in oil.
Hoping for the best!
You can do this!
Just keep it simple.
According to some researchers, bone broth and or collagen supplements is controversial.
Might feed the cancer.
Cancer eats glucose and glutamine. Collagen and bone broth supply glutamine, if you need it for strength, try using it when doing exercise, so that the muscles will absorb it and not the cancer.
Ms. Amaral needs to give credit to the founder of metabollic therapy. Dr. Seyfried developed this and she shouldn't take credit
The doctors believe I have a slow growing glioma, but to proceed with conventional treatment they want a biopsy and even take a decent amount of the most inflamed area (there is no solid tumor). All of this sounds profoundly dangerous... I am using the keto diet to great effect as far as my symptoms (seizures), and hoping that I can find a non harmful regimen to get my body to heal itself essentially. Any thoughts on that approach? I have heard of cases with people doing this successfully
Have you seen Thomas Seyfried's work?
Does sound risky considering the area ,
U could look around at the ray peat forum for potentially useful information
@@ogeoge6000 Yeah. I don't have access to HBOT or DON or some of the other things he uses in his recommended protocols. Though in a recent interview he seemed to be saying that just fasting might be enough if it was extended (like 40 days? Maybe a couple times? Or at least that he has seen it work)
In one long interview I think he said ‘might be’ enough. He’s a bona fide biologist, careful in any claims. He also hinted at some clinics (Turkey is one place) using his theory and the established empirical knowledge of fasting Keto diet and the glucamite intake (to ca cells) drugs such as DON . I’ve been trying to find such clinics myself (I have Pancreas tumour).
@@tomg2946 I do believe Tom Seyfried is approachable. Can't hurt to try. He may give you, and original poster, some direct instruction.
Best wishes❤❤
Shocking that she could actually be a nutritionist with no knowledge or training with a ketogenic diet or metabolic therapy. This is proof positive that the Medical industry is not looking at the research successes out there outside of the box.
The involvement of the processed food industry in dietician training and research, gets in the way of progress
How do we contact you?
Could you pls explain the "Ratios" mentioned in this interview? Could we get ketones as a supplement or any other way? Would MCT oil help? I think that is what you mean by Exogenous Ketones, am I right?
Yes. Dr. Boz discusses this at length. Exogenous ketones can be quite useful for getting your body to transition to fat burning mode.
First start with getting rid of all processed and highly processed foods, no fast food, eat real food, get a blood glucose/ketone monitor, start taking readings, I don’t like the Dr boz ratio no matter how well conceived it was do the GKI index=glucose/(ketones*18) it’s bad enough people have trouble with ratios let alone formulas. If your ketones do not come up and blood sugar going down you need to cut your carbs and increase healthy fats. Some people have to fast to get into therapeutic ketosis (GKI=1or2) but you need the blood monitor it’s a big help.
give examples of meals don't talk in ingeneralities. I do not believe it until you give some good meals that someone can used. I view it as someone trying to make money on the dieing,, prove me wrong.
I developed some meals using info from Dr Berg website and some others on the internet.
Dr Livingood is good also but he doesn't go very low carb and definitely not keto.
I think these people are prohibited by law to get real specific because they can be sued.
I really like Dr Valter Longo approach, but it also isn't really keto. My husband was able to get better from a major issue and he was able to do a much needed shoulder replacement surgery.
I really appreciate the metabolic therapy approach.
Thanks for the info and application.
Why dont these so call expert just state the fact : eat alkalize diet, rather use technical"Metabolic" jargon to confuse peopsle.
What is therapy for patients , unnecessary talk irreverent
Goodness please stop talking about yourselves-your really not that important.
Give us the knowledge people need to be aware of!🙄
AVOID. This is promotional. Advertisement for her business. Scattered info but no step wise plan..just blabber. Doesnt match to thumbnail. More 'I' and 'you'. AVOID.
If not Iron - RESTRICTION diet, Keto-diet may NOT improving CA.
Kudos to you for helping to make this protocol more mainstream. Keto is NOT hard if you do it right. The only hard part will be the psychological stress of giving up your favorite foods. Often those are carb/sugars and there's also an addiction component. IF you have a good reason to try the diet and stick with it long enough to get the benefits, you're quickly sold. Luckily for me I've not had cancer. It has touched my family. But, keto/carnivore has helped me fix my type 2 diabetes (25+years on insulin). I've kept an A1C of 5.0 for the last 4.5 years w/o any insulin. Fixed stage 3 kidney disease by more than doubling my filtration and helped me lose 200# so far. The makeup of the diet is extremely nutritionally dense. This adds to the satiety and the repair of the whole body. IMHO, it is the proper human diet. Not a fad. To learn more about how it affects cancer, I'd also study the work of professor Thomas Seyfried. You can find him interviewed a lot on CZcams. To learn more about the myriad benefits of keto and latest research, check out www.doctorstotrust.com
Thanks for this)