What your ANA Pattern means
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- čas přidán 31. 05. 2024
- Is your ANA test leaving you with more questions than answers? (Yikes! Is it lupus?!) Today's video dives deep into ANA patterns and their implications. In this video you'll gain a clearer understanding of how the results are reported and what they do, and don’t, mean. *2024 update
🔗 Links:
Your Appointment Home Run Handbook - connectedrheumatology.com/app...
The guide you need to be able to tell your doc your story -and find get answers once and for all!
⏱Time Stamps:
00:00 Intro
00:40 What is the ANA test?
03:00 What does the ANA pattern mean?
04:35 Homogenous pattern
05:19 Speckled pattern
05:56 Dense Fine Speckled pattern
07:02 Centromere pattern
07:34 Cytoplasmic pattern
09:27 Convo Starters (Qs for you and your doc)
🎥 watch more:
5 things you need to know about your positive ANA - • 5 Things You Need To K...
Top 3 Facts about the anti-centromere Antibody - • Top 3 Facts about the ...
Top 10 Things to know about lupus - part 1 - • Top 10 Things to Know ...
Top 10 Things to know about lupus - part 2 - • Top 10 things to know ...
📖 References:
Damoiseaux, J. et al. Clinical relevance of HEp-2 indirect immunofluorescence patterns: the international Consensus on ANA patterns (ICAP) perspective. Ann Rheum Dis 2019; 78: 879-889.
Pisetsky, D. et al. New Insights into the role of antinuclear antibodies in systemic lupus erythematosus. Nat Rev Rheumatol. 2020 Oct; 16(10): 565-579.
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👩🏻⚕️ About me:
Hello! I am Dr. Elizabeth Ortiz and I’m so happy you are here. I am a double board certified Rheumatologist with over 15 years experience practicing Rheumatology and am passionate about teaching & empowering patients to partner with their doctor.
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✏️ BLOG : connectedrheumatology.com/blog/
🖥 WEBSITE: www.connectedrheumatology.com
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* The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional. Any comments and/or recommendations made in the comment section by anyone other than Connected Rheumatology does not reflect the opinion or recommendation of Connected Rheumatology.*
Welcome back to CZcams, Dr. Ortiz! Your great information and videos were truly missed by our community. So happy to see you back!
My pattern keeps changing. Speckled, then homogenous, then both speckled & homogenous, then speckled, then nuclear/dense fine speckled, all from Quest Lab. 1:320 for some years, now staying at 1:80. I keep asking about the pattern changing, told it probably doesn’t mean anthing (brushing me off). Low C3 complement, C4 is ok. Sensitive Sjogren’s panel negative. Lupus 12 panel was ok except ANA’s and Low c3. Severely unwell since 2012 with recurrent cluster of systemic lupus-like symptoms, tendon/connective tissue problems in my whole body. Recurrently peeing blood, no infection-bright red blood or microhematuria, leukocytes, protein, and “mild acute inflammation” in my urine tests. Scope was fine. Getting brushed off, being disbelieved then told “you’re doing something to make this happen there’s nothing wrong with you” when I show photos. It’s been a nightmare.
I was a lab technician who worked in autoimmune and reading ANAs was one of my jobs. Interesting to learn how things have changed in the 10 years since I retired.
I'm so thankful for this particular video and l was so stressed out with my ANA Centromere patters, and your video has calmed me.
I am hoping on Thursday when my doctor reads my test results that he will pay clear attention to these results and pay attention to how l have been feeling.
And most importantly that he will care.
Thank you so much for being available for us all with your informative videos.
It’s great to have you back doctor. I was just looking for you on the web last week and this first episode today has really made me feel great. You look good. I hope you are feeling well. Patricia.
My ANA comes out 1:1280 homogeneous pattern with a lot of symptoms. Further tests came back with elevated RF and Chromatin. I was diagnosed with Lupus. This was 6 years ago. Since then, I’ve developed a few other AI conditions that go hand in hand with Lupus, as well as Lupus complications. Good job in explaining ANA
Great new video!
I love your presentation! You give serious and helpful information but add a touch of humor and a refreshing amount of honesty! Appreciate you!
Thank you. This was very helpful. 🙏
Love the depth of discussion ❤
Thank you so much for your information. Very helpful!!❤
So good to see u here again. These videos r really helpful
Can you tell me anything about the Centriole Mitotic pattern? Thank you for posting♥️🤗
My ana and speckled pattern 1:160 came back positive. Drs did a 12 panel ana and all the panels were low positive. But Drs said it's negative and I don't have lupus.. I have a lot of musculoskeletal issues and psoriasis. Extreme fatigue, hair loss, lack of sleep and lots of nerve pain, numbness, tingling, prickly feeling and burning but the Drs say still no lupus.. esr, ana, CK and components c3,c4 elevated.
Hi, thanks for this video! Very helpful! What does the titre result mean, please?
I am so happy to see you on CZcams again. It feel like I just went to visit my Rheumatologist which I wish it was you. I am Maria the one who did the painting for you. Hope to see you soon.
Thanks got diagnosed with a titer and pattern
You rock!
Thanks
Is the IFA standard for the anti-ds dna? Thank you.
I have a positive ANA, dense fine speckled pattern and 180 titer. I was diagnosed with autoimmune hypothyroidism with multi nodules and enlarged thyroid. I feel like I have another auto immune disease because I have extreme fatigue, joint pain, facial rash and many more symptoms. My endocrinologist referred me to a rheumatologist and the rheumatologist said my chances of having another autoimmune disease were low. My dsdna and smith were negative. C3 was normal but c4 was elevated. I was feeling good at the time of those blood test. Had just finished taking amoxicillin for a UTI. Any thoughts or maybe a different rheumatologist. He seems very disinterested in everything. Thanks
Does it matter if you take the ANA test when you are in a flare up or not?
I'm negative on everything except antihistone any words or wisdom on drug induced lupus? Thxss
Can you please possibly help me understand my results. I am currently diagnosed with Ehlers danlos syndrome, POTS, SLE, then IC. My ANA pattern is always speckled however, I am always also positive for centromere antibodies. My rheumatologist is confused because my ANA pattern is not centromere. She has redone blood tests for this three times and it's always positive. She's doing one more test in April to check for the centromere antibodies again. Any thoughts on what could be going on? I questioned her about if my Speckled ANA pattern could change into the Centromere pattern in which she said no. I also remember an older video in which you said blood work can show signs of things to come up later in life, so I'm concerned about the Centromere antibodies that have been consistently showing up. I'm not sure if I need to go to another rheumatologist for a second opinion. Any advice would be so incredibly helpful thank you.
Mine was positive and speckled, positive SSA but negative SSB, IM CONFUSED sjogrens was positive
Is a positive ANA A way of testing for Celiac Disease?
I’m so confused. I was diagnosed with Antiphospholipid Syndrome in 2000 after PEs , stillborn daughter at 36 weeks, migraine and TIA symptoms as well as other symptoms. After years of being followed at Cedar Sinai I was finally diagnosed with Lupus by a rheumatology attending dr in 2011. By that time I had already had PE x 5 , bunches of TIAs and numerous superficial clots. I moved in 2020 and the new rheumatologist doesn’t think I have Lupus. I have symptoms of Lupus as well. Thing is that he’s convinced I don’t because I have dense fine specked patten 1:320 and I think one was 1:6 something. Any suggestions would be greatly appreciated. As far as I know even Antiphospholipid Syndrome is an autoimmune disease so how can I not have an autoimmune disease?
I can totally relate I’ve had a few ANA results back positive 1:320 homogenous pattern. My Rheumatologist doesn’t think I have lupus because I don’t present all the “classical” symptoms of lupus. It’s frustrating because I have a lot going on and with no specific answer.
My mother was diagnosed with Lupus back in the early 1980's. She was put on medication for it, but later was told it was a misdiagnosis, that she did not have it but actually some rare form of Cirosis of the liver. Seems its one they still have a hard time diagnosing.
Mine was Nucleolar 1:1280
I didn’t hear her list this one. Anyone have ideas?
That's what mine was too. I'm waiting to hear back from my doctor what this means. On the portal it says something about Sjogrens syndrome and systemic sclerosis/polymyositis. Have you heard anymore?
At this point I am being treated for Limited Cutaneous Scleroderma. Systemic sclerosis but a limited form of it. After further testing they found anti- centromere antibodies. Hopefully you find some answers
I’m Ana positive with cytoplasmic pattern and my doctors act confused. Why is it they don’t know it can be associated with Lupus, Hepatitis, dermatomyositis?? So frustrating. I already meet the Lupus point criteria. I have major weight loss, severe stomach pain, numbness, Raynauds, joint pain, muscle weakness photosensitive rashes, burning knuckle rash, dry mouth and eyes, blood vessel inflammation, blood in urine from my kidney bleeding and still no diagnosis! After 3 years that finally suspect Lupus but won’t say for sure. I just want to feel better! Any tips or advice from anyone is appreciated! The burning knuckle rash has me thinking more Dermatomyositis.
Ask them to give it a try and treat you as if you have Lupus, just to see if it works. For example, get on Plaquenile for a few months and see if it helps your symptoms. Don’t push for diagnosis but rather for treatment of your symptoms.
@@DJ-nk4dq thank you, I was wondering why they haven't tried that route yet but ironically was just diagnosed today via lymph node biopsy. Of course I didnt want any disease but I knew I was sick just a matter of what it was or what they could do to treat me and get my quality of life back.
@@DJ-nk4dq Lupus that is.
My pattern was nucleolar, you didn't mention that one.
Mine was too
Same :/
I believe that’s homegeneous
I have an ANA of 1:320, high esr and crp. Multiple joints with pain and multiple other conditions. My first round of antibody test have come back neg. Should my rheumatologist continue with more lab tests? I've been suffering for over 5 years now.
My understanding is that 320 points to possible AI condition but it doesn’t have to mean that one is present. Your # is sort of a cut off point for suspicion. If you have other conditions, antibodies can be a little elevated but, most importantly, if you have joint pain with high ESR and CRP that should be treated. Hope you are getting some help already.
I do have joint pain and both my CRP and ESR are elevated but the doctors seem to blow me off so I have given up and will have to deal with it myself.
@@CallOnJesus sorry to hear. Hope you find some relief
Check into AVISE testing by Exagen. It is a highly sensitive test. If you call the company, they can tell you names of doctors in your area who are familiar with the testing and the results. You’ve been suffering for five years, so that should tell you something. You know your body.
@@jillhontz3145 thank you so nuch!
I am suffering from ankylosing spondylitis. I m 40 yr old. My penis is hanging down and is becoming very loose and soft. Is this happening because of my illness??
The two are not connected.
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Hi I had a positive Ana
My Teter was 1:320
Pattern nuclear dense fine speckled
I read that a nuclear dense fine speckled means I don’t really of autoimmune?
I had a positive ana now 2 years later I have pulmonary fibrosis and RA. When I was in my 20's diagnosed with Addison's disease.