The impact of donor KIR genotypes on alloSCT outcomes in AML/MDS, and the value of biobanks

Johannes Schetelig, MD, MSc, University Hospital TU Dresden, Dresden, Germany, discusses a study investigating the impact of donor killer-cell immunoglobulin-like receptor (KIR) genotypes on allogeneic stem cell transplantation (alloSCT) outcomes in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). The study failed to validate any of the previously proposed models that were predictive of patient outcomes following alloSCT. Prof. Schetelig goes on to discuss a biobank of more than 50,000 donor samples supported by German transplant and collection centers, which is open for use by researchers from around the world. This interview took place at the 50th Annual Meeting of the EBMT in Glasgow, Scotland.
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