3 advances in brain research (organoids, chips, microscopy)
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- čas přidán 9. 07. 2024
- Today we’re going to talk about a toolbox - a toolbox for brain research, looking at organs on a chip, organoids and microscopy and why you should be excited about them. Why should you care?
We still don’t know how to treat many different neurodegenerative diseases. We don’t fully understand the cause? We don’t know how personalised it is/how genetics affect things? Part of this has been due to a limitation in models and experimental techniques. We can’t just take biopsy of brain from healthy people, cell lines lack complexity and mouse models have been scrutinized as not representing the full process of disease manifestation resulting in poor translatability to human therapeutics.
So, in this video, i thought i would put my optimistic hat on, it’s almost always on, and provide you with an overview of the 3 novel methods being employed that may act as a better model for brains to advance neuroscience research.
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TIMESTAMPS:
Intro - 00:00
Brain-on-chip - 01:50
Brain organoids - 03:40
Expansion microscopy - 06:40
References:
Generation of Functional Human 3D Cortico-Motor Assembloids - doi.org/10.1016/j.cell.2020.1...
Pașca, S. The rise of three-dimensional human brain cultures. Nature 553, 437-445 (2018). doi.org/10.1038/nature25032
www.science.org/content/artic...
Leung, C.M., de Haan, P., Ronaldson-Bouchard, K. et al. A guide to the organ-on-a-chip. Nat Rev Methods Primers 2, 33 (2022). doi.org/10.1038/s43586-022-00...
Choi, S., Kim, Y., Hebisch, M. et al. A three-dimensional human neural cell culture model of Alzheimer’s disease. Nature 515, 274-278 (2014). doi.org/10.1038/nature13800
Expansion microscopy - doi.org/10.1126/science.1260088
Sarkar, D., Kang, J., Wassie, A.T. et al. Revealing nanostructures in brain tissue via protein decrowding by iterative expansion microscopy. Nat. Biomed. Eng (2022). doi.org/10.1038/s41551-022-00...
wyss.harvard.edu/technology/h...
emulatebio.com/brain-chip/
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "www.freepik.com/free-photos-v..."Background vector created by freepik - www.freepik.com - Věda a technologie
Mind expanding or mind your own business?
My brain my business lol
Great video Sheekey! Would love a deep dive into organs/brain on a chip :)
This is incredible. The brain is so hard to research. I am most excited about organoids.
Maybe these new tools can be a stepping stone so we can eventually develop high quality and wearable brain-computer interfaces that can be used for further research, diagnostics, medical monitoring and imaging, helping to improve prosthetics, improving quality of life for disorders of consciousnesses, and VR which can be used for training, education, communication, therapy, rehabilitation, recreation, and more...
Expansion Microscopy, wow very cool! Well, guess that's today's new lab technique I learned about :)
Very cool to see! The Methuselah Foundation has also spoken recently about the need for more pre-clinical models such as organs on a chip and organoids.
🔥🔥🔥
Eleanor, could you comment on the research concerning fucoidens ?
Great video!! Sad to hear about the fabrications in papers and collusion etc.; hopefully both scientists and companies alike will learn there's more prestige and money in doing legitimate work.
There was no fabricaton in the papers and/or the science whatsoever. It was false accusation organized by short sellers in an attempt to make money on the stock price drop, which they did. Unfortunatelly. I hope at least some of them will end up in jail. The case was dismissed recently since nobody could find no real evidence.
Have you heard of the Dr. in Florida who has patented a process whereby he injects an anti-inflammatory drug (Etanercept, I believe?) into the spinal cord of patients then tips the table they are lying on down to facilitate the drug entering into the brain directly? In the videos he has published, many people report amazing recovery from symptoms related to brain injury from stroke, MS, etc. While these videos are heartening to watch, I am waiting for someone like yourself to do research on this to see if there is indeed a possibility of success with this treatment. Right now, he claims to have about an 80% success rate with this treatment. I believe his office is in Boca Raton, FL and if you search for "IFL" I think you'd be able to not only find his channel, but also see many of the videos that have been posted to his site. Right now, there are people from all over the world who are flocking to his clinic for treatment. If this treatment is indeed viable, this could truly change the state of aging as we know it-
Yes, I think I seen one of those very heart warming videos on stroke recovery on a 60 minutes Australia video. Very heart warming. I. Thought as I watched it that we are limited to only drugs that can cross the blood brain barrier. Other drugs, we don't get. Spinal fluid, or a hole drilled in the skull is the only other way around that. I believe that nobody should breech the blood brain barrier to deliver such drugs. It would open up a big ol' can of worms, (ugly worms). Then on the other hand, spinal fluid or hole drilled in the skull might be ok for delivering such drugs, I don't know. But I wouldn't think that anything should be breeching the tight junctions in the blood brain barrier those tight junctions should be maintained, and secured. Spinal fluid delivery, or other, might be just fine to deliver such drugs, I don't know, it's over my head.