Neurology | Basal Ganglia Anatomy & Function | Direct & Indirect Pathways

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  • čas přidán 19. 07. 2024
  • Official Ninja Nerd Website: ninjanerd.org
    Ninja Nerds!
    In this lecture Professor Zach Murphy will present on the anatomy and function of the basal ganglia. We will begin by discussing the anatomy and function of the basal ganglia and then go into more detail on the direct, indirect and nigrostriatal pathway! We will also be including a short description on the pathway and structures that are damaged in Parkinson's and Huntington's Disease. We hope you enjoy this lecture and be sure to support us below!
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Komentáře • 857

  • @mimiboobies
    @mimiboobies Před 3 lety +471

    I don't think you know the impact you have in our lives. Some of us would not be able to reach our goals if it wasn't for you. The way you explain this very complex subjects with such an ease is really remarkable. May you be blessed for all the work you do, You sir are gifted and we thank you for all that you do! I know you can do so many things with your talent, but PLEASE don't stop making this videos!!

    • @mhlorenzo
      @mhlorenzo Před 2 lety +3

      See, people do wish him well!

  • @antoinettegoosby
    @antoinettegoosby Před 3 lety +280

    The fact that I’ve followed you since my prenursing days and now I’m in graduate school working on my masters in neuroscience and your videos are still helping me.

    • @antoinettegoosby
      @antoinettegoosby Před 3 lety +7

      Also side note. I’m pretty sure you gave me a tour of penn state a long time ago. Were you an ambassador there?

  • @Comrade_Sergei
    @Comrade_Sergei Před 3 lety +654

    Me and my med school classmates thank you from the bottom of our hearts as we're currently in the thick of our neuro block and have found your neuro videos very helpful.

    • @dranthonyasturi9790
      @dranthonyasturi9790 Před 2 lety +3

      I and my med school classmates would do well repeating high school and learning the difference between object and subject.

    • @kabeerthaker4727
      @kabeerthaker4727 Před 2 lety +12

      @@dranthonyasturi9790 what you meant to say was "My med school classmates and I..."? Hopefully they'll teach syntax as well ;)

    • @bentenyson6570
      @bentenyson6570 Před 2 lety +6

      @@kabeerthaker4727 ok boomer

  • @fairpurenature
    @fairpurenature Před 7 měsíci +68

    I am a neurologist. This is the best explanation and tutorial I ever came across. Much better than ANY med school. Unbelievable value. Thanks so much. 😀

    • @ernestopanza4194
      @ernestopanza4194 Před 5 měsíci +2

      I'm an MS2, this guy is nuts isn't he lol. I'm going to destroy my exams and I'm not sharing this with anyone until after lol.

    • @EIonsMusk
      @EIonsMusk Před 5 měsíci +7

      @@ernestopanza4194 don’t be a gunner…

    • @ernestopanza4194
      @ernestopanza4194 Před 5 měsíci

      Witholding info doesn't make me a gunner. Sabotaging someone else would though@@EIonsMusk

    • @sanafsanaf7933
      @sanafsanaf7933 Před 2 měsíci +1

      Dr najeeb

  • @ameisha2471
    @ameisha2471 Před 3 lety +101

    I’m in medical school and the lectures in class make no sense but you make it simple. Thank you so much for this. Please donate to this guy!

  • @patrickblackwell777
    @patrickblackwell777 Před 2 lety +29

    You're one of the best teachers I've ever come come across be it the internet or otherwise. Thank you for being an invaluable resource for students around the world!

  • @metronidazole5681
    @metronidazole5681 Před 3 lety +98

    Your neurology lectures giving me boost to build career in neuro science. Thank you so much

  • @alih6953
    @alih6953 Před 3 lety +568

    Dear Zach, I want to thank you for all the hard work! I hope every desire of your heart gets granted! You are awesome!

    • @myplaylist3859
      @myplaylist3859 Před 3 lety +1

      Thankyou well wisher may god also fullfill yours

    • @alih6953
      @alih6953 Před 3 lety +2

      @@myplaylist3859 God bless you

    • @giuseppelernetti8667
      @giuseppelernetti8667 Před 2 lety

      You are Grest.

    • @mhlorenzo
      @mhlorenzo Před 2 lety +2

      Funny, every time I watch one of his videos, I wish him happiness... and feel curious about whether he is in fact happy. I certainly hope so.

  • @besttiktoks4352
    @besttiktoks4352 Před 3 lety +29

    Even a study hater like me willing to engage myself in study after seeing this guy's video.
    I mean wooooh man

  • @debadritaraha2462
    @debadritaraha2462 Před 3 lety +6

    The details you dive into, the lucidity of your explanation, you make med school all the more interesting. Don't think I could ever thank you enough.

  • @jenessalemon6848
    @jenessalemon6848 Před 3 lety +91

    Covering this in med school now with a really...challenging professor. Life saver! Thanks.

  • @yoanadenkova4335
    @yoanadenkova4335 Před 3 lety +6

    The amount of help these videos provide me as a med student in Germany is crazy - i have never found a more helpful lecturer on CZcams

  • @amelonlord654
    @amelonlord654 Před 3 lety +11

    Everytime you smile and say something is "cool" or "interesting" it makes me remember one extra thing or process:) Thanks

  • @yamamasajed6341
    @yamamasajed6341 Před 2 lety +13

    Hi Zach, it’s 3 am in Czech republic and right now Im struggling hard with my pathophysiology exam and im here just to tell u that u helped me a lot AND without u i would never had reached my goal. So Thank you a lot❤️

  • @xtecco4752
    @xtecco4752 Před 3 lety +15

    Note-taking on this video was assigned as homework for my high-school anatomy class. I have learned more in the first 20 minutes of this than I have in any of our two-hour lectures.

    • @Mikesco10
      @Mikesco10 Před 2 lety +6

      high school... that's pretty impressive most people here are med students or students in other health-related specialties

  • @lukadangadze8283
    @lukadangadze8283 Před 3 lety +20

    I barely meet such a talented people as you. Your explanations are very excellent and very helpful for every medical student. Keep going! 🙌🏻❤️

  • @MD-ot8ff
    @MD-ot8ff Před 3 lety +61

    Yo can we get a ninja nerd shirt that says "Fire like a mofo"? 😂Super helpful vid! Thank you!

  • @kunli9609
    @kunli9609 Před 2 lety +10

    thank you soooo much, can't even pass my exams without your lectures. I've been learning your videos since I entered medical school (from bachelor to master now), amazing !!

  • @djstax28
    @djstax28 Před rokem +3

    Zach my man you are an absolute time and lifesaver and I seriously mean that. I've been scouring the internet to understand the direct/indirect pathways and never seemed to get it. I even watched my professor's 90 minute lecture and still did not understand it. Then I watched like 20 minutes of your video and I have a complete understanding. Thank you for all that you do!

  • @grishagautam2517
    @grishagautam2517 Před rokem +14

    Why is substantia nigra inhibiting indirect pathway and causing an increase in unwanted motor activity....in the last pathway??

    • @Maissablm90
      @Maissablm90 Před měsícem +1

      Sameeeeee questionn!!!!!! If someone know pls tell meee

  • @marcellachmely5206
    @marcellachmely5206 Před 4 měsíci +130

    My 2 year old thinks you're Dwayne The Rock Johnson

    • @bassam4965
      @bassam4965 Před 3 měsíci +7

      😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭

    • @wencca3062
      @wencca3062 Před 2 měsíci +4

      based

    • @chottabacha1705
      @chottabacha1705 Před měsícem +5

      It's too good , he will learn very much things

    • @harishchad.
      @harishchad. Před 12 dny +1

      ​@@chottabacha1705chota bacha🍼👶

    • @ratneshr_mehta
      @ratneshr_mehta Před 15 hodinami

      Do show him/her these videos, who knows next Einstein is in your home 😂😂

  • @qixinzhang1648
    @qixinzhang1648 Před 7 měsíci +3

    This video about basal ganglia is amazing! I get clear details and a whole picture of these three complex pathways at the same time! Fight on! Dr. Ninja!

  • @user-bc1sr5bw4b
    @user-bc1sr5bw4b Před 3 dny

    feeling really relieved after listening, realizing myself that yes their are some specials who are always their for you not to worry always their to help you teach you and light you when you really need them. you deserve more than a word of thanks but what can i do is just the word thank you.

  • @professor_shao
    @professor_shao Před 3 lety +20

    I hope neurology lecture series won't end without having a video on traumatic brain injury and management😚

    • @Ellen5e
      @Ellen5e Před rokem

      Same! TBI and manifestations of damage would be a particularly interesting series. 😊

  • @joudizawet7573
    @joudizawet7573 Před 3 lety +14

    Words can't thank enough ")❤
    I really can't imagine studying physiology and neuroanatomy without your videos this semester ⭐⭐⭐

  • @noahlande2211
    @noahlande2211 Před 3 lety +7

    You make an already fascinating subject a thousand times more interesting and, not to mention, understandable.

  • @daianesoethecoan8572
    @daianesoethecoan8572 Před rokem +2

    There's no words to explain your tallent and dedication.
    I was trying to understand this a couple days, and you made it feels simple.
    THANK YOU SO MUCH

  • @mohab_68
    @mohab_68 Před rokem +9

    This is totally one of the coolest, most awesome, mind-tickling physiology lectures I have ever studied, with your great & easy explanations I really can't thank you enough for this ❤️

  • @its_rachel1
    @its_rachel1 Před 3 lety +3

    HONESTLY speaking, your videos are the first thing I search for if I have difficulty with a topic! Thank you so much Zach 💕

  • @bibimoosa2844
    @bibimoosa2844 Před 3 lety +3

    These videos are amazing! Thank you so much! I'm so excited to see you posting more neurology videos. I'm actually looking forward to studying these topics again.

  • @celiasunvoice
    @celiasunvoice Před 2 lety +1

    I cannot express how much you have helped me. I am in a 7 week Neuro course and your videos are the only reason I have any idea what is going on!

  • @user-vp8dl9xq3y
    @user-vp8dl9xq3y Před 3 lety +12

    We appreciate every moment you give us with your wonderful videos. Thank you so much zack

  • @alaashadad9598
    @alaashadad9598 Před 2 lety

    The passion you explain with such complicated topics is just beautiful!
    Keep the great videos coming!
    Thank you

  • @gpetaluma
    @gpetaluma Před 2 lety +3

    In a land where patients may sometimes have to manage ... doctors or medication ... your little video classes expand ones understanding to the point a little power is obtained! Thanks Zach!!

  • @neelo14
    @neelo14 Před 3 lety +2

    The way you teach Dr zach is amazing.I fall in love with medicine.
    Thankyou so much for your good work.

  • @EIonsMusk
    @EIonsMusk Před 8 měsíci +10

    I pay $48,000 a year in medical school.... you explained this in a way that was more comprehensible than any medical school likely has. Bravo!

  • @margarytamaksimtseva2322
    @margarytamaksimtseva2322 Před 3 lety +12

    I love how excited you are about this complexity! 'They are going to fire like a mofo' LOL! THANK YOU

    • @cecesarinana1272
      @cecesarinana1272 Před 3 lety +2

      I don't think you know the impact you have in our lives. Some of us would not be able to reach our goals if it wasn't for you. The way you explain this very complex subjects with such an ease is really remarkable. May you be blessed for all the work you do, You sir are gifted and we thank you for all that you do! I know you can do so many things with your talent, but PLEASE don't stop making this videos!!

  • @louis9833
    @louis9833 Před 3 lety +3

    You literally are saving my degree - thank you so much I cannot actually put it into words!! When I graduate as a doctor I will remember to donate to your channel as you've helped me sooooo much :)

  • @Priya_Dutta
    @Priya_Dutta Před rokem +11

    Thank you so much! This demonstration is really very helpful and one of the best illustrations out there. I have my Neuroanatomy exam in two days, and this video helped me clear my confusion.

  • @chococoveredlemons
    @chococoveredlemons Před 3 lety +1

    This made everything so clear for me!! Your enthusiasm is contagious and you explain everything so well! Thank you thank you thank you!!

  • @TheLabutterfly1
    @TheLabutterfly1 Před rokem +8

    Excellent explanation, you're a gifted communicator and teacher. Thanks for this.

  • @abelincolnparth
    @abelincolnparth Před 2 lety

    Best presentation ever of basal ganglia I have seen/heard/read in my 30 years as a pharmacist.

  • @brenogoes7920
    @brenogoes7920 Před 3 lety

    Dear Zach, I'm from Brazil and I have to tell you how grateful I am for your hard work! Thank you so much!!!

  • @Top_G.609
    @Top_G.609 Před 2 lety +2

    Man you are my hero. Your neurology playlist is awesome. You have helped me cover topics that were alot more difficult for me to understand.

  • @Nicole20397
    @Nicole20397 Před rokem +1

    This video was so excellent. I've alway struggled with neuro material and all the structures that lie within the cerebrum and what they do. This by far one of the best lectures on the basal ganglia I've ever seen. I finally get it know. Thank you for everything you do!

  • @katelynleong9479
    @katelynleong9479 Před 3 lety +2

    These videos are life savers and delivered in a way that is so much better than the lectures at physio school. Currently studying for my upcoming exams and videos like these are helping me manage my exam stress so much!

  • @nicole9007
    @nicole9007 Před 3 lety +4

    Basal ganglia topic finally made sense to mee. Will always support this channel and will not skip ads! Thank you Zach and all the ninja nerd team! You're all blessing to med students. The best teaching style! :))))

  • @garrettdyess1110
    @garrettdyess1110 Před 2 lety +1

    So good. Allows a novice to understand the concepts in an easy and natural fashion. Thank you.

  • @tjvh493
    @tjvh493 Před rokem +1

    So much respect for your teachings. As person who never had the oppertuinity to study Neurology, this certianly helped me with my self studies, thank you thank you thank you.

  • @jadeykins28
    @jadeykins28 Před rokem +2

    This was the best one of your videos I've watched! You're such a fantastic teacher, thank you so much for making these videos, they really are invaluble.

  • @kathyswatosh1875
    @kathyswatosh1875 Před 3 lety +3

    Thank you so much for your energy, and thoughtful descriptions/diagrams. You are terrific!!

  • @sashacraig5977
    @sashacraig5977 Před 2 lety +3

    I never comment on CZcams, but WOW, I thought I would never understand this but now it makes so much sense! Thank you, Zach and the team. When I graduate and have the money the first thing I will do is donate to this channel!

  • @jessicaqian7527
    @jessicaqian7527 Před rokem +1

    I cannot express my gratitude enough. You explain things so clearly!! Thank u!!!

  • @gigachad8961
    @gigachad8961 Před 3 lety +3

    I’m having an exam next week and the best lecturer just posted the main subject of it, Big Heart ❤️

  • @duhaal-qaderi689
    @duhaal-qaderi689 Před rokem +1

    You don't know the impact you have in my life! Thank you dear Zach!

  • @happyduck70
    @happyduck70 Před 3 lety

    You have a beautiful and calm way of clarifying all the information about the basal ganglia. Thank you from the Netherlands!

  • @chithoyip684
    @chithoyip684 Před 6 měsíci +1

    It is a very awesome video!! I am occupational therapist and I learned a lot from your channel. School may not teach these medical stuffs in such a detail. It really helped me to understand more and train my patient.

  • @tanurathore4664
    @tanurathore4664 Před rokem +2

    The way you explain everything in such an easy and interesting manner is just amazing!! Thankyou so much sir😊

  • @daniellakallicharan3457
    @daniellakallicharan3457 Před 3 lety +30

    Literally have an exam on this tomorrow, thank you!

  • @tolika7979
    @tolika7979 Před 9 měsíci +1

    You are a great man! Keep up the good work! The planet needs people like you!

  • @remak3819
    @remak3819 Před 3 lety +2

    I really don't know what I would've done without these videos.... thanks a lot!!

  • @aspirant4759
    @aspirant4759 Před 5 měsíci

    I can never imagined understanding neurology with this much of clarity..but you made it possible ❤❤

  • @lenaingram3055
    @lenaingram3055 Před rokem

    wow, I wish my lectures were structured like this. having everything connected visually makes it so easy for me to understand what's being spoken about!!

  • @buthinahammod7858
    @buthinahammod7858 Před 2 lety +2

    Man you are just amazing
    Keep uploading such great videos
    I don’t know what would medical students do without your videos🥰

  • @Tacticalgamerofficial
    @Tacticalgamerofficial Před 3 lety

    wanted to brush up on my neuro for my first shadowing of neurosurgery and this is exactly the in depth video I was looking for. Thanks!

  • @ricardolombe8614
    @ricardolombe8614 Před 2 lety

    I really cant imagine med school without your lectures. they hit different,. Thank you so much Zach

  • @sabrinamendes8406
    @sabrinamendes8406 Před 2 lety +2

    And, once again, your videos are saving me this semester 😭❤️ thank you!

  • @sherifabdelhalim5912
    @sherifabdelhalim5912 Před 8 měsíci

    The way you explain such complicated subject is phenomenal. You are talented and gifted. Thank you

  • @raghadalmazrouei9485
    @raghadalmazrouei9485 Před 3 měsíci

    I don’t know if saying thank you can ever describe of how much you’re saving lives! And how much you ease much to us.
    May god give you the best always, ALWAYS!

  • @liabevilaqua3305
    @liabevilaqua3305 Před 3 lety +1

    Hi Zach, yours sure is one of the best explanations about this subject ever!

  • @Inuishon
    @Inuishon Před 2 lety +3

    Zach you are a superb teacher. Learning how to restore the Basil Ganglia back to a healthy state of channeling :) Autoimmune based disoders

  • @peytonstaab4424
    @peytonstaab4424 Před 2 lety +1

    Your videos are SO helpful as I'm going through my med school neuro block. Thank you thank you thank you, you are amazing!!!

  • @dochala8400
    @dochala8400 Před 3 lety +1

    Want to say that your neurology playlist is absolutely thiiii best 😍

  • @mdramaqueen121
    @mdramaqueen121 Před 3 lety +1

    I can never thank you enough. We are so grateful of you and your content!

  • @user-bk3kr4dc4o
    @user-bk3kr4dc4o Před rokem +2

    Excellent, systematic, informing, inspiring and friendly presentation. Thank you.

  • @annieorben
    @annieorben Před 2 lety +2

    Wow, this is so interesting! It helps me understand the mechanics behind the different issues I'm facing because of diet choices and my ability to absorb different types of nutrients. Another part that is of great interest to me is how the different pathways interact with each other. I know this is just touching the surface of the interactions, but it gives me a mental model to formulate and reason with.

  • @tinabrahim7085
    @tinabrahim7085 Před 3 lety

    Amazing video. The illustrations are so easy to follow and understand! Made such a tricky topic super simple

  • @AndreaOgSilver
    @AndreaOgSilver Před 3 lety

    This is the best video about basal ganglia in the entire universe. Thank you so much!

  • @emagenie
    @emagenie Před 2 lety

    Zach , you're in a class of your own ! Kudos!

  • @neuropsychologist
    @neuropsychologist Před 3 měsíci

    That is literally the best visual explanation of basal ganglia I have ever seen! Genius. Life changing. A big thank you to you and your team 🧠 ❤

  • @hafsasaud3037
    @hafsasaud3037 Před 3 lety +2

    Dear Zach, you have made my life so easy. May God bless in many ways possible ♥️

  • @ghazalamfarrukh1769
    @ghazalamfarrukh1769 Před 3 lety

    As always AMAZING !
    THE WAY YOU KEEP IT AND PRESENT SIMPLY !

  • @84sounakmajumdar45
    @84sounakmajumdar45 Před 3 lety

    It really hurts when your video ends ... feel like to watch more and more.... Thank you Zach ❤️❤️❤️

  • @nursejax9152
    @nursejax9152 Před 2 lety +1

    Came across a basal ganglia bleed case recently and this video helped put things in perspective.

  • @user-cz8fm6jr9b
    @user-cz8fm6jr9b Před 8 měsíci

    So many of us would probably have given up if it wasn't for your videos. I can't even begin to explain the impact you have on my life. THANK YOU Zach!

  • @mujtabaali992
    @mujtabaali992 Před rokem +1

    you're a legend Zach, truly you're a inspiration for me to do hard work ❤️

  • @shifarahman99
    @shifarahman99 Před 3 lety +1

    Thank you so much Zach!!! You are a really wonderful teacher❤️😊

  • @salam7905
    @salam7905 Před 3 lety +3

    okay I am ending my year with ninja nerd.. an awesome ending!. happy new year ninja nerd I hope this year will be productive for you and you will shine our minds with alot of amazing videos.. thank you so much and stay safe ^-^

  • @fahrinaulfah1552
    @fahrinaulfah1552 Před 3 lety +9

    thank you! I've always fascinated by neurology but i found it hard too study it, with your lecture it feels easier to understand

  • @andrewmaleto-uz5bu
    @andrewmaleto-uz5bu Před 10 měsíci +1

    This particular one is a master piece. Thank you Zach

  • @MyDarer
    @MyDarer Před 3 lety

    Dear Zach Murphy, thank you so much for the great work. You have no idea how much you have simplified medical school. Thank you so much, ASANTE SANA (thank you in kiswahili)

  • @jaredheath2184
    @jaredheath2184 Před 2 lety

    my doctorate level neuro professor can't even lay it out this well. thank you so much, sir!

  • @samarshreshtha1305
    @samarshreshtha1305 Před 3 lety +1

    Thank You so much for this!! ❤
    Such a beautiful and simple explanation for this topic!!! 😊

  • @duhaal-qaderi689
    @duhaal-qaderi689 Před rokem

    This is the real mind-tickling neuroscience lectures.

  • @dalinalaffita650
    @dalinalaffita650 Před 3 lety

    Holy cow, this is the best video on a hard topic I have seen in a long time!!! Write your own book man!

  • @user-me3ur5ek9m
    @user-me3ur5ek9m Před 5 měsíci

    Thank you so much for all your Videos! Your explanations are so good. I'm a Speech Language Pathologist working in Neurology and now understand Anatomy, function and lesions much better! Thank you very much!!!

  • @trackman07
    @trackman07 Před rokem

    Thank you. You prove, when appropriate effort is applied, online learning is very impactful and can be done, improving education on the whole. Cheers

  • @MrAdmiralKush
    @MrAdmiralKush Před 3 lety +98

    Ok, I have a question though. Near the end, you said that the niagrastratial pathway modulates movement, I get how it enhances the direct pathway, but for the indirect pathway it seems like it increases the motor movement of unwanted motor movements. Isnt this counter productive? why would your body do that.

    • @yochinoinazaki3813
      @yochinoinazaki3813 Před 3 lety +12

      I didn t get that either..

    • @lukamiljic8193
      @lukamiljic8193 Před 3 lety +18

      Well, unwanted movement can become wanted movement if it is suddenly needed. So this pathway would be useful for adapting the movement according to your needs. It isn't something that exists to cause spasms, just to ease the transition of a movement going from the indirect to the direct pathway. At least that's how I see it.

    • @ash_xclusive
      @ash_xclusive Před 3 lety +8

      I think that is because there also exist cholinergic fibres which affect the neurons in the putamen. But the difference is that dopaminergic fibres from the nigrastriatal pathway and cholinergic fibres have antagonistic action, so the net amount of ach and dopamine decides whether the indirect pathway is inhibited or stimulated. So, nigrastriatal pathway does help in modulation of movement. I hope I was of some help😇

    • @mukulgidney
      @mukulgidney Před 3 lety

      Similar question arose here

    • @MrAdmiralKush
      @MrAdmiralKush Před 3 lety +3

      This question is still bothering me, even though I’m well past neuro. I just can’t get over it. Even the doctors as I ask can’t give me a clear answer. Hmmm. Well I’m going to visit my family soon some of which are doctors. So I’ll be showing them this video and maybe they can sit me down and go over it with me. If I can make sense of it I’ll share it here for the rest of you who seem to be in a similar position.

  • @2guptanshu
    @2guptanshu Před 2 lety

    Dear Zach
    Thank you so much for such a lovely and detailed explanation.

  • @keithedward
    @keithedward Před 3 lety +3

    Test on Tuesday, perfect timing.