Thank you for this video! I will be doing Soxhlet extraction for the first time tomorrow and this helped me understand the setup and the working of the extraction.
I would like to know if you can connect a vertical vacuum adaptor between the soxhlet extractor and the condensor in order to work under reduce pressure, thanks, for your video.
I have been watching organic chemistry videos on CZcams for a couple of weeks now, and have now seen about a half dozen videos where this extractor is featured. I'm still waiting for the obvious comparison between a Soxhlet extractor and a flush toilet, but alas... not yet!
is it okay if my extraction solvent does not "siphon off" it just flows down drip by drip...i put 40g of my sample in a 100ml soxhlet ectractor and use 250ml of solvent..do i need to change the amount of sample or solvent?
Thank you very much for the video. Very professional. Question, I am new to distillation/extraction and wanted to know is there an advantage to using alcohol base vs. water and using dry material vs. fresh plant matter. Thank you.
I found these pieces of info to be very helpful: "The solvent selection for isolation of any phyto-constituent depend upon its solubility in that solvent. water are used if nature of phyto-constituents is polar Alcohol is used for if its slightly non-polar (used for both polar and non polar) Non polar solvent like ether and acetone are used for highly non polar solvent." "Factors should be considered when selecting a solvent: polarity; boiling temperature - this should be low in order to facilitate removal of the solvent from the product; reactivity - the solvent should not react chemically with the extract, nor should it readily decompose; viscosity - must be low; stability to heat, oxygen and light; The organic solvents more frequently used are: aliphatic hydrocarbons: propane, butane, hexane alcohols: methanol, ethanol, 2-propanol hydrocarbons with a carbonyl group: acetone, methyl acetate halogen derivation: dichloromethane, dichloroethane, freons."
First thank you for this demonstration! I need to extract fat from adipose tissue. Do I need to crush the sample before putting it in the extractor? Thank you
HI! I need an advice. I have to extracted lipids from a solid matrix. I used a Soxhlet; I fill the flask with dichloromethan and methanol. At the end of the extraction how can i recover the extract? i have no rotary evaporator in the lab. I think that lipids are dissolved in dichlorometane but both of the liquid solvents are transparent. Can you suggest me some strategy? I was thinking to aspire with a pipet the suspansion but i'm not sure it's is a good idea.
so basically, it's kinda like making coffee with a coffee filter, that eventually evaporates the water from the "pot" and then runs it over the coffee beans again?
I have a question I see that many people put the solvent directly into the chamber of the sohxlet apparatus before starting the extraction. in this video i see that the solvent is in the round bottom flask which technique is correct or what does it depend on?
Short answer, is it doesn't matter most of the time, the long answer, is it depends on the type of thimble used. When using a glass thimble, with a rosin or cellulose bag, it is probably better to pour the solvent directly into the soxhlett, whereas in this example with the cellulose thimble, leaving the solvent in the boiling flask is more ideal. Overall, the solvent will get siphoned out and cycled regardless, so it the option only really affects the first or second cycle.
He is not using the fume hood correctly (the door is up), so HSE- requirements are not being met. Please keep the door down as far as possible, especially when working with volatile (and toxic) liquids such as methylene chloride.
It depends on the boiling point of the solvent, and the amount of vacuum. He's using a low boiling point solvent, so it only takes a few minutes. You could boil off 100 mL in 10 minutes for sure.
Yes and no, I've pondered myself if it's worth the time rather then just dumping some alcohol and your product in a bowl then letting in sit and then filtering it but it's hard to get everything out doing that, depends if you want every drop of your product collected or just 60 percent
He used a Rotary evaporator to boil the solvent off. So if you dont want to get your solvent back, just boil it off. If you want to collect it, use a simple destillation. Idk which solvent you used, but most people use butane for it, where you cant really use a soxhlet. There are Videos how to do this then. Search for "making shatter". I asume you live in a state where this is legal ;)
magic wizard man Hi man! I am from The Netherlands actualy, so still illegal :( I am a leukemia patiënt and i want to make my own medical grade oil. I can make RSO now, but i want to step it up so i bought a soxhlet for extration. And it is quitte easy to understand the basics. Bassicly what i want to achieve now is to make a clean as possible product with as less as loss of solvent as possible. The solvent i use is ethanol and that is taxed highly in my country (netherlands) So i am looking for a way to distillate the solvent from the oil and catch it for re-use. Besides that, i produce free thc oil for other cancer patients and give that away for free. So i want to make as clean as possible products, with the lowest costs possible. What exactly is short path distilation, and what other methods are there to use. Bassicly, i saw the video on youtube from Open steel source and Jon Brown and i want to learn that stuff! So i want to learn the tricks, but also the theorie behind it! but i have no clue as of where to start, study books wise.
predjee i only said it so i am on the safe side :D So you can learn good Chemistry "tricks" from Nile Red and NurdRage, they make High Quality Chemistry Videos here on CZcams. Also ChemPlayer. They also explain many things like mechanism etc. You can use a Soxhlet extractor if you work with Ethanol. After that you distille it off, you will recollect your clean Ethanol then and you can reuse it then. You just need a Heating source, a "Destillierbrücke" (English translation would be Destillation Bridge, but idk if they really call it like that, you can use the german word to google it :D) and a Collecting Flask. That would be the easiest way. Dont heat to high or you will destroy the THC. Ethanol boils at around 78°C, so you know you dont need to go much higher. But i actually think Ethanol is not the best choice. I never did something like a THC extraction, i just can tell you from my experience in chemistry. i think you will get better results with diethylether, it boils of it 35°C, but its actually pretty dangerous in the wrong hands. But i think Ethanol will extract more than the THC, because its also a good solvent for things like Chlorophyll. Also, before you use chemicals, please check the safety data sheets for the chemicals before handling with them. i hope i could help you a bit.
If you are going to do one illegal thing, it won't make much difference if you do another as well ...like making your own ethanol... just don't announce it on the internet!
Yes that is why Philippines was colonized for more than 300 years by Spain. They accidentally discovered Philippines when their supposed destination is in Moluccas.
I need to cure fistula, I have been suffering for many many MANY years and I REALLY am desperate to get something done at this point, can anyone please HELP 🙏 I'm thinking that this could be used but I have no idea what to use with it, please please can anyone help me, I am NOW DESPERATE X
I think the advantage over reflux that this has is that less solvent is required and the yield of extract is higher. Think of it this way; the solvent is sitting in the flask and being heated. The solvent evaporates and leaves the boiling flask, and then it condenses as CLEAN solvent in the soxhlet apparatus; sort of like a continuous process of distillation and then using the purified solvent to run an extraction. The fact that the solvent is being recycled is more efficient. The fact that the constantly recycled solvent is free of previously extracted material, which is always in the boiling flask, means more is able to dissolve in it than a solvent that is saturated and being heated under reflux. Heating under reflux is less efficient because eventually you have to change out the solvent which requires a messy filtration process (in which some yield is inevitably lost upon transfer) or use a bigger flask with more solvent to extract the same amount.
THIS IS INCREDIBLY MAJESTUOUS!
I agree that (at least where I study) many undergraduate students do not learn/use this technique, so thank you for the demonstration!
Can't wait to use this for weed
@@sergiocaldera6568for mushrooms is nice too
Thank you! We're going to be trying to set this up ourselves in our senior chemical engineering lab so it's very helpful to see a demo.
Really enjoyed the video Dr. Not a bunch of side talking, just pure, straight forward information. Thanks
Thank you! First video I see which clarifies all my doubts about the process :)
Outstanding demonstration, doctor. Thank you very much.
Very informative and helpful, the information given was clear and easy for me to understand how to use soxhlet for extraction. Thank you so much !
thx dr mark niemczyk your explanation really brought light to the us of it. Quiet straightforward.
thank you dr mark! Beautiful explanation
Thank you for this video! I will be doing Soxhlet extraction for the first time tomorrow and this helped me understand the setup and the working of the extraction.
Hey could you help me please
Thank you for this informative video. It was wonderful to see the practical.
Great video! I'll be doing Soxhlet extraction for the first time tomorrow and this cleared many things up for me, thank you!
Sarvajna Potturi same 23/10/2019😂😂✌️
Very, very interesting with great presentation, thank you very much
thank you Dr. Mark your video surely made me understand the principle of soxhlet extraction method. :-)
great explanation, helped me greatly
Thank you very much for the great explanation
Thanks much! Very nicely done.
Feels like I'm back in orgo lab. Thanks Dr. Niemczyk!
Great explanations along the way, and fantastic demonstration. Thank you very much
Thank you, it was very helpful.
Thank you so much from Brazil
Great! Thank You, and keep recording :)))
Thank you
Great explanation
I finally understand, thank you!!!
I would like to know if you can connect a vertical vacuum adaptor between the soxhlet extractor and the condensor in order to work under reduce pressure, thanks, for your video.
kindly please, how to remove the oil and take out the powder extract? Please I need an answer I will really appreciate it. thank you
¿How many liters did you use of methylene chloride for the extraction soxhlet?
How do we know which size thimbles to buy?
Thank you so much
do you have any writing guidelines for the procedures?
Where do you recommend Nutmeg? In my opinion Nutmeg and smashed potatoes are an excellent combination.
Thank you.
I have been watching organic chemistry videos on CZcams for a couple of weeks now, and have now seen about a half dozen videos where this extractor is featured. I'm still waiting for the obvious comparison between a Soxhlet extractor and a flush toilet, but alas... not yet!
Tak ten film zmienił moje życie
I could learn from this dude.
very nice video. Question, in extracting an alkaloid, can i use distilled water as solvent then purify the extract? :) thank you.
It is very useful device. What about using vacuum with Soxhlet extractor? Could be useful for some temperature sensitive substances I guess?
thank you sir
is it okay if my extraction solvent does not "siphon off" it just flows down drip by drip...i put 40g of my sample in a 100ml soxhlet ectractor and use 250ml of solvent..do i need to change the amount of sample or solvent?
Is the oil extracted is in oleic acid?
Whats that cloth sandbag on the top of the heating mantle called?
Very underused technique.... nice video.
thank you
how long does it take for one cycle?
Thank you very much for the video. Very professional. Question, I am new to distillation/extraction and wanted to know is there an advantage to using alcohol base vs. water and using dry material vs. fresh plant matter. Thank you.
lol fresh plant matter... I see what you're after ;)
I found these pieces of info to be very helpful:
"The solvent selection for isolation of any phyto-constituent depend upon its solubility in that solvent.
water are used if nature of phyto-constituents is polar
Alcohol is used for if its slightly non-polar (used for both polar and non polar)
Non polar solvent like ether and acetone are used for highly non polar solvent."
"Factors should be considered when selecting a solvent:
polarity;
boiling temperature - this should be low in order to facilitate removal of the solvent from the product;
reactivity - the solvent should not react chemically with the extract, nor should it readily decompose;
viscosity - must be low;
stability to heat, oxygen and light;
The organic solvents more frequently used are:
aliphatic hydrocarbons: propane, butane, hexane
alcohols: methanol, ethanol, 2-propanol
hydrocarbons with a carbonyl group: acetone, methyl acetate
halogen derivation: dichloromethane, dichloroethane, freons."
hexan used for soxlet appratus in mayonnaise oil extraction?
If I want to use this for making mushroom tincture how long should I let it cycle? Thanks 😊
Ur making hallucinogenic concentrate of nutmeg... awesome
for how long the process can be complete?tnx alot for sharing with us.
Imagine the coffee you can get out of this thing lol straight caffeine
Fantastic
So you are
good video. i use distilled water in my soxhlet extractor.
do you mind sharing with me the power point slide of the presentation
Thank you! Great video! How could I make a filter paper thimble?
Yes we can
First thank you for this demonstration! I need to extract fat from adipose tissue. Do I need to crush the sample before putting it in the extractor? Thank you
Yes you, do it'll be efficient.
What can be use in the absence of rotatory evaporator
thanks bro
What happens if i do that with used motor oil?
Thank you very much :-)
Effective demo
Two thumbs up!
Thinking I need to invest in one of these
HI! I need an advice. I have to extracted lipids from a solid matrix. I used a Soxhlet; I fill the flask with dichloromethan and methanol. At the end of the extraction how can i recover the extract? i have no rotary evaporator in the lab. I think that lipids are dissolved in dichlorometane but both of the liquid solvents are transparent. Can you suggest me some strategy? I was thinking to aspire with a pipet the suspansion but i'm not sure it's is a good idea.
Maybe seperatory funnel
so basically, it's kinda like making coffee with a coffee filter, that eventually evaporates the water from the "pot" and then runs it over the coffee beans again?
Those Thimbles are ridiculously expensive. £100+ for 25. Is there anything cheaper I can use?
so how do you end up getting that brown oil after the solvent is evaporated in to the white powder form?
+Brendan Lampman (Ranger50792) Crystallization, I think.
Thank youu
Can I use propylene glycol as a solvent to extract my tincture from dry fruit, cococa and tobacco?
It's better to use edible alcohol (ethanol)
I have a question
I see that many people put the solvent directly into the chamber of the sohxlet apparatus before starting the extraction.
in this video i see that the solvent is in the round bottom flask
which technique is correct or what does it depend on?
Short answer, is it doesn't matter most of the time, the long answer, is it depends on the type of thimble used. When using a glass thimble, with a rosin or cellulose bag, it is probably better to pour the solvent directly into the soxhlett, whereas in this example with the cellulose thimble, leaving the solvent in the boiling flask is more ideal. Overall, the solvent will get siphoned out and cycled regardless, so it the option only really affects the first or second cycle.
great!
Why exactly 12 grams of nutmeg? What determines it? And why the solvent is methylene chloride, couldn't it be ethanole?
thanks
This is pretty cool, but it might be more useful for me to see how you can make a diamond in the lab. Thanks!
He is not using the fume hood correctly (the door is up), so HSE- requirements are not being met. Please keep the door down as far as possible, especially when working with volatile (and toxic) liquids such as methylene chloride.
How long will u put the extract in a rotary evaporatory? Minutes? Hours? Need this for research purposes. Thank u
It depends on the boiling point of the solvent, and the amount of vacuum. He's using a low boiling point solvent, so it only takes a few minutes. You could boil off 100 mL in 10 minutes for sure.
why don't we pour solvent into soxhlet extractor at the first in order to shorten the extraction time, sir ? thank you!
you can do this in the first time, but after that it does it for you
thats the objective of the soxhlet, to automate it
So, this is essentially an endless coffemaker with an integrated pythagorean cup?
Yes bro
Yes... Or a toilet... or an aquaponics "bell siphon", but I like your description better.
@@buckstarchaser2376 lol
Yes and no, I've pondered myself if it's worth the time rather then just dumping some alcohol and your product in a bowl then letting in sit and then filtering it but it's hard to get everything out doing that, depends if you want every drop of your product collected or just 60 percent
i'm indonesian anybody have the subtitle can download? please
Does anyone know what the surround is around the bottom of the flask??? What's it called? A heat resistant flask sock??
Heating mantle
Namkeen mai seaseing kitna percentage hai kaise nikalte hai
Ek vedio sir bana do ya formula share kar do
Panie Niemczyk a można nagrać nową wersje po Polsku
very interest brada :)
the quality of this video tho!
What dont understand is: in the end; how do you seperate the solvent from in my case, the thc oil.
He used a Rotary evaporator to boil the solvent off. So if you dont want to get your solvent back, just boil it off. If you want to collect it, use a simple destillation. Idk which solvent you used, but most people use butane for it, where you cant really use a soxhlet. There are Videos how to do this then. Search for "making shatter".
I asume you live in a state where this is legal ;)
magic wizard man Hi man! I am from The Netherlands actualy, so still illegal :(
I am a leukemia patiënt and i want to make my own medical grade oil.
I can make RSO now, but i want to step it up so i bought a soxhlet for extration. And it is quitte easy to understand the basics.
Bassicly what i want to achieve now is to make a clean as possible product with as less as loss of solvent as possible.
The solvent i use is ethanol and that is taxed highly in my country (netherlands)
So i am looking for a way to distillate the solvent from the oil and catch it for re-use. Besides that, i produce free thc oil for other cancer patients and give that away for free.
So i want to make as clean as possible products, with the lowest costs possible.
What exactly is short path distilation, and what other methods are there to use.
Bassicly, i saw the video on youtube from Open steel source and Jon Brown and i want to learn that stuff!
So i want to learn the tricks, but also the theorie behind it! but i have no clue as of where to start, study books wise.
predjee i only said it so i am on the safe side :D
So you can learn good Chemistry "tricks" from Nile Red and NurdRage, they make High Quality Chemistry Videos here on CZcams. Also ChemPlayer. They also explain many things like mechanism etc.
You can use a Soxhlet extractor if you work with Ethanol. After that you distille it off, you will recollect your clean Ethanol then and you can reuse it then. You just need a Heating source, a "Destillierbrücke" (English translation would be Destillation Bridge, but idk if they really call it like that, you can use the german word to google it :D) and a Collecting Flask. That would be the easiest way. Dont heat to high or you will destroy the THC. Ethanol boils at around 78°C, so you know you dont need to go much higher.
But i actually think Ethanol is not the best choice. I never did something like a THC extraction, i just can tell you from my experience in chemistry. i think you will get better results with diethylether, it boils of it 35°C, but its actually pretty dangerous in the wrong hands. But i think Ethanol will extract more than the THC, because its also a good solvent for things like Chlorophyll.
Also, before you use chemicals, please check the safety data sheets for the chemicals before handling with them.
i hope i could help you a bit.
If you are going to do one illegal thing, it won't make much difference if you do another as well ...like making your own ethanol... just don't announce it on the internet!
predjee freeze it and it will separate
Thank you. 0:11:31 👍
He sounds like he's exhausted
he is so happy cause afterwards he added ammonia and that made....
Yes that is why Philippines was colonized for more than 300 years by Spain. They accidentally discovered Philippines when their supposed destination is in Moluccas.
neat!
I need to cure fistula, I have been suffering for many many MANY years and I REALLY am desperate to get something done at this point, can anyone please HELP 🙏 I'm thinking that this could be used but I have no idea what to use with it, please please can anyone help me, I am NOW DESPERATE X
Is that you De Niro?!
"Since we're working with methylene chloride we'll be wearing gloves".
Burns like hell if you get it on your gloves and can't evaporate lmao
So the soxhlet procedure was just thr beginning afterall
Why not just wash and filter it?
You got it you gotta use it, right?
It does it for you, while you can watch cat videos
That is what he is doing however then automated.
Grease that joint!!
its just like a pythagorus cup!
👌👌
why not just heat under reflux?? what advantage does this have over reflux extraction?
I think the advantage over reflux that this has is that less solvent is required and the yield of extract is higher. Think of it this way; the solvent is sitting in the flask and being heated. The solvent evaporates and leaves the boiling flask, and then it condenses as CLEAN solvent in the soxhlet apparatus; sort of like a continuous process of distillation and then using the purified solvent to run an extraction. The fact that the solvent is being recycled is more efficient. The fact that the constantly recycled solvent is free of previously extracted material, which is always in the boiling flask, means more is able to dissolve in it than a solvent that is saturated and being heated under reflux. Heating under reflux is less efficient because eventually you have to change out the solvent which requires a messy filtration process (in which some yield is inevitably lost upon transfer) or use a bigger flask with more solvent to extract the same amount.
Can you exlain to me how to use a soxhlet extractor?
I am a cancer patient and want to make my own THC oil.
ya'll, what do you call that bean bag chair looking thing the roundbottom flask is sitting on?