Tyruko Vs. Tysabri for Multiple Sclerosis Explained by Neurologist
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- čas přidán 10. 10. 2023
- Tyruko is a Tysabri biosimilar which has been FDA approved for multiple sclerosis. But is Tyruko just as good as Tysabri? Is it as effective and safe? Can you shift directly from Tyruko to Tysabri? This video explains Tyruko and reviews a head-to-head trial comparing Tysabri and Tyruko.
Selected sources:
Tyruko product label: www.accessdata.fda.gov/drugsa...
Novartis wins FDA nod for first biosimilar version of Biogen's MS blockbuster Tysabri: www.fiercepharma.com/pharma/n...
FDA Approves Biosimilar Tyruko for Multiple Sclerosis, Crohn Disease: www.empr.com/home/news/generi...
Efficacy and Safety of Proposed Biosimilar Natalizumab (PB006) in Patients With Relapsing-Remitting Multiple Sclerosis The Antelope Phase 3 Randomized Clinical Trial: jamanetwork.com/journals/jama...
Natalizumab (Tysabri): www.ajnr.org/content/31/9/1588
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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.
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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information. - Věda a technologie
Very interesting and informative. I’ve been on Tysabri for over a year now. It did take a few months for me to notice anything. However, when starting, my MS was very active. Now, I have a much better quality of life. It’s keeping things quiet. Can’t imagine life now without it. I’d be willing to try it. The way I look at it is, I wouldn’t be taking Tysabri if people hadn’t stepped up and participated in studies. Thanks again!
Thank you for this, I was struggling to find a flowing information about Tyruko.
I’ve been on Tysabri for 15 years, only having relapsed 2/3 times.
My hospital here in the UK had informed us that the change was coming, they gave us no notice and so we’ve all been trying to find information. Your video is very informative and I thank you for it!
I have asked to continue on Tysabri for further two months, I’ve asked that because I am treated between two jurisdictions, the United Kingdom and Italy and obviously, the medicines have to match, I’m quite sure you can’t mix and match. 🥴
So I’ll be starting Tyruko in September, I feel a lot more confident about it having seen your video. 🙏
Very informative and excellent summary of the trial. I am a pharmacy resident preparing to present a journal club on the Antelope Phase 3 trial to the MS clinic and pharmacy staff at my hospital. This video was a great starting point. Thank you!
:) I'm glad it was helpful. My institution doesn't use Tyruko, so I have no firsthand experience yet.
Outstanding summary of the data. Thank you for making this video. Will you feel comfortable switching Tysabri patients to Tyruko in your practice?
100% yes
Dr. Beaber im only second year diagnosed and already in a wheelchair. I have disabling dizziness to the point i cant sit up straight. Is constant dizziness common in MS and how do u personaly treat it to make daily activities easier for patients? If i dont get it under control ill never be able to do physiotherapy. Im bedbound. Ive become so weak from sitting in a wheelchair for months. I just cant describe the dizziness. But im being told MS doesnt do ths. I cant even do thngs sitting up i cant be still in my chair or bed.
Thank you so much for your analysis.
Awesome! Thanks for this breakdown! It's really helpful!
Great vid Doc!
Thank you dr. Brandon or this video, unfortunately I just recently switched from tysabri to keisempta due to testing positive for the JC virus. So far the injections seem to be pretty easy as compared to the older ones. Doing this once a month is not bad at all and I don't even have to get in my truck and drive to an infusion center anymore I'm not is another Plus.
Interesting, thanks Dr. Beaber. I started treatment with Tysabri about 2 years ago and had to switch to Ocrevus after 6 months due to JCV. My first JCV test was negative, a second at 5 months was mildly positive, and the last at 6 months was solidly positive. I also elected to 6 week infusion intervals from the start because of the PML risk (even though I originally tested negative). Is it possible that my first test was a false negative? Also, is it also possible that Tysabri caused JCV to re-activate, which increased my antibody levels over time?
Hi Dr. Brandon😊off topic but i wanted to ask about MS relapses..my sciatica is inflamed snd it resulted in a pseudo or real attavk im not sure..if CRP levels are normal does that mean lesions are not inflamed? And are low grade fevers like 37.6 considered high enough to trigger symptoms?.. would u give steroids if a patient has this fever and the sciatic nerve is inflamed?..ive taken steroids in the past for dizziness while on low grade fever and i worsened because they didnt have proof of infection
What about the cost? That's my main concern. If insurance pushes this, is there a co-pay program?
I have been off Tysabri since January. My last lot of bloods were good. How long do I have to worry about Rebound? My new Neuro said I don't need to be on any DMT. Watch and wait approach. I was diagnosed with highly active RRMS in 2021 and had 17 treatments of Tysabri.
That’s concerning to read.
I am worried as the previous neurologist was adamant that I needed to stay on Tysabri even though I had new enhancing lesions while on Tysabri, plus UTIs every month. That's part of the reason why I changed neuro and I had no treatment while waiting the appointment with the new Neuro. He said no treatment is ness, watch and wait see you in a year.
How are you now ?
Had a hypersensitivity reaction to Tysabri-2 weeks of extreme pain-after being on it since 2012. My Neuro is unsure if Tyruko would do the same since they are different, but worth a try. Would you agree?
Hi Dr Beaber. I have been following your content on autoimmune diseases of the nervous system and would love to schedule a time to speak with you about your research. I work for a consultancy company in Copenhagen and would very much like to get your opinion on the various treatments available. Can I send you an email to connect?
What is the cost of Tyruko vs Tysabri? More importantly, how many hoops do you have to jump through for insurance companies to pay for each one.
Is it better then Ocrevus?
Hi from Israel although the war in Israel I don't miss your chanel thank you for the important data my daughter is onTysabri and who knows if the insurance company will order to change the treatment to Tyruko so this data is very important for us thanks❤
😂😂😂 leave that place is not for you
Ive had muscle weakness, cant stand on my feet for more than couple of minutes, tingling in my face and in my tongue, extremely tired, dizzy and feeling sick. My doctor keeps telling me its because I had my ear blocked 4 weeks ago. But I had that treated and nothing has changed. I feel unwell. Are these symptoms warrant visit to a neurologist?
The brain fog and speech impairment is also big. I am sure it is not my ear 😢
I am tired of “biosimilar” products. We need to focus on stopping stopping this condition, maybe remyelination. Maybe work on improving Ampyara bc that pill is a step in the right direction
I understand Mohammed. The only benefit of this is cost and more availability of natalizumab to more people with MS.
Thanks for the video Dr. Beaber. I will not risk myself using a drug without a phase III trial. I prefer using mature drugs with long-term follow-up trials. Long-term side effects are important for us.
But it not a new drug. It is natalizumab with a different manufacturer.
@@DrBrandonBeaber Even though they are the same, Grade III side-effects are not similar which concerns me.
Good morning doctor, I'm starting the tyruko today. Can you explain to me in a few words the difference between tysabry and tyruko? I don't understand much English. I understand Italian.
There is no difference in my opinion. They are the exact same drug.
Thanks for another informative, (but not performative) educating video Dr. Beaber.
Question #1 : 8:44 anti drug antibodies 87 vs 91 - aren't both numbers showing fairly high probability?
Question #2: Is the occurrence of anti drug antibodies something that occurs inherently in all immune suppressants (and is a delicate dance aimed at more help than hindrance)?
Yes the risk of anti-drug antibodies is very high but they do not generally prevent the drug (Tysabri/Tyruko) from being effective.
Many drugs (particularly large protein biologics) induce anti-drug antibodies which may or may not be significant.
Would you recommend a antiviral routinely if someone had HPV with this?
Interesting video. I had never heard of Tyruko - but the more tricks you neurologists have at your disposal the better to treat us with.
#Sharingiscaring
#MavencladMilf
I personal don't think Tysabri/Tyruko would be likely to reactivate HPV or cause cervical cancer but talk to your own provider.
Well, watching my hives and inflammation dissolve every day until it all disappeared was definitely appeasing, I went with what I mentioned and after 20 days my urticaria disappeared. I just go'ogled the latest by Shane Zormander and now my skin is as smooth and healthy as it has ever been!
DONT TAKE DRUGS FOR MS!!! I had it. Now I don't. YOU DONT NEED DRUGS.
How do you know you don't have it anymore?
I SECOND THIS. My neurologist stopped scheduling appointments with me after 4 years of failed attempts at getting me on an MS drug. Instead I just changed my diet, sleep and exercise. I've also had all the attacks in the book, but it all stopped after eliminating chicken and meat fat, diary, soda (sugary drinks) and alcohol.
Sigh.
@@zadocklong I was in a wheelchair now I walk run workout climb. Do everything I did prior to my diagnosis when I went into the neurologists in a wheelchair originally? 12 years ago.
@@Miceliism thank you for you story . I was diagnosed last month and I changed my diet and exercising a lot more because I agree I think that will help tremendously. Although I plan on taking a DMT cause I am afraid of not doing everything I can.