Thank you doctor, it's an invaluable presentation, I have the DIP. I wish every neurologist, particularly those focused on Parkinsonism should watch it!
I was on escitalopram and went from 10mg to 5mg and developed jaw tremor (very minor) and hand tremor. I am now very slowly tapering off the medication. Even though the jaw tremor is not noticiable should I do something about it? It's not going away.
Thank you for the comment. I believe you should consult your physician or neurologist: if the jaw tremor is bothering your daily activities, it is advisable to have it thoroughly investigated. I hope you agree with me that giving medical advise without actual physical examination is not advisable for either of us.
Escitalopram is an SSRI: selective serotionin reuptake inhibitor. It blocks SERT transporter: that is its main MoA. Its action on D2 receptor is minor, not clinically significant, and may (if at all) contribute to some ADRs.
@@pharmacology.simplified my wife was in depression and anxiety, ans she was prescribed escitalopram , she took it almost two years, but she developed several side effects when the drug was tapered she starts developing parkinson type disease, as the drug was tapered she developed more these sort of symptoms, is her symptoms are drug induced or parkinson disease.plz suggest, her neurologist has started synodopa 110 mg .
Unfortunately I cannot provide medical advice here, but if PD developed after stopping the medicine then the chances that it is DIP is low: usually DIP resolves after withdrawing the offending drug. You must consult your neurologist for best advice and course of action.
She has only problem of freezing or sticking of legs,this kind of symptoms developed while taking the drug, but each step on tapering the drug the symptom intensified, she has no shaking of hands , only legs numbness or senseless while sitting.
You are correct; dopamine depletors such as reserpine and tetrabenazine have a different mechanism of inducing parkinsonism that does not involve D2 receptor blockade, and hence levodopa can be used to manage this, along with replacement of reserpine with a safer alternative. Thank you for pointing this out!
Extremely helpful. Thank you
Nice explanation..Thank you
Thank you doctor, it's an invaluable presentation, I have the DIP. I wish every neurologist, particularly those focused on Parkinsonism should watch it!
Thanks for the video. Very conceptual and informative. Really cleared my doubts on the topic🙏❣️
Are Parkinson's disease and DIP both same?
I was on escitalopram and went from 10mg to 5mg and developed jaw tremor (very minor) and hand tremor. I am now very slowly tapering off the medication. Even though the jaw tremor is not noticiable should I do something about it? It's not going away.
Thank you for the comment. I believe you should consult your physician or neurologist: if the jaw tremor is bothering your daily activities, it is advisable to have it thoroughly investigated. I hope you agree with me that giving medical advise without actual physical examination is not advisable for either of us.
Can escitalopram block the D2 receptors.
Escitalopram is an SSRI: selective serotionin reuptake inhibitor. It blocks SERT transporter: that is its main MoA. Its action on D2 receptor is minor, not clinically significant, and may (if at all) contribute to some ADRs.
@@pharmacology.simplified my wife was in depression and anxiety, ans she was prescribed escitalopram , she took it almost two years, but she developed several side effects when the drug was tapered she starts developing parkinson type disease, as the drug was tapered she developed more these sort of symptoms, is her symptoms are drug induced or parkinson disease.plz suggest, her neurologist has started synodopa 110 mg .
Unfortunately I cannot provide medical advice here, but if PD developed after stopping the medicine then the chances that it is DIP is low: usually DIP resolves after withdrawing the offending drug. You must consult your neurologist for best advice and course of action.
@@pharmacology.simplified ok thank you sir.
She has only problem of freezing or sticking of legs,this kind of symptoms developed while taking the drug, but each step on tapering the drug the symptom intensified, she has no shaking of hands , only legs numbness or senseless while sitting.
But sir reserpine is dopamine depleter so dopamine levels will be decreased , then why cant we use levodopa there?
You are correct; dopamine depletors such as reserpine and tetrabenazine have a different mechanism of inducing parkinsonism that does not involve D2 receptor blockade, and hence levodopa can be used to manage this, along with replacement of reserpine with a safer alternative. Thank you for pointing this out!
@@pharmacology.simplified thank u sir
Can sodium valproate cause drig induced parkinson ?
Parkinsonism is a rare ADR with sodium valproate; check this publication: www.ncbi.nlm.nih.gov/pmc/articles/PMC7381881/