As a medical student who JUST came out of the basal ganglia lecture for the direct/indirect pathways, you are amazing. This clears all the foggy debris my professor was spewing our way. Can you please teach the rest of my neuro course?
Thank you Emma for all these explanations. They are clear and well illustrated, it is a pleasure for me to finally understand these concepts. Your language is very fluid, ...much pleasant for non english-native people!
THANK YOU so much for this video!! It makes it clear how the Basal Ganglia work :) your voice is also very soothing which is nice when you are stressed about upcoming exams
I have an exam about GTS, which is a complex syndrome... and to understand where the tics are coming from - I had to understand the basal ganglia circuit. There are some hypothesis about how the connection between the substantia nigra and subthalamic nuclei isn't working as it should - the substantia nigra should be telling the subthalamic nuclei stop, when it receives too much dopamin - but it seems as if it never does, when a person has GTS. Because when a person has GTS there's an increase of dopamin production and that's where the chemical dysfunction is being expressed. I am so thankful for your help. It's the only way I could understand this.
Marry me Emma, after weeks of frustrating study I found that my lecturer was wrong and so were my peers. I spent days trying to understand something that was wrong with my friends who just ended up rote memorising the pathway.
Hey does anyone know if the Substantia Nigra inhibits the subthalamic nucleus with D2 NT like in the Indirect pathway. or is the substantia nigra using GABA like the rest of the CNS? I'm assuming that the Subthalamic nucleus excites the SNcompacta with glutamate like it would the Globus Pallidus Interna. Thanks!
William McGilberry Hey hope this isn't too late The STN receives input from both the cerebral cortex and the GPe (indirect pathway). The cortex stimulates the STN whereas the GPe inhibits the STN. Also, the SNc receives input from the limbic system and prefrontal cortex. Consequently, it is thought that the SNc plays a role in facilitating movement that seeks the most rewarding outcomes.
this is real teaching. thanks. simple and not boring. and, that beautiful voices makes it so much fun to understand.
As a medical student who JUST came out of the basal ganglia lecture for the direct/indirect pathways, you are amazing. This clears all the foggy debris my professor was spewing our way. Can you please teach the rest of my neuro course?
I love you Emma!! Why professors can't explain it like this? It is even interesting now, thank you very much.
I was going to comment this exactly. word for word
Thank you for the clear explanation. Your voice is amazing!
I've watched videos like this all morning and this is the best yet.thanks!
Absolutely OUTSTANDING! Your description is so very clear and exceeds any neuroanatomy explanation I heard in University. Thank you!
A professor in my university explained this pathway as if he was explaining a new Quantum theory. Thank you Emma.
You explained this better than my professor! Thank you! Keep making more
Probably the best video on CZcams
Omg, I have to give a presentation of this subject, all the books where so vague but now it all makes sense! You explain it so well, thank you!
Thank you Emma for all these explanations. They are clear and well illustrated, it is a pleasure for me to finally understand these concepts. Your language is very fluid, ...much pleasant for non english-native people!
Killer Video!!!
Really!...wow! 10/10 Impeccable quality, presentation, and deliery.
Thank you so much for making the material so crystal clear!!! ^__^
This is very helpful! Your explanations are clear and simple. You've got a very calm and clear voice. THANK YOU!!!
wonderfully expalined it help me a lot before i couldnt understand basal ganglia, thank you so much keep it up.
your explanation is literally gorgeous , Amazing job , Thank you ❤
I'm so grateful to your videos about basal ganglia, life saving thanks so much!
Your voice is so nice, it makes it really easy and calming to listen to. Plus your explanation is awesome. Thank you!
Well done, beautifully presented and executed.
I'm astounded by how short and easy this was to follow compared to the articles I've been reading.
Very simple explanation of a very complex phenomenon. Thank you
WOW amazing, my prof was even having trouble explaining this and you helped me understand! you explain it so simply, keep it up! thanks
THANK YOU so much for this video!! It makes it clear how the Basal Ganglia work :) your voice is also very soothing which is nice when you are stressed about upcoming exams
Perfect video! Thank you!
one of the best explanations Ever!!! great job
Thank you so much! Was really struggling to understand this until now.
This was a really helpful overview / review of basal ganglia. Thank you so much.
I really like the way you make these videos, Khan Academy! KUDOS to you. It was of great help for me to understand this topic of Neuroscience subject.
this is gold...well done
Emma you're the best!! Plz make more and more videos! It helped me a lot in my studies! You're doing a great job! keep it up!
XOXO
Currently studying for a neuropsychology exam, thank you so much!
You rock! Thank you so much, this has been very helpful.
Such a great explanation . Thank you .
OMG you explained it so well. Thanks you!
This is AMAZINGGGGGGGGGG. I CANT HANDLE IT. THANK YOU!
Absolutely Brilliant!
This is wonderful. You made things so easy. Thanks.
Fantastic video- well explained, thank you!
Loved this Video!!! She really broke it down!!
god bless youuuuuuu ,,,,,you saved me , keep posting more please
perfect perfect...thank you Emma..you are great.congratulations
Clear, concise, and pleasing to the ear. Don't get me wrong, but if I enjoy the sound of someones voice I am more likely to retain more,
best ever described basal ganglia thanks a ton
I appreciate your word. And love your voice :)
Awesome !!!
THANKS A MILLION EMMA
Oh my god,I love you,You saved my exam,Thanks.
Very good explanation! Thanks a lot
Thank you for this you made this so much easier
Great video, thanks so much
Really satisfied! i am working for an exam and this video helped me so much. thank you:)
omg thank u! i have been trying to figure it out for like an hour! i was going mad! xD thank u! everything got very clear in 10 min!
God bless you! Please keep teaching
You are an angel.
Thank you, thank you, thank you!!!!!!!!! such a clear explanation!
great video. so easy to understand. Thanks
Very good explanation easy to follow and understand. This will help me in my current college class. Thanks!
Very nice explanation, thank you.
What an explanation! .thank u so much.
I have an exam about GTS, which is a complex syndrome... and to understand where the tics are coming from - I had to understand the basal ganglia circuit.
There are some hypothesis about how the connection between the substantia nigra and subthalamic nuclei isn't working as it should - the substantia nigra should be telling the subthalamic nuclei stop, when it receives too much dopamin - but it seems as if it never does, when a person has GTS. Because when a person has GTS there's an increase of dopamin production and that's where the chemical dysfunction is being expressed.
I am so thankful for your help. It's the only way I could understand this.
What is GTS?
+Justin denson Fancy way of saying Tourette..
well done u r amazing ..keep going on
Beautiful
Thanks a lot, amazing.
Pretty AND smart. You're the whole package Emma!
THANK YOU SO MUCH.
amazing!
Very well explained. TY
very great wok and helpful thank you so much
You’re the best❤️❤️❤️
THANK YOU SO MUCH!!!!!!!!!!!!!!
it is the best I saw ever
OMG THANK YOUUUUUUUUUUUUUUUUUUUUUUUUUUU!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! i wish you were my teacher for everything in med school!!!!!!!
Wonderful
fantastic :)
Thank you so much!
hello karolina
Thanks so much~
Excellent👌
thank you
Emma, your name should be on my graduation certificate lol
I love you. Thanks :)
Thank you thank you than you too much!!!
great explanation
Dr. Giles,
Do you plan on releasing more videos on neuroscience? I find your explanations to be fantastic!
Thank you
❤❤ i love it
thanks a lot
thank you very much!! 😭😭 this vid saved my ass for my pcol exam. 😄😊
i love your voice lab dub lab dub lab dub :)
Marry me Emma, after weeks of frustrating study I found that my lecturer was wrong and so were my peers. I spent days trying to understand something that was wrong with my friends who just ended up rote memorising the pathway.
omg tysm
Love the accent
Hey does anyone know if the Substantia Nigra inhibits the subthalamic nucleus with D2 NT like in the Indirect pathway. or is the substantia nigra using GABA like the rest of the CNS? I'm assuming that the Subthalamic nucleus excites the SNcompacta with glutamate like it would the Globus Pallidus Interna. Thanks!
Excellent presentation. 1 question. What excites or inhibits the STN so as to further excite or inhibit the SN?
William McGilberry Hey hope this isn't too late
The STN receives input from both the cerebral cortex and the GPe (indirect pathway). The cortex stimulates the STN whereas the GPe inhibits the STN.
Also, the SNc receives input from the limbic system and prefrontal cortex. Consequently, it is thought that the SNc plays a role in facilitating movement that seeks the most rewarding outcomes.
Does the basal ganglia control fine motor skills such as typing or moving of a mouse or even playing an instrument?
Taylor Swift... Is that you?
What starts the subthalamic nucleus ?how does it know to excite the substantia nigra?
cortical input to the medium spiny neurons in the striatum project to the GPE and then to the subthalamic nucleus, but ONLY in the INDIRECT pathway.
Copy!
well done u r amazing ..keep going on