Can taurine and vitamin B12 improve your health? - Vijay Yadav
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- čas přidán 28. 07. 2024
- In this video I spoke with Vijay Yadav, Assistant Professor at the Department of Genetics and Development at Columbia university researching functional connections between human metabolism and disorders. Earlier this year his team published on the role of taurine and how supplementation in a mouse models improved many markers of health. Here we discuss Vijay’s interest and research further.
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TIMESTAMPS:
Intro - 00:00
Early work in reproductive endocrinology - 01:00
Vitamin B12 - 08:00
Taurine - 19:00
Human clinical trials - 41:30
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "www.freepik.com/free-photos-v..."Background vector created by freepik - www.freepik.com - Věda a technologie
Hearing this research just validate more my decision to become a carnivore. I've been on a Ketogenic diet for the last 5 years as a carnivore eating 90%+ animal products. Going into my 60's it's turned out to be the best decision I could of made. At 55 I was 10% overweight, congested with systemic inflammation, hay fever, Irritable Bowel Syndrome, flaky skin and was flabby and unfit. All of that is reversed or eliminated and I feel healthier in my 60's than my 40's or 50's.
Also Time Restricted eating from the work of Dr. Satchin Panda on Circadian Insights into Exercise Timing, Melatonin Biology, and Peak Cognition has been a life changer.
Happy New Year everyone.
They it causes heart disease. The fat content. Low carb diet shortens life according to literature
Also, animal foods, especially animal fat, are among the lowest deuterium foods. That is even more true for pasture-raised and wild-caught. Plus, fat--burning produces deuterium-free metabolic water.
Domestic cat aging / longevity is interesting. Feral cats live on average only 2-5 yrs. Pet cats live 12- 18 yrs. But the record lifespan for a pet cat is a whopping 38 yrs, held by Creme Puff. Creme Puff's human, Jake Perry, fed her 'on top of dry commercial cat food, a home-cooked breakfast of eggs, turkey bacon, broccoli, coffee with cream, and-every two days-about an eyedropper full of red wine to “circulate the arteries.” ' He also gave them lots of enrichment and love. I can't help thinking the capacity for radical lifespan extension in domestic cats might have something to do with bile acid metabolism, which is dependent on taurine.
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Aside - I notice in comments a wide range of reactions to the level of technical detail provided in this video. Personally, I prefer more detail. It must be difficult to find the right balance.
A topic I would really like to see addressed is harmful B12 analogues. They can be present in B12 supplements, which is why some prefer cyanocobalamin as opposed to methylcobalamin since the former is more shelf stable. But even more interesting is that harmful B12 analogues are made endogenously and they are higher in Alzheimer disease (see 'Analogues, ageing and aberrant assimilation of vitamin B12 in Alzheimer's disease'). I suspect they may be a by-product of itaconate production (see 'The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12'). Another possibility is generation of harmful B12 analogues by gut microbiota, but they should not be able to enter the blood stream.
This was a SAVAGE episode. Sheekey is no joke with it; mad respect for her hustle and grind.
Taurine is a key sulfonic acid. Very much the most underrated health compound/supplement! P s. I went to school with Patrick and I've been waiting for a response from you for around a year.
We appreciate your work , may I suggest if you do a summary at the end of video in a simple English “ for the normal person “ as what is the result and if you recommend the supplement or not etc , thank you.
Great show. Great topics.
It would be neat to have the values (and plot) of Taurine levels in different age groups. This would help inform dosage recommendations per age. (e.g., how much do I take if I'm 60 years old?)
No reply so far?
@@jhakku1401of course not, it is easier to prescribe the same dosage for everybody...there is no penalty for malpractice anyway...
Amazing interview and guest!
Wonderful episode! Fascinating information on the history and research of taurine.
Awesome conversation! Thank you!
This one is DENSE with content! Thanks for this great interview. Would love a TLDR/TLDW on this episode.
Wow! This interview is fabulous!
This was a fascinating interview!! Tyvm
Interesting show. Not only from a scientific point of view, but a human story of Dr. Yadav playing in the lab at 9 yo, becoming inspired. Good interview to bring this out.
Looking forward to this one
Thank you both
Excellent! Thank you for posting!
Swapping green smoothies for raw liver smoothies😂
Love the history on B12. Especially, burning down the lab. 😂😂Those were the days❤
When you think you know it all, there is always more - excellent work. Thank you for maintaining your passion.
Does supplementation with cystein increase Taurine in our body? And does supplementation with cystein reduce the level of methionine?
Very useful information. Thank you.
They should start studying plasmalogen content of liver and it's impact. It's not just b12.
Thank you for this - makes sense to me. :)
I think there was mention of a transporter for absorption of taurine from the GI tract? Would be good to know what the transport limit is, as supplementing above that limit would presumably not accomplish anything.
If increasing the level of taurine is advantageous, but we can’t absorb enough from diet/supplementation to reach the maximum beneficial level, then would need another way. Like shots, or even gene therapy to ramp up the body’s own production.
I’m also curious now, if B12’s only purpose is to help the body make its own taurine, or if B12 has additional functions…
And with the various functions that taurine supports, I wonder if it is the foundation for a whole set of processes.
B12 does a lot of stuff; the Linus Pauling Institute has an entry on it in their micronutrient database. In addition to the stuff listed on the LPI entry, B12 is an LRRK2 inhibitor - may be beneficial in some types of Parkinson's, but also could be implicated in lung adenocarcinoma (and possibly other cancer types).
@@rhyothemisprinceps1617did he ever stop saying what his qualifications were and what he did and how important he was and ACTUALLY discuss the facts versus talking AROUND it???
Or mixing up taurine with water and sipping it throughout the day instead of taking it all at once. Isn't it how they gave it to mice?
@@jb_1971 RedBull? 😅
@@rreddingcaffeine and high sugar .
Thanks❤
I wonder if fish could have some co factors that help taurine?
65 yrs female, want to GAIN weight, don’t need more energy, but wish for increased bone density and muscle maintenance/growth. Ideas?
I would look into creatine, protein (whey) and magnesium supplementation (you can choose magnesium taurate to get both magnesium & taurine at the same time) together with some strength training according to your needs & abilities. The strength training is IMHO more important but those supplements should be safe & efficient for most people.
Thank you for you ideas. And I agree on the strength training, which is less inspiring as the joints are worn and more inflamed/less cushioned.
I tend not to eat 'magic powders' (like whey protein, for example), it seems so 'processed'/unnatural. How can I, or should I?, get over this aversion? How would you sell me on organic/grassfed etc etc whey protein.. Thanks! (brand names encouraged)
@@ayasugihada
@@eugeniebreida1583 Take baby formulas - the stuff that goes in is also processed to the same degree. But it really ain't that big of a problem if you choose CFM filtered. It is mechanical not chemical filtration. The level of processing does not differ all that much from cheese production. I always go for unsweetened, natural protein & add high quality cocoa powder with a bit of sweetener - like honey, agave sirup or stevia if you want 0 callories. High quality cocoa powder (undutched) has a lot of polyphenols. That being said, you absolutely don't need to eat whey protein. For the joint pain - consider astaxanthin. It is pretty safe even at a very high doses. Yet always better to consult with your physician.
Hi maybe you could look into this product called Grow Bone supplement but do your own research. This is what I take.
@@ayasugihada 8:59 8:59
Hello I am interested in the multinational trial of taurine supplementation please. Can you put me in contact with Vijay Yadev please.
seems like video actually starts around 10:00 ??? It just seems like:
did he ever stop saying what his qualifications were and what he did and how important he was and ACTUALLY discuss the facts versus talking AROUND it???
She asked lol
I began taking taurine because I know cats need it. On vit b12 also 😊
Are there health effects in vegetarians or vegans from not getting enough taurine?
Who can say for sure. I'm taking the usual amount omnivores eat to stay on the safe side. From another point of view, veg diet can be low on methionine, which together with cysteine I think is requirement for synth taurine. That's my layman's perspective.
💯💯💯💪👊👍
Very good ! !! Eleanor still needs to improve her spelling, it s a pain for the ears.... ARTICULATE AND SPEACK SLOWLY, you re not a teen anymore
Speaking, not spelling. Both were difficult to understand.
Wait, cooking liver destroys B12?
Yep,