having a little puppy thats a little bit of a trouble maker, i completely related with the example of this video. really helped me understand the vid! really nice vid
You are amazing thank you so much. great handwritten great examples a clear voice and lots of pictures. I genuinely wish I could trade you with my professor.
This is so helpful! I'm taking a class on motor speech disorders & I was having a really hard time getting these pathways until I saw your videos. Thank you!!!
I love how clear your explanation is and your puppy metaphor is golden. One question: the role of the SN your discuss, is that referring to the pars compacta (SNc)? Or is there some SNr in there somewhere too?
I'm able to understand everything about this except the first step. In the Direct Path video you said, that motor cortex first communicates with the striatum and striatum blocks the activity of G. Pallidus Int. And in this video you say that when striatum is excited by a signal from the motor cortex it inhibits the G. Pallidus Ext.! So, my question is, how do Striatum know, which part of GP it should talk to after receiving an impulse from motor cortex? And secondly, if the aim of indirect pathway is to keep up from moving why does the pathway start with a signal from the motor cortex? That doesn't actually make sense to me :(
+ksufler Answer is simple. It depends whether the motor cortex wants to activate the direct or indirect pathway i.e (does it want to increase movement or decrease movement)
+cj7ification but how does it know?! It excites the Striatum either way - are there different exitatory neurotransmitters from the motor cortex to the striatum? Thanks :)
I believe there is an error in the video. Dopamine on D2 receptors will increase the indirect pathway therefore decrease movement. D1 receptors increase direct pathway leading to more movement.
dopamine D2-receptors decreases activity of the indirect pathway - which means more movement. (also D1 receptors in direct pathway increases movement) Action of dopamine increases movement both ways.
having a little puppy thats a little bit of a trouble maker, i completely related with the example of this video. really helped me understand the vid! really nice vid
I like the puppy and leash analogy. It made it easier for me to understand.
You are amazing thank you so much. great handwritten great examples a clear voice and lots of pictures. I genuinely wish I could trade you with my professor.
i guess it is kinda randomly asking but do anybody know a good website to watch new tv shows online?
This is so helpful! I'm taking a class on motor speech disorders & I was having a really hard time getting these pathways until I saw your videos. Thank you!!!
this is amazing , you illustrated it in such an easy clear way , thank you.
Honestly, this video is very well made. This visual resource is awesome, with colorfulness and simple yet funny examples to aid my understanding!!
Emma, this is fantastic work! Thank you for taking the time to make such a wonderful set of videos!
Thank you so much! Khan Academy has basically got me through everything so far! Your explanations and analogies are fantasic :)
sometime i wish my brain was more simple to study so my brain can study itself more easy. #justhumanproblems
Thank you, I really enjoy your videos. this was a massive help
Thank you! Very clear explanation.
Dese explanations r amazing! Make more videos! They are REALLY helpful!
i love your videos! it makes everything easier.. thank God i found your channel
puppy on a leash... best analogy ever. Thanks!
This is absolutely amazing! Thank you so very much!
I love how clear your explanation is and your puppy metaphor is golden. One question: the role of the SN your discuss, is that referring to the pars compacta (SNc)? Or is there some SNr in there somewhere too?
great video mam...love from india....
Thanks for the video. I did not learn this well in Neuroscience, but now I definitely feel more comfortable with it.
When I leave the dorms of med school and be able to have a dog again, I'll certainly name it thalamus haha. Amazing video!
I'm able to understand everything about this except the first step. In the Direct Path video you said, that motor cortex first communicates with the striatum and striatum blocks the activity of G. Pallidus Int. And in this video you say that when striatum is excited by a signal from the motor cortex it inhibits the G. Pallidus Ext.! So, my question is, how do Striatum know, which part of GP it should talk to after receiving an impulse from motor cortex? And secondly, if the aim of indirect pathway is to keep up from moving why does the pathway start with a signal from the motor cortex? That doesn't actually make sense to me :(
+ksufler Answer is simple. It depends whether the motor cortex wants to activate the direct or indirect pathway i.e (does it want to increase movement or decrease movement)
+cj7ification but how does it know?! It excites the Striatum either way - are there different exitatory neurotransmitters from the motor cortex to the striatum? Thanks :)
check meetpatel,s youtube video on basalganglia pathways. you shall get it cleared.
Very useful! Thanks!
So helpful ! Thanks so much :)
I believe there is an error in the video. Dopamine on D2 receptors will increase the indirect pathway therefore decrease movement. D1 receptors increase direct pathway leading to more movement.
ya i was thinking the same thing
dopamine D2-receptors decreases activity of the indirect pathway - which means more movement. (also D1 receptors in direct pathway increases movement) Action of dopamine increases movement both ways.
This is absolutely amazing and helped so much on my Neuro Exam!
You should make more about the Hypothalamus, Limbic system and Cerebellum :)
Nice voice .. so comfortable
THIS IS AWESOME! THANK YOU SO MUCH
awesome analogy! thnx!!!
I love your videos. Thanks. :-)
You are amazing thank you!
When you say they talk to each other, should I imagine this more like a power station or actual movements encoded in the communication?
really good lecture more helpful
Mam can u please add subtitles for upcoming videos like previous i.e,direct pathway of basal ganglia
so about that first date...... I have this weekend open
Lol thanks for the laugh as I desperately cram for MedChem
Awesome
awesome
Agreed!!