A Grape Made of... Meat?? - Tissue Recellularization
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- čas přidán 28. 10. 2019
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Decellularization is a pretty strange process. Using a special type of soap, it's possible to remove all the cellular material from a piece of tissue, leaving only the connective proteins and polymers behind that normally hold the cells in place. It leaves you with something that looks like the starting material, but is really just an empty sponge called a scaffold.
Doctors and scientists have been exploring this technique for many years because those empty scaffolds are extremely useful for cell culture. By seeding them with cells taken from a patient, it's possible to grow a brand new organ or tissue able to be transplanted into a patient, potentially saving their life. The same technique could even be used to make lab grown meat.
Today we explore this amazing process and turn an ordinary grape, into meat.
More reading:
Review paper - onlinelibrary.wiley.com/doi/p...
Andrew Pelling papers - journals.plos.org/plosone/art...
pubs.acs.org/doi/abs/10.1021/...
Gabriels stuff:
www.scihouse.space/
/ glimsd
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_____________________________________________________ - Věda a technologie
![Eminem - Houdini [Official Music Video]](http://i.ytimg.com/vi/22tVWwmTie8/mqdefault.jpg)
2025: The grape did surgery on me
You forgot “in Russia”
@@idioticbosd7995 IN SOVIET RUSSIA GRAPES DOES SURGERY ON YOU
Quoc anh Vu Pham yes
If we make it past 2020😥
Well you should thank him grapes are putting their lives on the line to save humans.
I like how this seems to have two applications:
1. Organ transplants
2. mmmm meat berry
mmmm meat berry
Mmmm me gusta
mmmm meat berry
Mmmm me gusta
mmmm meat berry
the idea that lab-grown organs can exist within my lifetime is insane. it's something my family has been hoping for since my brother got his kidney transplant
I'll eat his other kidney
Yes that's a threat
@@TylerTMG I'll defeat you before you can do that.
@@pinkfurret6245 nice pfp btw
@@Prime501 cool thanks
I like how he asks, "Why don't we make a meat berry?" with the candour of asking, "Why don't we get some Macdonald's icecream?"
Is there even any ice or cream in that stuff?
both difficult
2018: they did surgery on a grape
2019: they did surgery with a grape
big boi angle 2020: they got surgery from a grape
2021 grapes have defeated apes...
2009: "do you have any grapes?"
2022 grapeocalypse...
progress
So Groot is basically a decellularized human with plant cells.
@@DShKa. there's only one way to find out :)
Yes... only one way to find out..
CUT OPEN HIS BODY AND SEE WHATS INSIDE!
That’s one way to put it
Yes but why?
no hes a completely different race
I remember my friend said that he could turn a grape into an onion, he just peeled the skin of and I believed it was an onion.
I’m sorry what
bro were you 8 months old
Holy crap that's hilarious and also pretty disturbing, wtf
So grapes are ogres. Makes sense
Yeah my dad did that with his face once. Peeled it off and then suddenly he was my mom.
Ever since we have had no milk at home.
The full video you made three years ago was actually what inspired me to study biology! And this semester I'm going to write my bachelor thesis :) thanks for that, you are awesome!
hey man hows your thesis going? did you already finish?
@@dedusmuln Yes! I got my certification in September
@@flamezero.x2957good shit man
"Nice ear"
"Thanks, they're from Apple"
Wait for it... this comment is gonna get lots of likes and replies if we wait long enough when people say it’s underrated
I'm more scared that someone complemented your *EAR*
I-ear
Nice earphones
Randome person walking past: love your ear shape
The era of plant-based meat is over. The era of meat-based plant has begun
LET'S FUCKING GOOOOOO
@@rojoscostanada8685 LETS GOOO
WOOOOH
YASSSS!!!
WHY YALL HAPPY THEY GONNA TAKE OVER THE WORLD
It's amazing that I read a scifi comic that's at least 20 years old by now where they had this exact concept of decelluarising an entire human and fill him back up with new cells to extend their lifespan to several centuries.
Idk why but thus is funny to me
That's an entirely different human, at that point...
I guess it'd have to be genetically identical stem cells...
Given your title this is NOT what I was expecting. You’re a fantastic speaker, and this script, it’s at a peak of greatness. I love this. I learned something today. Thanks a lot man.
2018: They did surgery on a grape
2019: They did cell replacement therapy on a grape
2020: We have become the grape
Detroit: Become frutal.
3020: Grapekind gain rights to vote
3021: All of humanity is destroyed. The grapes have created human death camps and eliminated all members of our species. They fucking won. Grapes now rule the world.
Yes but the surgery was from a few more years back
draconiusultamius I was waiting for a comment like this😂😂👍🏾
Doctor: Congratulations we found a heart to replace yours!
Patient: Oh, well who's the donor?
Doctor: Grape
G r a p e
patient: aw man, I was hoping for apple
@@omnical6135 no, only grape
@@insertcoolnamehere937 can I choose what kind of grape
@@josephdavison4189 no just grape
From "they did surgery on a grape" to "the made a meat grape". Amazing
"I need suction, we're going to lose this grape if we can't find the bleed and seal it! Get me another bag of Type G blood, stat!"
1:03 Ah crap.. I forgot to water my liver…
I guess that would make it a Liverpool
@@jackpaxton9391i laughed 😂
"can I have some boneless grapes?"
"no, unfortunately we've ran out of those. Would you like some seedless meat instead?"
LOL
This is a conversation that is going to happen in the future.
Yes, screenshot this to post on aged like wine when it happens. And don't blur my name.
lol true
Its gonna happen
sure I want seedless meat
I came here for meat berries and I came out actually educated on cells growing and organs and I feel smart
Peter Parker your username makes this so much funnier
Now i can grow a beeftree
@@averypleasedbakedpotato8609 dude can i have one?
thank you peter parker, very cool
Name Peter Parker profile picture mii bob ross so I am confusion
Embedding tissues in paraffin could enhance the quality of the slices for microscopic visualization. I'm very interested in seeing comparative images of grape tissue, hollow grape cellulose, and meat berry tissue prepared using this method. The results must be fascinating. Although I found a video on this topic informative, I'd appreciate more detailed visual comparisons.
Patient: *lost a testicle*
Doctor: *puts a grape instead*
world in 10 years:
-meatberry steaks only 2.99$
Original old style cow steak only 49.99$
Still, meatberry sounds tasty and cute at the same time. With just a hint of nasty😅
Ngl 'Meatberry Steak' sounds really nice as a name
@Electric Pheonix stfu its a joke
@Electric Pheonix not exactly, as when scientists perfect the science they'll be able to do it globally, easily to the point you could almost make it in your kitchen, drastically dropping the price of foods as we could mass replicate them. this could be true, or heck, it could be pennies!
Noone’s gonna talk about how he made this a full blown tutorial
WaTeR LeMoN and? I’m gonna make this during the summer holidays.
@@kingjdog tell us how it tastes
thats the point
Jashak You think the average viewer has access to equipment to make these?
They also teach how to design your own GMOs.
Suggestion here! Why not try using unripe jackfruit as scaffolding? Since jackfruit flesh has this very fibrous texture that it's used in my country, the Philippines, as a meat substitute in a dish.
That ear looks so much better than when one was growing on the back of a mouse!
2018: "They did surgery on a grape"
2019: "They turned a grape into a monkey kidney"
@pulpnonfiction bruh
@pulpnonfiction I mean, to be honest, Quake was a good game.....
ok boomer
@Nick Gerr bruh
SrLupinotuum ok boomer
Breaking news:
Scientists just pulled the UNO reverse card on vegans
Lmaooo
lol
Meat based plant
Given the ingredients you need to create this thing I doubt vegans would eat it lol
Carnivore diet from plants o0o
This was in my recommendation for quite a while and now that I have finally watched this, I feel BIG BRAINED.
Wouldn't it make more sense to, in addition to staining the meat berry slices properly with the correct type of stain, maybe try fixing it in formalin first before slicing for a better slice. Or use the same technique used for a frozen section in an operating room, as formalin may not work well given the mechanism of action is essentially crosslinking proteins and cellulose is, well, obviously not a protein. But a frozen section methodology would likely do a decent enough job of fixing it before slicing, such that it doesn't just disintegrate into mush
"Yellow means VERY bad!" Apparently this is consistent across the sciences, it's not just chemistry.
Snow too
@@skanderman8769 😂😂
@@skanderman8769 God tier comment 🤣
@@Sockfish-jj6on this isn't reddit
So banana is bad?
I love when smart people do cursed shit like this, simply because its possible.
*yes*
Cursed? More like the blessing of science.
Everything science doing is literally miracle.
Having a pig heart as replacement sounds cursed to me, cool science regardless 😂
This is literally my BFF talking about me. I do cursed shit on a daily basis and prank her with it
"the shells become fragile" - proceeds to pour water from a gallon bottle directly on them - XD
This is so mindblowingly awesome!
Thank you for this!
2010 Me thinking the future is going to be full of cyborgs.
2020 Me realizing the future is gonna be full of fruitborgs.
@Hussam Almahdwai you still understood what he meant so it made sense
@Hussam Almahdwai wow dude he was joking chill out
Creepy confusion
Oh CrAp ThEyVe EsCaPeD
People are fruits
1950: "we will have flying cars in the future"
2019: meat grapes and apple ears
Still cool so. :)
Don't forget mushroom furniture.
and flying cars
Delicious.
Better than flying cars which was a stupid idea to begin with.
How large a scaffold can this technique use? I'm thinking that if you were using this to make lab-grown meat and used, say, a watermelon (once you dealt with the seed issue) the quantity wouldn't be as much of a problem.
PS apparently one of the main ethical roadblocks with lab-grown meat is that the petri dish technique requires a cow's uterine fluid (so in other words you have to kill calf foetuses to get it), does FBS avoid that matter if it's derived from blood plasma?
Just watched this from my watch later playlist. This is so cool and mindblowing, motivates me to join the microbiology/biotechnology
2 Kinds of people truly impress me:
1) Musicians.
2) Crazy science people.
Woah there, I'm both of those! Are you proud of me
@@CedarTallman musician is viable I started making music digitally since I was 12
@@clakscovsky same-
@@CedarTallman HEY IM AN ORCHESTRA KID AND A LAB ASSISTANT
@@clakscovsky so you aren't a "crazy science person"
2094: "See that dude over there?" "His body is made out of apples."
the iperson
lol
LOL
"Oh really? My niece was an apple as well!"
Honestly that would be so funny and so cool
Watching this 3 years ago and I don't know a single thing because I don't know English and a lot about science. Watching this now amazes me how simple they explain things.
Those shabriri grapes from elden ring suddenly feel so much more plausible
de-cellularization is literally just removing in-game texture files on an object in real-time
Pallet swapped grape, or meat berry. You decide!
Fun perspective
This is why I’m a crustacean main. Only octopuses have texture changers, so I don’t have to worry about it too much in the newer Southern Ocean server.
Max Crustacean mains no skill, Cephalopod mains have high skill floor
cephalopod mains ftw
😂 texture packs
the fact this kind/quality of content is completely free on yt is insane to me.
mad props to the educational section of yt.
Consider becoming a patron, biology is expensive and this video doesn't have ads paying him for it.
Google agrees, that's why they paid respect to educational YT channels in the rewind by doing a "science experiment".
Alex Hamon> this video doesn't have ads paying him for it
Yes, it does, it's just that even without an ad-blocker, ads don't always run on videos, sometimes they do, sometimes they don't.
@@user-vn7ce5ig1z
If you see yellow marker dots in the bottom timeline, then it has ads. This video doesnt. Anyway it is sponsored by Nord VPN.
Kketansa Art
Only if there are adverts running on the video at the time, and only on CZcams desktop site. Anyway, instead of arguing about it, there's a ko-fi link in the description, so why not donate and claim the moral high ground of not expecting a reward?
This is like a horror movie concept, once we discover how to make functional organs out of plants, we will consume every single piece of biomass in the world until there's nothing left-and that sounded waaaaay better in my head, DANG IT
So you're saying we will harvest earth into a void?
Is there anyway you could do this in the opposite way like replace the cells in sandwich meat with berry or plant cells??? That would be interesting.
They don’t have the same scaffolding as a grape or a heart and it’s generally ground up but I would think there’s a possibility
@@TheBaumcm Perhaps if it wasn't ground up... lol
Them: *puts animal cells in grape meat*
Vegans: wait, thats illegal
*toxic vegans
PETA: WRITE THAT DOWN
Tshadowangel no. It’s a joke bro
This isn’t reddit *toxic vegans
😂😂😂
Imagine going to a restaurant and asking for
*MEAT GRAPE*
Meat berry
G I V E M E M E A T G R A P E
I can only dream...
Useless Shroob it’ll happen. Trust me.
Popcorn chicken
If you put two similar types of cells into the structure, could this be used to create cross-bred plants?
I don’t understand anything he’s talking about but it’s still so interesting to watch
The chemical “gently” disintegrates every single one of the cells.
@Dukaag Cola screaming gently, of course.
@Dukaag Cola Every night I gently and peacefully cover the grapes with acid and fall asleep with ease.
not only that, SLS is a common ingredient in shampoos, which is why it's known to damage hair / scalp cells
@Katie Greenstein new shampoo not only provides a deep clean but also gently liberates your cells from your weak useless human body
I wanna be gently disintegrated 😩
Just imagine telling someone, "my ears were once apples"...
wouldn't you say "my ears ARE apples"?
@@guh2908 no because I ate your ears
😂
Cauliflower ear can take a whole other meaning now
@The guy you see in a mirror kommunist
wow, my mind blown. keep this science going!
I feel like my dad saying this, but that lil handheld vacuum gadget is nifty as hell
This brings "We did surgery on a grape" to a whole new level.
Stfu
TKOR?
@@xtcrider8270 chill
THAT IS WHAT I THOUGHT
“We made a grape perform surgery on a grape.”
I thought this would just be a meme but I actually learned something
[REDACTED] then it's memeing time
@[REDACTED]_ I'm you but better.
@[REDACTED]_ *engineer ho down on you*
How would it be a meme?
Yep. It’s possible to build structures as long as you have a good scaffold, which is the ECM. Ultra high resolution 3d printing will be instrumental here.
5:25 thanks for the advice sir
I was really worried when my sds solution wasn't dissolving
Btw I was making a finger for my dog in the backyard
Me too
This started out looking like something you could do at home
I was so hopefull
Dukaag Cola no, i dont think so.
You can make a centrifuge with string and a disk. Not sure how to get your hands on all the ingredients, but I bet you could if you searched enough.
Christopher Thompson yeah, not so sure about the water insulated incubator and the fetus juice
Exactly what I thought! :D Grapes? Check. Scalpels? Obtainable. SDS? Never heard of, but I'm gonna check on eBay. And slowly it went into bottles and plates I've never seen.
Imagine being they guy who says “I have the heart of a pig”
Inevitably, someone's going to figure out how to build and plug in a heart based on a lion's heart, just for novelty. Even if it requires a fair bit of over/underclocking the thing or changing the channel diameters to get it to roughly match human spec.
Imagine being the guy who says "I have the heart of a berry"
My friend name is Anne Leonhardt AND yes she's from attack on titan lol
Where you on my discord?-
I know a guy with a pig heart. He has had one since he was a child.
This is crazy. Crazily cool!
i’m watching this at midnight before school
They did biology on a grape
I forgot about this meme
Biotechnology
Grape is biology itself
It would be biotechnology in this case
@@Doct0rLekter shut up, it's just a meme
I clicked on this just 'cause I wanted to watch a cursed video and by the time it ended I had a medical license.
Zech underrated comment lmao
Lol
This is how you impress your parents who have high expectations
yah like we have a lab
Never knew that SDS/SLS was used for decellularization. Explains why shampoos and soaps that contain it tend to be the ones most people are sensitive to-I myself am highly reactive to it.
Today I went to the doctor where I had a medical procedure done and I was in a lot of pain trying to recover. I started talking casually with a nurse to help distract myself from the pain and I vaguely remember that I introduced the concept of meat berries to her. She said she is now going to watch your CZcams channel. I don’t fully remember what happened but I think it went well.
can i have it in my will that i want my corpse recellularized with cucumber tissue and then pickled in vinegar and put on display in museum
I wonder if seeds would grow we could grow u
Yes
Pickled? Why am I wondering what that would taste like?
Im pickle riiick
Woooah pickle liqueli
Are you winning son?
Yeah dad I'm watching a man make meat out of grapes.
It’s kiwami japan all over again
Xx Selena xX even more quality content
grapes out of meat*
400th like
hope i made your day better
It's missing lamb sauce... Don't tell him until we find it.
Hannibal would love this
woah what an explanation!
broke: vegan hamburger
woke: non-vegan grape
Coke: we have weed in our stuff :)
Joke: *am I a joke to you*
*:3*
Amelia Price oo snizzle
Technically the grape should be vegan as even though it's meat, it's not meat that was harvested from an animal but grown in a lab, which is how lab grown meat can be labelled as vegan even though it is actual meat. Veganism by definition isn't about the meat, it's about where the meat comes from.
Endo Heart Cookie it was cocaine not weed, it’s in the name.
Endo Heart Cookie ew
“Yo why u carving that apple”
“Oh, I’m just making someone’s future ear”
“You’re WHAT”
I ear you
A sentence I never thought I'd hear
That’s not how it works
Reality Rupture BuT you didn’t
@@felix.mp3639 they read it. XD
im in tears
I took a fat nap watching this video, thank you!
“Hey, i’m buying grapes what color you want? Purple or gre-“
“Meat.”
M e a t
M E A T
M e a t
M e a t
M e A t
" Vegetarians developing trust issue with Grapes"
Lmao 😂😂😂
ahahaha
🤣🤣🤣
@@a1.onnat_ silence
@@a1.onnat_ no
I'm fascinated and grossed out at the same time.
ooooommmmmmmggggg so detailed so many chemicals contradicting each other 😮😮😮😮
2019: vegetable meat
2020: meat vegetable
Perro Gang uhh you mean fruit??
@@kylejohnson2977 both
Mmmmmmmm
Kyle Johnson vegetable sometimes just refers to the edible parts of a plant so technically fruits are vegetables
The time is now
Vegans: “Eat vegetables and fruit instead of animals!”
Scientists: “Yesn’t”
Lol
Shut up you veganistic statistic lover
@@coolxg4357
Woah now, where did this come from
@@coolxg4357 Woah woah woah! Vegans are OK, but Vegans that acts like a d*** head to non vegans is NOT Ok.
No I’m pretty sure that’s the vegan teacher
That process is exceedingly simple. It's basically just growing animal cells with a few extra steps.
I know this from my laboratory assistant education.
You can use fluorescent nuclear stains instead like DAPI or Hoechst 33342 to pinpoint where the cells are at least (by staining their nuclei). You can also use Phalloidin conjugated with fluorescent probes (more costly) to stain the actin and you can visually see the cell body. Lastly you can use lipid-friendly (lipophilic) stains like DiO or DiI to stain the cell membranes of your cells first before injecting them to the grape matrix. That way you can tell apart the grape parts form the cells.
"I picked grapes because it's the ultimate punchline for my joke" Just love it, seriously, I love that mentality.
Interviewer: so what makes you so special?
Me: my ear is made out of apple
Link da Man Sponsored by Apple Biotech Earphone
It's a nice snack.
@@ZodiacBlack11 you can connect earphones to it, only airpods though, technically you can't use anything else
Only airpods
Why did I say this? It's just like if in the future apple cibernitized everyone making them apple cyborgs
The equivalent of this video.
Now thats a whole new level of kink
2:25 until now
This is as interesting as it gets to me
"how do you like your grapes?" "oh i like them meat"
catgrain animations meatium rare
A man underwent a pig heart transplant, they didn't expect him to survive the surgery, but he actually lived two months longer than he would've. Not perfected, but they're making a LOT of progress compared to where they were when this video was made
Okay but imagine living with a pig heart. Wouldn’t that just be so odd?
Aside from that, that’s really cool!
@@epicjay8615 it would be a bit wild to be going about your day normally iust to remember "oh huh, the heart pumping in my body rn once belonged to a swine"
baby kitten heart, 2x the beats
and they probably learnt a LOT from that experiment
@@darkmoondeath00 You're weird
crazy work keep it up man!
Vegans: *confused screaming*
Cannibals: *YES IT CAN BE DONE, WE CAN MAKE THE FORBIDDEN FRUIT!*
Mr. Smoosh Let’s go! I want a meat melon!
This reminds me of a strange dream I had when scientists perfected this technology and created “Yeat” or yam meat.
*_YEET_*
@@Davis... YEEET
Lmao
YEET
YAYEET
Horrifying. I love it.
You are playing with fire, my guy.
"Moral baggage" is my new favorite science term
When you said moral bandage in class 😑😐
@@Smol.Gillian wot
@@tigersandflowers medieval bandage
@@Mari-gq2jp mama ducal band dash
@@badanimationstudios3358 funni
at first i was like "moral baggage" is a weird way to say "ethics" but then i saw you were making meat grapes out of liquidized cow fetuses and monkey kidneys and i understood
I mean-
Shibriri gonna be so happy
This looks like it belong in a Goosebumps book.
If high school science classes taught me anything it’s that you don’t wear flip flops in the lab
Nice profile pic
*anywhere
"Hey dude, I made a meat berry" *plap plap plap plap*
YOU WEAR THIC BOOTS
Oh yeah?! Im going to wear flip flops in the lab AND run with scissors, HOW ABOUT THAT?!
This is the most cursed name you can give a fruit
Flesh Berries
*M E A T B E R R I E S*
M E A T G R A P E
@@chanterelles3319 mmmm sweet sweet *f l e s h b e r r i e s*
_They did_ [CELLULAR DECONSTRUCTION AND GROWING OF MAMALLIAN TISSUES ON DONOR SCAFFOLDS] *_on a grape!_*
2:01 plant based heart💀
1970: in 2019 were gunna have flying cars
2019: *Meat berry*
2027: berry substitute organs