CAR-Ts in multiple myeloma: their current role and the future

Hermann Einsele, MD, FRCP, University of Würzburg, Würzburg, Germany, provides an overview of CAR T-cell therapy in treating myeloma. The currently approved CAR-T therapies, ide-cel and cilta-cel, have shown impressive progression-free survival (PFS) and overall response rates (ORR) in the KarMMa (NCT03361748) and CARTITUDE-1 (NCT03548207) trials, respectively. Dr Einsele predicts CAR-Ts will be used earlier in treatment based on results from the CARTITUDE-4 trial (NCT04181827), as early T-cell extraction and less pretreatment enhance their efficacy. Research is also exploring targeting different antigens like BCMA and GPRC5D to counteract antigen loss in myeloma cells, and combining CAR-Ts with other agents to boost their effectiveness. This interview took place at The 10th World Congress on Controversies in Multiple Myeloma (COMy) in Paris, France.
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