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MMPs - A surprising ingredient in healthy wound repair
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- čas přidán 14. 08. 2024
- How much do you really know about MMPs? MMPs are often portrayed as the adversary in wound repair and TIMPs are frequently considered the hero. The truth is more complex than this. The proper functioning of each depends on the other and they work together to help create a balanced environment that keeps tissue healthy. Click play for a 10-minute video on the compound roles of these proteins and the ways they work to facilitate tissue restoration.
I would never imagine finding a video as good as this about MMP & TIMP, thank you very much
Great explanation! Thank you!
I really loved this video, I finaly undestood this thing. Thank you so much!
Thanks for your informative video.
Excellent job! Thank you.
That was fantastic! Thanks :)
Excellent video, very well explained
Thank you.... very informative
hi, i wanted to ask if this explanation can be used to explain :- Role of metalloproteinases in etiology of osteoarthritis?
excellent representation
How do regular people interact with scientists who know about this stuff???? I have a fun genetic glitch where my body builds vascular tumors/lesions after injury or illness - randomly. Also I have hyper mobility and it’s assumed to be Ehlers Danlos syndrome. But I feel like my MMP’s & my TIMPs are probably malfunctioning. But maybe it’s just that my extra cellular matrix is all loosey-goosey 🤓from the collagen disorder-? Chicken egg situation 🤷🏼♀️ I think my genetics should be studied bcuz I’m fairly freaking interesting. I live in a strange state of sick, chronic pain, inflammation, endometriosis and fun dysautonomia symptoms. The more they study people like me the more they can figure out what’s different and ya know - help other people. I feel like surfactants could be involved in regulation of some of my symptoms- since it signals growth to stop but also signals some cells to tighten up (repair & strengthen?) I dunno enough to know what I’m REALLY saying. But I can’t believe not one single doctor thru my whole life has ever even slightly talked to me about my ECM or how protein signaling effects all the things I suffer with. I’m 45 years old and basically studying medicine/biology myself to attempt to help find some hope for my children. Two biological daughters just starting to have symptoms. What kind of doctors talk/know about this stuff? Geneticists I’ve seen seriously seemed completely oblivious. Endocrinologist was really unhelpful- he just told me I needed to see a pediatric dermatologist (I was 25 years old)… when I met with him at the MAYO CLINIC to try to diagnose my strange vascular tumor situation. I did (and still do) have a number of external “hemangiomas” (small tho- like the size of a pencil eraser or smaller) and had a typical hemangioma on my shoulder that acted normally and shrunk by puberty. But dermatologists simply preform surgery & remove them if not simply leave them alone. Some cases may attempt some steroid treatment but NONE get into the actual cause & consequences of the hemangiomas much less deal with complex internal multi systemic hemangiomas. Ugh 😑 I’m back at the Mayo Clinic as of last week seeing a fancy neurologist now that I know I have EDS (or some hyper mobility syndrome) so we’re gonna be checking all sorts of cool stuff but I’m not expecting a deep look at this kind of genetic/biochemistry level stuff. I want that. Anyone want to tell me how?
I'm on the same quest to find a researcher or clinician that can help deep dive to this level of detail. The closest I've found so far is someone like chrismasterjohn who takes whole genome test results and then deep dives them for customers looking at genomic variants from a genetic/biochemistry perspective. But he's not going to necessarily catch those types of issues that aren't well understood from a genetic variant perspective. Also there's a waitlist to see him.
Would be very curious if other similar researchers offer guidance to people like us, in pain and looking for answers or clues that are beyond the scope of nearly all clinicians. Post covid, I have a leaky bbb (according to elevated brain proteins found in my blood) and nearly anything that modulates my immune system will cause painful inflammation. Most doctors just throw their hands up or turn me away since my labs are otherwise normal and they don't know how to help me. There's not diagnostic markers that I've found to indicate issues beyond Cyrex immune labs.
thank you for the knowledge and information [: what influences the imbalance/ the bodies ability to regulate the balance of TIMPS and MMPS? From a holistic perspective, it interests me to consider the internal/psycho-social/emotional states in relation to wellbeing and experiences of chronic pain/inflammation - TIMPS remind me of boundaries while MMPS are like the addictive, indulgent (maybe destructive) impulses that we may engage in (ruminating thoughts/addictive behaviours, etc.). When a person maintains a healthy harmonic balance of their internal world then they engage in impulsive desires but maintain boundaries to recuperate and maintain a healthy balanced life, but when out of balance they may engage excessively in impulsive behaviours while unaware of personal boundaries that are needed for balance. Maybe these lifestyles have a long-term, low-level but consistent impact on the ratio of TIMPS and MMPs in the body, and if so, then a long-term regenerative treatment would include conscious choices and lifestyle changes to put in place boundaries on a psycho-social level to I guess modify the roots of a person's chemical imbalances on a kinda macro scale
Look, there is Plankton from Spongebob Squarepants in the ECM!
Soo nicely explained thnx.
I want to ask something about this, I have read about antioxidant activity and anti-collagenase journal.. but I havent find how the antioxidant inhibit the collagenase? is the antioxidant support the TIMPs, or the MMPs is directly inhibited by the antioxidant? maybe u can answer my question... Thank u btw for explain this material.. greeting from Indonesia
Can downregulation of specific TIMP clear out fibrotic plaque in Peyronie's disease? Or is there a risk healthy collagen degradation by MMP?
Theoretically, would it be possible to release a whole bunch of TIMP around a cancerous tissue in a time-delayed capsule in an attempt to prevent cancer cells breaking off and clearing pathways to blood vessels and other vessels of the body?
In the perfect world of theory, yes it should work. But in reality, more complications come up.
As Frank E said in theory yes. I think the main problem is that multiple proteolytic networks exist f.e. serin proteases or cystein proteases may be also important. And as a result of cancer cell evolution and selection knocking down one component, could result in upregulating another component which gives the cancer cell the ability to invade/metastasize despite TIMPs.
Do TIMPs and MMPs function differently in haemophilia