A 3D animation of mismatch repair in E. coli

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  • čas přidán 20. 03. 2016
  • Made using Blender 2.75 as part of my third year Practical Project (BSc Medical Biochemistry).
    March 2016
  • Věda a technologie

Komentáře • 142

  • @Gamelover882
    @Gamelover882 Před rokem +19

    My professor recommended this video and I see why. It's quick, in plain English, well animated and accurate without over complicating things. Thank you!

  • @DendyJungle
    @DendyJungle Před 7 lety +95

    dont know why you are giving this away for free but i am glad you are. Usually have to pay for really good educational videos

  • @samarrowsmith1396
    @samarrowsmith1396  Před 6 lety +105

    If anyone enjoyed this video and would like to see another of the sort, please suggest your ideas! I'm looking for suggestions for the next topic to animate!

    • @axellir
      @axellir Před 6 lety +3

      The video really helped me to visualize the process! Thanks! How about an animation about homologous recombination?

    • @holden2966
      @holden2966 Před 5 lety

      DNA techniques ?

    • @blandon93
      @blandon93 Před 5 lety

      How dna polymerase select nucleotudes in replication. Does it take nucleotides freely or they stick?

    • @singhmilandip
      @singhmilandip Před 5 lety +3

      I would like to see SOS response...

    • @srikantadash4603
      @srikantadash4603 Před 4 lety

      Transcription Translation post translational modification

  • @truth2power528
    @truth2power528 Před 6 lety +14

    Great video Sam. This helps tremendously in visualizing the process and makes it easier to understand.

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety +1

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @hoshi1599
    @hoshi1599 Před 2 lety +5

    Beautiful. I didn't realise there was going to be a bend with mutH while studying. This clears up so much .

  • @peednas711
    @peednas711 Před měsícem

    Bro I have a professor in molecular cell biology. He's been a professor there for 10-15 years. And still, you were able to explain this mechanism better than him. Good job to you. This is your calling

  • @holden2966
    @holden2966 Před 5 lety +11

    Wow! This great! Made perfect sense in just 3 minutes. Great animation! Keep it up Sam

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

    • @holden2966
      @holden2966 Před 3 lety

      @@samarrowsmith1396 I just searched it up

  • @trudyandgeorge
    @trudyandgeorge Před rokem +1

    Went looking for explanations on cyclical redundancy checks and wound up here. So Mother Nature did it first! Bravo 👏

  • @Lillith9008
    @Lillith9008 Před 3 lety

    This is one of the most aesthetically narrated biology videos I have seen. Thank you :D

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

    • @factualbiology7769
      @factualbiology7769 Před 2 lety

      czcams.com/video/iO32xJF1cTk/video.html

  • @carlosalbertolararojas3610

    Thank you for this video I was trying to study methods of DNA respiration and I could not visualize this in my mind , you made it a lot easier for me many thanks.

  • @johnhenry4389
    @johnhenry4389 Před 8 lety +7

    That was one of the best videos of DNA-enzyme interaction I've seen.

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety +2

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

    • @parth2615
      @parth2615 Před 3 lety

      @@samarrowsmith1396 I was studying for my molecular genetics course, I couldn't visualize the mismatch repair system so I searched "DNA mismatch repair" on youtube. This was the second recommendation.
      PS. It's a great video. I recently learned the basics of blender, I will also try making such nice little animations just for fun.
      Hope this was helpful.

    • @factualbiology7769
      @factualbiology7769 Před 2 lety

      czcams.com/video/iO32xJF1cTk/video.html

    • @Ragunath21
      @Ragunath21 Před 2 měsíci

      ​@@parth2615 now it's first in recommendation

  • @sliceofnoob2885
    @sliceofnoob2885 Před 3 lety +1

    Thanks the best vid I've found on mismatch repair....a real life saver

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @adityakale6064
    @adityakale6064 Před 4 měsíci

    It was so simple to understand and you saved me for my exams

  • @hafsaamzim1901
    @hafsaamzim1901 Před 2 lety +1

    It’s amazing and very clear. Thank you a lot.

  • @shivamverma2754
    @shivamverma2754 Před 2 lety

    wow so much wow ... great job Sam

  • @satabdideka8832
    @satabdideka8832 Před 2 měsíci

    Ahh, you made it so easy! Thanks a lot

  • @nikitamaurya6644
    @nikitamaurya6644 Před 6 lety +2

    Thank you so much,it helped me a lot.

  • @nitukharsel3625
    @nitukharsel3625 Před rokem

    A well animated vdo 😊. I liked it very much .please animate mor topics of Molecular biology😢

  • @a.i892
    @a.i892 Před 3 lety

    One of the best educational videos i've ever seen

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @harvey2733
    @harvey2733 Před 3 lety

    Such an amazing presentation. Loved it.

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @pulgimole5
    @pulgimole5 Před 8 lety +6

    Very helpful! thank you

  • @noorulhassankhan
    @noorulhassankhan Před 3 lety

    Wonderful video, thank you so much!

  • @litchfirmian7562
    @litchfirmian7562 Před 2 lety

    This is really helpful, thank you, sir.

  • @twisampatidas9965
    @twisampatidas9965 Před 4 měsíci

    Awesome brother

  • @maryamsediqi3726
    @maryamsediqi3726 Před rokem

    Awesome, thank you so much

  • @hayilee9601
    @hayilee9601 Před 2 lety

    you just saved me! thank you so much :)

  • @feliscatus4921
    @feliscatus4921 Před 2 lety

    this is an informative and useful video!

  • @wealllovelina
    @wealllovelina Před 3 lety

    awesome animation! thanks!

  • @lisarichards3217
    @lisarichards3217 Před 7 lety +2

    More science videos! This is well done.

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @DL551997
    @DL551997 Před 7 lety +2

    extremely helpful. thank you very much!

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @niharikagovindjha8919
    @niharikagovindjha8919 Před 6 lety +2

    it's really good but a bit more clarity about methylation and also references to RecJ and endonuclease VII would have been great

  • @Mk-hc9jm
    @Mk-hc9jm Před 3 lety

    Legend, thank you so much

  • @ayeshaqamar5972
    @ayeshaqamar5972 Před 4 lety

    Thank you so much for the video

  • @musicspeaks0101
    @musicspeaks0101 Před 6 lety +1

    thank you so much!!!

  • @malekmohamad4815
    @malekmohamad4815 Před 2 lety

    that was epic..my regards from syria

  • @ubaldogennaromastrominico786

    Great job!

  • @corvette724
    @corvette724 Před 4 lety

    well done Blender job

  • @arvindshankar7679
    @arvindshankar7679 Před 5 lety +1

    Good work fam, this is helpful.

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @lapetiteloutre9345
    @lapetiteloutre9345 Před 5 lety +1

    Great video, thanks a lot :)

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @wasifullahdawar6962
    @wasifullahdawar6962 Před 3 lety

    Thank you

  • @Ssalma6338
    @Ssalma6338 Před 10 měsíci

    About the DNA polymerase , is it polymerase III which is responsible for the resynthesise of the new strand or the Polymerse I ? I get confused

  • @blancaparraga3006
    @blancaparraga3006 Před 3 lety

    Thank you so much

  • @reviewsbymithy8532
    @reviewsbymithy8532 Před 3 lety

    Question please
    Why Dna is looped out in search of nearest d(GATC) methylation site?

  • @kalpanamurmu3776
    @kalpanamurmu3776 Před 5 lety

    Thanks you sir .

  • @shafiamobasheri830
    @shafiamobasheri830 Před 3 lety

    The best ever

  • @ryanisber2353
    @ryanisber2353 Před 2 lety

    So good

  • @asifhamid9676
    @asifhamid9676 Před 6 lety +1

    Superb.....

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @aisheebhattacharya4228
    @aisheebhattacharya4228 Před 5 lety +1

    Wht abt uvrD helicase?

  • @user-hq8mx7mn3u
    @user-hq8mx7mn3u Před 6 lety

    Infinitely helpful

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @zuhaltatar935
    @zuhaltatar935 Před 5 lety +2

    İts very helpfull! Thank you so much :)

    • @SURESHKUMAR-gt7eo
      @SURESHKUMAR-gt7eo Před 4 lety

      Hello

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @matthewgrammatico8434
    @matthewgrammatico8434 Před 7 lety +1

    thanks mate. great video!

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

    • @matthewgrammatico8434
      @matthewgrammatico8434 Před 3 lety

      I was doing a genetics module at the university of Nottingham and just searched mismatch repair on CZcams. It's a great video because of the visual aspect.

  • @atanasatanasov9036
    @atanasatanasov9036 Před 7 lety

    Awesome! Thanks

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @saja4887
    @saja4887 Před 4 lety

    Thanks a lot :)

  • @adammiah235
    @adammiah235 Před 5 lety

    It is a very good video.......thanks ....

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @superiorslush5147
    @superiorslush5147 Před 2 měsíci

    every good 3d biochemistry animation has a british accent

  • @katarinala
    @katarinala Před 7 lety +1

    THANK YOU, it was so confusing in my book!

  • @zaynas2100
    @zaynas2100 Před 7 lety

    It's a very good video thanks

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @AlessandroDonaggio
    @AlessandroDonaggio Před 3 lety

    hope you got a first for this!

  • @richachawla7931
    @richachawla7931 Před 7 lety +1

    Amazing

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @user-de3qh4os7s
    @user-de3qh4os7s Před 7 lety +1

    thank you...... please how can download this video

    • @Ahnzhie
      @Ahnzhie Před 7 lety

      1. Go to www.keepvid.site/
      2. Copy the link of this video and paste it on keepvid site
      3. Click download and you can find more options down :)

  • @elnazzeinali3240
    @elnazzeinali3240 Před rokem

    Thats good tnx

  • @stephenhawking9155
    @stephenhawking9155 Před 2 lety

    How can i pay you. You just saved me ❣️❣️❣️

  • @anilk1241
    @anilk1241 Před 7 lety +2

    great video !!
    - a medical student

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @wassmmd8521
    @wassmmd8521 Před 4 lety

    Very nice

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @nareshsheoran2298
    @nareshsheoran2298 Před 6 lety

    Very nice sir

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @maheenejaz360
    @maheenejaz360 Před 5 lety

    Kindly tell mismatch repair of e. Coli and eukaryotes differs? Pls answer as soon as possible.

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Hi Maheen, I realise this is a VERY late reply on my part so I can only apologise. I imagine my hesitation to answer this question is because I don't fully know the answer myself. There are analogues of the mismatch proteins across life, but the difficulty comes of looking at things within the chromatin environment. Making an accurate animation of the movement of histones and unzipping the DNA strands that have been exposed would be a comparative nightmare (for me anyway, there are probably skilled animators who could try making a representation of this). The wikipedia article for mismatch repair has a basic outline of the analogues: en.wikipedia.org/wiki/DNA_mismatch_repair

  • @ej_stories
    @ej_stories Před 3 lety

    👌👌👌

  • @abhiriseagain9303
    @abhiriseagain9303 Před 4 lety

    awesome vid thank youu

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety +1

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

    • @abhiriseagain9303
      @abhiriseagain9303 Před 3 lety

      @@samarrowsmith1396 Hey thank you so much for your video. I searched for DNA repair and your video came up in search results..I watched many , this was the best one. For me this video was very beneficial in understanding the topic easily. And the animation was amazing, gave a clear picture. These are the topics which confuses some, so people tend to search for this kind of videos maybe thats why and you did a great job with the video.

  • @7mikepd
    @7mikepd Před 7 lety +12

    i think it's dna polymerase I that fills in the nucleotides before ligase fills in the nick.

    • @camelliaxie9381
      @camelliaxie9381 Před 7 lety +8

      Pol I is for proof reading and Nick translation (replacing RNA primers between Okazaki fragments). Pol III is for elongation, so the video is correct.

    • @zsusanner
      @zsusanner Před 6 lety +2

      The video is correct. It is DNA polymerase III that fills the gap

  • @mcpba3857
    @mcpba3857 Před 5 lety +3

    1:15

  • @agri_lover_boy1292
    @agri_lover_boy1292 Před 3 lety

    Please apki volume high kordo

  • @priyasultania8943
    @priyasultania8943 Před 5 měsíci

    Dam good

  • @muskanpathan7623
    @muskanpathan7623 Před 6 lety

    Wow!!!!

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @JamSlapper
    @JamSlapper Před 5 lety +1

    MutS and MutL are heterodimers not homodimers, good vid though

  • @sanauzma6192
    @sanauzma6192 Před 3 lety

    pleas sir be lauder i cant heat uhh

  • @eugenealice6839
    @eugenealice6839 Před 5 lety +2

    nice

    • @NT20817
      @NT20817 Před 5 lety +1

      rlly nice

    • @aliceeugene6871
      @aliceeugene6871 Před 5 lety +1

      Hey what’s up Nate ?

    • @NT20817
      @NT20817 Před 5 lety +1

      Alice Eugène chillin like a villain, n you?

    • @aliceeugene6871
      @aliceeugene6871 Před 5 lety

      Cool, not me, I’m an hard worker today !

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety +1

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

  • @jinglingu3465
    @jinglingu3465 Před 7 lety

    旺德福!!!

  • @Futurescientist_
    @Futurescientist_ Před rokem

    This is wrong first step hemimethylated GATC pe

  • @user-hf9wy5jp6x
    @user-hf9wy5jp6x Před 3 lety

    перевод на русский

  • @theeducationtree8272
    @theeducationtree8272 Před 5 lety +1

    AMAZING!! THANK YOU.

  • @tarannumkhatoon5070
    @tarannumkhatoon5070 Před 6 lety

    👌👌👌

  • @crazyfilms6562
    @crazyfilms6562 Před 6 lety

    Very nice

    • @samarrowsmith1396
      @samarrowsmith1396  Před 3 lety

      Thank you! I realise it's been a very long time since I made a video of this nature, but I wanted to ask a couple of questions: how did you find this video and what makes this video work? I'm curious as to how this particular video became successful compared to others, so any feedback is appreciated!

    • @crazyfilms6562
      @crazyfilms6562 Před 3 lety

      Sir it's been 2 years now and I was in 12th standard at that time, after watching your video It made me easier to understand the concept and visualization makes it more memorable, now sir I am doing mbbs and hopefully became a doctor.🙏