Serotonin Hypothesis of Depression: Is It Accurate? | Neuro3

In this episode of Neuro3, we at Psyched! discuss a paper conducted by Moncrieff, et al. (2022). In this umbrella review, various meta-analyses, reviews, and other large studies, on the topic of the serotonin hypothesis of depression were analyzed. This well-established hypothesis argues that depression is associated with the lower concentration of the neurotransmitter serotonin in the brain,
In this review, hundreds of publications were initially gathered in the literature search, but ultimately, 17 studies were included in the final analysis. This analysis yielded findings that seem to contradict the serotonin hypothesis of depression. Specifically, the authors failed to find convincing evidence for an association between the availability of serotonin, serotonin receptors, and serotonin transporters (SERT), and depression.
Despite these findings, it is important to note that, although serotonin levels may not directly correlate with depression severity, this does not mean that serotonin is irrelevant in the context of depression. Effective antidepressant medication, such as SSRIs, specifically target serotonin reuptake, which points to serotonin at least playing some role in the etiology of depression.
Reference:
Moncrieff, J., Cooper, T. S., Amendola, S., Hengartner, M. P., & Horowitz, M. A. (2022). The serotonin theory of depression: A systematic review of the evidence. Molecular Psychiatry (2022). doi: 10.1038/s41380-022-01661-0
Narrated by: Michael Horberg
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[@knabellaks]

A bit confusing ending, but great work and editing. The term "effective ssri's" is perhaps not the way to end the video? Great that this topic is lifted up! Thanks

[@real.psyched]

Thanks for the feedback :D

[@dayab2905]

Very interesting 👏🏼👏🏼👏🏼👌🏼👌🏼👌🏼

[@real.psyched]

Thank you! :)